{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:21:14Z","timestamp":1773674474293,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2000,6,1]]},"DOI":"10.1038\/sj.leu.2401786","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T18:35:35Z","timestamp":1031164535000},"page":"1097-1104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Demonstration of the mineralocorticoid hormone receptor and action in human leukemic cell lines"],"prefix":"10.1038","volume":"14","author":[{"given":"M","family":"Mirshahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mirshahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Golestaneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Mishal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hecquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MK","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,6,6]]},"reference":[{"key":"BF2401786_CR1","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","volume":"83","author":"DJ Mengelsdorf","year":"1995","unstructured":"Mengelsdorf DJ, Thummel C, Beato M, Herrlich P, Sc\u00fctz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM . The nuclear receptor superfamily: the second decade Cell 1995 83: 835\u2013839","journal-title":"Cell"},{"key":"BF2401786_CR2","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.3283939","volume":"240","author":"RM Evans","year":"1988","unstructured":"Evans RM . The steroid and thyroid hormone receptor superfamily Science 1988 240: 889\u2013895","journal-title":"Science"},{"key":"BF2401786_CR3","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/j.1460-2075.1992.tb05139.x","volume":"11","author":"V Laudet","year":"1992","unstructured":"Laudet V, Hanni C, Coll J, Catzeflis F, St\u00e9h\u00e9lin D . Evolution of the nuclear receptor gene superfamily EMBO J 1992 11: 1003\u20131013","journal-title":"EMBO J"},{"key":"BF2401786_CR4","first-page":"67","volume":"46","author":"MK Agarwal","year":"1994","unstructured":"Agarwal MK . Perspectives in receptor mediated mineralocorticoid hormone action Pharmacol Rev 1994 46: 67\u201387","journal-title":"Pharmacol Rev"},{"key":"BF2401786_CR5","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0163-7258(96)00016-2","volume":"70","author":"MK Agarwal","year":"1996","unstructured":"Agarwal MK . The antiglucocorticoid action of Mifepristone Pharmacol Ther 1996 70: 183\u2013213","journal-title":"Pharmacol Ther"},{"key":"BF2401786_CR6","first-page":"133","volume":"10","author":"CL Billat","year":"1982","unstructured":"Billat CL, Felix JM, Jacquot RL . In vitro and in vivo regulation of hepatic erythropoiesis by erythropoietin and glucocorticoids in rat fetus Exp Hematol 1982 10: 133\u2013140","journal-title":"Exp Hematol"},{"key":"BF2401786_CR7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1172\/JCI108269","volume":"57","author":"DW Golde","year":"1976","unstructured":"Golde DW, Bersch N, Cline JM . Potentiation of erythropiesis in vitro by dexamethasone J Clin Invest 1976 57: 57\u201362","journal-title":"J Clin Invest"},{"key":"BF2401786_CR8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/j.1365-2141.1986.tb04094.x","volume":"62","author":"KB Udupa","year":"1986","unstructured":"Udupa KB, Crabtree HB, Lipschitz DA . In vitro culture of proerythroblasts: characterization of proliferative response to erythropoietin and steroids Br J Haematol 1986 62: 705\u2013714","journal-title":"Br J Haematol"},{"key":"BF2401786_CR9","doi-asserted-by":"publisher","first-page":"5020","DOI":"10.1073\/pnas.82.15.5020","volume":"82","author":"T Kaneda","year":"1995","unstructured":"Kaneda T, Murate T, Sheffrey M, Brown K, Rifkind RA, Marks PA . Gene expression during terminal differentiation: dexamethasone suppression of inducer-mediated alpha-1 and beta-hemoglobin gene expression Proc Natl Acad Sci USA 1995 82: 5020\u20135024","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2401786_CR10","first-page":"528","volume":"7","author":"TJ Chang","year":"1993","unstructured":"Chang TJ, Scher BM, Waxman S, Scher W . Inhibition of mouse GATA-1 function by the glucocorticoid receptor: possible mechanism of steroid inhibition of erythroleukemia cell differentiation Mol Endocrinol 1993 7: 528\u2013542","journal-title":"Mol Endocrinol"},{"key":"BF2401786_CR11","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3109\/10428199409049738","volume":"15","author":"PA Moalli","year":"1994","unstructured":"Moalli PA, Rosen ST . Glucocorticoid receptors and resistance to glucocorticoids in hematologic malignancies Leuk Lymphoma 1994 15: 363\u2013374","journal-title":"Leuk Lymphoma"},{"key":"BF2401786_CR12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/978-1-4615-2926-2_18","volume":"330","author":"AJ Ashraf","year":"1993","unstructured":"Ashraf AJ, Thompson EB . Glucocorticoid receptors in leukemia, lymphomas and myelomas of young and old Adv Exp Med Biol 1993 330: 241\u2013269","journal-title":"Adv Exp Med Biol"},{"key":"BF2401786_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0304-3835(94)90381-6","volume":"76","author":"MV