{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:48:57Z","timestamp":1792057737788,"version":"4.4.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2002,4,1]]},"DOI":"10.1038\/sj.leu.2402419","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T18:42:14Z","timestamp":1031251334000},"page":"608-616","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":153,"title":["Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells"],"prefix":"10.1038","volume":"16","author":[{"given":"O","family":"Fingrut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Flescher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,4,16]]},"reference":[{"key":"BF2402419_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0968-4328(99)00083-9","volume":"31","author":"Z Somozy","year":"2000","unstructured":"Somozy Z . Radiation response of cell organelles Micron 2000 31: 165\u2013181","journal-title":"Micron"},{"key":"BF2402419_CR2","first-page":"261","volume":"69","author":"YM Janssen","year":"1993","unstructured":"Janssen YM, Van Houten B, Borm PJ, Mossman BT . Cell and tissue responses to oxidative damage Lab Invest 1993 69: 261\u2013274","journal-title":"Lab Invest"},{"key":"BF2402419_CR3","first-page":"243","volume":"1","author":"J Fujita","year":"1999","unstructured":"Fujita J . Cold shock response in mammalian cells J Mol Microbiol Biotechnol 1999 1: 243\u2013255","journal-title":"J Mol Microbiol Biotechnol"},{"key":"BF2402419_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0168-1605(00)00209-9","volume":"55","author":"J Guzzo","year":"2000","unstructured":"Guzzo J, Jobin MP, Delmas F, Fortier LC, Garmyn D, Tourdot-Marechal R, Lee B, Divies C . Regulation of stress response in Oenococcus oeni as a function of environmental changes and growth phase Int J Food Microbiol 2000 55: 27\u201331","journal-title":"Int J Food Microbiol"},{"key":"BF2402419_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/713803463","volume":"48","author":"KJ Davies","year":"1999","unstructured":"Davies KJ . The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress IUBMB Life 1999 48: 41\u201347","journal-title":"IUBMB Life"},{"key":"BF2402419_CR6","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1177\/002215549904700901","volume":"47","author":"MC Willingham","year":"1999","unstructured":"Willingham MC . Cytochemical methods for the detection of apoptosis J Histochem Cytochem 1999 47: 1101\u20131109","journal-title":"J Histochem Cytochem"},{"key":"BF2402419_CR7","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1093\/jnci\/86.17.1286","volume":"86","author":"BW Stewart","year":"1994","unstructured":"Stewart BW . Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators J Cancer Inst 1994 86: 1286\u20131295","journal-title":"J Cancer Inst"},{"key":"BF2402419_CR8","first-page":"593","volume":"136","author":"MJ Arends","year":"1990","unstructured":"Arends MJ, Moris RG, Wyllie AH . Apoptosis: the role of the endonuclease Am J Pathol 1990 136: 593\u2013608","journal-title":"Am J Pathol"},{"key":"BF2402419_CR9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0968-0004(97)01085-2","volume":"22","author":"DW Nicholson","year":"1997","unstructured":"Nicholson DW, Thomberry A . Caspases: killer proteases Trends Biochem Sci 1997 22: 299\u2013306","journal-title":"Trends Biochem Sci"},{"key":"BF2402419_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","volume":"6","author":"AG Porter","year":"1999","unstructured":"Porter AG, Janicke RU . Emerging roles of caspases-3 in apoptosis Cell Death Differ 1999 6: 99\u2013104","journal-title":"Cell Death Differ"},{"key":"BF2402419_CR11","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/sj.leu.2400762","volume":"11","author":"JD Bailly","year":"1997","unstructured":"Bailly JD, Skladanowski A, Bettaieb A, Mansat V, Larsen AK, Laurent G . Natural resistance of acute myeloid leukemia cells lines to mitoxantrone is associated with lack of apoptosis Leukemia 1997 11: 1523\u20131532","journal-title":"Leukemia"},{"key":"BF2402419_CR12","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1182\/blood.V93.7.2386","volume":"93","author":"L Klampfer","year":"1999","unstructured":"Klampfer L, Cammenga J, Wisniewski HG, Nimer SD . Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines Blood 1999 93: 2386\u20132394","journal-title":"Blood"},{"key":"BF2402419_CR13","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1073\/pnas.94.7.2869","volume":"94","author":"P Schwenger","year":"1997","unstructured":"Schwenger P, Bellosta P, Vietor I, Basilico C, Skolnik EY, Vil\u010dek J . Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase\/stress-activated protein kinase activation Proc Natl Acad Sci USA 1997 94: 2869\u20132873","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2402419_CR14","first-page":"2997","volume":"19","author":"C Sotiriou","year":"1999","unstructured":"Sotiriou C, Lacroix M, Lagneaux L, Berchem G, Body JJ . The aspirin metabolite salicylate inhibits breast cancer cells growth and their synthesis of the osteolytic cytokines interleukins-6 and-11 Anticancer Res 1999 19: 2997\u20133006","journal-title":"Anticancer Res"},{"key":"BF2402419_CR15","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1146\/annurev.pp.44.060193.003033","volume":"44","author":"G Sembdner","year":"1993","unstructured":"Sembdner G, Parthier B . The biochemistry and the physiological and molecular actions of jasmonates Annu Rev Physiol Plant Mol Biol 1993 44: 569\u2013589","journal-title":"Annu Rev Physiol Plant Mol Biol"},{"key":"BF2402419_CR16","doi-asserted-by":"publisher","first-page":"7713","DOI":"10.1073\/pnas.87.19.7713","volume":"87","author":"EE Farmer","year":"1990","unstructured":"Farmer EE, Ryan CA . Interplant communication: air-borne methyl jasmonate induces synthesis of proteinase inhibitors in plant leaves Proc Natl Acad Sci USA 1990 87: 7713\u20137716","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2402419_CR17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/0966-842X(96)81499-5","volume":"4","author":"R Mitler","year":"1996","unstructured":"Mitler R, Lam E . Sacrifice in the face of foes: pathogen-induced programmed cell death in higher plants Trends Microbiol 1996 4: 10\u201315","journal-title":"Trends Microbiol"},{"key":"BF2402419_CR18","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1105\/tpc.8.10.1793","volume":"8","author":"JL Dangl","year":"1996","unstructured":"Dangl JL, Dietrich RA, Richberg MH . Death don't have no mercy: cell death programs in plant\u2013microbe interactions Plant Cell 1996 8: 1793\u20131807","journal-title":"Plant Cell"},{"key":"BF2402419_CR19","unstructured":"Goodman RN, Novacky AJ . The hypersensitive response reaction in plants to pathogens: a resistance phenomenon American Phytopathological Society: St Paul, MN 1994 (Abstr.)"},{"key":"BF2402419_CR20","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/(SICI)1097-4652(199904)179:1<109::AID-JCP13>3.0.CO;2-W","volume":"179","author":"P Schwenger","year":"1999","unstructured":"Schwenger P, Alpert D, Skolnik EY, Vil\u010dek J . Cell-type-specific activation of c-Jun N-terminal kinase by salicylates J Cell Physiol 1999 179: 109\u2013114","journal-title":"J Cell Physiol"},{"key":"BF2402419_CR21","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1006\/cyto.1999.0571","volume":"12","author":"E Flescher","year":"2000","unstructured":"Flescher E, Fingrut O . Suppression of interleukin-2 biosynthesis by three modes of oxidative cellular stress: selective prevention by N-acetyl cysteine Cytokine 2000 12: 495\u2013498","journal-title":"Cytokine"},{"key":"BF2402419_CR22","first-page":"583","volume-title":"Basic and Clinical Pharmacology, 7th edn","author":"BG Katzung","year":"1998","unstructured":"Katzung BG . Nonsteroidal anti-inflammatory drugs; disease-modifying antirheumatic drugs; nonopioid analgesics; drugs used in gout In: Katzung BG (ed.) Basic and Clinical Pharmacology, 7th edn Appleton & Lange: Stamford 1998 p 583"},{"key":"BF2402419_CR23","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1126\/science.8052854","volume":"265","author":"E Kopp","year":"1994","unstructured":"Kopp E, Ghosh S . Inhibition of NF-\u03baB by sodium salicylate and aspirin Science 1994 265: 956\u2013959","journal-title":"Science"},{"key":"BF2402419_CR24","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1126\/science.1546322","volume":"255","author":"DA Jurivich","year":"1992","unstructured":"Jurivich DA, Sistonen L, Kroes RA, Morimoto I . Effect of sodium salicylate on the human heat shock response Science 1992 255: 1243\u20131245","journal-title":"Science"},{"key":"BF2402419_CR25","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1105\/tpc.8.10.1809","volume":"8","author":"JA Ryals","year":"1996","unstructured":"Ryals JA, Neuenschwander UH, Willits MG, Molina