{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:26:44Z","timestamp":1790364404053,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":3203,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1038\/sj.ki.5002104","type":"journal-article","created":{"date-parts":[[2007,1,24]],"date-time":"2007-01-24T05:44:49Z","timestamp":1169617489000},"page":"539-547","source":"Crossref","is-referenced-by-count":92,"title":["Downregulation of organic anion transporters in rat kidney under ischemia\/reperfusion-induced qacute renal failure"],"prefix":"10.1016","volume":"71","author":[{"given":"T.","family":"Matsuzaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yoshitome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Morisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nonoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kohda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.ki.5002104_bb0010","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1046\/j.1523-1755.2000.00251.x","article-title":"Cellular and molecular aspects of drug transport in the kidney","volume":"58","author":"Inui","year":"2000","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5002104_bb0015","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/ki.1996.240","article-title":"Renal secretion of organic anions and cations","volume":"49","author":"Pritchard","year":"1996","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5002104_bb0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-4157(94)90018-3","article-title":"Specificity of transporters for \u2018organic anions\u2019 and \u2018organic cations\u2019 in the kidney","volume":"1197","author":"Ullrich","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/sj.ki.5002104_bb0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s004240000297","article-title":"The multispecific organic anion transporter (OAT) family","volume":"440","author":"Sekine","year":"2000","journal-title":"Pflugers Arch"},{"key":"10.1038\/sj.ki.5002104_bb0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF02738157","article-title":"The molecular biology of renal organic anion and organic cation transporters","volume":"31","author":"Sweet","year":"1999","journal-title":"Cell Biochem Biophys"},{"key":"10.1038\/sj.ki.5002104_bb0035","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1124\/pr.55.3.1","article-title":"Impact of drug transporter studies on drug discovery and development","volume":"55","author":"Mizuno","year":"2003","journal-title":"Pharmacol Rev"},{"key":"10.1038\/sj.ki.5002104_bb0040","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI200422353","article-title":"Acute renal failure: definitions diagnosis pathogenesis and therapy","volume":"114","author":"Schrier","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.ki.5002104_bb0045","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1046\/j.1523-1755.1998.00210.x","article-title":"Treatment of acute renal failure","volume":"54","author":"Star","year":"1998","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5002104_bb0050","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJM199605303342207","article-title":"Acute renal failure","volume":"334","author":"Thadhani","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.ki.5002104_bb0055","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1097\/01.ASN.0000079785.13922.F6","article-title":"Recent advances in the pathophysiology of ischemic acute renal failure","volume":"14","author":"Bonventre","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5002104_bb0060","first-page":"462","article-title":"Topography of focal proximal tubular necrosis after ischemia with reflow in the rat kidney","volume":"122","author":"Shanley","year":"1986","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.ki.5002104_bb0065","first-page":"F623","article-title":"Acute renal failure. I. Relative importance of proximal vs. distal tubular injury","volume":"275","author":"Lieberthal","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1038\/sj.ki.5002104_bb0070","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1097\/01.ASN.0000074239.22357.06","article-title":"Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats","volume":"14","author":"Matsumoto","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5002104_bb0075","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.ki.5002104_bb0080","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1097\/01.ASN.0000092792.97122.E0","article-title":"HIF-1: an oxygen response system with special relevance to the kidney","volume":"14","author":"Maxwell","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5002104_bb0085","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/gad.12.2.149","article-title":"Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha","volume":"12","author":"Iyer","year":"1998","journal-title":"Genes Dev"},{"key":"10.1038\/sj.ki.5002104_bb0090","first-page":"3387","article-title":"Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene","volume":"62","author":"Comerford","year":"2002","journal-title":"Cancer Res"},{"issue":"Suppl 62","key":"10.1038\/sj.ki.5002104_bb0095","first-page":"S23","article-title":"The protein metabolite hypothesis, a model for the progression of renal failure: an oral adsorbent lowers indoxyl sulfate levels in undialyzed uremic patients","volume":"52","author":"Niwa","year":"1997","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5002104_bb0100","first-page":"96","article-title":"Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis","volume":"124","author":"Niwa","year":"1994","journal-title":"J