{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:45:27Z","timestamp":1789872327243,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":3568,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1038\/sj.ki.5000163","type":"journal-article","created":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T14:31:03Z","timestamp":1138199463000},"page":"823-831","source":"Crossref","is-referenced-by-count":98,"title":["Morphometric evidence for impairment of renal autoregulation in advanced essential hypertension"],"prefix":"10.1016","volume":"69","author":[{"given":"G.S.","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Heudes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Jacquot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bari\u00e9ty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.ki.5000163_bb0010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11906-004-0091-8","article-title":"Hypertensive renal damage: insights from animal models and clinical relevance","volume":"6","author":"Griffin","year":"2004","journal-title":"Curr Hypertens Rep"},{"key":"10.1038\/sj.ki.5000163_bb0015","first-page":"F1003","article-title":"Renal autoregulation and vulnerability to hypertensive injury in remnant kidney","volume":"252","author":"Bidani","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1038\/sj.ki.5000163_bb0020","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1681\/ASN.V2111578","article-title":"Impaired myogenic responsiveness of the afferent arteriole in streptozotocin-induced diabetic rats: role of eicosanoid derangements","volume":"2","author":"Hayashi","year":"1992","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5000163_bb0025","first-page":"608","article-title":"Chloride alters renal blood flow autoregulation in deoxycorticosterone-treated rats","volume":"121","author":"Imig","year":"1993","journal-title":"J Lab Clin Med"},{"key":"10.1038\/sj.ki.5000163_bb0030","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0002-9629(15)33943-4","article-title":"Disturbances in renal autoregulation and the susceptibility to hypertension-induced chronic kidney disease","volume":"328","author":"Palmer","year":"2004","journal-title":"Am J Med Sci"},{"key":"10.1038\/sj.ki.5000163_bb0035","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1046\/j.1523-1755.1999.00676.x","article-title":"Impaired autoregulation of the glomerular filtration rate in patients with nondiabetic nephropathies","volume":"56","author":"Christensen","year":"1999","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000163_bb0040","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/ki.1997.463","article-title":"Impaired autoregulation of GFR in hypertensive non-insulin dependent diabetic patients","volume":"52","author":"Christensen","year":"1997","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000163_bb0045","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF01605783","article-title":"Morphometric analysis of arteriolar diameters in experimental nephropathies: application of microvascular casts","volume":"417","author":"Kimura","year":"1990","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"10.1038\/sj.ki.5000163_bb0050","first-page":"273","article-title":"Morphometric analysis of renal arterioles in subtotally nephrectomized rats","volume":"122","author":"Kimura","year":"1993","journal-title":"J Lab Clin Med"},{"key":"10.1038\/sj.ki.5000163_bb0055","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1172\/JCI112377","article-title":"Glomerular injury in uninephrectomized spontaneously hypertensive rats. A consequence of glomerular capillary hypertension","volume":"77","author":"Dworkin","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.ki.5000163_bb0060","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ki.1989.35","article-title":"Glomerular hemodynamic changes vs hypertrophy in experimental glomerular sclerosis","volume":"35","author":"Yoshida","year":"1989","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000163_bb0065","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1046\/j.1523-1755.2003.00831.x","article-title":"Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation","volume":"63","author":"Hill","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000163_bb0070","first-page":"271","article-title":"Clinical features of benign hypertensive nephrosclerosis at time of renal biopsy","volume":"86","author":"Innes","year":"1993","journal-title":"Q J Med"},{"key":"10.1038\/sj.ki.5000163_bb0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000166931","article-title":"Marked proteinuria in hypertensive nephrosclerosis","volume":"5","author":"Mujais","year":"1985","journal-title":"Am J Nephrol"},{"key":"10.1038\/sj.ki.5000163_bb0080","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1523-1755.2002.00420.x","article-title":"Hypertensive nephrosclerosis in African Americans versus Caucasians","volume":"62","author":"Marcantoni","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000163_bb0085","first-page":"275","article-title":"Quantitative ultrastructural study of afferent and efferent arterioles in IgA glomerulonephritis and benign nephrosclerosis","volume":"429","author":"Razga","year":"1996","journal-title":"Virchows Arch"},{"key":"10.1038\/sj.ki.5000163_bb0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJMoa020549","article-title":"Nephron number in patients with primary hypertension","volume":"348","author":"Keller","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.ki.5000163_bb0095","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJMoa020549","article-title":"Nephron number in patients with primary hypertension","volume":"348","author":"Keller","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.ki.5000163_bb0100","first-page":"1","article-title":"Steroid-induced hypertension in the rat. A microangiographic and histologic study on the pathogenesis of hypertensive vascular and glomerular lesions","volume":"52","author":"Hill","year":"1968","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.ki.5000163_bb0105","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1523-1755.2004.00356.x","article-title":"Blood pressure lability and glomerulosclerosis after normotensive 5\/6 renal mass