{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:53:16Z","timestamp":1787500396845,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T00:00:00Z","timestamp":1161216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T00:00:00Z","timestamp":1161216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2007,1,1]]},"DOI":"10.1038\/sj.jp.7211612","type":"journal-article","created":{"date-parts":[[2006,10,19]],"date-time":"2006-10-19T08:43:08Z","timestamp":1161247388000},"page":"22-27","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effects of indomethacin tocolysis on the postnatal response of the ductus arteriosus to indomethacin in extremely low birth weight infants"],"prefix":"10.1038","volume":"27","author":[{"given":"L","family":"Cordero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"Nankervis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Giannone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,10,19]]},"reference":[{"key":"BF7211612_CR1","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1038\/sj.jp.7211465","volume":"26","author":"ER Hermes-DeSantis","year":"2006","unstructured":"Hermes-DeSantis ER, Clyman RI . Patent ductus arteriosus: pathophysiology and management. J Perinatol 2006; 26: S14\u2013S18.","journal-title":"J Perinatol"},{"key":"BF7211612_CR2","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0022-3476(96)80123-5","volume":"128","author":"RI Clyman","year":"1996","unstructured":"Clyman RI . Recommendations for the postnatal use of indomethacin: an analysis of four separate treatment strategies. J Pediatr 1996; 128: 601\u2013607.","journal-title":"J Pediatr"},{"key":"BF7211612_CR3","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1542\/peds.2005-1528","volume":"117","author":"J Koch","year":"2006","unstructured":"Koch J, Hensley G, Roy L, Brown S, Ramaciotti C, Rosenfeld CR . Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less. Pediatrics 2006; 117: 1113\u20131121.","journal-title":"Pediatrics"},{"key":"BF7211612_CR4","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1056\/NEJM200106283442602","volume":"344","author":"B Schmidt","year":"2001","unstructured":"Schmidt B, Davis P, Modemann D, Ohlsson A, Roberts RS, Saigal S et al. Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med 2001; 344: 1966\u20131972.","journal-title":"N Engl J Med"},{"key":"BF7211612_CR5","doi-asserted-by":"publisher","first-page":"F464","DOI":"10.1136\/fn.88.6.F464","volume":"88","author":"PW Fowlie","year":"2003","unstructured":"Fowlie PW, Davis PG . Prophylactic indomethacin for preterm infants; a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 2003; 88: F464\u2013F466.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BF7211612_CR6","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1067\/mpd.2000.103414","volume":"136","author":"M Narayanan","year":"2000","unstructured":"Narayanan M, Cooper B, Weiss H, Clyman RI . Prophylactic indomethacin: factors determining permanent ductus arteriosus closure. J Pediatr 2000; 136: 330\u2013337.","journal-title":"J Pediatr"},{"key":"BF7211612_CR7","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1056\/NEJM199311253292202","volume":"329","author":"M Norton","year":"1993","unstructured":"Norton M, Merrill J, Cooper B, Kuller J, Clyman R . Neonatal complications after the administration of indomethacin for preterm labor. N Engl J Med 1993; 329: 1602\u20131607.","journal-title":"N Engl J Med"},{"key":"BF7211612_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1479-828X.1998.tb02949.x","volume":"38","author":"D Souter","year":"1998","unstructured":"Souter D, Harding J, McCowan L, O'Donnell C, McLeay E, Baxendale H . Antenatal indomethacin \u2013 adverse fetal effects confirmed. Aust NZ J Obstet Gynaecol 1998; 38: 11\u201316.","journal-title":"Aust NZ J Obstet Gynaecol"},{"key":"BF7211612_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.102.5.e56","volume":"102","author":"C Hammerman","year":"1998","unstructured":"Hammerman C, Glaser J, Kaplan M, Schimmel M, Ferber B, Eidelman A . Indomethacin tocolysis increases postnatal patent ductus arteriosus severity. Pediatrics 1998; 102: 1\u20134.","journal-title":"Pediatrics"},{"key":"BF7211612_CR10","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1067\/mob.2002.127464","volume":"187","author":"VR Suarez","year":"2002","unstructured":"Suarez VR, Thompson LL, Jain V, Olson GL, Hankins GDV, Belfort MA et al. The effect of in utero exposure to indomethacin on the need for surgical closure of a patent ductus arteriosus in the neonate. Am J Obstet Gynecol 2002; 187: 886\u2013888.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211612_CR11","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1053\/sper.2001.27549","volume":"25","author":"ST Vermillion","year":"2001","unstructured":"Vermillion ST, Landen CN . Prostaglandin inhibitors as tocolytic agents. Semin Perinatol 2001; 25: 256\u2013262.","journal-title":"Semin Perinatol"},{"key":"BF7211612_CR12","first-page":"623","volume-title":"Maternal-Fetal Medicine: Principles and Practice","author":"JD Iams","year":"2004","unstructured":"Iams JD, Creasy RK . Preterm labor and delivery In: Creasy RJ, Resnik R, Iams JD (eds). Maternal-Fetal Medicine: Principles and Practice. 5th edn Saunders: Philadelphia, PA, 2004, p 623\u2013651."