{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T21:43:22Z","timestamp":1695678202126},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1038\/sj.leu.2401931","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T18:27:23Z","timestamp":1031164043000},"page":"1785-1795","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Differentiation commitment and regulator-specific granulocyte\u2013macrophage maturation in a novel pro-B murine leukemic cell line"],"prefix":"10.1038","volume":"14","author":[{"given":"Y","family":"La\u00e2bi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Metcalf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mifsud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LDi","family":"Rago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,10,10]]},"reference":[{"key":"BF2401931_CR1","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1038\/sj.leu.2400831","volume":"11","author":"D Metcalf","year":"1997","unstructured":"Metcalf D . The Charlotte Friend Memorial Lecture. The role of hematopoietic growth factors in the development and suppression of myeloid leukemias Leukemia 1997 11: 1599\u20131604","journal-title":"Leukemia"},{"key":"BF2401931_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1749-6632.1999.tb08473.x","volume":"872","author":"D Metcalf","year":"1999","unstructured":"Metcalf D . Stem cells, pre-progenitor cells and lineage-committed cells: Are our dogmas correct? Ann NY Acad Sci 1999 872: 289\u2013303","journal-title":"Ann NY Acad Sci"},{"key":"BF2401931_CR3","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1182\/blood.V72.6.2070.2070","volume":"72","author":"Y Shabo","year":"1988","unstructured":"Shabo Y, Lotem J, Rubinstein M, Revel M, Clark SC, Wolf SF, Kamen R, Sachs L . The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin 6 Blood 1988 72: 2070\u20132073","journal-title":"Blood"},{"key":"BF2401931_CR4","first-page":"349","volume":"3","author":"D Metcalf","year":"1989","unstructured":"Metcalf D . Actions and interactions of G-CSF, LIF and IL-6 on normal and leukemic murine cells Leukemia 1989 3: 349\u2013355","journal-title":"Leukemia"},{"key":"BF2401931_CR5","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4049\/jimmunol.149.4.1271","volume":"49","author":"AG Bruce","year":"1992","unstructured":"Bruce AG, Hoggatt IH, Rose TM . Oncostatin M is a differentiation factor for myeloid leukemic cells J Immunol 1992 49: 1271\u20131275","journal-title":"J Immunol"},{"key":"BF2401931_CR6","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1016\/S0021-9258(18)32158-6","volume":"258","author":"NA Nicola","year":"1983","unstructured":"Nicola NA, Metcalf D, Matsumoto M, Johnson GR . Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells: identification as granulocyte colony-stimulating factor (G-CSF) J Biol Chem 1983 258: 9017\u20139023","journal-title":"J Biol Chem"},{"key":"BF2401931_CR7","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/jnci\/50.3.603","volume":"50","author":"MAS Moore","year":"1973","unstructured":"Moore MAS, Williams N, Metcalf D . In vitro colony formation by normal and leukemic human hematopoietic cells: characterisation of the colony-forming cells J Natl Cancer Inst 1973 50: 603\u2013623","journal-title":"J Natl Cancer Inst"},{"key":"BF2401931_CR8","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S0950-3536(87)80033-1","volume":"1","author":"CJ Eaves","year":"1987","unstructured":"Eaves CJ, Eaves AC . Cell culture studies in CML Bailli\u00e8re Clin Hematol 1987 1: 931\u2013961","journal-title":"Bailli\u00e8re Clin Hematol"},{"key":"BF2401931_CR9","first-page":"796","volume":"3","author":"U D\u00fchrsen","year":"1989","unstructured":"D\u00fchrsen U, Metcalf D, Spangrude GJ, Nicola NA . PGM-1: a transplantable murine leukemia of granulocyte\u2013macrophage progenitor cells Leukemia 1989 3: 796\u2013803","journal-title":"Leukemia"},{"key":"BF2401931_CR10","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.4049\/jimmunol.150.10.4395","volume":"150","author":"M Martin","year":"1993","unstructured":"Martin