{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:58:40Z","timestamp":1761310720249},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2001,11,29]],"date-time":"2001-11-29T00:00:00Z","timestamp":1006992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,11,29]],"date-time":"2001-11-29T00:00:00Z","timestamp":1006992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2001,12,1]]},"DOI":"10.1038\/sj.leu.2402306","type":"journal-article","created":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T06:31:08Z","timestamp":1313130668000},"page":"1898-1905","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Accumulation of somatic mutations in proliferating T cell clones from children treated for leukemia"],"prefix":"10.1038","volume":"15","author":[{"given":"BA","family":"Finette","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AC","family":"Homans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rivers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Messier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RJ","family":"Albertini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,11,29]]},"reference":[{"key":"BF2402306_CR1","doi-asserted-by":"publisher","first-page":"15121","DOI":"10.1073\/pnas.96.26.15121","volume":"96","author":"DL Stoler","year":"1999","unstructured":"Stoler DL, Chen N, Basik M, Kahlenberg MS, Rodriguez-Bigas MA, Petrelli NJ, Anderson GR . The onset and extent of genomic instability in sporadic colorectal tumor progression Proc Natl Acad Sci USA 1999 96: 15121\u201315126","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2402306_CR2","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/363558a0","volume":"363","author":"Y Ionov","year":"1993","unstructured":"Ionov Y, Peinado M, Malkhosyan S, Shivata D, Perucho M . Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis Nature 1993 363: 558\u2013561","journal-title":"Nature"},{"key":"BF2402306_CR3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1126\/science.959840","volume":"194","author":"PC Nowell","year":"1976","unstructured":"Nowell PC . The clonal evolution of tumor cell populations Science 1976 194: 23\u201328","journal-title":"Science"},{"key":"BF2402306_CR4","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/0168-9525(93)90209-Z","volume":"9","author":"B Vogelstein","year":"1993","unstructured":"Vogelstein B, Kinzler KW . The multistep nature of cancer Trends Genet 1993 9: 138\u2013141","journal-title":"Trends Genet"},{"key":"BF2402306_CR5","first-page":"26","volume-title":"Advances in Cancer Research","author":"LA Loeb","year":"1998","unstructured":"Loeb LA . Cancer cells exhibit a mutator phenotype. In: Vande Woude GF, Klein G (eds) Advances in Cancer Research Academic Press: San Diego 1998 pp 26\u201356"},{"key":"BF2402306_CR6","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/25292","volume":"396","author":"C Lengauer","year":"1998","unstructured":"Lengauer C, Kinzler KW, Vogelstein B . Genetic instabilities in human cancers Nature 1998 396: 643\u2013649","journal-title":"Nature"},{"key":"BF2402306_CR7","first-page":"5059","volume":"54","author":"LA Loeb","year":"1994","unstructured":"Loeb LA . Microsatellite instability: marker of a mutator phenotype in cancer Cancer Res 1994 54: 5059\u20135063","journal-title":"Cancer Res"},{"key":"BF2402306_CR8","first-page":"675","volume":"377","author":"M Perucho","year":"1996","unstructured":"Perucho M . Cancer of the microsatellite mutator phenotype Biol Chem 1996 377: 675\u2013684","journal-title":"Biol Chem"},{"key":"BF2402306_CR9","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/0092-8674(93)90546-3","volume":"75","author":"R Fishel","year":"1993","unstructured":"Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R . The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer Cell 1993 75: 1027\u20131038","journal-title":"Cell"},{"key":"BF2402306_CR10","first-page":"775","volume":"105","author":"P Peltomaki","year":"1997","unstructured":"Peltomaki P . DNA Mismatch repair gene mutations in human cancer Environ Health Perspect 1997 105: 775\u2013780","journal-title":"Environ Health Perspect"},{"key":"BF2402306_CR11","doi-asserted-by":"publisher","first-page":"14800","DOI":"10.1073\/pnas.93.25.14800","volume":"93","author":"IPM Tomlinson","year":"1996","unstructured":"Tomlinson IPM, Novelli MR, Bodmer WF . The mutation rate and cancer Proc Natl Acad Sci USA 1996 93: 14800\u201314803","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2402306_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/4687","volume":"5","author":"I Tomlinson","year":"1999","unstructured":"Tomlinson I, Bodmer W . Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog Nat Med 1999 5: 11\u201312","journal-title":"Nat Med"},{"key":"BF2402306_CR13","first-page":"7415","volume":"50","author":"S Preston-Martin","year":"1990","unstructured":"Preston-Martin S, Pike MC, Ross RK, Jones PA, Henderson BE . Increased cell division as a cause of human cancer Cancer Res 1990 50: 7415\u20137421","journal-title":"Cancer Res"},{"key":"BF2402306_CR14","first-page":"6510","volume":"60","author":"M Chow","year":"2000","unstructured":"Chow M, Rubin H . Clonal selection versus genetic instability as the driving force in neoplastic transformation Cancer Res 2000 60: 6510\u20136518","journal-title":"Cancer Res"},{"key":"BF2402306_CR15","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/0027-5107(93)90115-V","volume":"285","author":"RF Branda","year":"1993","unstructured":"Branda RF, Sullivan LM, O'Neil JP, Falta MT, Nicklas JA, Hirsch B, Vacek PM, Albertini RJ . Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations Mutat Res 1993 285: 267\u2013279","journal-title":"Mutat Res"},{"key":"BF2402306_CR16","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0027-5107(94)90157-0","volume":"308","author":"BA Finette","year":"1994","unstructured":"Finette BA, Sullivan LM, O'Neill JP, Nicklas JA, Vacek PM, Albertini RJ . Determination of HPRT mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age Mutat Res 1994 308: 223\u2013231","journal-title":"Mutat Res"},{"key":"BF2402306_CR17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0165-1161(94)90053-1","volume":"313","author":"D Robinson","year":"1994","unstructured":"Robinson D, Goodall K, Albertini RJ, O'Neill JP, Finette BA, Sala-Trepat M, Tates AD, Beare D, Green MHL, Cole J . An analysis of in vivo HPRT mutant frequency in circulating T-lymphocytes in the normal human population: a comparison of four databases Mutat Res 1994 313: 227\u2013247","journal-title":"Mutat Res"},{"key":"BF2402306_CR18","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/em.2850250302","volume":"25","author":"J Curry","year":"1995","unstructured":"Curry J, Rowley GT, Saddi V, Beare D, Cole J, Glickman BW . Determination of HPRT mutant and mutation frequencies and the molecular characterization of human derived in vivo T-lymphocyte mutants Environ Mol Mutagen 1995 25: 169\u2013179","journal-title":"Environ Mol Mutagen"},{"key":"BF2402306_CR19","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/978-1-4615-5381-6_132","volume-title":"Purine and Pyrimidine Metabolism in Man IX","author":"Y-W Lin","year":"1998","unstructured":"Lin Y-W, Kubota M, Akiyama Y, Sawada M, Furusho K . Measurement of mutation frequency at the HPRT locus in peripheral lymphocytes Purine and Pyrimidine Metabolism in Man IX Plenum Press: New York 1998 pp 681\u2013686"},{"key":"BF2402306_CR20","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/em.2850170403","volume":"17","author":"JP O'Neill","year":"1991","unstructured":"O'Neill JP, Sullivan LM, Hunter TC, Nicklas JA . Cytosine arabinoside enhancement of gamma irradiation induced mutations in human T-lymphocytes Environ Mol Mutagen 1991 17: 231\u2013237","journal-title":"Environ Mol Mutagen"},{"key":"BF2402306_CR21","first-page":"1615","volume":"52","author":"EA Bookland","year":"1992","unstructured":"Bookland EA, Reznikoff CA, Lindstrom M, Swaminathan S . Induction of thioguanine-resistant mutations in human uroepithelial cells by 4-aminobiphenyl and its N-hydroxy derivatives Cancer Res 1992 52: 1615\u20131621","journal-title":"Cancer