{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:24:01Z","timestamp":1790637841841,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2000,7,1]]},"DOI":"10.1038\/sj.leu.2401765","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T18:36:05Z","timestamp":1031164565000},"page":"1208-1214","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["T cell receptor gamma (TCRG) gene rearrangements in T cell acute lymphoblastic leukemia reflect \u2018end-stage\u2019 recombinations: implications for minimal residual disease monitoring"],"prefix":"10.1038","volume":"14","author":[{"given":"T","family":"Szczepa\u0144ski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AW","family":"Langerak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJ","family":"Willemse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ILM","family":"Wolvers-Tettero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ER","family":"van Wering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJM","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2000,7,17]]},"reference":[{"key":"BF2401765_CR1","first-page":"1015","volume":"5","author":"CA Felix","year":"1991","unstructured":"Felix CA, Poplack DG . Characterization of acute lymphoblastic leukemia of childhood by immunoglobulin and T-cell receptor gene patterns Leukemia 1991 5: 1015\u20131025","journal-title":"Leukemia"},{"key":"BF2401765_CR2","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/sj.leu.2401277","volume":"13","author":"T Szczepanski","year":"1999","unstructured":"Szczepanski T, Beishuizen A, Pongers-Willemse MJ, H\u00e4hlen K, van Wering ER, Wijkhuijs JM, Tibbe GJM, De Bruijn MAC, van Dongen JJM . Cross-lineage T-cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B-acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease Leukemia 1999 13: 196\u2013205","journal-title":"Leukemia"},{"key":"BF2401765_CR3","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1182\/blood.V90.3.1226","volume":"90","author":"SP Dibenedetto","year":"1997","unstructured":"Dibenedetto SP, Lo Nigro L, Mayer SP, Rovera G, Schiliro G . Detectable molecular residual disease at the beginning of maintenance therapy indicates poor outcome in children with T-cell acute lymphoblastic leukemia Blood 1997 90: 1226\u20131232","journal-title":"Blood"},{"key":"BF2401765_CR4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/sj.leu.2400542","volume":"11","author":"PJ Sykes","year":"1997","unstructured":"Sykes PJ, Snell LE, Brisco MJ, Neoh SH, Hughes E, Dolman G, Peng LM, Bennett A, Toogood I, Morley AA . The use of monoclonal gene rearrangement for detection of minimal residual disease in acute lymphoblastic leukemia of childhood Leukemia 1997 11: 153\u2013158","journal-title":"Leukemia"},{"key":"BF2401765_CR5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1046\/j.1365-2141.1998.00574.x","volume":"100","author":"NJ Goulden","year":"1998","unstructured":"Goulden NJ, Knechtli CJ, Garland RJ, Langlands K, Hancock JP, Potter MN, Steward CG, Oakhill A . Minimal residual disease analysis for the prediction of relapse in children with standard-risk acute lymphoblastic leukaemia Br J Haematol 1998 100: 235\u2013244","journal-title":"Br J Haematol"},{"key":"BF2401765_CR6","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1056\/NEJM199808273390904","volume":"339","author":"H Cave","year":"1998","unstructured":"Cave H, van der Werff ten Bosch J, Suciu S, Guidal C, Waterkeyn C, Otten J, Bakkus M, Thielemans K, Grandchamp B, Vilmer E, Nelken B, Fournier M, Boutard P, Lebrun E, Mechinaud F, Garand R, Robert A, Dastugue N, Plouvier E, Racadot E, Ferster A, Gyselinck J, Fenneteau O, Duval M, Solbu G, Manel AM . Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia New Engl J Med 1998 339: 591\u2013598","journal-title":"New Engl J Med"},{"key":"BF2401765_CR7","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/S0140-6736(98)04058-6","volume":"352","author":"JJM Van Dongen","year":"1998","unstructured":"Van Dongen JJM, Seriu T, Panzer-Grumayer ER, Biondi A, Pongers-Willemse MJ, Corral L, Stolz F, Schrappe M, Masera G, Kamps WA, Gadner H, van Wering ER, Ludwig W-D, Basso G, de Bruijn MAC, Cazzaniga G, Hettinger K, van der Does-van den Berg A, Hop WCJ, Riehm H, Bartram CR . Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood Lancet 1998 352: 1731\u20131738","journal-title":"Lancet"},{"key":"BF2401765_CR8","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1172\/JCI113103","volume":"80","author":"CA Felix","year":"1987","unstructured":"Felix CA, Wright JJ, Poplack DG, Reaman GH, Cole D, Goldman P, Korsmeyer SJ . T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia J Clin Invest 1987 80: 545\u2013556","journal-title":"J Clin Invest"},{"key":"BF2401765_CR9","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1182\/blood.V70.6.1933.1933","volume":"70","author":"A Tawa","year":"1987","unstructured":"Tawa A, Benedict SH, Hara J, Hozumi N, Gelfand EW . Rearrangement of the T cell receptor gamma-chain gene in childhood acute lymphoblastic leukemia Blood 1987 70: 1933\u20131939","journal-title":"Blood"},{"key":"BF2401765_CR10","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1002\/eji.1830171111","volume":"17","author":"TL Boehm","year":"1987","unstructured":"Boehm TL, Werle A, Ganser A, Kornhuber B, Drahovsky D . T cell receptor gamma chain variable gene rearrangements in acute lymphoblastic leukemias of T and B lineage Eur J Immunol 1987 17: 1593\u20131597","journal-title":"Eur J Immunol"},{"key":"BF2401765_CR11","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1172\/JCI114012","volume":"83","author":"J Hara","year":"1989","unstructured":"Hara J, Benedict SH, Yumura K, Ha-Kawa K, Gelfand EW . Rearrangement of variable region T cell receptor gamma genes in acute lymphoblastic leukemia. V gamma gene usage differs in mature and immature T cells J Clin Invest 1989 83: 1277\u20131283","journal-title":"J Clin Invest"},{"key":"BF2401765_CR12","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1038\/sj.leu.2401540","volume":"13","author":"EJ Moreau","year":"1999","unstructured":"Moreau EJ, Langerak AW, van Gastel-Mol EJ, Wolvers-Tettero ILM, Zhan M, Zhou Q, Koop BF, van Dongen JJM . Easy detection of all T cell receptor gamma (TCRG) gene rearrangements by Southern blot analysis: recommendations for optimal results Leukemia 1999 13: 1620\u20131626","journal-title":"Leukemia"},{"key":"BF2401765_CR13","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1182\/blood.V77.9.1989.1989","volume":"77","author":"JJ Taylor","year":"1991","unstructured":"Taylor JJ, Rowe D, Williamson IK, Christmas SE, Proctor SJ, Middleton PG . Detection of T-cell receptor gamma chain V gene rearrangements using the polymerase chain reaction: application to the study of clonal disease cells in acute lymphoblastic leukemia Blood 1991 77: 1989\u20131995","journal-title":"Blood"},{"key":"BF2401765_CR14","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1182\/blood.V84.2.574.574","volume":"84","author":"M Kneba","year":"1994","unstructured":"Kneba M, Bolz I, Linke B, Bertram J, Rothaupt D, Hiddemann W . Characterization of clone-specific rearrangement T-cell receptor gamma-chain genes in lymphomas and leukemias by the polymerase chain reaction and DNA sequencing Blood 1994 84: 574\u2013581","journal-title":"Blood"},{"key":"BF2401765_CR15","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1046\/j.1365-2141.1996.6372268.x","volume":"94","author":"M Fodinger","year":"1996","unstructured":"Fodinger M, Buchmayer H, Schwarzinger I, Simonitsch I, Winkler K, Jager U, Knobler R, Mannhalter C . Multiplex PCR for rapid detection of T-cell receptor-gamma chain gene rearrangements in patients with lymphoproliferative diseases Br J Haematol 1996 94: 136\u2013139","journal-title":"Br J Haematol"},{"key":"BF2401765_CR16","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/sj.leu.2401071","volume":"12","author":"T Szczepanski","year":"1998","unstructured":"Szczepanski T, Langerak AW, Wolvers-Tettero ILM, Ossenkoppele GJ, Verhoef G, Stul M, Petersen EJ, de Bruijn MAC, van't Veer MB, van Dongen JJM . Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease Leukemia 1998 12: 1081\u20131088","journal-title":"Leukemia"},{"key":"BF2401765_CR17","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/sj.leu.2401276","volume":"13","author":"AW Langerak","year":"1999","unstructured":"Langerak AW, Wolvers-Tettero ILM, van den Beemd MWM, van Wering ER, Ludwig W-D, H\u00e4hlen K, Necker A, van Dongen JJM . Immunophenotypic and immunogenotypic characteristics of TCR\u03b3\u03b4+ T cell acute lymphoblastic leukemia Leukemia 1999 13: 206\u2013214","journal-title":"Leukemia"},{"key":"BF2401765_CR18","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1182\/blood.V82.10.3063.3063","volume":"82","author":"TM