M, Strasser A, Baumgarth N, Cicuttini FM, Welch K, Salvaris E, Boyd AW . A novel cellular model (SPGM 1) of switching between the pre-B cell and myelomonocytic lineages J Immunol 1993 150: 4395\u20134406","journal-title":"J Immunol"},{"key":"BF2401931_CR11","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/1074-7613(94)90094-9","volume":"1","author":"GJ Lindeman","year":"1994","unstructured":"Lindeman GJ, Adams JM, Cory S, Harris AW . B-lymphoid to granulocytic switch during hematopoiesis in a transgenic mouse strain Immunity 1994 1: 517\u2013527","journal-title":"Immunity"},{"key":"BF2401931_CR12","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1182\/blood.V85.9.2364.bloodjournal8592364","volume":"85","author":"D Metcalf","year":"1995","unstructured":"Metcalf D, Lindeman GJ, Nicola NA . Analysis of hemopoiesis in max 41 transgenic mice that exhibit sustained elevations of blood granulocytes and monocytes Blood 1995 85: 2364\u20132370","journal-title":"Blood"},{"key":"BF2401931_CR13","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0167-5699(97)01203-6","volume":"19","author":"DG Osmond","year":"1998","unstructured":"Osmond DG, Rolink A, Melchers F . Murine B lymphopoiesis: towards a unified model Immunol Today 1998 19: 65\u201368","journal-title":"Immunol Today"},{"key":"BF2401931_CR14","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S1074-7613(00)80268-X","volume":"5","author":"YS Li","year":"1996","unstructured":"Li YS, Wasserman R, Hayakawa K, Hardy RR . Identification of the earliest B lineage stage in mouse bone marrow Immunity 1996 5: 527\u2013535","journal-title":"Immunity"},{"key":"BF2401931_CR15","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1084\/jem.174.6.1617","volume":"174","author":"L Wu","year":"1991","unstructured":"Wu L, Antica M, Johnson GR, Scollay R, Shortman K . Developmental potential of the earliest precursor cells from the adult mouse thymus J Exp Med 1991 174: 1617\u20131627","journal-title":"J Exp Med"},{"key":"BF2401931_CR16","first-page":"1556","volume":"9","author":"D Metcalf","year":"1995","unstructured":"Metcalf D, Willson TA, Hilton DJ, Di Rago L, Misfud S . Production of hematopoietic regulatory factors in cultures of adult and fetal mouse organs: measurement by specific bioassays Leukemia 1995 9: 1556\u20131564","journal-title":"Leukemia"},{"key":"BF2401931_CR17","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/jcp.1041280311","volume":"128","author":"D Metcalf","year":"1986","unstructured":"Metcalf D, Burgess AW, Johnson GR, Nicola NA, Nice EC, DeLamarter J, Thatcher DR, Mermod J-J . In vitro actions on hemopoietic cells of recombinant murine GM-CSF purified after production in E coli: comparison with purified native GM-CSF J Cell Physiol 1986 128: 421\u2013431","journal-title":"J Cell Physiol"},{"key":"BF2401931_CR18","first-page":"288","volume":"15","author":"D Metcalf","year":"1987","unstructured":"Metcalf D, Begley CG, Nicola NA, Johnson GR . Quantitative responsiveness of murine hemopoietic populations in vitro and in vivo to recombinant multi-CSF (IL-3) Exp Hematol 1987 15: 288\u2013295","journal-title":"Exp Hematol"},{"key":"BF2401931_CR19","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/jcp.1041160211","volume":"116","author":"D Metcalf","year":"1983","unstructured":"Metcalf D, Nicola NA . Proliferative effects of purified granulocyte colony-stimulating factor (G-CSF) on normal mouse hemopoietic cells J Cell Physiol 1983 116: 198\u2013206","journal-title":"J Cell Physiol"},{"key":"BF2401931_CR20","doi-asserted-by":"publisher","first-page":"6239","DOI":"10.1073\/pnas.88.14.6239","volume":"88","author":"D Metcalf","year":"1991","unstructured":"Metcalf D, Nicola NA . Direct proliferative actions of stem cell factor on murine bone marrow cells in vitro: effects of combination with colony stimulating factors Proc Natl Acad Sci USA 1991 88: 6239\u20136243","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2401931_CR21","first-page":"311","volume":"10","author":"D Metcalf","year":"1996","unstructured":"Metcalf