{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:39:46Z","timestamp":1790739586132,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2002,10,28]],"date-time":"2002-10-28T00:00:00Z","timestamp":1035763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,10,28]],"date-time":"2002-10-28T00:00:00Z","timestamp":1035763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2002,11,1]]},"DOI":"10.1038\/sj.leu.2402707","type":"journal-article","created":{"date-parts":[[2002,11,7]],"date-time":"2002-11-07T12:20:43Z","timestamp":1036671643000},"page":"2309-2317","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics"],"prefix":"10.1038","volume":"16","author":[{"given":"F","family":"Jardin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Gaulard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Buchonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Contentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lepr\u00eatre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lenain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Stamatoullas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Picquenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Duval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Parmentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Tilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bastard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,10,28]]},"reference":[{"key":"BF2402707_CR1","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1056\/NEJM198211113072002","volume":"307","author":"JJ Yunis","year":"1982","unstructured":"Yunis JJ, Oken MM, Kaplan ME, Ensrud KM, Howe RR, Theologides A . Distinctive chromosomal abnormalities in histologic subtypes of non- Hodgkin's lymphoma N Engl J Med 1982 307: 1231\u20131236","journal-title":"N Engl J Med"},{"key":"BF2402707_CR2","doi-asserted-by":"publisher","first-page":"4869","DOI":"10.1073\/pnas.85.13.4869","volume":"85","author":"M Crescenzi","year":"1988","unstructured":"Crescenzi M, Seto M, Herzig GP, Weiss PD, Griffith RC, Korsmeyer SJ . Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease Proc Natl Acad Sci USA 1988 85: 4869\u20134873","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2402707_CR3","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1126\/science.6093263","volume":"226","author":"Y Tsujimoto","year":"1984","unstructured":"Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM . Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation Science 1984 226: 1097\u20131099","journal-title":"Science"},{"key":"BF2402707_CR4","first-page":"1089","volume":"140","author":"P Gaulard","year":"1992","unstructured":"Gaulard P, d'Agay MF, Peuchmaur M, Brousse N, Gisselbrecht C, Solal-Celigny P, Diebold J, Mason DY . Expression of the bcl-2 gene product in follicular lymphoma Am J Pathol 1992 140: 1089\u20131095","journal-title":"Am J Pathol"},{"key":"BF2402707_CR5","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1038\/sj.leu.2400849","volume":"11","author":"JP Meijerink","year":"1997","unstructured":"Meijerink JP . t(14;18), a journey to eternity Leukemia 1997 11: 2175\u20132187","journal-title":"Leukemia"},{"key":"BF2402707_CR6","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1182\/blood.V80.4.879.879","volume":"80","author":"SJ Korsmeyer","year":"1992","unstructured":"Korsmeyer SJ . Bcl-2 initiates a new category of oncogenes: regulators of cell death Blood 1992 80: 879\u2013886","journal-title":"Blood"},{"key":"BF2402707_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1182\/blood.V99.2.409","volume":"99","author":"B Falini","year":"2002","unstructured":"Falini B, Mason DY . Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry Blood 2002 99: 409\u2013426","journal-title":"Blood"},{"key":"BF2402707_CR8","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","volume":"84","author":"NL Harris","year":"1994","unstructured":"Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC . A revised European\u2013American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group Blood 1994 84: 1361\u20131392","journal-title":"Blood"},{"key":"BF2402707_CR9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/ng0993-66","volume":"5","author":"JP Kerckaert","year":"1993","unstructured":"Kerckaert JP, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C . LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas Nat Genet 1993 5: 66\u201370","journal-title":"Nat Genet"},{"key":"BF2402707_CR10","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1182\/blood.V87.12.5257.bloodjournal87125257","volume":"87","author":"D Allman","year":"1996","unstructured":"Allman D, Jain A, Dent A, Maile RR, Selvaggi T, Kehry MR, Staudt LM . BCL-6 expression during B-cell activation Blood 1996 87: 5257\u20135268","journal-title":"Blood"},{"key":"BF2402707_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/ng0697-161","volume":"16","author":"BH Ye","year":"1997","unstructured":"Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, Leung