{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:35:18Z","timestamp":1790516118639,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2002,7,31]],"date-time":"2002-07-31T00:00:00Z","timestamp":1028073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,7,31]],"date-time":"2002-07-31T00:00:00Z","timestamp":1028073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2002,8,1]]},"DOI":"10.1038\/sj.leu.2402553","type":"journal-article","created":{"date-parts":[[2002,10,21]],"date-time":"2002-10-21T10:59:36Z","timestamp":1035197976000},"page":"1454-1459","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Simultaneous diagnosis of hairy cell leukemia and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a frequent association?"],"prefix":"10.1038","volume":"16","author":[{"given":"E","family":"Gin\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Villamor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rozman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Colomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"L\u00f3pez-Guillermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,7,31]]},"reference":[{"key":"BF2402553_CR1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1182\/blood.V13.7.609.609","volume":"13","author":"BA Bouroncle","year":"1958","unstructured":"Bouroncle BA, Wiseman BK, Doan CA . Leukemic reticuloendotheliosis Blood 1958 13: 609\u2013616","journal-title":"Blood"},{"key":"BF2402553_CR2","first-page":"109","volume":"14 (Suppl. 1)","author":"D Catovsky","year":"1994","unstructured":"Catovsky D, Matutes E, Talavera JG, O'Connor JG, Johnson SA, Emmet E, Corbett L, Swansbury J . Long-term results with 2-deoxycoformycin in hairy cell leukemia Leuk Lymphoma 1994 14 (Suppl. 1): 109\u2013113","journal-title":"Leuk Lymphoma"},{"key":"BF2402553_CR3","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1200\/JCO.1995.13.4.974","volume":"13","author":"M Grever","year":"1995","unstructured":"Grever M, Kopecky K, Foucar MK, Head D, Bennett J, Hutchinson RE, Corbett W, Cassileth P, Habermann T, Golomb H . Randomised comparison of pentostatin vs. interferon Alfa-2a in previously untreated patients with hairy cell leukemia: An intergroup study J Clin Oncol 1995 13: 974\u2013982","journal-title":"J Clin Oncol"},{"key":"BF2402553_CR4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<352::AID-CNCR15>3.0.CO;2-8","volume":"88","author":"M Rafel","year":"2000","unstructured":"Rafel M, Cervantes F, Beltr\u00e1n JM, Zuazu F, Hern\u00e1ndez Nieto L, Ray\u00f3n C, Garc\u00eda Talavera J, Montserrat E . Deoxycoformycin in the treatment of patients with hairy cell leukemia Cancer 2000 88: 352\u2013357","journal-title":"Cancer"},{"key":"BF2402553_CR5","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1182\/blood.V83.9.2637.2637","volume":"83","author":"U Haglund","year":"1994","unstructured":"Haglund U, Juliusson G, Stellan B . Hairy cell leukemia is characterized by clonal chromosome abnormalities clustered to specific regions Blood 1994 83: 2637\u20132645","journal-title":"Blood"},{"key":"BF2402553_CR6","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1111\/j.1365-2141.1995.tb05429.x","volume":"91","author":"F Bosch","year":"1995","unstructured":"Bosch F, Campo E, Jares P, Pittaluga S, Mu\u00f1oz J . Nayach I, Piris MA, Dewolf-Peeters C, Jaffe ES, Rozman C. Increased expression of the PRAD-1\/CCND 1 gene in hairy cell leukaemia Br J Haematol 1995 91: 1025\u20131030","journal-title":"Br J Haematol"},{"key":"BF2402553_CR7","first-page":"389","volume":"1","author":"L Foroni","year":"1987","unstructured":"Foroni L, Catovsky D, Luzzatto L . Immunoglobulin gene rearrangements in hairy cell leukemia and other chronic B-cell lymphoproliferative disorders Leukemia 1987 1: 389\u2013392","journal-title":"Leukemia"},{"key":"BF2402553_CR8","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1182\/blood.V83.12.3647.3647","volume":"83","author":"SD Wagner","year":"1994","unstructured":"Wagner SD, Martinelli V, Luzzatto L . Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldestr\u00f6ms's macroglobulinemia, and myeloma Blood 1994 83: 3647\u20133653","journal-title":"Blood"},{"key":"BF2402553_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/ajh.2830130210","volume":"13","author":"DJ Stewart","year":"1982","unstructured":"Stewart DJ, Keating MJ . Second malignancies in hairy cell leukemia (leukemic reticuloendotheliosis) Am J Hematol 1982 13: 167\u2013169","journal-title":"Am J Hematol"},{"key":"BF2402553_CR10","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1182\/blood.V83.10.2931.2931","volume":"83","author":"P Kampmeier","year":"1994","unstructured":"Kampmeier P, Spielberger R, Dickstein J, Mick R, Golomb H, Vardiman JW . Increased incidence of second neoplasms in patients treated with interferon alpha for hairy cell leukemia: a clinicopathologic assessment Blood 1994 83: 