{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:00:28Z","timestamp":1768518028615,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2002,5,1]]},"DOI":"10.1038\/sj.leu.2402455","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T18:32:24Z","timestamp":1031164344000},"page":"920-927","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Pharmacokinetic interactions of cyclosporine with etoposide and mitoxantrone in children with acute myeloid leukemia"],"prefix":"10.1038","volume":"16","author":[{"given":"NJ","family":"Lacayo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BL","family":"Lum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DL","family":"Becton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Ravindranath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MN","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Bomgaars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SJ","family":"Lauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BI","family":"Sikic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GV","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,5,2]]},"reference":[{"key":"BF2402455_CR1","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1002\/1097-0142(19920515)69:10<2603::AID-CNCR2820691034>3.0.CO;2-E","volume":"69","author":"V Ling","year":"1992","unstructured":"Ling V . Charles F. Kettering prize. P-glycoprotein and resistance to anticancer drugs Cancer 1992 69: 2603\u20132609","journal-title":"Cancer"},{"key":"BF2402455_CR2","first-page":"363","volume-title":"Drug Resistance in Clinical Oncology and Hematology. Hematology\/Oncology Clinics of North America","author":"GA Fisher","year":"1995","unstructured":"Fisher GA, Sikic BI . Clinical studies with modulators of multidrug resistance In: Fisher GA and Sikic BI (eds) Drug Resistance in Clinical Oncology and Hematology. Hematology\/Oncology Clinics of North America Vol. 9, No. 2: WB Saunders Co: Philadelphia, PA 1995 pp 363\u2013382"},{"key":"BF2402455_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0145-2126(95)00134-4","volume":"20","author":"A Samdani","year":"1996","unstructured":"Samdani A, Vijapurkar U, Grimm MA, Spier CS, Grogan TM, Glinsmann-Gibson BJ, List AF . Cytogenetics and P-glycoprotein (PGP) are independent predictors of treatment outcome in acute myeloid leukemia (AML) Leuk Res 1996 20: 175\u2013180","journal-title":"Leuk Res"},{"key":"BF2402455_CR4","first-page":"974","volume":"8","author":"S Zochbauer","year":"1994","unstructured":"Zochbauer S, Gsur A, Brunner R, Kyrle PA, Lechner K, Pirker R . P-glycoprotein expression as unfavorable prognostic factor in acute myeloid leukemia Leukemia 1994 8: 974\u2013977","journal-title":"Leukemia"},{"key":"BF2402455_CR5","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1046\/j.1365-2141.1998.01111.x","volume":"103","author":"AG Borg","year":"1998","unstructured":"Borg AG, Burgess R, Green LM, Scheper RJ, Yin JA . Overexpression of lung-resistance protein and increased P-glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival Br J Haematol 1998 103: 1083\u20131091","journal-title":"Br J Haematol"},{"key":"BF2402455_CR6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood.V88.1.309.309","volume":"88","author":"SP Ivy","year":"1996","unstructured":"Ivy SP, Olshefski RS, Taylor BJ, Patel KM, Reaman GH . Correlation of P-glycoprotein expression and function in childhood acute leukemia: a Children's Cancer Group study Blood 1996 88: 309\u2013318","journal-title":"Blood"},{"key":"BF2402455_CR7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1159\/000227039","volume":"49","author":"A O'Meara","year":"1992","unstructured":"O'Meara A, Imamura A, Johnson P, Ball R, Rooney S, Kierce B, Tsuruo T, Dervan P . Reactivity of P-glycoprotein monoclonal antibodies in childhood cancers Oncology 1992 49: 203\u2013208","journal-title":"Oncology"},{"key":"BF2402455_CR8","first-page":"275","volume-title":"Drug Resistance in Clinical Oncology and Hematology. Hematology\/Oncology Clinics of North America","author":"HSL Chan","year":"1995","unstructured":"Chan HSL, DeBoer G, Haddad G, Gallie BL, Ling V . Multidrug resistance in pediatric malignancies In: Fisher GA, Sikic BI (eds) Drug Resistance in Clinical Oncology and Hematology. Hematology\/Oncology Clinics of North America Vol. 9, No. 2: WB Saunders Co; Philadelphia, PA 1995 pp 