Blagosklonny","year":"1994","unstructured":"Blagosklonny MV, Neckers LM . Cytostatic and cytotoxic activity of sex steroids against human leukemic cell lines Cancer Lett 1994 76: 81\u201386","journal-title":"Cancer Lett"},{"key":"BF2401786_CR14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0163-7258(99)00038-8","volume":"84","author":"MK Agarwal","year":"1999","unstructured":"Agarwal MK, Mirshahi M . General overview of mineralocorticoid hormone action Pharmacol Ther 1999 84: 273\u2013326","journal-title":"Pharmacol Ther"},{"key":"BF2401786_CR15","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/ajh.2830090407","volume":"9","author":"N Dainiak","year":"1980","unstructured":"Dainiak N, Hoffman R, Ritchey AK, Floyd V, Callahan M . In vitro steroid sensitivity testing: a possible means to predict response to therapy in primary hyperproliferative anemia Am J Hematol 1980 9: 401\u2013412","journal-title":"Am J Hematol"},{"key":"BF2401786_CR16","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1203\/00006450-198206000-00014","volume":"16","author":"HS Chan","year":"1982","unstructured":"Chan HS, Saunders EF, Freedman MH . Diamond\u2013Blackfan syndrome. I. Erythropoiesis in prednisone-responsive and resistant disease Pediatr Res 1982 16: 474\u2013476","journal-title":"Pediatr Res"},{"key":"BF2401786_CR17","first-page":"263","volume":"15","author":"M Kalmanti","year":"1993","unstructured":"Kalmanti M, Kalmantis T, Dimitriou H, Kattamis C . Correlation of in vitro enhancement of erythropoiesis and clinical response to steroids in Diamond\u2013Blackfan syndrome Haematologia 1993 15: 263\u2013269","journal-title":"Haematologia"},{"key":"BF2401786_CR18","doi-asserted-by":"crossref","first-page":"C1088-C1095","DOI":"10.1152\/ajpcell.1996.270.4.C1088","volume":"270","author":"Agarwal MK","year":"1996","unstructured":"MK Agarwal, Mirshahi F, Mirshahi M, Bracq S, Chentoufi J, Hott M, Jullienne A, Marie PJ . Evidence for receptor mediated mineralocorticoid action in rat osteoblastic cells Am J Physiol 1996 270: C1088-C1095","journal-title":"Am J Physiol"},{"key":"BF2401786_CR19","doi-asserted-by":"publisher","first-page":"C295","DOI":"10.1152\/ajpcell.1995.269.2.C295","volume":"269","author":"HS Ewart","year":"1995","unstructured":"Ewart HS, Klip A . Hormone regulation of the Na+\u2212K+ ATPase: mechanisms underlying rapid and sustained changes in pump activity Am J Physiol 1995 269: C295\u2013C311","journal-title":"Am J Physiol"},{"key":"BF2401786_CR20","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1152\/physrev.1980.60.3.615","volume":"60","author":"ADC MacKnight","year":"1980","unstructured":"MacKnight ADC, DiBona DR, Leaf A . Sodium transport across toad urinary bladder: a model tight epithelium Annu Rev Physiol 1980 60: 615\u2013715","journal-title":"Annu Rev Physiol"},{"key":"BF2401786_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1152\/physrev.1997.77.2.359","volume":"77","author":"H Garty","year":"1997","unstructured":"Garty H, Palmer LG . Epithelial sodium channels: function, structure and regulation Physiol Rev 1997 77: 359\u2013396","journal-title":"Physiol Rev"},{"key":"BF2401786_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0167-4838(92)90419-E","volume":"1120","author":"M Mirshahi","year":"1992","unstructured":"Mirshahi M, Pagano M, Mirshahi A, Agarwal MK . Generation of polyclonal antibodies against the mineralocorticoid receptor and analysis of mineralocortin in rat myocardium by immunophotochemistry Biochim Biophys Acta 1992 1120: 17\u201323","journal-title":"Biochim Biophys Acta"},{"key":"BF2401786_CR23","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/0006-291X(92)90495-7","volume":"83","author":"MK Agarwal","year":"1992","unstructured":"Agarwal MK, Mirshahi M . Rat lung possesses the mineralocorticoid receptor Biochem Biophys Res Commun 1992 83: 405\u2013410","journal-title":"Biochem Biophys Res Commun"},{"key":"BF2401786_CR24","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1159\/000126593","volume":"58","author":"MK Agarwal","year":"1993","unstructured":"Agarwal MK, Mirshahi F, Mirshahi M, Rostene W . Immunochemical detection of the mineralocorticoid receptor in rat brain Neuroendocrinology 1993 58: 575\u2013580","journal-title":"Neuroendocrinology"},{"key":"BF2401786_CR25","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1006\/bbrc.1996.0197","volume":"219","author":"M Mirshahi","year":"1996","unstructured":"Mirshahi M, Nicolas C, Mirshahi A, Hecquet C, d'Hermies F, Faure JP, Agarwal MK . The mineralocorticoid hormone receptor and action in the eye Biochem Biophys Res Commun 1996 219: 150\u2013156","journal-title":"Biochem Biophys Res Commun"},{"key":"BF2401786_CR26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000127166","volume":"65","author":"M Mirshahi","year":"1997","unstructured":"Mirshahi M, Mirshahi A, Sedighian R, Hecquet C, Faure JP, Agarwal MK . Immunochemical demonstration of the mineralocorticoid receptor in ocular tissues Neuroendocrinology 1997 65: 70\u201378","journal-title":"Neuroendocrinology"},{"key":"BF2401786_CR27","first-page":"63","volume":"1","author":"S Mirshahi","year":"1994","unstructured":"Mirshahi S, Soria J, Mishal Z, Mirshahi M, Lenoble M, Soria C . Pentoxifylline inhibits calcium-mediated activation by tumor necrotic factor in human monocytes Cell Pharmacol 1994 1: 63\u201366","journal-title":"Cell Pharmacol"},{"key":"BF2401786_CR28","volume-title":"Molecular Cloning, a Laboratory Manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsch EF, Maniatis T . Molecular Cloning, a Laboratory Manual Cold Spring Harbor Laboratory Press: New York 1989"},{"key":"BF2401786_CR29","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczinsky","year":"1987","unstructured":"Chomczinsky P, Sacchi N . Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 1987 162: 156\u2013159","journal-title":"Anal Biochem"},{"key":"BF2401786_CR30","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1006\/abio.1993.1539","volume":"214","author":"S Ferraboli","year":"1993","unstructured":"Ferraboli S, Negri R, Di Mauro E, Barati S . One lane chemical sequencing of 3\u2032-fluorescent-labeled DNA Anal Biochem 1993 214: 566\u2013570","journal-title":"Anal Biochem"},{"key":"BF2401786_CR31","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1006\/exer.1999.0675","volume":"69","author":"M Mirshahi","year":"1999","unstructured":"Mirshahi M, Nicolas C, Mirshahi S, Golestaneh N, d'Hermies F, Agarwal MK . Immunochemical analysis of the sodium channel in rodent and human eye Exptl Eye Res 1999 69: 21\u201332","journal-title":"Exptl Eye Res"},{"key":"BF2401786_CR32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/367463a0","volume":"367","author":"CM Canessa","year":"1994","unstructured":"Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC . Amiloride-sensitive epithelial sodium channel is made up of three homologous subunits Nature 1994 367: 463\u2013467","journal-title":"Nature"},{"key":"BF2401786_CR33","doi-asserted-by":"crossref","first-page":"12981","DOI":"10.1016\/S0021-9258(18)99972-2","volume":"269","author":"S Renard","year":"1994","unstructured":"Renard S, Lingueglia E, Voilley N, Lazdunski M, Barbry P . Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel J Biol Chem 1994 269: 12981\u201312986","journal-title":"J Biol Chem"},{"key":"BF2401786_CR34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0960-0760(97)00034-4","volume":"62","author":"DA Tonetti","year":"1997","unstructured":"Tonetti DA, Jordan VC . The role of estrogen receptor mutations in tamoxifen-stimulated breast cancer J Steroid Biochem Mol Biol 1997 62: 119\u2013128","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BF2401786_CR35","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1210\/mend.12.4.0089","volume":"12","author":"X Zhang","year":"1998","unstructured":"Zhang X, Jeyakumar M, Petukhov S, Bagchi MK . A nuclear receptor corepressor modulates transcriptional activity of antagonist-occupied steroid hormone receptor Mol Endocrinol 1998 12: 513\u2013524","journal-title":"Mol Endocrinol"},{"key":"BF2401786_CR36","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1038\/ki.1995.378","volume":"48","author":"SS Sohraby","year":"1995","unstructured":"Sohraby SS, Fisher RS . Guanine nucleotide-dependent carboxymethylation: a pathway for aldosterone modulation of apical Na+ permeability in epithelia Kidney Int 1995 48: 965\u2013969","journal-title":"Kidney Int"},{"key":"BF2401786_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/bbrc.1997.6890","volume":"236","author":"M Lesit","year":"1997","unstructured":"Lesit M, Nicotera P . The shape of cell death Biochem Biophys Res Commun 1997 236: 1\u20139","journal-title":"Biochem Biophys Res Commun"},{"key":"BF2401786_CR38","doi-asserted-by":"publisher","first-page":"F1-F10","DOI":"10.1152\/ajpcell.1989.257.1.C110","volume":"257","author":"BA Stanton","year":"1989","unstructured":"Stanton BA, Kaissling B . Regulation of renal ion transport and cell growth by sodium Am J Physiol 1989 257: F1-F10","journal-title":"Am J Physiol"},{"key":"BF2401786_CR39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0006-8993(82)90392-4","volume":"252","author":"G Reiser","year":"1982","unstructured":"Reiser G, Duhm J . Transport pathways for lithium ions in neuroblastoma\u00d7glioma hybrid cells at \u2018therapeutic\u2019 concentrations of Li+ Brain Res 1982 252: 247\u2013258","journal-title":"Brain Res"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2401786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401786","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:03:10Z","timestamp":1648760590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2401786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6,1]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6,1]]}},"alternative-id":["BF2401786"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2401786","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6,1]]},"assertion":[{"value":"2 December 1999","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}