2931\u20132938","journal-title":"Blood"},{"key":"BF2402553_CR11","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1182\/blood.V84.12.4061.bloodjournal84124061","volume":"84","author":"EH Kraut","year":"1994","unstructured":"Kraut EH, Grever MR, Bouroncle BA . Long term follow-up of patients with hairy cell leukemia after treatment with 2-deoxycoformycin Blood 1994 84: 4061\u20134063","journal-title":"Blood"},{"key":"BF2402553_CR12","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1182\/blood.V92.4.1160","volume":"92","author":"WY Au","year":"1998","unstructured":"Au WY, Klasa RJ, Gallagher R, Le N, Gascoyne RD, Connors JM . Second malignancies in patients with hairy cell leukemia in British Columbia: a 20-year experience Blood 1998 92: 1160\u20131164","journal-title":"Blood"},{"key":"BF2402553_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3109\/10428199409056295","volume":"13","author":"A Frassoldati","year":"1994","unstructured":"Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V for the Italian Cooperative Group for Hairy Cell Leukemia. Hairy Cell Leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL) Leuk Lymphoma 1994 13: 307\u2013316","journal-title":"Leuk Lymphoma"},{"key":"BF2402553_CR14","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1182\/blood.V96.1.71","volume":"96","author":"IW Flinn","year":"2000","unstructured":"Flinn IW, Kopecky KJ, Foucar MK, Head D, Bennet JM, Hutchinson R, Corbett W, Cassileth P, Habermann T, Golomb H, Rai K, Eisenhauer E, Appelbaum F, Cheson B, Grever MR . Long-term follow-up of remission duration, mortality and second malignancies in hairy cell leukemia patients treated with pentostatin Blood 2000 96: 2981\u20132986","journal-title":"Blood"},{"key":"BF2402553_CR15","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1200\/JCO.1997.15.5.1803","volume":"15","author":"R Kurzrock","year":"1997","unstructured":"Kurzrock R, Strom SS, Estey E, O'Brien S, Keating MJ, Jiang H, Adams T, Talpaz M . Second cancer risk in hairy cell leukemia: analysis of 350 patients J Clin Oncol 1997 15: 1803\u20131810","journal-title":"J Clin Oncol"},{"key":"BF2402553_CR16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/(SICI)1097-0142(19990101)85:1<65::AID-CNCR9>3.0.CO;2-B","volume":"85","author":"P Ribeiro","year":"1999","unstructured":"Ribeiro P, Bouaffia F, Peaud PY, Blanc M, Salles B, Salles G, Coiffier B . Long term outcome of patients with hairy cell leukemia treated with pentostatin Cancer 1999 85: 65\u201371","journal-title":"Cancer"},{"key":"BF2402553_CR17","first-page":"150","volume":"5","author":"E Duchayne","year":"1991","unstructured":"Duchayne E, Delsol G, Kuhlein E, Klein B, Zhang XG, Attal M, Cassard G, Laurent G . Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and molecular study Leukemia 1991 5: 150\u2013155","journal-title":"Leukemia"},{"key":"BF2402553_CR18","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3109\/10428199809050945","volume":"30","author":"SA Brown","year":"1998","unstructured":"Brown SA, Phillips J, Ahsan G, Slater NGP . Coexistent hairy cell leukemia and chronic lymphocytic leukemia Leuk Lymphoma 1998 30: 203\u2013209","journal-title":"Leuk Lymphoma"},{"key":"BF2402553_CR19","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/hon.2900080506","volume":"8","author":"T Sun","year":"1990","unstructured":"Sun T, Susin M, Shevde N, Teichberg S . Hybrid form of hairy cell leukemia and chronic lymphocytic leukemia Hematol Oncol 1990 8: 283\u2013294","journal-title":"Hematol Oncol"},{"key":"BF2402553_CR20","first-page":"99","volume":"8","author":"M Aljurf","year":"1994","unstructured":"Aljurf M, Cornbleet PJ, Michel F . CD5+ chronic B-cell leukemia with features intermediate to chronic lymphocytic leukemia and hairy cell leukemia Hematol Pathol 1994 8: 99\u2013109","journal-title":"Hematol Pathol"},{"key":"BF2402553_CR21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1182\/blood.V76.1.123.123","volume":"76","author":"S Wormsley","year":"1990","unstructured":"Wormsley S, Baird S, Gadol N, Rai K, Sobol R . Characteristics of CD11c+ CD5+ chronic B-cell leukemias and the identification of novel peripheral blood B-cell subsets with chronic lymphoid leukemia immunophenotypes Blood 1990 76: 123\u2013130","journal-title":"Blood"},{"key":"BF2402553_CR22","first-page":"138","volume-title":"Tumors of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumors","author":"K Foucar","year":"2001","unstructured":"Foucar K, Catovsky D . Hairy cell leukemia In: ES Saffe, NL Harris, H Stain, DW Vardiman (eds) Tumors of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumors IARC Press: Lyon 2001 pp 138\u2013141"},{"key":"BF2402553_CR23","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990","volume":"87","author":"BD Cheson","year":"1996","unstructured":"Cheson BD, Bennet JM, Grever M . National cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment Blood 1996 87: 