A, Steiner H-Y, Hunt MD . Systemic acquired resistance Plant Cell 1996 8: 1809\u20131819","journal-title":"Plant Cell"},{"key":"BF2402419_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/anr.1780320102","volume":"32","author":"SB Abramson","year":"1989","unstructured":"Abramson SB, Weissmann G . The mechanisms of action of nonsteroidal antiinflammatory drugs Arthritis Rheum 1989 32: 1\u20139","journal-title":"Arthritis Rheum"},{"key":"BF2402419_CR27","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1136\/gut.38.5.646","volume":"38","author":"G Morgan","year":"1996","unstructured":"Morgan G . Non-steroidal anti-inflammatory drugs and the chemoprevention of colorectal and oesophageal cancers Gut 1996 38: 646\u2013648","journal-title":"Gut"},{"key":"BF2402419_CR28","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/BF02088554","volume":"41","author":"II Peleg","year":"1996","unstructured":"Peleg II, Lubin MF, Cotsonis GA, Clark WS, Wilcox CM . Long-term use of non-steroidal antiinflammatory drugs and other chemopreventors and risk of subsequent colorectal neoplasia Dig Dis Sci 1996 41: 1319\u20131326","journal-title":"Dig Dis Sci"},{"key":"BF2402419_CR29","first-page":"749","volume":"6","author":"H Vainio","year":"1997","unstructured":"Vainio H, Morgan G, Kleihues P . An international evaluation of the cancer-preventive potential of nonsteroidal anti-inflammatory drugs Cancer Epidemiol Biomarkers Prev 1997 6: 749\u2013753","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BF2402419_CR30","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1172\/JCI118060","volume":"96","author":"SJ Shiff","year":"1995","unstructured":"Shiff SJ, Qiao L, Tsai LL, Rigas B . Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells J Clin Invest 1995 96: 491\u2013503","journal-title":"J Clin Invest"},{"key":"BF2402419_CR31","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0167-4889(96)00005-5","volume":"1311","author":"CM Bunce","year":"1996","unstructured":"Bunce CM, Mountford JC, French PJ, Mole DJ, Durham J, Michell RH, Brown G . Potentiation of myeloid differentiation by anti-inflammatory agents, by steroids and by retinoic acid involves a single intracellular target, probably an enzyme of the aldoketoreductase family Biochem Biophys Acta 1996 1311: 189\u2013198","journal-title":"Biochem Biophys Acta"},{"key":"BF2402419_CR32","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/excr.1996.0023","volume":"222","author":"SJ Shiff","year":"1996","unstructured":"Shiff SJ, Koutsos MI, Qiao L, Rigas B . Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis Exp Cell Res 1996 222: 179\u2013188","journal-title":"Exp Cell Res"},{"key":"BF2402419_CR33","first-page":"446","volume":"202","author":"V Hial","year":"1977","unstructured":"Hial V, De Mello MC, Horakova Z, Beaven MA . Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines J Pharmacol Exp Ther 1977 202: 446\u2013454","journal-title":"J Pharmacol Exp Ther"},{"key":"BF2402419_CR34","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1093\/oxfordjournals.bmb.a011623","volume":"53","author":"AH Wyllie","year":"1997","unstructured":"Wyllie AH . Apoptosis: an overview Br Med Bull 1997 53: 451\u2013465","journal-title":"Br Med Bull"},{"key":"BF2402419_CR35","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1182\/blood.V92.4.1406","volume":"92","author":"B Bellosillo","year":"1998","unstructured":"Bellosillo B, Pique M, Barragan M, Castano E, Villamor N, Colomer D, Montserrat E, Pons G, Gil J . Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells Blood 1998 92: 1406\u20131414","journal-title":"Blood"},{"key":"BF2402419_CR36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1006\/jsre.1998.5560","volume":"83","author":"TP McDade","year":"1999","unstructured":"McDade TP, Perugini RA, Vittimberga FJ Jr, Carrigan RC, Callery MP . Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer J Surg Res 1999 83: 56\u201361","journal-title":"J Surg Res"},{"key":"BF2402419_CR37","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/383826a0","volume":"383","author":"A Conconi","year":"1996","unstructured":"Conconi A, Smerdon MJ, Howe GA, Ryan CA . The octadecanoid signalling pathway in plants mediates a response to ultraviolet radiation Nature 1996 383: 826\u2013829","journal-title":"Nature"},{"key":"BF2402419_CR38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev.bi.55.070186.000441","volume":"55","author":"P Needleman","year":"1986","unstructured":"Needleman P, Turk J, Jakschik BA, Morrison AR, Lefkowith JB . Arachidonic acid metabolism Ann Rev Biochem 1986 55: 69\u2013102","journal-title":"Ann Rev Biochem"},{"key":"BF2402419_CR39","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/ijc.2910510324","volume":"51","author":"C D'Onofrio","year":"1992","unstructured":"D'Onofrio C, Amici C, Puglianiello A, Faraoni I, Lanzilli G, Santoro MG, Bonmassar E . Comparative anti-viral and anti-proliferative activity of PGA1 and PGJ2 against HTLV-I-infected MT-2 cells Int J Cancer 1992 51: 481\u2013488","journal-title":"Int J Cancer"},{"key":"BF2402419_CR40","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1128\/MCB.16.3.762","volume":"16","author":"M Gorospe","year":"1996","unstructured":"Gorospe M, Liu Y, Xu Q, Cherst FJ, Holbrook NJ . Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2 Mol Cell Biol 1996 16: 762\u2013770","journal-title":"Mol Cell Biol"},{"key":"BF2402419_CR41","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/00001813-199404000-00002","volume":"5","author":"H Sasaki","year":"1994","unstructured":"Sasaki H, Fukushima M . Prostaglandins in the treatment of cancer Anti-Cancer Drugs 1994 5: 131\u2013138","journal-title":"Anti-Cancer Drugs"},{"key":"BF2402419_CR42","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0092-8674(95)90402-6","volume":"80","author":"I Herskowitz","year":"1995","unstructured":"Herskowitz I . MAP kinase pathways in yeast: for mating and more Cell 1995 80: 187\u2013197","journal-title":"Cell"},{"key":"BF2402419_CR43","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S1360-1385(96)10048-0","volume":"2","author":"H Hirt","year":"1997","unstructured":"Hirt H . Multiple roles of MAP kinases in plant signal transduction Trends Plant Sci 1997 2: 11\u201315","journal-title":"Trends Plant Sci"},{"key":"BF2402419_CR44","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1105\/tpc.9.5.809","volume":"9","author":"S Zhang","year":"1997","unstructured":"Zhang S, Klessig DF . Salicylic acid activates a 48-kD MAP kinase in tobacco Plant Cell 1997 9: 809\u2013824","journal-title":"Plant Cell"},{"key":"BF2402419_CR45","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1753-4887.1994.tb01453.x","volume":"52","author":"B Halliwell","year":"1994","unstructured":"Halliwell B . Free radicals and antioxidants: a personal view Nutr Rev 1994 52: 253\u2013265","journal-title":"Nutr Rev"},{"key":"BF2402419_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0167-5699(94)90018-3","volume":"15","author":"TM Buttke","year":"1994","unstructured":"Buttke TM, Sandstrom PA . Oxidative stress as a mediator of apoptosis Immunol Today 1994 15: 7\u201310","journal-title":"Immunol Today"},{"key":"BF2402419_CR47","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1105\/tpc.8.11.1991","volume":"8","author":"R Mittler","year":"1996","unstructured":"Mittler R, Shulaev V, Seskar M, Lam E . Inhibition of programmed cell death in tobacco plants during a pathogen-induced hypersensitive response at low oxygen pressure Plant Cell 1996 8: 1991\u20132001","journal-title":"Plant Cell"},{"key":"BF2402419_CR48","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1101\/gad.11.13.1621","volume":"11","author":"Y Yang","year":"1997","unstructured":"Yang Y, Shah J, Klessig DF . Signal perception and transduction in plant defense responses Genes Dev 1997 11: 1621\u20131639","journal-title":"Genes Dev"},{"key":"BF2402419_CR49","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1105\/tpc.10.3.461","volume":"10","author":"R Mittler","year":"1998","unstructured":"Mittler R, Feng X, Cohen M . Post-transcriptional suppression of cytosolic ascorbate peroxidase expression during pathogen-induced programmed cell death in tobacco Plant Cell 1998 10: 461\u2013473","journal-title":"Plant Cell"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2402419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402419","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:20:55Z","timestamp":1648761655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2402419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4,1]]}},"alternative-id":["BF2402419"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2402419","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,1]]},"assertion":[{"value":"2 July 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}