275\u2013318"},{"key":"BF2402455_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/BF00173683","volume":"14","author":"JF Kuttesch","year":"1996","unstructured":"Kuttesch JF . Multidrug resistance in pediatric oncology Invest New Drugs 1996 14: 55\u201367","journal-title":"Invest New Drugs"},{"key":"BF2402455_CR10","first-page":"1499","volume":"3","author":"HSL Chan","year":"1996","unstructured":"Chan HSL, DeBoer G, Thiessen JJ, Budning A, Kingston JE, O'Brien JM, Koren G, Giesbrecht E, Haddad G, Berjee Z, Hungerford JL, Ling V, Gallie BL . Combining cyclosporin with chemotherapy controls intraocular retinoblastoma without requiring radiation Clin Cancer Res 1996 3: 1499\u20131508","journal-title":"Clin Cancer Res"},{"key":"BF2402455_CR11","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1002\/(SICI)1096-911X(200004)34:4<242::AID-MPO2>3.0.CO;2-U","volume":"34","author":"JG Theis","year":"2000","unstructured":"Theis JG, Chan HS, Greenberg ML, Malkin D, Karaskov V, Moncica M, Korne G, Doyle J . Assessment of systemic toxicity in children receiving chemotherapy with cyclosporine for sarcoma Med Pediatr Oncol 2000 34: 242\u2013249","journal-title":"Med Pediatr Oncol"},{"key":"BF2402455_CR12","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1200\/JCO.2000.18.9.1867","volume":"18","author":"GV Dahl","year":"2000","unstructured":"Dahl GV, Lacayo NJ, Brophy N, Dunussi-Joannopoulos K, Weinstein HJ, Chang M, Sikic BI, Arceci RJ . Mitoxantrone, etoposide and cyclosporine (MEC) therapy in pediatric patients with recurrent or refractory acute myeloid leukemia J Clin Oncol 2000 18: 1867\u20131875","journal-title":"J Clin Oncol"},{"key":"BF2402455_CR13","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1200\/JCO.1999.17.9.2781","volume":"17","author":"R Gorlick","year":"1999","unstructured":"Gorlick R, Huvos AG, Heller G, Aledo A, Beardsley GP, Healey JH, Meyers PA . Expression of HER2\/erbB-2 correlates with survival in osteosarcoma J Clin Oncol 1999 17: 2781\u20132788","journal-title":"J Clin Oncol"},{"key":"BF2402455_CR14","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/0145-2126(95)00092-5","volume":"19","author":"A Tafuri","year":"1995","unstructured":"Tafuri A, Sommaggio A, Burba L, Albergoni MP, Petrucci MT, Mascolo MG, Testi AM, Basso G . Prognostic value of rhodamine-efflux and MDR-1\/P-170 expression in childhood acute leukemia Leuk Res 1995 19: 927\u2013931","journal-title":"Leuk Res"},{"key":"BF2402455_CR15","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/j.1365-2141.1995.tb03312.x","volume":"89","author":"J Beck","year":"1995","unstructured":"Beck J, Handgretinger R, Dopfer R, Klingebiel T, Niethammer D, Gekeler V . Expression of mdr1, mrp, topoisomerase II, and cyclin A in primary or relapsed states of acute lymphoblastic leukaemias Br J Haematol 1995 89: 356\u2013363","journal-title":"Br J Haematol"},{"key":"BF2402455_CR16","first-page":"426","volume":"10","author":"J Beck","year":"1996","unstructured":"Beck J, Handgretinger R, Klingebiel T, Dopfer R, Schaich M, Ehninger G, Niethammer D, Gekeler V . Expression of PKC isozyme and MDR-associated genes in primary and relapsed state AML Leukemia 1996 10: 426\u2013433","journal-title":"Leukemia"},{"key":"BF2402455_CR17","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/bjc.1994.462","volume":"70","author":"A Sauerbrey","year":"1994","unstructured":"Sauerbrey A, Zintl F, Volm M . P-glycoprotein and glutathione S-transferase in childhood acute lymphoblastic leukaemia Br J Cancer 1994 70: 1144\u20131149","journal-title":"Br J Cancer"},{"key":"BF2402455_CR18","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1182\/blood.V81.9.2394.2394","volume":"81","author":"JE Goasguen","year":"1993","unstructured":"Goasguen JE, Dossot JM, Fardel O, Le Mee F, Le Gall E, Leblay R, LePrise PY, Chaperon J, Fauchet R . Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications Blood 1993 81: 2394\u20132398","journal-title":"Blood"},{"key":"BF2402455_CR19","first-page":"2042","volume":"9","author":"EL Sievers","year":"1995","unstructured":"Sievers EL, Smith FO, Woods WG, Lee JW, Bleyer WA, Willman CL, Bernstein ID . Cell surface expression of the multidrug resistance P-glycoprotein (P-170) as detected by monoclonal antibody MRK-16 in pediatric acute myeloid leukemia fails to define a poor prognostic group: a report from the Childrens Cancer Group Leukemia 1995 9: 2042\u20132048","journal-title":"Leukemia"},{"key":"BF2402455_CR20","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/bjc.1992.146","volume":"65","author":"R Pieters","year":"1992","unstructured":"Pieters R, Hongo T, Loonen AH, Huismans DR, Broxterman HJ, Hahlen K, Veerman AJ . Different types of non-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukaemia Br J Cancer 1992 65: 691\u2013697","journal-title":"Br J Cancer"},{"key":"BF2402455_CR21","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1200\/JCO.1996.14.3.886","volume":"14","author":"JF Kuttesch","year":"1996","unstructured":"Kuttesch JF, Parham DM, Luo X, Meyer WH, Bowman L, Shapiro DN, Pappo AS, Crist WM, Beck WT, Houghton PJ . P-glycoprotein expression at diagnosis may not be a primary mechanism of therapeutic failure in childhood rhabdomyosarcoma J Clin Oncol 1996 14: 886\u2013900","journal-title":"J Clin Oncol"},{"key":"BF2402455_CR22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/(SICI)1097-0320(19991001)37:2<125::AID-CYTO5>3.0.CO;2-E","volume":"37","author":"B De Moerloose","year":"1999","unstructured":"De Moerloose B, Dhooge C, Laureys G, Benoit Y, Demarche M, Devalck C, Plantaz D, Leroy J, Philippe J . Discrepant flow cytometric expression and function of P-glycoprotein in neuroblastic tumors Cytometry 1999 37: 125\u2013132","journal-title":"Cytometry"},{"key":"BF2402455_CR23","first-page":"1063","volume":"49","author":"MS Cairo","year":"1989","unstructured":"Cairo MS, Siegel S, Anas N, Sender L . Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors Cancer Res 1989 49: 1063\u20131066","journal-title":"Cancer Res"},{"key":"BF2402455_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/mpo.2950130408","volume":"13","author":"F Bessho","year":"1985","unstructured":"Bessho F, Kinumaki H, Kobayashi M, Habu H, Nakamura K, Yokota S, Tsuruo T, Kobayashi N . Treatment of children with refractory acute lymphocytic leukemia with vincristine and diltiazem Med Pediatr Oncol 1985 13: 199\u2013202","journal-title":"Med Pediatr Oncol"},{"key":"BF2402455_CR25","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1200\/JCO.1995.13.10.2508","volume":"13","author":"JG Theis","year":"1995","unstructured":"Theis JG, Liau-Chu M, Chan HS, Doyle J, Greenberg ML, Koren G . Anaphylactoid reactions in children receiving high-dose intravenous cyclosporine for reversal of tumor resistance: the causative role of improper dissolution of cremophor EL J Clin Oncol 1995 13: 2508\u20132516","journal-title":"J Clin Oncol"},{"key":"BF2402455_CR26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1182\/blood.V93.3.787","volume":"93","author":"R Advani","year":"1999","unstructured":"Advani R, Saba HI, Tallman MS, Rowe JM, Wiernik PH, Ramek J, Dugan K, Lum B, Villena J, Davis E, Paietta E, Litchman M, Sikic BI, Greenberg PL . Treatment of refractory and relapsed acute myelogenous leukemia with combination chemotherapy plus the multidrug resistance modulator PSC 833 (Valspodar) Blood 1999 93: 787\u2013795","journal-title":"Blood"},{"key":"BF2402455_CR27","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1200\/JCO.1993.11.9.1652","volume":"11","author":"AF List","year":"1993","unstructured":"List AF, Spier C, Greer J, Wolff S, Hutter J, Dorr R, Salmon S, Futsch B, Baier M, Dalton W . Phase I\/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia J Clin Oncol 1993 11: 1652\u20131660","journal-title":"J Clin Oncol"},{"key":"BF2402455_CR28","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.1182\/blood.V98.12.3212","volume":"98","author":"AF List","year":"2001","unstructured":"List AF, Kopecky KJ, Willman CL, Head DR, Persons DL, Slovak ML, Dorr R, Karanes C, Hynes HE, Doroshow HJ, Shurafa M, Applebaum FR . Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study Blood 2001 98: 3212\u20133220","journal-title":"Blood"},{"key":"BF2402455_CR29","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1097\/00007890-198811000-00002","volume":"46","author":"BD Kahan","year":"1988","unstructured":"Kahan BD, Grevil J . Optimization of cyclosporin therapy in renal transplantation by a pharmacokinetic strategy Transplantation 1988 46: 631\u2013644","journal-title":"Transplantation"},{"key":"BF2402455_CR30","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/BF00686238","volume":"25","author":"AA Miller","year":"1990","unstructured":"Miller AA, Stewart CF, Tolley EA . Clinical pharmacodynamics of