4990\u20134997","journal-title":"Blood"},{"key":"BF2402553_CR24","first-page":"127","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"HK M\u00fcller-Hermelink","year":"2001","unstructured":"M\u00fcller-Hermelink HK, Montserrat E, Catovsky D, Harris NL . Chronic lymphocytic leukemia\/small lymphocytic lymphoma In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues IARC Press: Lyon 2001 pp 127\u2013130"},{"key":"BF2402553_CR25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1046\/j.1365-2141.1999.01500.x","volume":"106","author":"AR Pettitt","year":"1999","unstructured":"Pettitt AR, Zuzel M, Cawley JC . Hairy-cell leukemia: biology and management Br J Haematol 1999 106: 2\u20138","journal-title":"Br J Haematol"},{"key":"BF2402553_CR26","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3109\/10428199209053623","volume":"7","author":"F Vuillier","year":"1992","unstructured":"Vuillier F, Claisse JF, Vandenvelde C, Travade P, Magnac C, Chevret S, Desablens B, Binet JL, Dighiero G . Evaluation of residual disease in B-cell chronic lymphocytic leukemia patients in clinical and bone marrow remission using CD5-CD19 markers and PCR study of gene rearrangements Leuk Lymphoma 1992 7: 195\u2013204","journal-title":"Leuk Lymphoma"},{"key":"BF2402553_CR27","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1182\/blood.V67.3.739.739","volume":"67","author":"JR Downing","year":"1986","unstructured":"Downing JR, Grossi CE, Smedberg CT, Burrows PD . Diffuse large cell lymphoma in a patient with hairy cell leukemia. Immunoglobulin gene analysis reveals separate clonal origins Blood 1986 67: 739\u2013744","journal-title":"Blood"},{"key":"BF2402553_CR28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1600-0609.1969.tb01810.x","volume":"6","author":"GA Hyman","year":"1969","unstructured":"Hyman GA . Increased incidence of neoplasia in association with chronic lymphocytic leukemia Scand J Haematol 1969 6: 99\u2013104","journal-title":"Scand J Haematol"},{"key":"BF2402553_CR29","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1093\/jnci\/84.18.1422","volume":"84","author":"LB Travis","year":"1992","unstructured":"Travis LB, Curtis RE, Hankey BF, Fraumeni JF . Second cancers in patients with chronic lymphocytic leukemia J Natl Cancer Inst 1992 84: 1422\u20131427","journal-title":"J Natl Cancer Inst"},{"key":"BF2402553_CR30","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1046\/j.1365-2141.1997.00087.x","volume":"97","author":"J Burthem","year":"1997","unstructured":"Burthem J, Zuzel M, Cawley JC . What is the nature of the hairy cell and why should we be interested? Br J Haematol 1997 97: 511\u2013514","journal-title":"Br J Haematol"},{"key":"BF2402553_CR31","doi-asserted-by":"publisher","first-page":"4955","DOI":"10.1002\/j.1460-2075.1993.tb06189.x","volume":"12","author":"R K\u00fcppers","year":"1993","unstructured":"K\u00fcppers R, Zhao M, Hansmann ML, Rajewsky K . Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections EMBO J 1993 12: 4955\u20134967","journal-title":"EMBO J"},{"key":"BF2402553_CR32","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1056\/NEJM199911113412007","volume":"11","author":"R K\u00fcppers","year":"1999","unstructured":"K\u00fcppers R, Klein U, Hansmann ML, Rajewsky K . Cellular origin of human B-cell lymphomas N Engl J Med 1999 11: 1520\u20131529","journal-title":"N Engl J Med"},{"key":"BF2402553_CR33","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1172\/JCI3009","volume":"102","author":"F Fais","year":"1998","unstructured":"Fais F, Ghiotto, Hashimoto S, Sellars B, Valetto A, Allen SL, Schulman P, Vinciguerra VP, Rai K, Rassenti LZ, Kipps TJ, Dighiero G, Schroeder HW Jr, Ferrarini M, Chiorazzi N . Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors J Clin Invest 1998 102: 1515\u20131525","journal-title":"J Clin Invest"},{"key":"BF2402553_CR34","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1182\/blood.V66.5.1035.1035","volume":"66","author":"F Caligaris-Cappio","year":"1985","unstructured":"Caligaris-Cappio F, Pizzolo G, Chilosi M, Bergui L, Smenzato G, Tesio L, Morittu L, Malavasi F, Gobbi M, Schwarting R, Campana D, Janossi G . Phorbol ester induces abnormal chronic lymphocytic leukemia cells to express features of hairy cell leukemia Blood 1985 66: 1035\u20131042","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2402553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402553","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:35:59Z","timestamp":1648762559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2402553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,31]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8,1]]}},"alternative-id":["BF2402553"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2402553","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,31]]},"assertion":[{"value":"4 September 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}