reduction in the rat","volume":"65","author":"Griffin","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000163_bb0110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.HYP.24.3.309","article-title":"Renal ablation acutely transforms \u2018benign\u2019 hypertension to \u2018malignant\u2019 nephrosclerosis in hypertensive rats","volume":"24","author":"Bidani","year":"1994","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0115","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1046\/j.1523-1755.1999.00434.x","article-title":"Class differences in the effects of calcium channel blockers in the rat remnant kidney model","volume":"55","author":"Griffin","year":"1999","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000163_bb0120","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1172\/JCI118125","article-title":"Deleterious effects of calcium channel blockade on pressure transmission and glomerular injury in rat remnant kidneys","volume":"96","author":"Griffin","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.ki.5000163_bb0125","first-page":"R855","article-title":"Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat","volume":"276","author":"van Dokkum","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1038\/sj.ki.5000163_bb0130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/hy1201.096817","article-title":"Reduced reactivity of renal microvessels to pressure and angiotensin II in fawn-hooded rats","volume":"39","author":"van Rodijnen","year":"2002","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0135","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/01.RES.71.2.471","article-title":"Impaired myogenic responsiveness of renal microvessels in Dahl salt-sensitive rats","volume":"71","author":"Takenaka","year":"1992","journal-title":"Circ Res"},{"key":"10.1038\/sj.ki.5000163_bb0140","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1161\/01.HYP.30.4.975","article-title":"Dynamic autoregulation and renal injury in Dahl rats","volume":"30","author":"Karlsen","year":"1997","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2337\/diacare.26.1.156","article-title":"Autoregulation of glomerular filtration rate in patients with type 2 diabetes during isradipine therapy","volume":"26","author":"Christensen","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1038\/sj.ki.5000163_bb0150","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1046\/j.1523-1755.2001.00946.x","article-title":"Autoregulated glomerular filtration rate during candesartan treatment in hypertensive type 2 diabetic patients","volume":"60","author":"Christensen","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000163_bb0155","doi-asserted-by":"crossref","first-page":"II279","DOI":"10.1161\/01.HYP.19.2_Suppl.II279","article-title":"Severe hypertension induces disturbances of renal autoregulation","volume":"19","author":"Almeida","year":"1992","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0160","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/01.HYP.35.3.822","article-title":"Glomerular hyperfiltration in hypertensive African Americans. Changes in renal autacoids in aged human hypertensives","volume":"35","author":"Kotchen","year":"2000","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0165","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/01.HYP.35.3.822","article-title":"Glomerular hyperfiltration in hypertensive African Americans. Changes in renal autacoids in aged human hypertensives","volume":"35","author":"Kotchen","year":"2000","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0170","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1161\/01.HYP.24.6.752","article-title":"Renal hemodynamics in essential hypertension. Racial differences in response to changes in dietary sodium","volume":"24","author":"Parmer","year":"1994","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0175","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1081\/CEH-200031985","article-title":"Microalbuminuria","volume":"26","author":"Segura","year":"2004","journal-title":"Clin Exp Hypertens"},{"key":"10.1038\/sj.ki.5000163_bb0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/01.HYP.0000169153.78459.50","article-title":"New definition of microalbuminuria in hypertensive subjects: association with incident coronary heart disease and death","volume":"46","author":"Klausen","year":"2005","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0185","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/00000441-200106000-00005","article-title":"Impaired renal autoregulation: implications for the genesis of hypertension and hypertension-induced renal injury","volume":"321","author":"Palmer","year":"2001","journal-title":"Am J Med Sci"},{"key":"10.1038\/sj.ki.5000163_bb0190","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/01.HYP.35.3.822","article-title":"Glomerular hyperfiltration in hypertensive African Americans. Changes in renal autacoids in aged human hypertensives","volume":"35","author":"Kotchen","year":"2000","journal-title":"Hypertension"},{"key":"10.1038\/sj.ki.5000163_bb0195","first-page":"126","article-title":"Renovasculopathies of hypertension and the rise of blood pressure with age in blacks and whites","volume":"16","author":"Tracy","year":"1996","journal-title":"Semin Nephrol"},{"key":"10.1038\/sj.ki.5000163_bb0200","first-page":"602","article-title":"Blood pressure and nephrosclerosis in black and white men and women aged 25\u201354","volume":"4","author":"Tracy","year":"1991","journal-title":"Mod Pathol"},{"key":"10.1038\/sj.ki.5000163_bb0205","first-page":"R1038","article-title":"Effect of chronic ANG I-converting enzyme inhibition on aging processes. I. Kidney structure and function","volume":"266","author":"Heudes","year":"1994","journal-title":"Am J Physiol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381551569X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381551569X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T09:35:35Z","timestamp":1626860135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525381551569X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S008525381551569X"],"URL":"https:\/\/doi.org\/10.1038\/sj.ki.5000163","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}