continuos infusion etoposide Cancer Chemother Pharmacol 1990 25: 361\u2013366","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF2402455_CR31","first-page":"1879","volume":"45","author":"DS Alberts","year":"1985","unstructured":"Alberts DS, Peng YM, Leigh S, Davis TP, Woodward DL . Disposition of mitoxantrone in cancer patients Cancer Res 1985 45: 1879\u20131884","journal-title":"Cancer Res"},{"key":"BF2402455_CR32","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0378-4347(00)81750-8","volume":"233","author":"YM Peng","year":"1982","unstructured":"Peng YM, Ormberg D, Alberts DS, Davis TP . Improved high-performance liquid chromatography of the new antineoplastic agents bisantrene and mitoxantrone J Chromatogr 1982 233: 235\u2013247","journal-title":"J Chromatogr"},{"key":"BF2402455_CR33","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0010-468X(79)90025-4","volume":"9","author":"DZ D'Argenio","year":"1979","unstructured":"D'Argenio DZ, Schumitzsky A . A program package for simulation and parameter estimation in pharmacokinetics Computs Meth Prog Biomed 1979 9: 115\u2013134","journal-title":"Computs Meth Prog Biomed"},{"key":"BF2402455_CR34","volume-title":"ADAPT II Users Guide: Pharmacokinetic and Pharmacodynamic Systems Analysis Software","author":"DZ D'Argenio","year":"1997","unstructured":"D'Argenio DZ, Schumitzsky A . ADAPT II Users Guide: Pharmacokinetic and Pharmacodynamic Systems Analysis Software Biomedical Simulations Resource: University of Southern California, Los Angeles 1997"},{"key":"BF2402455_CR35","first-page":"4881","volume":"53","author":"SP Lowis","year":"1993","unstructured":"Lowis SP, Pearson ADJ, Newell DR, Cole M . Etoposide pharmacokinetics in children: the development and prospective validation of a dosing equation Cancer Res 1993 53: 4881\u20134889","journal-title":"Cancer Res"},{"key":"BF2402455_CR36","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/BF00254537","volume":"7","author":"WE Evans","year":"1982","unstructured":"Evans WE, Sinkule JA, Crom WR . Pharmacokinetics of teniposide (VM26) and etoposide (VP16\u2013213) in children with cancer Cancer Chemother Pharmacol 1982 7: 147\u2013150","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF2402455_CR37","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/BF00254536","volume":"7","author":"M D'Incalci","year":"1982","unstructured":"D'Incalci M, Farina P, Sessa C, Mangioni C, Conter V, Masera G, Rocchetti M, Pisoni MB, Piazza E, Beer M, Cavalli F . Pharmacokinetics of VP16\u2013213 given by different administration methods Cancer Chemother Pharmacol 1982 7: 141\u2013145","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF2402455_CR38","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1038\/bjc.1998.385","volume":"77","author":"SP Lowis","year":"1998","unstructured":"Lowis SP, Price L, Pearson AD, Newell DR, Cole M . A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children Br J Cancer 1998 77: 2318\u20132323","journal-title":"Br J Cancer"},{"key":"BF2402455_CR39","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/clpt.1994.171","volume":"56","author":"MV Relling","year":"1994","unstructured":"Relling MV, McLeod HL, Bowman LC, Santana VM . Etoposide pharmacokinetics and pharmacodynamics after acute and chronic exposure to cisplatin Clin Pharmacol Ther 1994 56: 503\u2013511","journal-title":"Clin Pharmacol Ther"},{"key":"BF2402455_CR40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1200\/JCO.1994.12.1.141","volume":"12","author":"M Attal","year":"1994","unstructured":"Attal M, Canal P, Schlaifer D, Chatelut E, Dezeuze A, Huguet F, Payen C, Pris J, Laurent G . Escalating dose of mitoxantrone with high dose cyclophosphamide, carmustine and etoposide in patients with lymphoma undergoing autologous bone marrow transplantation J Clin Oncol 1994 12: 141\u2013148","journal-title":"J Clin Oncol"},{"key":"BF2402455_CR41","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1002\/jps.2600781020","volume":"78","author":"MC Launay","year":"1989","unstructured":"Launay MC, Iliadis A, Richard B . Population pharmacokinetics of mitoxantrone performed by a NONMEM method J Pharm Sci 1989 78: 877\u2013880","journal-title":"J Pharm Sci"},{"key":"BF2402455_CR42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3109\/03602538409015066","volume":"15","author":"JL Steimer","year":"1984","unstructured":"Steimer JL, Mallet