D, Roberts AW, Willson TA . The regulation of hematopoiesis in max 41 transgenic mice with sustained excess granulopoiesis Leukemia 1996 10: 311\u2013320","journal-title":"Leukemia"},{"key":"BF2401931_CR22","first-page":"216","volume":"2","author":"D Metcalf","year":"1988","unstructured":"Metcalf D, Hilton DJ, Nicola NA . Clonal analysis of the actions of the murine leukemia inhibitory factor (LIF) on leukemic and normal murine hemopoietic cells Leukemia 1988 2: 216\u2013221","journal-title":"Leukemia"},{"key":"BF2401931_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/jcp.1041120315","volume":"112","author":"D Metcalf","year":"1982","unstructured":"Metcalf D, Merchav S . Effects of GM-CSF deprivation on precursors of granulocytes and macrophages J Cell Physiol 1982 112: 411\u2013418","journal-title":"J Cell Physiol"},{"key":"BF2401931_CR24","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/0092-8674(91)90643-D","volume":"64","author":"CL Sawyers","year":"1991","unstructured":"Sawyers CL, Denny CT, Witte ON . Leukemia and the disruption of normal hematopoiesis Cell 1991 64: 337\u2013350","journal-title":"Cell"},{"key":"BF2401931_CR25","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.1128\/MCB.10.7.3562","volume":"10","author":"M Principato","year":"1990","unstructured":"Principato M, Cleveland JL, Rapp UR, Holmes KL, Pierce JH, Morse HC III, Klinken SP . Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages Mol Cell Biol 1990 10: 3562\u20133568","journal-title":"Mol Cell Biol"},{"key":"BF2401931_CR26","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1128\/MCB.10.6.2703","volume":"10","author":"GV Borzillo","year":"1990","unstructured":"Borzillo GV, Ashmun RA, Sherr CJ . Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes Mol Cell Biol 1990 10: 2703\u20132714","journal-title":"Mol Cell Biol"},{"key":"BF2401931_CR27","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.4049\/jimmunol.136.12.4695","volume":"136","author":"SR Bauer","year":"1986","unstructured":"Bauer SR, Holmes KL, Morse HC III, Potter M . Clonal relationship of the lymphoblastic cell line P388 to the macrophage cell line P388D1 as evidenced by immunoglobulin gene rearrangements and expression of cell surface antigens J Immunol 1986 136: 4695\u20134699","journal-title":"J Immunol"},{"key":"BF2401931_CR28","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/297691a0","volume":"297","author":"AW Boyd","year":"1982","unstructured":"Boyd AW, Schrader JW . Derivation of macrophage-like lines from the pre-B lymphoma ABLS-8.1 using 5-azacytidine Nature 1982 297: 691\u2013693","journal-title":"Nature"},{"key":"BF2401931_CR29","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0092-8674(88)90309-1","volume":"53","author":"SP Klinken","year":"1988","unstructured":"Klinken SP, Alexander WS, Adams JM . Hemopoietic lineage switch: v-raf oncogene converts E\u03bc-myc transgenic B cells into macrophages Cell 1988 53: 857\u2013867","journal-title":"Cell"},{"key":"BF2401931_CR30","doi-asserted-by":"publisher","first-page":"3823","DOI":"10.1002\/j.1460-2075.1996.tb00756.x","volume":"15","author":"A Strasser","year":"1996","unstructured":"Strasser A, Elefanty AG, Harris AW, Cory S . Progenitor tumours from E\u03bc-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival EMBO J 1996 15: 3823\u20133834","journal-title":"EMBO J"},{"key":"BF2401931_CR31","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/356612a0","volume":"356","author":"A Cumano","year":"1992","unstructured":"Cumano A, Paige CJ, Iscove NN, Brady G . Bipotential precursors of B cells and macrophages in murine fetal liver Nature 1992 356: 612\u2013615","journal-title":"Nature"},{"key":"BF2401931_CR32","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/44076","volume":"401","author":"SL Nutt","year":"1999","unstructured":"Nutt SL, Heavey B, Rolink AG, Busslinger M . Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 Nature 1999 401: 556\u2013562","journal-title":"Nature"},{"key":"BF2401931_CR33","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/44164","volume":"401","author":"AG Rolink","year":"1999","unstructured":"Rolink AG, Nutt SL, Melchers F, Busslinger M . Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors Nature 1999 401: 603\u2013606","journal-title":"Nature"},{"key":"BF2401931_CR34","volume-title":"The Hemopoietic Colony Stimulating Factors","author":"D Metcalf","year":"1984","unstructured":"Metcalf D . The Hemopoietic Colony Stimulating Factors Elsevier: Amsterdam 1984"},{"key":"BF2401931_CR35","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/0092-8674(93)90462-Y","volume":"74","author":"LJ Fairbairn","year":"1993","unstructured":"Fairbairn LJ, Cowling GJ, Reipert BM, Dexter TM . Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors Cell 1993 74: 823\u2013832","journal-title":"Cell"},{"key":"BF2401931_CR36","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.4049\/jimmunol.138.11.3829","volume":"138","author":"M Valtieri","year":"1987","unstructured":"Valtieri M, Tweardy DJ, Caracciolo D, Johnson K, Mavilio F, Altmann S, Santoli D, Rovera G . Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line J Immunol 1987 138: 3829\u20133835","journal-title":"J Immunol"},{"key":"BF2401931_CR37","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3109\/08977199009071506","volume":"2","author":"CM Heyworth","year":"1990","unstructured":"Heyworth CM, Dexter TM, Kan O, Whetton AD . The role of hemopoietic growth factors in self-renewal and differentiation of IL-3-dependent multipotential stem cells Growth Factors 1990 2: 197\u2013211","journal-title":"Growth Factors"},{"key":"BF2401931_CR38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1182\/blood.V92.2.345b","volume":"92","author":"D Metcalf","year":"1998","unstructured":"Metcalf D . Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation Blood 1998 92: 345\u2013352","journal-title":"Blood"},{"key":"BF2401931_CR39","first-page":"645","volume":"23","author":"GA McArthur","year":"1995","unstructured":"McArthur GA, Longmore GL, Klingler K, Johnson GR . Lineage restricted recruitment of immature hemopoietic cells in response to erythropoietin after transfection of normal hemopoietic cells with the erythropoietin receptor Exp Hematol 1995 23: 645\u2013654","journal-title":"Exp Hematol"},{"key":"BF2401931_CR40","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1073\/pnas.96.2.698","volume":"96","author":"R Stoffel","year":"1999","unstructured":"Stoffel R, Ziegler S, Ghilardi N, Ledermann B, de Sauvage FJ, Skoda RC . Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo Proc Natl Acad Sci USA 1999 96: 698\u2013702","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2401931_CR41","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S1074-7613(00)80090-4","volume":"11","author":"CL Semerad","year":"1999","unstructured":"Semerad CL, Poursine-Laurent J, Liu F, Link DC . A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation Immunity 1999 11: 153\u2013161","journal-title":"Immunity"},{"key":"BF2401931_CR42","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1182\/blood.V79.11.2861.2861","volume":"79","author":"D Metcalf","year":"1992","unstructured":"Metcalf D, Nicola NA . The clonal proliferation of normal mouse hematopoietic cells: enhancement and suppression by colony-stimulating factor combinations Blood 1992 79: 2861\u20132866","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2401931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401931","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2401931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:20:14Z","timestamp":1682036414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2401931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["BF2401931"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2401931","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]},"assertion":[{"value":"11 July 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2000","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2000","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}