{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:47:16Z","timestamp":1790689636024,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:00:00Z","timestamp":1199923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:00:00Z","timestamp":1199923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1038\/sj.jp.7211914","type":"journal-article","created":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T09:30:57Z","timestamp":1199957457000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure"],"prefix":"10.1038","volume":"28","author":[{"given":"J-H","family":"Weitkamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ozdas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"LaFleur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Potts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"BF7211914_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1542\/peds.110.2.285","volume":"110","author":"BJ Stoll","year":"2002","unstructured":"Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002; 110: 285\u2013291.","journal-title":"Pediatrics"},{"key":"BF7211914_CR2","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jpeds.2005.02.021","volume":"147","author":"KN Feja","year":"2005","unstructured":"Feja KN, Wu F, Roberts K, Loughrey M, Nesin M, Larson E et al. Risk factors for candidemia in critically ill infants: a matched case-control study. J Pediatr 2005; 147: 156\u2013161.","journal-title":"J Pediatr"},{"key":"BF7211914_CR3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/00006454-200004000-00011","volume":"19","author":"L Saiman","year":"2000","unstructured":"Saiman L, Ludington E, Pfaller M, Rangel-Frausto S, Wiblin RT, Dawson J et al. Risk factors for candidemia in Neonatal Intensive Care Unit patients. The National Epidemiology of Mycosis Survey Study Group. Pediatr Infect Dis J 2000; 19: 319\u2013324.","journal-title":"Pediatr Infect Dis J"},{"key":"BF7211914_CR4","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1542\/peds.106.4.712","volume":"106","author":"DK Benjamin Jr","year":"2000","unstructured":"Benjamin Jr DK, Ross K, McKinney Jr RE, Benjamin DK, Auten R, Fisher RG . When to suspect fungal infection in neonates: a clinical comparison of Candida albicans and Candida parapsilosis fungemia with coagulase-negative staphylococcal bacteremia. Pediatrics 2000; 106: 712\u2013718.","journal-title":"Pediatrics"},{"key":"BF7211914_CR5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1542\/peds.78.2.225","volume":"78","author":"JE Baley","year":"1986","unstructured":"Baley JE, Kliegman RM, Boxerbaum B, Fanaroff AA . Fungal colonization in the very low birth weight infant. Pediatrics 1986; 78: 225\u2013232.","journal-title":"Pediatrics"},{"key":"BF7211914_CR6","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1097\/00006454-200112000-00005","volume":"20","author":"L Saiman","year":"2001","unstructured":"Saiman L, Ludington E, Dawson JD, Patterson JE, Rangel-Frausto S, Wiblin RT et al. Risk factors for Candida species colonization of neonatal intensive care unit patients. Pediatr Infect Dis J 2001; 20: 1119\u20131124.","journal-title":"Pediatr Infect Dis J"},{"key":"BF7211914_CR7","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1056\/NEJMoa010494","volume":"345","author":"D Kaufman","year":"2001","unstructured":"Kaufman D, Kaufman D, Boyle R, Hazen KC, Patrie JT, Robinson M et al. Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med 2001; 345: 1660\u20131666.","journal-title":"N Engl J Med"},{"key":"BF7211914_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/01.inf.0000253973.89097.c0","volume":"26","author":"PB Smith","year":"2007","unstructured":"Smith PB, Morgan J, Benjamin JD, Fridkin SK, Sanza LT, Harrison LH et al. Excess costs of hospital care associated with neonatal candidemia. Pediatr Infect Dis J 2007; 26: 197\u2013200.","journal-title":"Pediatr Infect Dis J"},{"key":"BF7211914_CR9","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jpeds.2005.03.036","volume":"147","author":"D Kaufman","year":"2005","unstructured":"Kaufman D, Boyle R, Hazen KC, Patrie JT, Robinson M, Grossman LB . Twice weekly fluconazole prophylaxis for prevention of invasive Candida infection in high-risk infants of <1000 grams birth weight. J Pediatr 2005; 147: 172\u2013179.","journal-title":"J Pediatr"},{"key":"BF7211914_CR10","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jpeds.2005.04.016","volume":"147","author":"CM Healy","year":"2005","unstructured":"Healy CM, Baker CJ, Zaccaria E, Campbell JR . Impact of fluconazole prophylaxis on incidence and outcome of invasive candidiasis in a neonatal intensive care unit. J Pediatr 2005; 147: 166\u2013171.","journal-title":"J Pediatr"},{"key":"BF7211914_CR11","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jpeds.2005.02.020","volume":"147","author":"G Bertini","year":"2005","unstructured":"Bertini G, Perugi S, Dani C, Filippi L, Pratesi S, Rubaltelli FF . Fluconazole prophylaxis prevents invasive fungal infection in high-risk, very low birth weight infants. J Pediatr 2005; 147: 162\u2013165.","journal-title":"J Pediatr"},{"key":"BF7211914_CR12","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1542\/peds.2004-2227","volume":"117","author":"P Manzoni","year":"2006","unstructured":"Manzoni P, Arisio R, Mostert M, Leonessa M, Farina D, Latino MA et al. Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study. Pediatrics 2006; 117: e22\u2013e32.","journal-title":"Pediatrics"},{"key":"BF7211914_CR13","doi-asserted-by":"publisher","first-page":"F454","DOI":"10.1136\/adc.2006.094359","volume":"92","author":"BA McCrossan","year":"2007","unstructured":"McCrossan BA, McHenry E, O'Neil F, Ong G, Sweet DG . Selective fluconazole prophylaxis in high risk babies to reduce invasive fungal infection. Arch Dis Child Fetal Neonatal Ed 2007; 92: F454\u2013F458.