Lab Clin Med"},{"key":"10.1038\/sj.ki.5002104_bb0105","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1097\/01.ASN.0000022017.96399.B2","article-title":"Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity","volume":"13","author":"Enomoto","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/sj.ki.5002104_bb0110","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1046\/j.1523-1755.2002.00318.x","article-title":"Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney","volume":"61","author":"Deguchi","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5002104_bb0115","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1053\/ajkd.2003.50075","article-title":"Effects of oral adsorbent on gene expression profile in uremic rat kidney: cDNA array analysis","volume":"41","author":"Aoyama","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/sj.ki.5002104_bb0120","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1124\/jpet.105.085613","article-title":"Renal clearance of endogenous hippurate correlates with expression levels of renal organic anion transporters in uremic rats","volume":"314","author":"Deguchi","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/sj.ki.5002104_bb0125","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1023\/B:PHAM.0000012153.71993.cb","article-title":"Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases","volume":"21","author":"Sakurai","year":"2004","journal-title":"Pharm Res"},{"key":"10.1038\/sj.ki.5002104_bb0130","doi-asserted-by":"crossref","first-page":"F925","DOI":"10.1152\/ajprenal.2000.278.6.F925","article-title":"Decreased abundance of major Na(+) transporters in kidneys of rats with ischemia-induced acute renal failure","volume":"278","author":"Kwon","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/sj.ki.5002104_bb0135","first-page":"F75","article-title":"Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia","volume":"267","author":"Van Why","year":"1994","journal-title":"Am J Physiol"},{"issue":"Suppl 2","key":"10.1038\/sj.ki.5002104_bb0140","first-page":"S142","article-title":"Pathophysiology of acute renal failure","volume":"12","author":"Kribben","year":"1999","journal-title":"J Nephrol"},{"key":"10.1038\/sj.ki.5002104_bb0145","first-page":"F488","article-title":"Cytoskeleton disruption and apical redistribution of proximal tubule Na(+)-K(+)-ATPase during ischemia","volume":"263","author":"Molitoris","year":"1992","journal-title":"Am J Physiol"},{"issue":"Suppl 62","key":"10.1038\/sj.ki.5002104_bb0150","first-page":"S15","article-title":"Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys","volume":"52","author":"Miyazaki","year":"1997","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5002104_bb0155","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1093\/ndt\/15.11.1773","article-title":"An oral sorbent reduces overload of indoxyl sulphate and gene expression of TGF-beta1 in uraemic rat kidneys","volume":"15","author":"Miyazaki","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/sj.ki.5002104_bb0160","first-page":"786","article-title":"Mechanism of stereoselective serum binding of ketoprofen after hemodialysis","volume":"278","author":"Sakai","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/sj.ki.5002104_bb0165","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1523-1755.2004.00354.x","article-title":"Characterization of uremic toxin transport by organic anion transporters in the kidney","volume":"65","author":"Deguchi","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/sj.ki.5002104_bb0170","doi-asserted-by":"crossref","first-page":"30088","DOI":"10.1074\/jbc.272.48.30088","article-title":"Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney","volume":"272","author":"Sweet","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.ki.5002104_bb0175","doi-asserted-by":"crossref","first-page":"F763","DOI":"10.1152\/ajprenal.00405.2002","article-title":"Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient","volume":"284","author":"Sweet","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/sj.ki.5002104_bb0180","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.taap.2004.10.016","article-title":"Organic anion transporter (Slc22a) family members as mediators of toxicity","volume":"204","author":"Sweet","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1038\/sj.ki.5002104_bb0185","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0014-2999(00)00699-3","article-title":"Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure","volume":"406","author":"Huang","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/sj.ki.5002104_bb0190","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0006-2952(03)00466-0","article-title":"Decreased activity of basolateral organic ion transports, in hyperuricemic rat kidney: roles of organic ion transporters rOAT1, rOAT3 and rOCT2","volume":"66","author":"Habu","year":"2003","journal-title":"Biochem Pharmacol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815524150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815524150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T15:37:38Z","timestamp":1656171458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815524150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0085253815524150"],"URL":"https:\/\/doi.org\/10.1038\/sj.ki.5002104","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}