},{"key":"BF7211612_CR13","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1097\/01.AOG.0000168622.56478.df","volume":"106","author":"S Loe","year":"2005","unstructured":"Loe S, Sanchez-Ramos L, Kaunitz A . Assessing the neonatal safety of indomethacin tocolysis: a systematic review with meta-analysis. Obstet Gynecol 2005; 106: 173\u2013179.","journal-title":"Obstet Gynecol"},{"key":"BF7211612_CR14","first-page":"500","volume":"82","author":"IB Van Den Veyver","year":"1993","unstructured":"Van Den Veyver IB, Moise KJ, Ou C, Carpenter RJ . The effect of gestational age and fetal indomethacin levels on the incidence of constriction of the fetal ductus arteriosus. Obstet Gynecol 1993; 82: 500\u2013503.","journal-title":"Obstet Gynecol"},{"key":"BF7211612_CR15","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/S0002-9378(97)70184-4","volume":"177","author":"S Vermillion","year":"1997","unstructured":"Vermillion S, Scardo J, Lashus A, Wiles H . The effect of indomethacin tocolysis on fetal ductus arteriosus constriction with advancing gestational age. Am J Obstet Gynecol 1997; 177: 256\u2013261.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211612_CR16","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1067\/S0002-9378(03)00662-8","volume":"189","author":"S Abbasi","year":"2003","unstructured":"Abbasi S, Gerdes JS, Sehdev HM, Samimi SS, Ludmir J . Neonatal outcome after exposure to indomethacin in utero: a retrospective case cohort study. Am J Obstet Gynecol 2003; 189: 782\u2013785.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211612_CR17","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","author":"LA Papile","year":"1978","unstructured":"Papile LA, Burstein J, Burstein R, Koffler H . Incidence and evolution of the subependymal intraventricular hemorrhage: a study of infants with weights less than 1500\u2009g. J Pediatr 1978; 92: 529\u2013534.","journal-title":"J Pediatr"},{"key":"BF7211612_CR18","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1067\/mob.2001.111718","volume":"184","author":"GA Macones","year":"2001","unstructured":"Macones GA, Marder SJ, Clothier B, Stamilio DM . The controversy surrounding indomethacin for tocolysis. Am J Obstet Gynecol 2001; 184: 264\u2013272.","journal-title":"Am J Obstet Gynecol"},{"key":"BF7211612_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s004310050040","volume":"159","author":"R Ojala","year":"2000","unstructured":"Ojala R, Ikonen S, Tammela O . Perinatal indomethacin treatment and neonatal complications in preterm infants. Eur J Pediatr 2000; 159: 153\u2013155.","journal-title":"Eur J Pediatr"},{"key":"BF7211612_CR20","first-page":"903","volume":"41","author":"MO Gardner","year":"1996","unstructured":"Gardner MO, Owen J, Skelly S, Hauth JC . Preterm delivery after indomethacin: a risk factor for neonatal complications? J Reprod Med 1996; 41: 903\u2013906.","journal-title":"J Reprod Med"},{"key":"BF7211612_CR21","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/sj.jp.7211256","volume":"25","author":"NM Doyle","year":"2005","unstructured":"Doyle NM, Gardner MO, Wells L, Qualls C, Papile LA . Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis. J Perinatol 2005; 25: 336\u2013340.","journal-title":"J Perinatol"},{"key":"BF7211612_CR22","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1001\/jama.1996.03540200031027","volume":"276","author":"JE Tyson","year":"1996","unstructured":"Tyson JE, Younes J, Verter J, Wright LL . Viability, morbidity, and resource use among newborns of 501\u2013800\u2009g birth weight. JAMA 1996; 276: 1645\u20131651.","journal-title":"JAMA"},{"key":"BF7211612_CR23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/sj.jp.7211429","volume":"26","author":"JT Attridge","year":"2006","unstructured":"Attridge JT, Clark R, Walker MW, Gordon PV . New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure. J Perinatol 2006; 26: 93\u201399.","journal-title":"J Perinatol"},{"key":"BF7211612_CR24","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1161\/01.CIR.103.13.1806","volume":"103","author":"RI Clyman","year":"2001","unstructured":"Clyman RI, Chen YQ, Chemtob S, Mauray F, Kohl T, Varma DR et al. In utero remodeling of the fetal lamb ductus arteriosus: the role of antenatal indomethacin and a vascular zone thickness on vasa basorum proliferation, neointima formation, and cell death. Circulation 2001; 103: 1806\u20131812.","journal-title":"Circulation"},{"key":"BF7211612_CR25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1203\/00006450-199901000-00005","volume":"45","author":"RI Clyman","year":"1999","unstructured":"Clyman RI, Chan CY, Mauray F, Chen YQ, Cox W, Seidner SR et al. Permanent anatomic closure of the ductus arteriosus in newborn baboons: the roles of postnatal constriction, hypoxia and gestation. Pediatr Res 1999; 45: 19\u201329.","journal-title":"Pediatr Res"},{"key":"BF7211612_CR26","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/S0022-3476(95)70084-6","volume":"127","author":"H Weiss","year":"1995","unstructured":"Weiss H, Cooper B, Brook M, Schlueter M, Clyman R . Factors determining reopening of the ductus arteriosus after successful clinical closure with indomethacin. J Pediatr 1995; 127: 466\u2013471.","journal-title":"J Pediatr"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7211612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211612","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T12:34:06Z","timestamp":1647606846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7211612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,19]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1,1]]}},"alternative-id":["BF7211612"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7211612","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,19]]},"assertion":[{"value":"12 June 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}