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BF7211914_CR14","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1542\/peds.2005-1969","volume":"117","author":"S Uko","year":"2006","unstructured":"Uko S, Soghier LM, Vega M, Marsh J, Reinersman GT, Herring L et al. Targeted short-term fluconazole prophylaxis among very low birth weight and extremely low birth weight infants. Pediatrics 2006; 117: 1243\u20131252.","journal-title":"Pediatrics"},{"key":"BF7211914_CR15","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1056\/NEJMoa065733","volume":"356","author":"P Manzoni","year":"2007","unstructured":"Manzoni P, Stolfi I, Pugni L, Decembrino L, Magnani C, Vetrano G et al. A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. N Engl J Med 2007; 356: 2483\u20132495.","journal-title":"N Engl J Med"},{"key":"BF7211914_CR16","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/sj.jp.7211570","volume":"26","author":"ZH Aghai","year":"2006","unstructured":"Aghai ZH, Mudduluru M, Nakhla TA, Amendolia B, Longo D, Kemble N et al. Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis. J Perinatol 2006; 26: 550\u2013555.","journal-title":"J Perinatol"},{"key":"BF7211914_CR17","doi-asserted-by":"crossref","unstructured":"McGuire W, Clerihew L, Austin N . Prophylactic intravenous antifungal agents to prevent mortality and morbidity in very low birth weight infants. Cochrane Database Syst Rev 2004; (1): CD003850.","DOI":"10.1002\/14651858.CD003850.pub2"},{"key":"BF7211914_CR18","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s11096-005-7909-6","volume":"27","author":"JM Martinez Sesmero","year":"2005","unstructured":"Martinez Sesmero JM, Farfan Sedano FJ, Molina Garcia T, Brussi MM, Sanchez-Rubio Ferrandez J, Diez Fernandez R et al. Fungal chemoprophylaxis with fluconazole in preterm infants. Pharm World Sci 2005; 27: 475\u2013477.","journal-title":"Pharm World Sci"},{"key":"BF7211914_CR19","first-page":"919","volume":"14","author":"G Alangaden","year":"1994","unstructured":"Alangaden G, Chandrasekar PH, Bailey E, Khaliq Y . Antifungal prophylaxis with low-dose fluconazole during bone marrow transplantation. The Bone Marrow Transplantation Team. Bone Marrow Transplant 1994; 14: 919\u2013924.","journal-title":"Bone Marrow Transplant"},{"key":"BF7211914_CR20","doi-asserted-by":"crossref","unstructured":"Playford EG, Webster AC, Sorell TC, Craig JC . Antifungal agents for preventing fungal infections in solid organ transplant recipients. Cochrane Database Syst Rev 2004; (3): CD004291.","DOI":"10.1002\/14651858.CD004291.pub2"},{"key":"BF7211914_CR21","doi-asserted-by":"publisher","first-page":"e1019","DOI":"10.1542\/peds.2006-0446","volume":"118","author":"LA Burwell","year":"2006","unstructured":"Burwell LA, Kaufman D, Blakely J, Stoll BJ, Fridkin SK . Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. Pediatrics 2006; 118: e1019\u2013e1026.","journal-title":"Pediatrics"},{"key":"BF7211914_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jpeds.2005.04.033","volume":"147","author":"SS Long","year":"2005","unstructured":"Long SS, Stevenson DK . Reducing Candida infections during neonatal intensive care: management choices, infection control, and fluconazole prophylaxis. J Pediatr 2005; 147: 135\u2013141.","journal-title":"J Pediatr"},{"key":"BF7211914_CR23","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1542\/peds.2005-2183","volume":"117","author":"AA Fanaroff","year":"2006","unstructured":"Fanaroff AA . Fluconazole for the prevention of fungal infections: get ready, get set, caution. Pediatrics 2006; 117: 214\u2013215.","journal-title":"Pediatrics"},{"key":"BF7211914_CR24","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1542\/peds.2005-1996","volume":"117","author":"SK Fridkin","year":"2006","unstructured":"Fridkin SK, Kaufman D, Edwards JR, Shetty S, Horan T . Changing incidence of Candida bloodstream infections among NICU patients in the United States: 1995\u20132004. Pediatrics 2006; 117: 1680\u20131687.","journal-title":"Pediatrics"},{"key":"BF7211914_CR25","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1086\/520194","volume":"29","author":"MS Rangel-Frausto","year":"1999","unstructured":"Rangel-Frausto MS, Wiblin T, Blumberg HM, Saiman L, Patterson J, Rinaldi M et al. National epidemiology of mycoses survey (NEMIS): variations in rates of bloodstream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units. Clin Infect Dis 1999; 29: 253\u2013258.","journal-title":"Clin Infect Dis"},{"key":"BF7211914_CR26","doi-asserted-by":"publisher","first-page":"4555","DOI":"10.1128\/AAC.49.11.4555-4560.2005","volume":"49","author":"MY Lin","year":"2005","unstructured":"Lin MY, Carmeli Y, Zumsteg J, Flores EL, Tolentino J, Sreeramoju P et al. Prior antimicrobial therapy and risk for hospital-acquired Candida glabrata and Candida krusei fungemia: a case-case-control study. Antimicrob Agents Chemother 2005; 49: 4555\u20134560.","journal-title":"Antimicrob Agents Chemother"},{"key":"BF7211914_CR27","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1128\/AAC.43.8.1955","volume":"43","author":"V Novelli","year":"1999","unstructured":"Novelli V, Holzel H . Safety and tolerability of fluconazole in children. Antimicrob Agents Chemother 1999; 43: 1955\u20131960.","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/7211914.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211914","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/7211914.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T16:53:51Z","timestamp":1647622431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/7211914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,10]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["BF7211914"],"URL":"https:\/\/doi.org\/10.1038\/sj.jp.7211914","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,10]]},"assertion":[{"value":"16 July 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}