{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:59:23Z","timestamp":1791115163099,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2001,6,1]]},"DOI":"10.1038\/sj.leu.2402124","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T21:05:13Z","timestamp":1032469513000},"page":"976-980","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Elevated vascular endothelial growth factor (VEGF) serum levels in idiopathic myelofibrosis"],"prefix":"10.1038","volume":"15","author":[{"given":"F","family":"Raimondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MP","family":"Azzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GA","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Stagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GM","family":"Giustolisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Cacciola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Sortino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Guglielmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Giustolisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,7,5]]},"reference":[{"key":"BF2402124_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","volume":"18","author":"N Ferrara","year":"1997","unstructured":"Ferrara N, Davis-Smyth T . Biology of vascular endothelial growth factor Endocr Rev 1997 18: 4\u201325","journal-title":"Endocr Rev"},{"key":"BF2402124_CR2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/(SICI)1097-0142(19990101)85:1<178::AID-CNCR25>3.0.CO;2-7","volume":"85","author":"A Kraft","year":"1999","unstructured":"Kraft A, Weindel K, Ochs A, Marth C, Zmija J, Schumacher P, Unger C, Marm\u00e8 D, Gastl G . Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease Cancer 1999 85: 178\u2013187","journal-title":"Cancer"},{"key":"BF2402124_CR3","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1046\/j.1365-2141.1998.01076.x","volume":"103","author":"MZ Ratajczak","year":"1998","unstructured":"Ratajczak MZ, Ratajczak J, Machalinski B, Majka M, Marlicz W, Carter A, Pietrzkowski Z, Gewirtz AM . Role of vascular endothelial growth factor (VEGF) and placenta-derived growth factor (P1GF) in regulating human haemopoietic cell growth Br J Haematol 1998 103: 969\u2013979","journal-title":"Br J Haematol"},{"key":"BF2402124_CR4","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1182\/blood.V93.9.3064.409k07_3064_3073","volume":"93","author":"A Vacca","year":"1999","unstructured":"Vacca A, Ribatti D, Presta M, Monischetti M, Iurlaro M, Ria R, Albini A, Bussolino F, Dammacco F . Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma Blood 1999 93: 3064\u20133073","journal-title":"Blood"},{"key":"BF2402124_CR5","first-page":"167","volume-title":"Important Advances in Oncology","author":"N Weidner","year":"1996","unstructured":"Weidner N, Folkman J . Tumor vascularity as a prognostic factor in cancer. In: De Vita VT, Hellman S, Rosenberg SA (eds) Important Advances in Oncology Lippincott-Raven: Philadelphia 1996 167\u2013190"},{"key":"BF2402124_CR6","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1182\/blood.V94.11.3717","volume":"94","author":"A Aguayo","year":"1999","unstructured":"Aguayo A, Estey E, Kantarjian H, Mansouri T, Gidel C, Keating M, Giles F, Estrov Z, Barlogie B, Albitar M . Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia Blood 1999 94: 3717\u20133721","journal-title":"Blood"},{"key":"BF2402124_CR7","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1016\/S0959-8049(96)00379-6","volume":"32A","author":"PB Vermeulen","year":"1996","unstructured":"Vermeulen PB, Gasparini G, Fox SB, Toi M, Martin L, McCulloch P, Pezzella F, Viale G, Weidner S, Harris AL, Dirix LY . Quantification of angiogenesis in solid human tumors: an international consensus on the methodology and criteria of evaluation Eur J Cancer 1996 32A: 2474\u20132484","journal-title":"Eur J Cancer"},{"key":"BF2402124_CR8","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/386671a0","volume":"386","author":"W Risau","year":"1997","unstructured":"Risau W . Mechanisms of angiogenesis Nature 1997 386: 671\u2013674","journal-title":"Nature"},{"key":"BF2402124_CR9","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/362841a0","volume":"362","author":"J Kim","year":"1993","unstructured":"Kim J . Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vitro Nature 1993 362: 841\u2013844","journal-title":"Nature"},{"key":"BF2402124_CR10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/bjc.1997.368","volume":"76","author":"LY Dirix","year":"1997","unstructured":"Dirix LY, Vermeulen PB, Pawinski A, Prove A, Benoy I, De Pooter C, Martin M, Van Oosterom AT . Elevated levels of the angiogenic cytokines basic fibroblastic growth factor and vascular endothelia growth factor in sera of cancer patients Br J Cancer 1997 76: 238\u2013243","journal-title":"Br J Cancer"},{"key":"BF2402124_CR11","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1182\/blood.V90.8.3167","volume":"90","author":"P Salven","year":"1997","unstructured":"Salven P, Teerenhovi L, Joensuu H . A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma Blood 1997 90: 3167\u20133172","journal-title":"Blood"},{"key":"BF2402124_CR12","first-page":"815","volume":"150","author":"AR Perez-Atayde","year":"1997","unstructured":"Perez-Atayde AR, Sallan SE, Tedrow U, Connors S, Allred E, Folkman J . Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia Am J Pathol 1997 150: 815\u2013821","journal-title":"Am J Pathol"},{"key":"BF2402124_CR13","first-page":"503a, (Abstr. 2","volume":"94 (Suppl. 1)","author":"A Aguayo","year":"1999","unstructured":"Aguayo A, Kantarjian H, Estey E, Cortes J, Beran M, O'Brien S, Keating M, Freireich E, Thomas D, Rogers A, Albitar M . Plasma levels of VEGF and bFGF in various leukemias and their correlation with angiogenesis Blood 1999 94 (Suppl. 1): 503a, (Abstr. 2252)","journal-title":"Blood"},{"key":"BF2402124_CR14","first-page":"389a, (Abstr. 1","volume":"94 (Suppl. 1)","author":"WT Bellamy","year":"1999","unstructured":"Bellamy WT, Richter L, Frutiger Y, Sirjani D, Glinsmann-Gibson B, Grogan TM, List AF . Vascular endothelial growth factor (VEGF) is an autocrine promoter of ALIP and leukemia progenitor formation in myelodysplastic syndromes (MDS) Blood 1999 94 (Suppl. 1): 389a, (Abstr. 1727)","journal-title":"Blood"},{"key":"BF2402124_CR15","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/bjc.1996.166","volume":"73","author":"J Mattern","year":"1996","unstructured":"Mattern J, Koomagi R, Volm M . Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumor cell proliferation in human epidermoid lung carcinoma Br J Cancer 1996 73: 931\u2013934","journal-title":"Br J Cancer"},{"key":"BF2402124_CR16","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1365-2141.1992.tb08905.x","volume":"80","author":"J Thiele","year":"1992","unstructured":"Thiele J, Rompcik V, Wagner S, Fisher R . Vascular architecture and collagen type IV in primary myelofibrosis and polycythaemia vera: an immunomorphometric study on trephine biopsies of the bone marrow Br J Haematol 1992 80: 227\u2013234","journal-title":"Br J Haematol"},{"key":"BF2402124_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0002-9440(10)64511-7","volume":"157","author":"LG Lundberg","year":"2000","unstructured":"Lundberg LG, Lerner R, Sundelin P, Rogers R, Folkman J, Palmblad J . Bone marrow in polycythemia vera, chronic myelocytic leukemia, and myelofibrosis has an increased vascularity Am J Pathol 2000 157: 15\u201319","journal-title":"Am J Pathol"},{"key":"BF2402124_CR18","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1056\/NEJM200004273421706","volume":"342","author":"A Tefferi","year":"2000","unstructured":"Tefferi A . Myelofibrosis with myeloid metaplasia N Engl J Med 2000 342: 1255\u20131265","journal-title":"N Engl J Med"},{"key":"BF2402124_CR19","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1182\/blood.V96.10.3374","volume":"96","author":"RA Mesa","year":"2000","unstructured":"Mesa RA, Hanson CA, Rajkumar SV, Schroeder GS, Tefferi A . Evaluation and clinical correlations of microvessel density in myelofibrosis with myeloid metaplasia Blood 2000 96: 3374\u20133380","journal-title":"Blood"},{"key":"BF2402124_CR20","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1046\/j.1365-2141.1996.d01-1739.x","volume":"93","author":"A Dalley","year":"1996","unstructured":"Dalley A, Smith JM, Reilly JT, MacNeil S . Investigation of calmodulin and basic fibroblast growth factor (bFGF) in idiopathic myelofibrosis: evidence for a role of extracellular calodulin in fibroblast proliferation Br J Haematol 1996 93: 856\u2013862","journal-title":"Br J Haematol"},{"key":"BF2402124_CR21","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.1182\/blood.V88.12.4534.bloodjournal88124534","volume":"88","author":"M-C Le Bousse-Kerdiles","year":"1996","unstructured":"Le Bousse-Kerdiles M-C, Chevillard S, Charpentier A, Romquin N, Clay D, Smadja-Joffe F, Praloran V, Dupriez B, Demory J-L, Jasmin C, Martir\u00e8 M-C . Differential expression of transforming growth factor-\u03b2, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia Blood 1996 88: 4534\u20134546","journal-title":"Blood"},{"key":"BF2402124_CR22","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1046\/j.1365-2141.1997.292671.x","volume":"97","author":"M-C Martir\u00e8","year":"1997","unstructured":"Martir\u00e8 M-C, Le Bousse-Kerdiles M-C, Romquin N, Chevillard S, Praloran V, Demory J-L, Dupriez B . Elevated levels of basic fibroblast grwoth factor in megakaryocyts and platelets from patients with idiopathic myeofibrosis Br J Haematol 1997 97: 441\u2013448","journal-title":"Br J Haematol"},{"key":"BF2402124_CR23","first-page":"487","volume":"5","author":"P Salven","year":"1999","unstructured":"Salven P, Oprana A, Joensuu H . Leukocyte and platelets of patients with cancer contain high levels of vascular endothelial growth factor Clin Cancer Res 1999 5: 487\u2013491","journal-title":"Clin Cancer Res"},{"key":"BF2402124_CR24","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1023\/A:1008377921886","volume":"10","author":"W Wynendaele","year":"1999","unstructured":"Wynendaele W, Derua R, Hoylaerts MF, Pawinski A, Waelkens E, de Bruijn EA, Paridaens R, Merlevede W, van Oosterom AT . Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: a key to study an angiogenic marker in vivo? Ann Oncol 1999 10: 965\u2013971","journal-title":"Ann Oncol"},{"key":"BF2402124_CR25","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1016\/S0021-9258(17)41787-X","volume":"269","author":"MA Goldberg","year":"1994","unstructured":"Goldberg MA, Schneider TJ . Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin J Biol Chem 1994 269: 4355\u20134361","journal-title":"J Biol Chem"},{"key":"BF2402124_CR26","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1038\/bjc.1998.158","volume":"76","author":"RE Banks","year":"1998","unstructured":"Banks RE, Forbes MA, Kinsey SE, Stanley A, Ingham E, Walters C, Selby PJ . Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology Br J Cancer 1998 76: 956\u2013964","journal-title":"Br J Cancer"},{"key":"BF2402124_CR27","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/sj.bjc.6690437","volume":"80","author":"R Salgado","year":"1999","unstructured":"Salgado R, Vermeulen PB, Benoy I, Weytjiens R, Huget P, Van Mark E, Dirix LY . Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients Br J Cancer 1999 80: 892\u2013897","journal-title":"Br J Cancer"},{"key":"BF2402124_CR28","first-page":"2187","volume":"3","author":"HMW Verheulen","year":"1997","unstructured":"Verheulen HMW, Hoekman K, Luykx-de Bakker S, Eekman CA, Folman CC, Broxtermann HJ, Pinedo HM . Platelet: transporter of vascular endothelial growth factor Clin Cancer Res 1997 3: 2187\u20132190","journal-title":"Clin Cancer Res"},{"key":"BF2402124_CR29","first-page":"5687","volume":"55","author":"O Katoh","year":"1995","unstructured":"Katoh O, Tauchi H, Kawaishi K, Kimura A, Satow Y . Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effet of VEGF on apoptotic cell death caused by ionizing radiation Cancer Res 1995 55: 5687\u20135692","journal-title":"Cancer Res"},{"key":"BF2402124_CR30","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1073\/pnas.94.2.663","volume":"94","author":"R Mohle","year":"1997","unstructured":"Mohle R, Green D, Moore MA, Nachman RL, Rafii S . Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets Proc Nat Acad Sci USA 1997 94: 663\u2013668","journal-title":"Proc Nat Acad Sci USA"},{"key":"BF2402124_CR31","first-page":"12a, (Abstr. 40","volume":"94 (Suppl. 1)","author":"Y-Q Huang","year":"1999","unstructured":"Huang Y-Q, Li J-J, Hu L, Karpatkin S . Thrombin induces vascular endothelial cell growth factor (VEGF) in human tumor cells and fibroblasts Blood 1999 94 (Suppl. 1): 12a, (Abstr. 40)","journal-title":"Blood"},{"key":"BF2402124_CR32","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1126\/science.285.5433.1553","volume":"285","author":"BL Ziegler","year":"1999","unstructured":"Ziegler BL, Valtieri M, Almeida Porada G, De Maria R, Muller R, Masella B, Gabbianelli M, Casella I, Pelosi E, Bock T, Zanjani ED, Peschle C . KDR receptor: a key marker defining hematopoietic stem cells Science 1999 285: 1553\u20131558","journal-title":"Science"},{"key":"BF2402124_CR33","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.1200\/JCO.1999.17.9.2954","volume":"17","author":"G Barosi","year":"1999","unstructured":"Barosi G . Myelofibrosis with myeloid metaplasia: diagnostic definition and prognostic classification for clinical studies and treatment guidelines J Clin Oncol 1999 17: 2954\u20132970","journal-title":"J Clin Oncol"},{"key":"BF2402124_CR34","first-page":"702a, (Abstr. 3","volume":"94 (Suppl. 1)","author":"DA Thomas","year":"1999","unstructured":"Thomas DA, Aguayo A, Giles FJ, Albitar M, O'Brien S, Cortes J, Faderl S, Bivins C, Zeldis J, Keating MJ, Barlogie B, Kantarjian MJ . Thalidomide anti-angiogenesis therapy (RX) in Philadelphia (Ph)-negative myeloproliferative disorders (MPD) and myelofibrosis (MF) Blood 1999 94 (Suppl. 1): 702a, (Abstr. 3102)","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2402124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402124","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:57:11Z","timestamp":1648763831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2402124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,1]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6,1]]}},"alternative-id":["BF2402124"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2402124","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6,1]]},"assertion":[{"value":"25 September 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}