A, Golmard JL, Boisvieux JF . Alternative approaches to estimation of population pharmacokinetic parameters: comparison with the nonlinear mixed-effect model Drug Metab Rev 1984 15: 265\u2013292","journal-title":"Drug Metab Rev"},{"key":"BF2402455_CR43","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/01621459.1972.10481232","volume":"67","author":"SS Shapiro","year":"1972","unstructured":"Shapiro SS, Francia RS . An approximate analysis of variance test for normality J Am Stat Assoc 1972 67: 215\u2013216","journal-title":"J Am Stat Assoc"},{"key":"BF2402455_CR44","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/9780470316474","volume-title":"Statistics: A Biomedical Introduction","author":"BW Brown","year":"1977","unstructured":"Brown BW, Hollander M . Statistics: A Biomedical Introduction John Wiley and Sons: New York 1977 pp 174\u2013177"},{"key":"BF2402455_CR45","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1200\/JCO.1992.10.10.1635","volume":"10","author":"BL Lum","year":"1992","unstructured":"Lum BL, Kaubisch S, Yahanda AM, Adler KM, Jew L, Ehsan MN, Brophy NA, Halsey J, Gosland MP, Sikic BI . Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate MDR J Clin Oncol 1992 10: 1635\u20131642","journal-title":"J Clin Oncol"},{"key":"BF2402455_CR46","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1038\/bjc.1998.383","volume":"77","author":"G Bisogno","year":"1998","unstructured":"Bisogno G, Cowie F, Boddy A, Thomas HD, Dick G, Pinkerton CR . High-dose cyclosporin with etoposide \u2013 toxicity and pharmacokinetic interaction in children with solid tumours Br J Cancer 1998 77: 2304\u20132309","journal-title":"Br J Cancer"},{"key":"BF2402455_CR47","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/clpt.1989.22","volume":"45","author":"MJ Ratain","year":"1989","unstructured":"Ratain MJ, Schilsky RL, Choi KE, Guarnieri C, Grimmer D, Vogelzang NJ, Senekjian E, Liebner MA . Adaptive control of etoposide administration: impact of interpatient pharmacodynamic variability Clin Pharmacol Ther 1989 45: 226\u2013233","journal-title":"Clin Pharmacol Ther"},{"key":"BF2402455_CR48","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1200\/JCO.1994.12.9.1946","volume":"12","author":"CF Stewart","year":"1994","unstructured":"Stewart CF, Baker SD, Heideman RL, Jones D, Crom WR, Pratt CB . Clinical pharmacodynamics of continuous infusion topotecan in children: systemic exposure predicts hematologic toxicity J Clin Oncol 1994 12: 1946\u20131954","journal-title":"J Clin Oncol"},{"key":"BF2402455_CR49","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1056\/NEJM199802193380803","volume":"338","author":"WE Evans","year":"1998","unstructured":"Evans WE, Relling MV, Rodman JH, Crom WR, Boyett JM, Pui CH . Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia N Engl J Med 1998 338: 499\u2013505","journal-title":"N Engl J Med"},{"key":"BF2402455_CR50","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1182\/blood.V91.3.1001","volume":"91","author":"C Ito","year":"1998","unstructured":"Ito C, Ribeiro RC, Behm FG, Raimondi SC, Pui CH, Campana D . Cyclosporin A induces apoptosis in childhood acute lymphoblastic leukemia cells Blood 1998 91: 1001\u20131007","journal-title":"Blood"},{"key":"BF2402455_CR51","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/(SICI)1097-0215(19990517)81:4<580::AID-IJC13>3.0.CO;2-T","volume":"81","author":"MG Come","year":"1999","unstructured":"Come MG, Bettaieb A, Skadanowski A, Larsen AK, Lauren G . Alteration of the daunorubicin-triggered shingomyelin-ceramide pathway and apoptosis in MDR cells: influence of drug transport abnormalities Int J Cancer 1999 81: 580\u2013587","journal-title":"Int J Cancer"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2402455.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402455","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402455.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T22:13:47Z","timestamp":1648764827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2402455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5,1]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5,1]]}},"alternative-id":["BF2402455"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2402455","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5,1]]},"assertion":[{"value":"30 April 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}