{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:42:27Z","timestamp":1790649747348,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":3507,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1038\/sj.ki.5000309","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T12:14:55Z","timestamp":1142424895000},"page":"1558-1563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Transcriptome analysis of a rat PKD model: Importance of genes involved in extracellular matrix metabolism"],"prefix":"10.1016","volume":"69","author":[{"given":"M.","family":"Riera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Burtey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Font\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.ki.5000309_bb0010","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1097\/01.ASN.0000028643.17901.42","article-title":"Genetics and pathogenesis of polycystic kidney disease","volume":"13","author":"Igarashi","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5000309_bb0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ygeno.2004.03.009","article-title":"New insights into ADPKD molecular pathways using combination of SAGE and microarray technologies","volume":"84","author":"Husson","year":"2004","journal-title":"Genomics"},{"key":"10.1038\/sj.ki.5000309_bb0020","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1101\/gr.2596504","article-title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)","volume":"14","author":"Gerhard","year":"2004","journal-title":"Genome Res"},{"key":"10.1038\/sj.ki.5000309_bb0025","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/35057157","article-title":"A physical map of the human genome","volume":"409","author":"McPherson","year":"2001","journal-title":"Nature"},{"key":"10.1038\/sj.ki.5000309_bb0030","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/ki.1993.79","article-title":"Autosomal-dominant polycystic kidney disease in the rat","volume":"43","author":"Cowley","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0035","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ki.1994.253","article-title":"Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease","volume":"46","author":"Schafer","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0040","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/hmg\/6.4.609","article-title":"Location of the first genetic locus, PKDr1, controlling autosomal dominant polycystic kidney disease in Han:SPRD cy\/+ rat","volume":"6","author":"Bihoreau","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1038\/sj.ki.5000309_bb0045","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1096\/fj.02-0460fje","article-title":"Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease","volume":"17","author":"Aukema","year":"2003","journal-title":"FASEB J"},{"key":"10.1038\/sj.ki.5000309_bb0050","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1046\/j.1523-1755.2002.00250.x","article-title":"Caspases, Bcl-2 proteins and apoptosis in autosomal-dominant polycystic kidney disease","volume":"61","author":"Ecder","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0055","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1523-1755.2003.00755.x","article-title":"Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease","volume":"63","author":"Nagao","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0060","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1046\/j.1523-1755.2003.00256.x","article-title":"EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats","volume":"64","author":"Torres","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0065","doi-asserted-by":"crossref","first-page":"C487","DOI":"10.1152\/ajpcell.1995.269.2.C487","article-title":"Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD","volume":"269","author":"Du","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1038\/sj.ki.5000309_bb0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0272-6386(12)70198-1","article-title":"Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcinoma","volume":"19","author":"Klingel","year":"1992","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/sj.ki.5000309_bb0075","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1172\/JCI2071","article-title":"Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease","volume":"101","author":"Richards","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.ki.5000309_bb0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ki.1993.17","article-title":"Polycystic kidney disease: primary extracellular matrix abnormality or defective cellular differentiation?","volume":"43","author":"Calvet","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0085","first-page":"437","article-title":"Biology of polycystic kidney disease","volume":"70","author":"Carone","year":"1994","journal-title":"Lab Invest"},{"key":"10.1038\/sj.ki.5000309_bb0090","doi-asserted-by":"crossref","first-page":"F540","DOI":"10.1152\/ajprenal.2001.280.3.F540","article-title":"A possible role for metalloproteinases in renal cyst development","volume":"280","author":"Obermuller","year":"2001","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/sj.ki.5000309_bb0095","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM199411103311907","article-title":"Transforming growth factor beta in tissue fibrosis","volume":"331","author":"Border","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.ki.5000309_bb0100","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1046\/j.1523-1755.2001.00723.x","article-title":"Cell surface heparan sulfate proteoglycans control the response of renal interstitial fibroblasts to fibroblast growth factor-2","volume":"59","author":"Clayton","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1681\/ASN.2004040339","article-title":"Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis","volume":"16","author":"Okada","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5000309_bb0110","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ydbio.2004.04.029","article-title":"Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney","volume":"272","author":"Steer","year":"2004","journal-title":"Dev Biol"},{"key":"10.1038\/sj.ki.5000309_bb0115","first-page":"1729","article-title":"Biochemical and immunohistochemical characterization of human type XIX defines a novel class of basement membrane zone collagens","volume":"151","author":"Myers","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.ki.5000309_bb0120","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1111\/j.1523-1755.2004.00900.x","article-title":"TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells","volume":"66","author":"Nee","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0125","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ki.1996.332","article-title":"Alterations of cathepsins B, H and L in proximal tubules from polycystic kidneys of the Han:SPRD rat","volume":"50","author":"Schaefer","year":"1996","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0130","doi-asserted-by":"crossref","first-page":"47929","DOI":"10.1074\/jbc.M400129200","article-title":"Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival","volume":"279","author":"Schafer","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.ki.5000309_bb0135","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1523-1755.2004.00897.x","article-title":"Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation","volume":"66","author":"Ye","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5000309_bb0140","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s004670000530","article-title":"Glypicans and the biology of renal malformations","volume":"16","author":"Grisaru","year":"2001","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/sj.ki.5000309_bb0145","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1242\/dev.01089","article-title":"Branching morphogenesis and kidney disease","volume":"131","author":"Shah","year":"2004","journal-title":"Development"},{"key":"10.1038\/sj.ki.5000309_bb0150","first-page":"S93","article-title":"Mechanisms of progression in autosomal dominant polycystic kidney disease","volume":"63","author":"Grantham","year":"1997","journal-title":"Kidney Int Suppl"},{"key":"10.1038\/sj.ki.5000309_bb0155","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/S0002-9440(10)63254-3","article-title":"Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway","volume":"165","author":"Zhou","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.ki.5000309_bb0160","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1681\/ASN.V96937","article-title":"Increased epithelial cell proliferation and abnormal extracellular matrix in rat polycystic kidney disease","volume":"9","author":"Ramasubbu","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5000309_bb0165","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1096\/fasebj.13.13.1774","article-title":"Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP","volume":"13","author":"Duncan","year":"1999","journal-title":"FASEB J"},{"key":"10.1038\/sj.ki.5000309_bb0170","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1018742807031","article-title":"Closely linked polymorphic markers for determining the autosomal dominant allele (Cy) in rat polycystic kidney disease","volume":"37","author":"Nagao","year":"1999","journal-title":"Biochem Genet"},{"key":"10.1038\/sj.ki.5000309_bb0175","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/01.TP.0000081398.65568.1B","article-title":"Microarray-based gene expression profiles of allograft rejection and immunosuppression in the rat heart transplantation model","volume":"76","author":"Erickson","year":"2003","journal-title":"Transplantation"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381551716X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381551716X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:48:24Z","timestamp":1758761304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525381551716X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S008525381551716X"],"URL":"https:\/\/doi.org\/10.1038\/sj.ki.5000309","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome analysis of a rat PKD model: Importance of genes involved in extracellular matrix metabolism","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/sj.ki.5000309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}