{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:14:14Z","timestamp":1769724854479,"version":"3.49.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2007,1,24]],"date-time":"2007-01-24T00:00:00Z","timestamp":1169596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,1,24]],"date-time":"2007-01-24T00:00:00Z","timestamp":1169596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2007,2,1]]},"DOI":"10.1038\/sj.jp.7211653","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T18:35:13Z","timestamp":1170441313000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["D-Penicillamine administration and the incidence of retinopathy of prematurity"],"prefix":"10.1038","volume":"27","author":[{"given":"R D","family":"Christensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S C","family":"Alder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S C","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D K","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Schmutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S E","family":"Wiedmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V L","family":"Baer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J T","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Barraza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,1,24]]},"reference":[{"key":"BF7211653_CR1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/sj.jp.7211440","volume":"26","author":"RD Christensen","year":"2006","unstructured":"Christensen RD, Alder SC, Richards SC, Horn JT, Lambert DK, Baer VL . A pilot trial testing the feasibility of administering D-penicillamine to extremely low birth weight neonates. J Perinatol 2006; 26: 120\u2013124.","journal-title":"J Perinatol"},{"key":"BF7211653_CR2","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1542\/peds.114.2.490","volume":"114","author":"DL Phelps","year":"2004","unstructured":"Phelps DL, ETROP Cooperative Group. The early treatment for retinopathy of prematurity study: better outcomes, changing strategy. Pediatrics 2004; 114: 490\u2013491.","journal-title":"Pediatrics"},{"key":"BF7211653_CR3","doi-asserted-by":"publisher","first-page":"F240","DOI":"10.1136\/adc.2004.057570","volume":"90","author":"L Haines","year":"2005","unstructured":"Haines L, Fielder AR, Baker H, Wilkinson AR . UK population based study of severe retinopathy of prematurity: screening, treatment, and outcome. Arch Dis Child Fetal Neonatal Ed 2005; 90: F240\u2013F244.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BF7211653_CR4","unstructured":"http:\/\/www.nei.nih.gov\/health\/rop\/index.asp."},{"key":"BF7211653_CR5","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1001\/archopht.1996.01100140452016","volume":"114","author":"LP Aiello","year":"1996","unstructured":"Aiello LP . Vascular endothelial growth factor and the eye \u2013 past, present, and future. Arch Ophthalmol 1996; 114: 1252\u20131254.","journal-title":"Arch Ophthalmol"},{"key":"BF7211653_CR6","first-page":"1647","volume":"38","author":"LP Aiello","year":"1997","unstructured":"Aiello LP . Vascular endothelial growth factor. 20th-century mechanisms, 21st-century therapies. Invest Ophthalmol Vis Sci 1997; 38: 1647\u20131652.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF7211653_CR7","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1080\/10715760410001684621","volume":"38","author":"C Polytarchou","year":"2004","unstructured":"Polytarchou C, Papadimitriou E . Antioxidants inhibit angiogenesis in vivo through down-regulation of nitric oxide synthase expression and activity. Free Radic Res 2004; 38: 501\u2013508.","journal-title":"Free Radic Res"},{"key":"BF7211653_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1080\/10623320214733","volume":"9","author":"JS Stone","year":"2002","unstructured":"Stone JS, Collins T . The role of hydrogen peroxide in endothelial proliferative responses. Endothelium 2002; 9: 231\u2013238.","journal-title":"Endothelium"},{"key":"BF7211653_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1023\/B:MCBI.0000044378.09409.b5","volume":"264","author":"M Ushio-Fukai","year":"2004","unstructured":"Ushio-Fukai M, Alexander RW . Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxide. Mol Cell Biochem 2004; 264: 85\u201397.","journal-title":"Mol Cell Biochem"},{"key":"BF7211653_CR10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1399-3011.1993.tb00139.x","volume":"42","author":"JT Hunt","year":"1993","unstructured":"Hunt JT, Lee VG, Liu ECK et al. Control of peptide disulfide regioisomer formation by mixed cysteine-penicillamine bridges. Int J Peptide Protein Res 1993; 42: 249\u2013258.","journal-title":"Int J Peptide Protein Res"},{"key":"BF7211653_CR11","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1172\/JCI113853","volume":"83","author":"T Matsubara","year":"1989","unstructured":"Matsubara T, Saura R, Hirohata K . Inhibition of human endothelial cell proliferation in vitro and neovasularization in vivo by D-penicillamine. J Clin Invest 1989; 83: 158\u2013167.","journal-title":"J Clin Invest"},{"key":"BF7211653_CR12","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1227\/00006123-199508000-00014","volume":"37","author":"D Yoshida","year":"1995","unstructured":"Yoshida D, Ikeda Y, Nakazawa S . Copper chelation inhibits tumor angiogenesis in the experimental 9L gliosarcoma model. Neurosurgery 1995; 37: 287\u2013292.","journal-title":"Neurosurgery"},{"key":"BF7211653_CR13","doi-asserted-by":"publisher","first-page":"7177","DOI":"10.1021\/bi00021a032","volume":"34","author":"D Pietraforte","year":"1995","unstructured":"Pietraforte D, Mallozzi C, Scorza G, Minetti M . Role of thiols in the targeting of S-nitroso thiols to red blood cells. Biochemistry 1995; 34: 7177\u20137185.","journal-title":"Biochemistry"},{"key":"BF7211653_CR14","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1006\/exer.1994.1133","volume":"59","author":"NA McBrien","year":"1994","unstructured":"McBrien NA, Norton TT . Prevention of collagen crosslinking increases form-deprivation myopia in tree shrew. Exp Eye Res 1994; 59: 475\u2013486.","journal-title":"Exp Eye Res"},{"key":"BF7211653_CR15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1006\/bbrc.1996.0730","volume":"222","author":"G Siemeister","year":"1996","unstructured":"Siemeister G, Schnurr B, Mohrs K, Schachtele C, Marme D, Martiny-Baron G . Expression of biologically active isoforms of the tumor angiogenesis factor VEGF in Escherichia coli. Biochem Biophys Res Commun 1996; 222: 249\u2013255.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF7211653_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/BF00442643","volume":"123","author":"L Lakatos","year":"1976","unstructured":"Lakatos L, Kover B, Oroszlan GY, Vekerdy ZS . -Penicillamine therapy in ABO hemolytic disease of the newborn infant. Eur J Pediatr 1976; 123: 133\u2013137.","journal-title":"Eur J Pediatr"},{"key":"BF7211653_CR17","first-page":"47","volume":"27","author":"L Lakatos","year":"1986","unstructured":"Lakatos L, Hatvani I, Oroszlan G, Balla G, Karmazsin L, Alaka O et al. Controlled trial of D-penicillamine to prevent retinopathy of prematurity. Acta Paediatr Hungar 1986; 27: 47\u201356.","journal-title":"Acta Paediatr Hungar"},{"key":"BF7211653_CR18","doi-asserted-by":"crossref","unstructured":"Phelps DL, Lakatos L, Watts JL . -Penicillamine for preventing retinopathy of prematurity in preterm infants. Cochrane Database Syst Rev 2001; (1): CD001073.","DOI":"10.1002\/14651858.CD001073"},{"key":"BF7211653_CR19","unstructured":"Lambert DK, Ercal N, Richards SC, Veng-Peterson P, Horn JT, Richards M et al. Pharmacokinetics of D-penicillamine after enteral administration to preterm neonates. Submitted for publication 2006."},{"key":"BF7211653_CR20","doi-asserted-by":"crossref","unstructured":"An International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity Revisited. Arch Ophthalmol 2005; 123: 991\u2013995.","DOI":"10.1001\/archopht.123.7.991"},{"key":"BF7211653_CR21","doi-asserted-by":"crossref","unstructured":"Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of cryotherapy for retinopathy of prematurity. One-year outcome \u2013 structure and function. Arch Ophthalmol 1990; 108: 1408\u20131416.","DOI":"10.1001\/archopht.1990.01070120056029"},{"key":"BF7211653_CR22","doi-asserted-by":"crossref","unstructured":"Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity \u2013 results of the ETROP randomized trial. Arch Ophthalmol 2003; 121: 1684\u20131696.","DOI":"10.1001\/archopht.121.12.1684"},{"key":"BF7211653_CR23","doi-asserted-by":"publisher","first-page":"e518","DOI":"10.1542\/peds.2004-1180","volume":"115","author":"C Gilbert","year":"2005","unstructured":"Gilbert C, Fielder A, Gordillo L, Guinn G, Semiglia R, Visintin P et al. Characteristics of infants with severe retinopathy of prematurity in countries with low, moderate, and high levels of development: implication for screening programs. Pediatrics 2005; 115: e518\u2013e525.","journal-title":"Pediatrics"},{"key":"BF7211653_CR24","doi-asserted-by":"crossref","unstructured":"Phelps