{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:12:42Z","timestamp":1789578762312,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":3596,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1038\/sj.ki.5000046","type":"journal-article","created":{"date-parts":[[2006,1,4]],"date-time":"2006-01-04T15:50:44Z","timestamp":1136389844000},"page":"679-684","source":"Crossref","is-referenced-by-count":38,"title":["Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects"],"prefix":"10.1016","volume":"69","author":[{"given":"H.","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.D.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.ki.5000046_bb0010","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1681\/ASN.V1092029","article-title":"An indistinct balance: the safety and efficacy of parenteral iron therapy","volume":"10","author":"Besarab","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5000046_bb0015","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1016\/S0272-6386(01)70008-X","article-title":"Clinical Practice Guidelines for Anemia of Chronic Kidney Disease: update 2000","volume":"37","author":"NKF-K\/DOQI","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/sj.ki.5000046_bb0020","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0140-6736(81)92463-6","article-title":"Iron and the sex difference in heart disease risk","volume":"1","author":"Sullivan","year":"1981","journal-title":"Lancet"},{"key":"10.1038\/sj.ki.5000046_bb0025","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1046\/j.1537-2995.2000.40081023.x","article-title":"The iron hypothesis: does iron play a role in atherosclerosis?","volume":"40","author":"Meyers","year":"2000","journal-title":"Transfusion"},{"key":"10.1038\/sj.ki.5000046_bb0030","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.lab.2004.10.006","article-title":"Is stored iron safe?","volume":"144","author":"Sullivan","year":"2004","journal-title":"J Lab Clin Med"},{"issue":"Suppl 2","key":"10.1038\/sj.ki.5000046_bb0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/ndt\/17.suppl_2.25","article-title":"Iron overload and cardiovascular complications in dialysis patients","volume":"17","author":"Kletzmayr","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/sj.ki.5000046_bb0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1056\/NEJM199007053230106","article-title":"Regulatory functions of the vascular endothelium","volume":"323","author":"Vane","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.ki.5000046_bb0045","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jacc.2003.11.017","article-title":"Vascular structure versus function: is endothelial dysfunction of independent prognostic importance or not?","volume":"43","author":"Mancini","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 1","key":"10.1038\/sj.ki.5000046_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2362.2002.0320s1009.x","article-title":"Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo","volume":"32","author":"Rooyakkers","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"10.1038\/sj.ki.5000046_bb0055","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/01.CIR.100.12.1268","article-title":"Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women","volume":"100","author":"Roest","year":"1999","journal-title":"Circulation"},{"key":"10.1038\/sj.ki.5000046_bb0060","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.CIR.100.12.1274","article-title":"Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation: a prospective cohort study in men in eastern Finland","volume":"100","author":"Tuomainen","year":"1999","journal-title":"Circulation"},{"key":"10.1038\/sj.ki.5000046_bb0065","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/01.CIR.98.18.1848","article-title":"Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults","volume":"98","author":"Bellamy","year":"1998","journal-title":"Circulation"},{"key":"10.1038\/sj.ki.5000046_bb0070","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/01.CIR.99.9.1156","article-title":"Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy","volume":"99","author":"Chambers","year":"1999","journal-title":"Circulation"},{"key":"10.1038\/sj.ki.5000046_bb0075","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1161\/01.ATV.0000023187.25914.5B","article-title":"Effect of dexrazoxane on homocysteine-induced endothelial dysfunction in normal subjects","volume":"22","author":"Zheng","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1038\/sj.ki.5000046_bb0080","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1053\/ajkd.2002.36853","article-title":"Iron sucrose: the oldest iron therapy becomes new","volume":"40","author":"Yee","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/sj.ki.5000046_bb0085","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1046\/j.1365-2141.1999.01179.x","article-title":"Pharmacokinetics and red cell utilization of iron(III) hydroxide\u2013sucrose complex in anaemic patients: a study using positron emission tomography","volume":"104","author":"Beshara","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1038\/sj.ki.5000046_bb0090","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1046\/j.1365-2141.1999.01170.x","article-title":"Kinetic analysis of 52Fe-labelled iron(III) hydroxide\u2013sucrose complex following bolus administration using positron emission tomography","volume":"104","author":"Beshara","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1038\/sj.ki.5000046_bb0095","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/ndt\/gfg579","article-title":"Labile iron in parenteral iron formulations: a quantitative and comparative study","volume":"19","author":"Van Wyck","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/sj.ki.5000046_bb0100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1053\/ajkd.2002.33917","article-title":"Parenteral