Res"},{"key":"BF2402306_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0165-7992(87)90171-0","volume":"191","author":"AM Seifert","year":"1987","unstructured":"Seifert AM, Bradley WC, Messing K . Exposure of nuclear medicine patients to ionizing radiation is associated with rises in HPRT-mutant frequency in peripheral T-lymphocytes Mutat Res 1987 191: 57\u201363","journal-title":"Mutat Res"},{"key":"BF2402306_CR23","first-page":"1405","volume":"56","author":"BA Finette","year":"1996","unstructured":"Finette BA, Poseno T, Albertini RJ . V(D)J recombinase-mediated HPRT mutations in peripheral blood lymphocytes of normal children Cancer Res 1996 56: 1405\u20131412","journal-title":"Cancer Res"},{"key":"BF2402306_CR24","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/2640","volume":"4","author":"BA Finette","year":"1998","unstructured":"Finette BA, O'Neill JP, Vacek PM, Albertini RJ . Gene mutations with characteristic deletions in cord blood T lymphocytes associated with passive maternal exposure to tobacco smoke Nat Med 1998 4: 1144\u20131151","journal-title":"Nat Med"},{"key":"BF2402306_CR25","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0027-5107(99)00172-4","volume":"431","author":"WL Bigbee","year":"1999","unstructured":"Bigbee WL, Day RD, Grant SG, Keohavong P, Xi L, Zhang L, Ness RB . Impact of maternal lifestyle factors on HPRT mutant frequencies and molecular spectrum \u2013 initial results from the Prenatal Exposures and Preeclampsia Prevention (PEPP) study Mutat Res 1999 431: 279\u2013289","journal-title":"Mutat Res"},{"key":"BF2402306_CR26","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/genetics\/152.3.1065","volume":"152","author":"J Curry","year":"1999","unstructured":"Curry J, Karnaoukhova L, Guenette GC, Glickman BW . Influence of sex, smoking and age on human HPRT mutation frequencies and spectra Genetics 1999 152: 1065\u20131077","journal-title":"Genetics"},{"key":"BF2402306_CR27","first-page":"65","volume":"173","author":"JA Nicklas","year":"1986","unstructured":"Nicklas JA, O'Neill JP, Albertini RJ . Use of T-cell receptor gene probes to quantify the in vivo HPRT mutations in human T-lymphocytes Mutat Res 1986 173: 65\u201372","journal-title":"Mutat Res"},{"key":"BF2402306_CR28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.154.1.17","volume":"154","author":"PA Baars","year":"1995","unstructured":"Baars PA, Maurice MM, Rep M, Hooibrink B, Lier RA . Heterogeneity of the circulating human CD4+ T cell population J Immunol 1995 154: 17\u201325","journal-title":"J Immunol"},{"key":"BF2402306_CR29","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1126\/science.288.5465.514","volume":"288","author":"BA Finette","year":"2000","unstructured":"Finette BA, Homans AC, Albertini RJ . Emergence of genetic instability in children treated for leukemia Science 2000 288: 514\u2013517","journal-title":"Science"},{"key":"BF2402306_CR30","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1046\/j.1365-3083.2000.00742.x","volume":"51","author":"MT Falta","year":"2000","unstructured":"Falta MT, Atkinson MA, Allegretta M, Vacek PM, Albertini RJ . Azathioprine associated T-cell mutations in insulin-dependent diabetes mellitus Scand J Immunol 2000 51: 626\u2013633","journal-title":"Scand J Immunol"},{"key":"BF2402306_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/mutage\/2.2.87","volume":"2","author":"JP O'Neill","year":"1987","unstructured":"O'Neill JP, McGinniss MJ, Berman JK, Sullivan LM, Nicklas JA, Albertini RJ . Refinement of a T-lymphocyte cloning assay to quantify the in vivo thioquanine-resistant mutant frequency in humans Mutagenesis 1987 2: 87\u201394","journal-title":"Mutagenesis"},{"key":"BF2402306_CR32","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0888-7543(90)90545-6","volume":"7","author":"RA Gibbs","year":"1990","unstructured":"Gibbs RA, Nguyen P-N, Edwards A, Civitello AB, Caskey CT . Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch\u2013Nyhan families Genomics 1990 7: 235\u2013244","journal-title":"Genomics"},{"key":"BF2402306_CR33","first-page":"6001","volume":"51","author":"JC Fuscoe","year":"1991","unstructured":"Fuscoe JC, Zimmerman LJ, Lippert MJ, Nicklas JA, O'Neill JP, Albertini RJ . V(D)J Recombinase-like activity mediates HPRT gene deletion in human fetal T-lymphocytes Cancer Res 1991 51: 6001\u20136005","journal-title":"Cancer Res"},{"key":"BF2402306_CR34","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1093\/nar\/26.1.198","volume":"26","author":"NF Cariello","year":"1998","unstructured":"Cariello NF, Douglas GR, Gorelick NJ, Hart DW, Wilson JD, Soussi T . Database and software for the analysis of mutations in the human p53 gene, human HPRT gene and both the lacl and lacz gene in transgenic rodents Nucleic Acids Res 1998 26: 198\u2013199","journal-title":"Nucleic Acids Res"},{"key":"BF2402306_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0165-7992(92)90116-Y","volume":"283","author":"JC Fuscoe","year":"1992","unstructured":"Fuscoe JC, Zimmerman LJ, Harrington-Brock K, Burnette L, Moore MM, Nicklas JA, O'Neill JP, Albertini RJ . V(D)J recombinase mediated deletion of the HPRT gene in T-lymphocytes from adult humans Mutat Res 1992 283: 13\u201320","journal-title":"Mutat Res"},{"key":"BF2402306_CR36","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1006\/clim.1998.4664","volume":"90","author":"MT Falta","year":"1999","unstructured":"Falta MT, Magin\u2019 GK, Allegretta M, Steinman L, Atkinson MA, Rostoff SW, Albertini RJ . Selection of HPRT mutant T-cells as surrogates for dividing cells reveals a restricted T cell receptor BV repertoire in insulin-dependent diabetes mellitus Clin Immunol 1999 90: 340\u2013351","journal-title":"Clin Immunol"},{"key":"BF2402306_CR37","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0165-1161(94)90052-3","volume":"313","author":"JP O'Neill","year":"1994","unstructured":"O'Neill JP, Nicklas JA, Hunter TC, Batson OB, Allegretta M, Falta MT, Branda RF, Albertini RJ . The effect of T-lymphocyte \u2018clonality\u2019 on the calculated HPRT mutation frequency occuring in vivo in humans Mutat Res 1994 313: 215\u2013225","journal-title":"Mutat Res"},{"key":"BF2402306_CR38","first-page":"167","volume-title":"Biomarkers: Medical and Workplace Applications","author":"RJ Albertini","year":"1998","unstructured":"Albertini RJ . Somatic mutations as multipurpose biomarkers. In: Mendelsohn ML, Mohr LC, Peeters JP (eds) Biomarkers: Medical and Workplace Applications Joseph Henry Press: Washington, DC 1998 pp 167\u2013185"},{"key":"BF2402306_CR39","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1146\/annurev.micro.50.1.625","volume":"50","author":"JH Miller","year":"1996","unstructured":"Miller JH . Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repair Annu Rev Microbiol 1996 50: 625\u2013643","journal-title":"Annu Rev Microbiol"},{"key":"BF2402306_CR40","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1128\/jb.179.2.417-422.1997","volume":"179","author":"EF Mao","year":"1997","unstructured":"Mao EF, Lane L, Lee J, Miller JH . Proliferation of mutators in a cell population J Bacteriol 1997 179: 417\u2013422","journal-title":"J Bacteriol"},{"key":"BF2402306_CR41","first-page":"3986","volume":"58","author":"CR Hunt","year":"1998","unstructured":"Hunt CR, Sim JE, Sullivan SJ, Featherstone T, Golden W, Kapp-Herr CV, Hock RA, Gomez RA, Parsian AJ, Spitz DR . Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress Cancer Res 1998 58: 3986\u20133992","journal-title":"Cancer Res"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2402306.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402306","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402306.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T17:57:36Z","timestamp":1686247056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2402306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,29]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12,1]]}},"alternative-id":["BF2402306"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2402306","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11,29]]},"assertion":[{"value":"12 April 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2001","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}