DL, Watts JL . Early light reduction to prevent retinopathy of prematurity in very low birth weight infants In: Cochrane Database Syst Rev. 2001; (1) CD 000122.","DOI":"10.1002\/14651858.CD000122"},{"key":"BF7211653_CR25","doi-asserted-by":"crossref","unstructured":"STOP-ROP Multicenter Trial. Supplemental therapeutic oxygen for prethrehold retinopathy of prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomes. Pediatrics 2000; 105: 295\u2013310.","DOI":"10.1542\/peds.105.2.295"},{"issue":"Suppl 2","key":"BF7211653_CR26","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1038\/sj.jp.7211321","volume":"25","author":"OD Saugstad","year":"2005","unstructured":"Saugstad OD . Oxygen for newborns: how much is too much? J Perinatol 2005; 25 (Suppl 2): S45\u2013S49.","journal-title":"J Perinatol"},{"key":"BF7211653_CR27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3928\/0191-3913-20000301-06","volume":"37","author":"CA Friedman","year":"2000","unstructured":"Friedman CA, McVey J, Borne MJ, James M, May WL, Temple DM et al. Relationship between serum inositol concentration and development of retinopathy of prematurity: a prospective study. J Pediatr Ophthalmol Strabismus 2000; 37: 79\u201386.","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"BF7211653_CR28","doi-asserted-by":"crossref","unstructured":"Howlett A, Ohlsson A . Inositol for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev 2003; (4): CD000366.","DOI":"10.1002\/14651858.CD000366"},{"key":"BF7211653_CR29","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ajo.2006.02.018","volume":"142","author":"JT Flynn","year":"2006","unstructured":"Flynn JT, Chan-Ling T . Retinopathy of prematurity: two distinct mechanisms that underlie zone 1 and zone 2 disease. Am J Ophthalmol 2006; 142: 46\u201359.","journal-title":"Am J Ophthalmol"},{"key":"BF7211653_CR30","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.exer.2004.07.006","volume":"79","author":"XQ Werdich","year":"2004","unstructured":"Werdich XQ, McCollum GW, Rajaratnam VS, Penn JS . Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygen-induced retinopathy. Exp Eye Res 2004; 79: 623\u2013630.","journal-title":"Exp Eye Res"},{"key":"BF7211653_CR31","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.exer.2005.07.005","volume":"82","author":"CA May","year":"2006","unstructured":"May CA, Ohlmann AV, Hammes H, Spandau UH . Proteins with an endostatin-like domain in a mouse model of oxygen-induced retinopathy. Exp Eye Res 2006; 82: 341\u2013348.","journal-title":"Exp Eye Res"},{"key":"BF7211653_CR32","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s10456-004-4184-4","volume":"7","author":"L Jensen","year":"2004","unstructured":"Jensen L, Schjerling P, Hellsten Y . Regulation of VEGF and bFGF mRNA expression and other proliferative compounds in skeletal muscle cells. Angiogenesis 2004; 7: 255\u2013267.","journal-title":"Angiogenesis"},{"key":"BF7211653_CR33","doi-asserted-by":"publisher","first-page":"L209","DOI":"10.1152\/ajplung.00185.2005","volume":"290","author":"NF Voelkel","year":"2006","unstructured":"Voelkel NF, Vandivier RW, Tuder RM . Vascular endothelial growth factor in the lung. Am J Physiol Lung Cell Mol Physiol 2006; 290: L209\u2013221.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BF7211653_CR34","first-page":"580","volume":"15","author":"AA Drosos","year":"1997","unstructured":"Drosos AA, Geogriou P, Politi EN, Voulgori PV . -penicillamine in early rheumatoid arthritis. Clin Exp Rheumatol 1997; 15: 580\u2013581.","journal-title":"Clin Exp Rheumatol"},{"key":"BF7211653_CR35","first-page":"9","volume":"28","author":"S Vekerdy-Lakatos","year":"1987","unstructured":"Vekerdy-Lakatos S, Lakatos L, Oroszlan G, Itzes B . One year longitudinal follow-up of premature infants treated with D-penicillamine in the neonatal period. Acta Paediatr Hung 1987; 28: 9\u201316.","journal-title":"Acta Paediatr Hung"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7211653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211653","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T13:23:24Z","timestamp":1647609804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7211653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,24]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2,1]]}},"alternative-id":["BF7211653"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7211653","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,24]]},"assertion":[{"value":"7 September 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}