Breit","year":"1993","unstructured":"Breit TM, Wolvers-Tettero ILM, Beishuizen A, Verhoeven M-AJ, van Wering ER, van Dongen JJM . Southern blot patterns, frequencies and junctional diversity of T-cell receptor \u03b4 gene rearrangements in acute lymphoblastic leukemia Blood 1993 82: 3063\u20133074","journal-title":"Blood"},{"key":"BF2401765_CR19","first-page":"298","volume":"33","author":"JJM Van Dongen","year":"1988","unstructured":"Van Dongen JJM, Adriaansen HJ, Hooijkaas H . Immunophenotyping of leukaemias and non-Hodgkin's lymphomas. Immunological markers and their CD codes Neth J Med 1988 33: 298\u2013314","journal-title":"Neth J Med"},{"key":"BF2401765_CR20","first-page":"1383","volume":"10","author":"K Groeneveld","year":"1996","unstructured":"Groeneveld K, te Marvelde JG, van den Beemd MW, Hooijkaas H, van Dongen JJM . Flow cytometric detection of intracellular antigens for immunophenotyping of normal and malignant leukocytes Leukemia 1996 10: 1383\u20131389","journal-title":"Leukemia"},{"key":"BF2401765_CR21","first-page":"207","volume":"16","author":"JJM Van Dongen","year":"1990","unstructured":"Van Dongen JJM, Comans-Bitter WM, Wolvers-Tettero ILM, Borst J . Development of human T lymphocytes and their thymus-dependency Thymus 1990 16: 207\u2013234","journal-title":"Thymus"},{"key":"BF2401765_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0009-8981(91)90246-9","volume":"198","author":"JJM Van Dongen","year":"1991","unstructured":"Van Dongen JJM, Wolvers-Tettero ILM . Analysis of immunoglobulin and T cell receptor genes. Part I: basic and technical aspects Clin Chim Acta 1991 198: 1\u201391","journal-title":"Clin Chim Acta"},{"key":"BF2401765_CR23","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.4049\/jimmunol.138.8.2687","volume":"138","author":"T Quertermous","year":"1987","unstructured":"Quertermous T, Strauss WM, Van Dongen JJM, Seidman JG . Human T cell gamma chain joining regions and T cell development J Immunol 1987 138: 2687\u20132690","journal-title":"J Immunol"},{"key":"BF2401765_CR24","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/sj.leu.2401245","volume":"13","author":"MJ Pongers-Willemse","year":"1999","unstructured":"Pongers-Willemse MJ, Seriu T, Stolz F, d'Aniello E, Gameiro P, Pisa P, Gonzalez M, Bartram CR, Panzer-Grumayer ER, Biondi A, San Miguel JF, van Dongen JJM . Primers and protocols for standardized MRD detection in ALL using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia Leukemia 1999 13: 110\u2013118","journal-title":"Leukemia"},{"key":"BF2401765_CR25","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1038\/sj.leu.2400887","volume":"11","author":"AW Langerak","year":"1997","unstructured":"Langerak AW, Szczepanski T, van der Burg M, Wolvers-Tettero ILM, van Dongen JJM . Heteroduplex PCR analysis of rearranged T cell receptor genes for clonality assessment in suspect T cell proliferations Leukemia 1997 11: 2192\u20132199","journal-title":"Leukemia"},{"key":"BF2401765_CR26","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1038\/sj.leu.2400904","volume":"11","author":"A Beishuizen","year":"1997","unstructured":"Beishuizen A, de Bruijn MAC, Pongers-Willemse MJ, Verhoeven M-AJ, van Wering ER, H\u00e4hlen K, Breit TM, de Bruin-Versteeg S, Hooijkaas H, van Dongen JJM . Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: a new molecular target for detection of minimal residual disease Leukemia 1997 11: 2200\u20132207","journal-title":"Leukemia"},{"key":"BF2401765_CR27","first-page":"177","volume":"22","author":"TM Breit","year":"1994","unstructured":"Breit TM, Van Dongen JJM . Unravelling human T-cell receptor junctional region sequences Thymus 1994 22: 177\u2013199","journal-title":"Thymus"},{"key":"BF2401765_CR28","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.4049\/jimmunol.152.6.2860","volume":"152","author":"TM Breit","year":"1994","unstructured":"Breit TM, Wolvers-Tettero ILM, van Dongen JJM . Unique selection determinant in polyclonal V delta 2-J delta 1 junctional regions of human peripheral gamma delta T lymphocytes J Immunol 1994 152: 2860\u20132864","journal-title":"J Immunol"},{"key":"BF2401765_CR29","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1200\/JCO.1990.8.3.431","volume":"8","author":"CA Felix","year":"1990","unstructured":"Felix CA, Poplack DG, Reaman GH, Steinberg SM, Cole DE, Taylor BJ, Begley CG, Kirsch IR . Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood J Clin Oncol 1990 8: 431\u2013442","journal-title":"J Clin Oncol"},{"key":"BF2401765_CR30","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/sj.leu.2400903","volume":"12","author":"A Castellanos","year":"1998","unstructured":"Castellanos A, Martin-Seisdedos C, Toribio ML, San Miguel JF, Gonzalez Sarmiento R . TCR-gamma gene rearrangement with interstitial deletion within the TRGV2 gene segment is not detected in normal T-lymphocytes Leukemia 1998 12: 251\u2013253","journal-title":"Leukemia"},{"key":"BF2401765_CR31","first-page":"205","volume":"246","author":"T Szczepanski","year":"1999","unstructured":"Szczepanski T, Pongers-Willemse MJ, Langerak AW, van Dongen JJM . Unusual immunoglobulin and T-cell receptor gene rearrangement patterns in acute lymphoblastic leukemias Curr Top Microbiol Immunol 1999 246: 205\u2013215","journal-title":"Curr Top Microbiol Immunol"},{"key":"BF2401765_CR32","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1182\/blood.V93.12.4079","volume":"93","author":"T Szczepanski","year":"1999","unstructured":"Szczepanski T, Pongers-Willemse MJ, Langerak AW, Harts WA, Wijkhuijs JM, van Wering ER, van Dongen JJM . Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6\u201319 and DH7\u201327 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor \u03b1\u03b2 lineage Blood 1999 93: 4079\u20134085","journal-title":"Blood"},{"key":"BF2401765_CR33","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1182\/blood.V83.8.2238.2238","volume":"83","author":"A Beishuizen","year":"1994","unstructured":"Beishuizen A, Verhoeven MA, van Wering ER, H\u00e4hlen K, Hooijkaas H, van Dongen JJM . Analysis of Ig and T-cell receptor genes in 40 childhood acute lymphoblastic leukemias at diagnosis and subsequent relapse: implications for the detection of minimal residual disease by polymerase chain reaction analysis Blood 1994 83: 2238\u20132247","journal-title":"Blood"},{"key":"BF2401765_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1365-2141.1995.tb03384.x","volume":"90","author":"A Baruchel","year":"1995","unstructured":"Baruchel A, Cayuela JM, MacIntyre E, Berger R, Sigaux F . Assessment of clonal evolution at Ig\/TCR loci in acute lymphoblastic leukaemia by single-strand conformation polymorphism studies and highly resolutive PCR derived methods: implication for a general strategy of minimal residual disease detection Br J Haematol 1995 90: 85\u201393","journal-title":"Br J Haematol"},{"key":"BF2401765_CR35","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/sj.leu.2401269","volume":"13","author":"L LoNigro","year":"1999","unstructured":"LoNigro L, Cazzaniga G, DiCataldo A, Pannunzio A, DAniello E, Masera G, Schiliro G, Biondi A . Clonal stability in children with acute lymphoblastic leukemia (ALL) who relapsed five or more years after diagnosis Leukemia 1999 13: 190\u2013195","journal-title":"Leukemia"},{"key":"BF2401765_CR36","first-page":"1847","volume":"9","author":"GM Marshall","year":"1995","unstructured":"Marshall GM, Kwan E, Haber M, Brisco MJ, Sykes PJ, Morley AA, Toogood I, Waters K, Tauro G, Ekert H, Norris MD . Characterization of clonal immunoglobulin heavy chain and T cell receptor gamma gene rearrangements during progression of childhood acute lymphoblastic leukemia Leukemia 1995 9: 1847\u20131850","journal-title":"Leukemia"},{"key":"BF2401765_CR37","first-page":"60","volume":"8","author":"JJ Taylor","year":"1994","unstructured":"Taylor JJ, Rowe D, Kylefjord H, Chessells J, Katz F, Proctor SJ, Middleton PG . Characterisation of non-concordance in the T-cell receptor gamma chain genes at presentation and clinical relapse in acute lymphoblastic leukemia Leukemia 1994 8: 60\u201366","journal-title":"Leukemia"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2401765.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401765","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401765.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:27:57Z","timestamp":1682036877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2401765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,7,1]]}},"alternative-id":["BF2401765"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2401765","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7,1]]},"assertion":[{"value":"27 December 1999","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}