{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:50:35Z","timestamp":1763967035823},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T00:00:00Z","timestamp":1176940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T00:00:00Z","timestamp":1176940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1038\/sj.jp.7211690","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T05:38:50Z","timestamp":1176961130000},"page":"347-352","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Inhaled nitric oxide in infants >1500\u2009g and <34 weeks gestation with severe respiratory failure"],"prefix":"10.1038","volume":"27","author":[{"given":"K P Van","family":"Meurs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Hintz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Ehrenkranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Lemons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M B","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W K","family":"Poole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Perritt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R D","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D K","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Preemie Inhaled Nitric Oxide Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"BF7211690_CR1","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1542\/peds.107.1.e1","volume":"107","author":"JA Lemons","year":"2001","unstructured":"Lemons JA, Bauer CR, Oh W, Korones SB, Papile LA, Stoll BJ et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. Pediatrics 2001; 107: E1.","journal-title":"Pediatrics"},{"key":"BF7211690_CR2","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S0146-0005(03)00056-9","volume":"27","author":"EB St. John","year":"2003","unstructured":"St. John EB, Carlo WA . Respiratory distress syndrome in VLBW infants: Changes in management and outcomes observed by the NICHD Neonatal Research Network. Semin Perinatol 2003; 27: 288\u2013292.","journal-title":"Semin Perinatol"},{"key":"BF7211690_CR3","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1056\/NEJM199702273360901","volume":"336","author":"The Neonatal Inhaled Nitric Oxide Study Group","year":"1997","unstructured":"The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997; 336: 597\u2013604.","journal-title":"N Engl J Med"},{"key":"BF7211690_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1056\/NEJM200002173420704","volume":"342","author":"RH Clark","year":"2000","unstructured":"Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. N Engl J Med 2000; 342: 469\u2013474.","journal-title":"N Engl J Med"},{"key":"BF7211690_CR5","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1161\/01.CIR.83.6.2038","volume":"83","author":"C Frostell","year":"1991","unstructured":"Frostell C, Fratacci M-D, Wain JC, Jones R, Zapol WM . Inhaled nitric oxide, a selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 1991; 83: 2038\u20132047.","journal-title":"Circulation"},{"key":"BF7211690_CR6","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1056\/NEJMe058124","volume":"353","author":"RJ Martin","year":"2005","unstructured":"Martin RJ, Walsh MC . Inhaled nitric oxide for preterm infants \u2013 who benefits? N Engl J Med 2005; 353: 82\u201385.","journal-title":"N Engl J Med"},{"key":"BF7211690_CR7","first-page":"L1178","volume":"288","author":"RD Bland","year":"2003","unstructured":"Bland RD, Ling CY, Albertine KH, Carlton DP, MacRitchie AJ, Day RW et al. Pulmonary vascular dysfunction in preterm lambs with chronic lung disease. Am J Physiol Lung Cell Mol Physiol 2003; 288: L1178\u2013L1185.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BF7211690_CR8","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1172\/JCI114081","volume":"83","author":"UC Garg","year":"1989","unstructured":"Garg UC, Hassid A . Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989; 83: 1774\u20131777.","journal-title":"J Clin Invest"},{"key":"BF7211690_CR9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1006\/jsre.1995.1173","volume":"59","author":"KR Thomae","year":"1995","unstructured":"Thomae KR, Nakayama DK, Billiar TR, Simmons RL, Pitt BR, Daies P . The effect of nitric oxide on fetal pulmonary artery smooth muscle growth. J Surg Res 1995; 59: 457\u2013463.","journal-title":"J Surg Res"},{"key":"BF7211690_CR10","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1161\/01.RES.76.2.215","volume":"76","author":"JD Roberts Jr","year":"1995","unstructured":"Roberts Jr JD, Roberts CT, Jones RC, Zapol WM, Bloch KD . Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res 1995; 76: 215\u2013222.","journal-title":"Circ Res"},{"key":"BF7211690_CR11","doi-asserted-by":"publisher","first-page":"L450","DOI":"10.1152\/ajplung.00347.2004","volume":"288","author":"DC McCurnin","year":"2005","unstructured":"McCurnin DC, Pierce RA, Chang LY, Gibson LL, Osborne-Lawrence S, Yoder BA et al. Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol 2005; 288: L450\u2013L459.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BF7211690_CR12","doi-asserted-by":"publisher","first-page":"L910","DOI":"10.1152\/ajplung.1999.277.5.L910","volume":"277","author":"AM Hamad","year":"1999","unstructured":"Hamad AM, Johnson SR, Knox AJ . Antiproliferative effects of NO and ANP in cultured human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 1999; 277: L910\u2013L918.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BF7211690_CR13","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1164\/rccm.200503-384OC","volume":"172","author":"RD Bland","year":"2005","unstructured":"Bland RD, Albertine KH, Carlton DP, MacRitchie AJ . Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs. Am J Respir Crit Care Med 2005; 172: 899\u2013906.","journal-title":"Am J Respir Crit Care Med"},{"key":"BF7211690_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1203\/00006450-199704000-00002","volume":"41","author":"JP Kinsella","year":"1997","unstructured":"Kinsella JP, Parker TA, Galan H, Sheridan BC, Halbower AC, Abman SH . Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res 1997; 41: 457\u2013463.","journal-title":"Pediatr Res"},{"key":"BF7211690_CR15","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1164\/ajrccm.164.10.2101140","volume":"164","author":"AJ Blatt","year":"2001","unstructured":"Blatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM . Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001; 164: 1971\u20131980.","journal-title":"Am J Respir Crit Care Med"},{"key":"BF7211690_CR16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1203\/01.PDR.0000163378.94837.3E","volume":"58","author":"Y-J Lin","year":"2005","unstructured":"Lin Y-J, Markham NE, Balasubramaniam V, Tang J-R, Maxey A, Kinsella JP et al. Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats. Pediatr Res 2005; 58: 22\u201329.","journal-title":"Pediatr Res"},{"key":"BF7211690_CR17","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1203\/00006450-199704000-00002","volume":"41","author":"JP Kinsella","year":"1997","unstructured":"Kinsella JP, Parker TA, Galan H . Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res 1997; 41: 457\u2013463.","journal-title":"Pediatr Res"},{"key":"BF7211690_CR18","doi-asserted-by":"publisher","first-page":"F185","DOI":"10.1136\/fn.77.3.F185","volume":"77","author":"NV Subhedar","year":"1997","unstructured":"Subhedar NV, Ryan SW, Shaw NJ . Open randomized controlled trial of inhaled nitric oxide and early dexamethasone in high risk premature infants. Arch Dis Child 1997; 77: F185\u2013F190.","journal-title":"Arch Dis Child"},{"key":"BF7211690_CR19","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/S0140-6736(99)03558-8","volume":"354","author":"JP Kinsella","year":"1999","unstructured":"Kinsella JP, Walsh WF, Bose CL, Gerstmann DR, Labella JJ, Sardesai S et al. Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomized controlled trial. Lancet 1999; 354: 1061\u20131065.","journal-title":"Lancet"},{"key":"BF7211690_CR20","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/S0140-6736(99)03309-7","volume":"354","author":"The Franco-Belgium Collaborative Trial Group","year":"1999","unstructured":"The Franco-Belgium Collaborative Trial Group. Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomized controlled trial. Lancet 1999; 354: 1066\u20131071.","journal-title":"Lancet"},{"key":"BF7211690_CR21","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.jpeds.2004.10.019","volume":"146","author":"JM Hascoet","year":"2005","unstructured":"Hascoet JM, Fresson J, Claris O, Hamon I, Lombet J, Liska A et al. The safety and efficacy of nitric oxide therapy in premature infants. J Pediatr 2005; 146: 318\u2013323.","journal-title":"J Pediatr"},{"key":"BF7211690_CR22","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1542\/peds.2004-1209","volume":"115","author":"D Field","year":"2005","unstructured":"Field D, Elbourne D, Truesdale A, Grieve R, Hardy P, Fenton AC et al. Neonatal ventilation with inhaled nitric oxide versus ventilatory support without inhaled nitric oxide for preterm infants with severe respiratory failure: the INNOVO multicentre randomized controlled trial. Pediatrics 2005; 115: 926\u2013936.","journal-title":"Pediatrics"},{"key":"BF7211690_CR23","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1056\/NEJMoa031154","volume":"349","author":"MD Schreiber","year":"2003","unstructured":"Schreiber MD, Gin-Mestran K, Marks JD, Huo D, Lee G, Srisuparp P . Inhaled nitric oxide in premature infants with respiratory distress syndrome. N Engl J Med 2003; 349: 2099\u20132107.","journal-title":"N Engl J Med"},{"key":"BF7211690_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa043927","volume":"353","author":"KP Van Meurs","year":"2005","unstructured":"Van Meurs KP, Wright LL, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK et al. Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med 2005; 353: 13\u201322.","journal-title":"N Engl J Med"},{"key":"BF7211690_CR25","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1056\/NEJMoa060442","volume":"355","author":"JP Kinsella","year":"2006","unstructured":"Kinsella JP, Cutter GR, Walsh WF, Gerstmann DR, Bose CL, Hart CL et al. Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med 2006; 355: 354\u2013364.","journal-title":"N Engl J Med"},{"key":"BF7211690_CR26","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1542\/peds.2004-0204","volume":"114","author":"MC Walsh","year":"2004","unstructured":"Walsh MC, Yao Q, Gettner P, Collins M, Hensman A, Everette R et al. Impact of a physiologic definition on bronchopulmonary dysplasia rates. Pediatrics 2004; 114: 1305\u20131311.","journal-title":"Pediatrics"},{"key":"BF7211690_CR27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1542\/peds.113.3.559","volume":"113","author":"GG Konduri","year":"2004","unstructured":"Konduri GG, Solimano A, Sokol GM, Singer J, Ehrenkranz RA, Singhal N et al. Neonatal inhaled nitric oxide study group. A randomized trial of early versus standard inhaled nitric oxide therapy in term and near-term newborn infants with hypoxic respiratory failure. Pediatrics 2004; 113: 559\u2013564.","journal-title":"Pediatrics"},{"key":"BF7211690_CR28","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1093\/aje\/kwh090","volume":"159","author":"G Zou","year":"2004","unstructured":"Zou G . A modified poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004; 159: 702\u2013706.","journal-title":"Am J Epidemiol"},{"key":"BF7211690_CR29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1056\/NEJMoa043514","volume":"353","author":"KK Mestan","year":"2005","unstructured":"Mestan KK, Marks JD, Hecox K, Huo D, Schreiber MD . Neurodevelopmental outcomes of premature infants treated with inhaled nitric oxide. N Engl J Med 2005; 353: 23\u201332.","journal-title":"N Engl J Med"},{"key":"BF7211690_CR30","first-page":"2755","volume":"59","author":"SR Hintz","year":"2006","unstructured":"Hintz SR, Van Meurs KP . Neurodevelopmental outcomes of the NICHD randomized controlled trial of iNO for premature infants with severe respiratory failure. E-PAS 2006; 59: 2755.","journal-title":"E-PAS"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7211690.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211690","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211690.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T12:24:53Z","timestamp":1647606293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7211690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,19]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["BF7211690"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7211690","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"type":"print","value":"0743-8346"},{"type":"electronic","value":"1476-5543"}],"subject":[],"published":{"date-parts":[[2007,4,19]]},"assertion":[{"value":"29 September 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}