iron formulations: a comparative toxicologic analysis and mechanisms of cell injury","volume":"40","author":"Zager","year":"2002","journal-title":"Am J Kidney Dis"},{"issue":"Suppl 1","key":"10.1038\/sj.ki.5000046_bb0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1046\/j.1365-2362.2002.0320s1042.x","article-title":"Labile iron in parenteral iron formulations and its potential for generating plasma nontransferrin-bound iron in dialysis patients","volume":"32","author":"Esposito","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"10.1038\/sj.ki.5000046_bb0110","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1093\/ndt\/15.11.1827","article-title":"Catalytically active iron and bacterial growth in serum of haemodialysis patients after i.v. iron\u2013saccharate administration","volume":"15","author":"Parkkinen","year":"2000","journal-title":"Nephrol Dial Transplant"},{"issue":"Suppl 1","key":"10.1038\/sj.ki.5000046_bb0115","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1046\/j.1365-2362.2002.0320s1036.x","article-title":"Nontransferrin-bound iron in the plasma of haemodialysis patients after intravenous iron saccharate infusion","volume":"32","author":"Kooistra","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"10.1038\/sj.ki.5000046_bb0120","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1681\/ASN.V113539","article-title":"Vitamin E attenuates oxidative stress induced by intravenous iron in patients on hemodialysis","volume":"11","author":"Roob","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5000046_bb0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/hh1401.093459","article-title":"Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects","volume":"89","author":"Chambers","year":"2001","journal-title":"Circ Res"},{"key":"10.1038\/sj.ki.5000046_bb0130","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/01.CIR.101.5.485","article-title":"Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults","volume":"101","author":"Chao","year":"2000","journal-title":"Circulation"},{"key":"10.1038\/sj.ki.5000046_bb0135","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.100.11.1161","article-title":"Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans","volume":"100","author":"Kanani","year":"1999","journal-title":"Circulation"},{"key":"10.1038\/sj.ki.5000046_bb0140","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0735-1097(00)00790-7","article-title":"Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure","volume":"36","author":"Katz","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/sj.ki.5000046_bb0145","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1172\/JCI8342","article-title":"Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia","volume":"106","author":"Eberhardt","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.ki.5000046_bb0150","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1073\/pnas.0307446101","article-title":"Nitric oxide, oxidants, and protein tyrosine nitration","volume":"101","author":"Radi","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.ki.5000046_bb0155","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1523-1755.2004.00648.x","article-title":"Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease","volume":"65","author":"Agarwal","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000046_bb0160","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/01.RES.85.10.950","article-title":"Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation in vivo","volume":"85","author":"Hazen","year":"1999","journal-title":"Circ Res"},{"key":"10.1038\/sj.ki.5000046_bb0165","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1152\/japplphysiol.00680.2001","article-title":"Biopsy coupled to quantitative immunofluorescence: a new method to study the human vascular endothelium","volume":"92","author":"Colombo","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1038\/sj.ki.5000046_bb0170","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1001\/jama.289.13.1675","article-title":"Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy","volume":"289","author":"Shishehbor","year":"2003","journal-title":"JAMA"},{"key":"10.1038\/sj.ki.5000046_bb0175","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/labinvest.3780275","article-title":"Impaired homocysteine metabolism and atherothrombotic disease","volume":"81","author":"Durand","year":"2001","journal-title":"Lab Invest"},{"key":"10.1038\/sj.ki.5000046_bb0180","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI118776","article-title":"The oxidant stress of hyperhomocyst(e)inemia","volume":"98","author":"Loscalzo","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.ki.5000046_bb0185","doi-asserted-by":"crossref","first-page":"17012","DOI":"10.1074\/jbc.272.27.17012","article-title":"Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase","volume":"272","author":"Upchurch","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.ki.5000046_bb0190","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1001\/jama.281.22.2113","article-title":"Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins","volume":"281","author":"Nappo","year":"1999","journal-title":"JAMA"},{"key":"10.1038\/sj.ki.5000046_bb0195","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.0022-3042.2001.00676.x","article-title":"Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease","volume":"80","author":"Duan","year":"2002","journal-title":"J Neurochem"},{"key":"10.1038\/sj.ki.5000046_bb0200","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1111\/j.1523-1755.2004.00580.x","article-title":"The effects of iron dextran on the oxidative stress in cardiovascular tissues of rats with chronic renal