{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:41:03Z","timestamp":1758634863841},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1038\/sj.leu.2401898","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T18:27:23Z","timestamp":1031164043000},"page":"1751-1756","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Colony-forming unit-megakaryocyte (CFU-meg) numbers and serum thrombopoietin concentrations in thrombocytopenic disorders: an inverse correlation in myelodysplastic syndromes"],"prefix":"10.1038","volume":"14","author":[{"given":"W","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Tomonaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,10,10]]},"reference":[{"key":"BF2401898_CR1","first-page":"25","volume":"5","author":"W Vainchenker","year":"1979","unstructured":"Vainchenker W, Guichard J, Breton-Gorius J . Growth of human megakaryocyte colonies in culture from fetal, neonatal, and adult peripheral blood cells: ultrastructural analysis Blood Cells 1979 5: 25\u201342","journal-title":"Blood Cells"},{"key":"BF2401898_CR2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1056\/NEJM198109033051001","volume":"305","author":"R Hoffman","year":"1981","unstructured":"Hoffman R, Mazur E, Bruno E, Floyd V . Assay of an activity in the serum of patients with disorders of thrombopoiesis that stimulates formation of megakaryocytic colonies New Engl J Med 1981 305: 533\u2013538","journal-title":"New Engl J Med"},{"key":"BF2401898_CR3","doi-asserted-by":"crossref","unstructured":"Messner HA, Jamal N, Izaguirre C . The growth of large megakaryocyte colonies from human bone marrow J Cell Physiol 1982 : (Suppl. 1) 45\u201351","DOI":"10.1002\/jcp.1041130410"},{"key":"BF2401898_CR4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1182\/blood.V85.2.391.391","volume":"85","author":"N Debili","year":"1995","unstructured":"Debili N, Wendling F, Cosman D, Titeux M, Florindo C, Dusanter-Fourt I, Schooley K, Methia N, Charon M, Nador R, Bettaieb A, Vainchenker W . The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets Blood 1995 85: 391\u2013401","journal-title":"Blood"},{"key":"BF2401898_CR5","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/369565a0","volume":"369","author":"S Lok","year":"1994","unstructured":"Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Helpel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC . Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo Nature 1994 369: 565\u2013568","journal-title":"Nature"},{"key":"BF2401898_CR6","doi-asserted-by":"publisher","first-page":"11104","DOI":"10.1073\/pnas.91.23.11104","volume":"91","author":"DJ Kuter","year":"1994","unstructured":"Kuter DJ, Beeler DL, Rosenberg RD . The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production Proc Natl Acad Sci USA 1994 91: 11104\u201311108","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2401898_CR7","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood.V84.5.1464.1464","volume":"84","author":"DJ Kuter","year":"1994","unstructured":"Kuter DJ, Rosenberg RD . Appearance of a megakaryocyte growth-promoting activity, megalopoietin, during acute thrombocytopenia in the rabbit Blood 1994 84: 1464\u20131472","journal-title":"Blood"},{"key":"BF2401898_CR8","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1182\/blood.V85.10.2720.bloodjournal85102720","volume":"85","author":"DJ Kuter","year":"1995","unstructured":"Kuter DJ, Rosenberg RD . The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit Blood 1995 85: 2720\u20132730","journal-title":"Blood"},{"key":"BF2401898_CR9","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1182\/blood.V86.3.971.971","volume":"86","author":"TR Ulich","year":"1995","unstructured":"Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, Bennett L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P . Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice Blood 1995 86: 971\u2013976","journal-title":"Blood"},{"key":"BF2401898_CR10","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V87.2.567.bloodjournal872567","volume":"87","author":"R Stoffel","year":"1996","unstructured":"Stoffel R, Wiestner A, Skoda RC . Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets Blood 1996 87: 567\u2013574","journal-title":"Blood"},{"key":"BF2401898_CR11","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1182\/blood.V86.10.3668.bloodjournal86103668","volume":"86","author":"JM McCarty","year":"1995","unstructured":"McCarty JM, Sprugel KH, Fox NE, Sabath DE, Kaushansky K . Murine thrombopoietin mRNA levels are modulated by platelet count Blood 1995 86: 3668\u20133675","journal-title":"Blood"},{"key":"BF2401898_CR12","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1046\/j.1365-2141.1996.d01-1702.x","volume":"93","author":"S Kosugi","year":"1996","unstructured":"Kosugi S, Kurata Y, Tomiyama T, Tahara T, Kato T, Tadokoro S, Shiraga M, Honda S, Kanakura T, Matsuzawa M . Circulating thrombopoietin level in chronic immune thrombocytopenic purpura Br J Haematol 1996 93: 704\u2013706","journal-title":"Br J Haematol"},{"key":"BF2401898_CR13","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1182\/blood.V87.10.4068.bloodjournal87104068","volume":"87","author":"RVB Emmons","year":"1996","unstructured":"Emmons RVB, Reid DM, Cohen RL, Meng G, Young NS, Dunbar CE, Shulman NR . Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction Blood 1996 87: 4068\u20134071","journal-title":"Blood"},{"key":"BF2401898_CR14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/00043426-199801000-00006","volume":"20","author":"MU Kuefer","year":"1998","unstructured":"Kuefer MU, Wang WC, Head DR, Wilimas JA, Furman WL, Liu Q, Hornkohl AC, Best DM, Jackson CW . Thrombopoietin level in young patients is related to megakaryocyte frequency and platelet count J Pediatr Hematol Oncol 1998 20: 36\u201343","journal-title":"J Pediatr Hematol Oncol"},{"key":"BF2401898_CR15","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1046\/j.1365-2141.1998.00747.x","volume":"101","author":"M Hou","year":"1998","unstructured":"Hou M, Andersson PO, Stockelberg D, Mellqvist UH, Ridell B, Wadenvik H . Plasma thrombopoietin levels in thrombocytopenic states: implication for a regulatory role of bone marrow megakaryocytes Br J Haematol 1998 101: 420\u2013424","journal-title":"Br J Haematol"},{"key":"BF2401898_CR16","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","volume":"51","author":"JM Bennett","year":"1982","unstructured":"Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C . Proposals for the classification of the myelodysplastic syndromes Br J Haematol 1982 51: 189\u2013199","journal-title":"Br J Haematol"},{"key":"BF2401898_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/BF01732882","volume":"61","author":"K Dan","year":"1990","unstructured":"Dan K, Gomi S, Nomura T . Kinetics of megakaryocyte progenitor cells in idiopathic thrombocytopenic purpura Blut 1990 61: 303\u2013306","journal-title":"Blut"},{"key":"BF2401898_CR18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000204502","volume":"89","author":"K Dan","year":"1993","unstructured":"Dan K, An E, Futaki M, Inokuchi K, Gomi S, Yamada T, Ogata K, Tanabe Y, Ohki I, Shinohara T, Nomura T . Megakaryocyte, erythroid and granulocyte\u2013macrophage colony formation in myelodysplastic syndromes Acta Haematol 1993 89: 113\u2013118","journal-title":"Acta Haematol"},{"key":"BF2401898_CR19","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/stem.5530100106","volume":"10","author":"JF Abgrall","year":"1992","unstructured":"Abgrall JF, El-Kassar N, Berthou C, Renard I, Cauvin JM, Le Pailleur A, Autrand C, Sensebe L, Guern G, Zilliken P, Le Gall G, Briere J . In vitro megakaryocyte colony formation in patients with idiopathic thrombocytopenic purpura: differences between acute and chronic ITP Int J Cell Cloning 1992 10: 28\u201332","journal-title":"Int J Cell Cloning"},{"key":"BF2401898_CR20","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1111\/j.1365-2141.1993.tb03227.x","volume":"85","author":"JF Abgrall","year":"1993","unstructured":"Abgrall JF, Berthou C, Sensebe L, Le Niger C, Escoffre M . Decreased in vitro megakaryocyte colony formation in chronic idiopathic thrombocytopenic purpura Br J Haematol 1993 85: 803\u2013804","journal-title":"Br J Haematol"},{"key":"BF2401898_CR21","first-page":"119","volume":"50","author":"H Sugiyama","year":"1986","unstructured":"Sugiyama H, Yagita M, Takahashi T, Nakamura K, Iho S, Hoshino T, Imura H . Megakaryocytopoiesis in idiopathic thrombocytopenic purpura Acta Haematol Japan 1986 50: 119\u2013128","journal-title":"Acta Haematol Japan"},{"key":"BF2401898_CR22","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/00001721-199709000-00004","volume":"8","author":"K Hiyoyama","year":"1997","unstructured":"Hiyoyama K, Wada H, Shimura M, Nakasaki T, Katayama N, Nishikawa M, Shiku H, Tahara T, Kato T . Increased serum levels of thrombopoietin in patients with thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, or disseminated intravascular coagulation Blood Coagul Fibrin 1997 8: 345\u2013349","journal-title":"Blood Coagul Fibrin"},{"key":"BF2401898_CR23","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1046\/j.1365-2141.1996.d01-1741.x","volume":"93","author":"T Tahara","year":"1996","unstructured":"Tahara T, Usuki K, Sato H, Ohashi H, Morita H, Tsumura H, Matsumoto A, Miyazaki H, Urabe A, Kato T . A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders Br J Haematol 1996 93: 783\u2013788","journal-title":"Br J Haematol"},{"key":"BF2401898_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1055\/s-0038-1650545","volume":"76","author":"N Ichikawa","year":"1996","unstructured":"Ichikawa N, Ishida F, Shimodaira S, Tahara T, Kato T, Kitano K . Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura Thromb Haemost 1996 76: 156\u2013160","journal-title":"Thromb Haemost"},{"key":"BF2401898_CR25","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1046\/j.1365-2141.1996.d01-1966.x","volume":"95","author":"JCW Marsh","year":"1996","unstructured":"Marsh JCW, Gibson FM, Prue RL, Bowen A, Dunn VT, Hornkohl AC, Nichol JL, Gordon-Smith EC . Serum thrombopoietin levels in patients with aplastic anaemia Br J Haematol 1996 95: 605\u2013610","journal-title":"Br J Haematol"},{"key":"BF2401898_CR26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1182\/blood.V92.1.46.413k44_46_52","volume":"92","author":"Y Hirayama","year":"1998","unstructured":"Hirayama Y, Sakamaki S, Matsunaga T, Kuga T, Kuroda H, Kusakabe T, Sasaki K, Fujiwara K, Kato J, Kogawa K, Koyama R, Niitsu Y . Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells Blood 1998 92: 46\u201352","journal-title":"Blood"},{"key":"BF2401898_CR27","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1046\/j.1365-2141.1998.00590.x","volume":"100","author":"H Schrezenmeier","year":"1998","unstructured":"Schrezenmeier H, Griesshammer M, Hornkohl A, Nichol JL, Hecht T, Heimpel H, Kubanek B, Raghavachar A . Thrombopoietin serum levels in patients with aplastic anaemia: correlation with platelet count and persistent elevation in remission Br J Haematol 1998 100: 571\u2013576","journal-title":"Br J Haematol"},{"key":"BF2401898_CR28","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1600-0609.1989.tb01230.x","volume":"42","author":"E Juvonen","year":"1989","unstructured":"Juvonen E, Partanen S, Knuutila S, Ruutu T . Colony formation by megakaryocyte progenitors in myelodysplastic syndromes Eur J Haematol 1989 42: 389\u2013395","journal-title":"Eur J Haematol"},{"key":"BF2401898_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-2141.1989.tb00214.x","volume":"73","author":"D Geissler","year":"1989","unstructured":"Geissler D, Zwierzina H, Pechlaner C, Gaggl S, Schmalzl F, Konwalinka G, Braunsteiner H . Abnormal megakaryopoiesis in patients with myelodysplastic syndromes: analysis of cellular and humoral defects Br J Haematol 1989 73: 29\u201335","journal-title":"Br J Haematol"},{"key":"BF2401898_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/sj.leu.2400901","volume":"12","author":"H Zwierzina","year":"1998","unstructured":"Zwierzina H, Rollinger-Holzinger I, Nuessler V, Herold M, Meng YG . Endogenous serum thrombopoietin concentrations in patients with myelodysplastic syndromes Leukemia 1998 12: 59\u201364","journal-title":"Leukemia"},{"key":"BF2401898_CR31","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1046\/j.1365-2141.1998.01054.x","volume":"103","author":"H Tamura","year":"1998","unstructured":"Tamura H, Ogata K, Luo S, Nakamura K, Yokose N, Dan K, Tohyama K, Yoshida Y, Hamaguchi H, Sakamaki H, Kuwaki T, Tahara T, Kato T, Nomura T . Plasma thrombopoietin (TPO) levels and expression of TPO receptor on platelets in patients with myelodysplastic syndromes Br J Haematol 1998 103: 778\u2013784","journal-title":"Br J Haematol"},{"key":"BF2401898_CR32","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0092-8674(95)90531-6","volume":"81","author":"RA Shivdasani","year":"1995","unstructured":"Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJM, Orkin H . Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietion\/MGDF in megakaryocyte development Cell 1995 81: 695\u2013704","journal-title":"Cell"},{"key":"BF2401898_CR33","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1182\/blood.V90.9.3444","volume":"90","author":"A Guerriero","year":"1997","unstructured":"Guerriero A, Worford L, Holland HK, Guo G-R, Sheehan K, Waller EK . Thrombopoietin is synthesized by bone marrow stromal cells Blood 1997 90: 444\u2013455","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2401898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401898","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:47:50Z","timestamp":1648763270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2401898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["BF2401898"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2401898","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]},"assertion":[{"value":"31 January 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}