failure","volume":"65","author":"Lim","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000046_bb0205","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1093\/ndt\/14.11.2680","article-title":"Enhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy","volume":"14","author":"Lim","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/sj.ki.5000046_bb0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/00365590310008758","article-title":"The effects of intravenous iron treatment on oxidant stress and erythrocyte deformability in hemodialysis patients","volume":"37","author":"Cavdar","year":"2003","journal-title":"Scand J Urol Nephrol"},{"key":"10.1038\/sj.ki.5000046_bb0215","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/01.ATV.20.6.1430","article-title":"Interactions of oxidants with vascular signaling systems","volume":"20","author":"Wolin","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1038\/sj.ki.5000046_bb0220","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1084\/jem.180.3.969","article-title":"Iron regulates nitric oxide synthase activity by controlling nuclear transcription","volume":"180","author":"Weiss","year":"1994","journal-title":"J Exp Med"},{"key":"10.1038\/sj.ki.5000046_bb0225","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1046\/j.1523-1755.1999.055Suppl.69002.x","article-title":"Cellular iron metabolism","volume":"69","author":"Ponka","year":"1999","journal-title":"Kidney Int Suppl"},{"key":"10.1038\/sj.ki.5000046_bb0230","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/ndt\/13.7.1782","article-title":"Endothelium-dependent vasodilatation is impaired in peritoneal dialysis patients","volume":"13","author":"van Guldener","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/sj.ki.5000046_bb0235","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/heart.83.2.205","article-title":"Abnormalities of endothelial function in patients with predialysis renal failure","volume":"83","author":"Thambyrajah","year":"2000","journal-title":"Heart"},{"key":"10.1038\/sj.ki.5000046_bb0240","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/hy0102.100540","article-title":"Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency","volume":"39","author":"Vaziri","year":"2002","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000046_bb0245","first-page":"336","article-title":"Oxidative stress and chronic renal failure: markers and management","volume":"15","author":"Massy","year":"2002","journal-title":"J Nephrol"},{"key":"10.1038\/sj.ki.5000046_bb0250","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000441-200304000-00002","article-title":"Cardiovascular mortality in end-stage renal disease","volume":"325","author":"Collins","year":"2003","journal-title":"Am J Med Sci"},{"key":"10.1038\/sj.ki.5000046_bb0255","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1053\/ajkd.2001.28587","article-title":"Intravenous iron sucrose: establishing a safe dose","volume":"38","author":"Chandler","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/sj.ki.5000046_bb0260","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJM199808273390903","article-title":"The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin","volume":"339","author":"Besarab","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.ki.5000046_bb0265","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/ndt\/18.2.353","article-title":"A randomized controlled trial of haemoglobin normalization with epoetin alfa in pre-dialysis and dialysis patients","volume":"18","author":"Furuland","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/sj.ki.5000046_bb0270","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1097\/01.ASN.0000128009.69594.BE","article-title":"Administration of parenteral iron and mortality among hemodialysis patients","volume":"15","author":"Feldman","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5000046_bb0275","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"Corretti","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/sj.ki.5000046_bb0280","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0361-090X(03)00027-8","article-title":"Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women","volume":"27","author":"Ali","year":"2003","journal-title":"Cancer Detect Prev"},{"key":"10.1038\/sj.ki.5000046_bb0285","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/A:1020642808437","article-title":"Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids","volume":"16","author":"Ali","year":"2003","journal-title":"Biometals"},{"key":"10.1038\/sj.ki.5000046_bb0290","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1006\/abbi.1997.9892","article-title":"Induction of ferritin synthesis in human lung epithelial cells treated with crocidolite asbestos","volume":"340","author":"Fang","year":"1997","journal-title":"Arch Biochem Biophys"},{"key":"10.1038\/sj.ki.5000046_bb0295","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/abio.1999.4216","article-title":"Quantification of non-transferrin-bound iron in the presence of unsaturated transferrin","volume":"273","author":"Gosriwatana","year":"1999","journal-title":"Anal Biochem"},{"key":"10.1038\/sj.ki.5000046_bb0300","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0378-4347(91)80407-4","article-title":"Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum","volume":"565","author":"Ubbink","year":"1991","journal-title":"J Chromatogr"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815515330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815515330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T09:54:58Z","timestamp":1626861298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815515330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0085253815515330"],"URL":"https:\/\/doi.org\/10.1038\/sj.ki.5000046","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}