C, Nouri-Shirazi M, Orazi A, Chaganti RS, Rothman P, Stall AM, Pandolfi PP, Dalla-Favera R . The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation Nat Genet 1997 16: 161\u2013170","journal-title":"Nat Genet"},{"key":"BF2402707_CR12","first-page":"405","volume":"147","author":"L Flenghi","year":"1995","unstructured":"Flenghi L, Ye BH, Fizzotti M, Bigerna B, Cattoretti G, Venturi S, Pacini R, Pileri S, Lo Coco F, Pescarmona E . A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells Am J Pathol 1995 147: 405\u2013411","journal-title":"Am J Pathol"},{"key":"BF2402707_CR13","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood.V83.9.2423.2423","volume":"83","author":"C Bastard","year":"1994","unstructured":"Bastard C, Deweindt C, Kerckaert JP, Lenormand B, Rossi A, Pezzella F, Fruchart C, Duval C, Monconduit M, Tilly H . LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients Blood 1994 83: 2423\u20132427","journal-title":"Blood"},{"key":"BF2402707_CR14","first-page":"318","volume":"11 (Suppl. 3)","author":"M Muramatsu","year":"1997","unstructured":"Muramatsu M, Akasaka T, Kadowaki N, Ohno H, Fukuhara S, Okuma M . Rearrangement of the BCL6 gene in B-cell lymphoid neoplasms Leukemia 1997 11 (Suppl. 3): 318\u2013320","journal-title":"Leukemia"},{"key":"BF2402707_CR15","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3109\/08830189909088490","volume":"18","author":"LM Staudt","year":"1999","unstructured":"Staudt LM, Dent AL, Shaffer AL, Yu X . Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6 Int Rev Immunol 1999 18: 381\u2013403","journal-title":"Int Rev Immunol"},{"key":"BF2402707_CR16","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S0046-8177(99)90141-7","volume":"30","author":"BF Skinnider","year":"1999","unstructured":"Skinnider BF, Horsman DE, Dupuis B, Gascoyne RD . Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities Hum Pathol 1999 30: 803\u2013808","journal-title":"Hum Pathol"},{"key":"BF2402707_CR17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3109\/10428199509054757","volume":"20","author":"K Offit","year":"1995","unstructured":"Offit K, Louie DC, Parsa NZ, Roy P, Leung D, Lo Coco F, Zelenetz A, Dalla-Favera R, Chaganti RS . BCL6 gene rearrangement and other cytogenetic abnormalities in diffuse large cell lymphoma Leuk Lymphoma 1995 20: 85\u201389","journal-title":"Leuk Lymphoma"},{"key":"BF2402707_CR18","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1056\/NEJM199407143310202","volume":"331","author":"K Offit","year":"1994","unstructured":"Offit K, Lo Coco F, Louie DC, Parsa NZ, Leung D, Portlock C, Ye BH, Lista F, Filippa DA, Rosenbaum A, Ladanyi M, Jhanwar S, Dalla-Favera R, Chaganti RS . Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma N Engl J Med 1994 331: 74\u201380","journal-title":"N Engl J Med"},{"key":"BF2402707_CR19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3109\/10428199709059687","volume":"27","author":"A Ohshima","year":"1997","unstructured":"Ohshima A, Miura I, Hashimoto K, Takahashi N, Utsumi S, Nimura T, Saito M, Miki T, Hirosawa S, Miura AB . Rearrangements of the BCL6 gene and chromosome aberrations affecting 3q27 in 54 patients with non-Hodgkin's lymphoma Leuk Lymphoma 1997 27: 329\u2013334","journal-title":"Leuk Lymphoma"},{"key":"BF2402707_CR20","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.1365-2141.1995.tb08365.x","volume":"89","author":"DE Horsman","year":"1995","unstructured":"Horsman DE, McNeil BK, Anderson M, Shenkier T, Gascoyne RD . Frequent association of t(3;14) or variant with other lymphoma-specific translocations Br J Haematol 1995 89: 569\u2013575","journal-title":"Br J Haematol"},{"key":"BF2402707_CR21","first-page":"651","volume":"95","author":"D Capello","year":"2000","unstructured":"Capello D, Vitolo U, Pasqualucci L, Quattrone S, Migliaretti G, Fassone L, Ariatti C, Vivenza D, Gloghini A, Pastore C, Lanza C, Nomdedeu J, Botto B, Freilone R, Buonaiuto D, Zagonel V, Gallo E, Palestro G, Saglio G, Dalla-Favera R, Carbone A, Gaidano G . Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia Blood 2000 95: 651\u2013659","journal-title":"Blood"},{"key":"BF2402707_CR22","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/sj.leu.2401766","volume":"14","author":"D Capello","year":"2000","unstructured":"Capello D, Fais F, Vivenza D, Migliaretti G, Chiorazzi N, Gaidano G, Ferrarini M . Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes Leukemia 2000 14: 811\u2013815","journal-title":"Leukemia"},{"key":"BF2402707_CR23","doi-asserted-by":"publisher","first-page":"11816","DOI":"10.1073\/pnas.95.20.11816","volume":"95","author":"L Pasqualucci","year":"1998","unstructured":"Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti RS, Klein U, Kuppers R, Rajewsky K, Dalla-Favera R . BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci Proc Natl Acad Sci USA 1998 95: 11816\u201311821","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2402707_CR24","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1126\/science.280.5370.1750","volume":"280","author":"HM Shen","year":"1998","unstructured":"Shen HM, Peters A, Baron B, Zhu X, Storb U . Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes Science 1998 280: 1750\u20131752","journal-title":"Science"},{"key":"BF2402707_CR25","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1182\/blood.V93.7.2167","volume":"93","author":"HZ Peng","year":"1999","unstructured":"Peng HZ, Du MQ, Koulis A, Aiello A, Dogan A, Pan LX, Isaacson PG . Nonimmunoglobulin gene hypermutation in germinal center B cells Blood 1999 93: 2167\u20132172","journal-title":"Blood"},{"key":"BF2402707_CR26","doi-asserted-by":"publisher","first-page":"12520","DOI":"10.1073\/pnas.92.26.12520","volume":"92","author":"A Migliazza","year":"1995","unstructured":"Migliazza A, Martinotti S, Chen W, Fusco C, Ye BH, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R . Frequent somatic hypermutation of the 5\u2019 noncoding region of the BCL6 gene in B-cell lymphoma Proc Natl Acad Sci USA 1995 92: 12520\u201312524","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2402707_CR27","volume-title":"ISCN (1995): An International System for Human Cytogenetic Nomenclature. S","author":"F Mitelman","year":"1995","unstructured":"Mitelman F (ed). ISCN (1995): An International System for Human Cytogenetic Nomenclature. S Karger: Basel, Switzerland 1995"},{"key":"BF2402707_CR28","first-page":"162","volume-title":"World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"B Nathwani","year":"2001","unstructured":"Nathwani B, Harris N, Weisenburger D, Isaacson P, Piris MA, Berger F, Muller-Hermelink HK, Swerdlow J . Follicular lymphoma In: Jaffe E, Harris N, Stein H, Vardiman J (eds) World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues IARC Press: Lyons 2001 pp 162\u2013167"},{"key":"BF2402707_CR29","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1182\/blood.V73.7.1759.1759","volume":"73","author":"BY Ngan","year":"1989","unstructured":"Ngan BY, Nourse J, Cleary ML . Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas Blood 1989 73: 1759\u20131762","journal-title":"Blood"},{"key":"BF2402707_CR30","first-page":"2335","volume":"60","author":"H Akasaka","year":"2000","unstructured":"Akasaka H, Akasaka T, Kurata M, Ueda C, Shimizu A, Uchiyama T, Ohno H . Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays Cancer Res 2000 60: 2335\u20132341","journal-title":"Cancer Res"},{"key":"BF2402707_CR31","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood.V95.4.1400.004k43_1400_1405","volume":"95","author":"IS Lossos","year":"2000","unstructured":"Lossos IS, Levy R . Mutation analysis of the 5\u2032 noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity Blood 2000 95: 1400\u20131405","journal-title":"Blood"},{"key":"BF2402707_CR32","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S1074-7613(00)00020-0","volume":"13","author":"AL Shaffer","year":"2000","unstructured":"Shaffer AL, Yu X, He Y, Boldrick J, Chan EP, Staudt LM . BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control Immunity 2000 13: 199\u2013212","journal-title":"Immunity"},{"key":"BF2402707_CR33","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1097\/00000478-200103000-00015","volume":"25","author":"L de Leval","year":"2001","unstructured":"de Leval L, Savilo E, Longtine J, Ferry JA, Harris NL . Peripheral T-cell lymphoma with follicular involvement and a CD4+\/bcl-6+ phenotype Am J Surg Pathol 2001 25: 395\u2013400","journal-title":"Am J Surg Pathol"},{"key":"BF2402707_CR34","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/sj.onc.1202306","volume":"18","author":"T Kumagai","year":"1999","unstructured":"Kumagai T, Miki T, Kikuchi M, Fukuda T, Miyasaka N, Kamiyama R, Hirosawa S . The proto-oncogene Bc16 inhibits apoptotic cell death in differentiation-induced mouse myogenic cells Oncogene 1999 18: 467\u2013475","journal-title":"Oncogene"},{"key":"BF2402707_CR35","doi-asserted-by":"publisher","first-page":"6240","DOI":"10.1038\/sj.onc.1203976","volume":"19","author":"P Dhordain","year":"2000","unstructured":"Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH . Colocalization and heteromerization between the two human oncogene POZ\/zinc finger proteins, LAZ3 (BCL6) and PLZF Oncogne 2000 19: 6240\u20136250","journal-title":"Oncogne"},{"key":"BF2402707_CR36","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/sj.onc.1202334","volume":"18","author":"T Yamochi","year":"1999","unstructured":"Yamochi T, Kaneita Y, Akiyama T, Mori S, Moriyama M . Adenovirus-mediated high expression of BCL-6 in CV-1 cells induces apoptotic cell death accompanied by down-regulation of BCL-2 and BCL-X(L) Oncogene 1999 18: 487\u2013494","journal-title":"Oncogene"},{"key":"BF2402707_CR37","doi-asserted-by":"publisher","first-page":"5063","DOI":"10.1038\/sj.onc.1202892","volume":"18","author":"O Albagli","year":"1999","unstructured":"Albagli O, Lantoine D, Quief S, Quignon F, Englert C, Kerckaert JP, Montarras D, Pinset C, Lindon C . Overexpressed BCL6 (LAZ3) oncoprotein triggers apoptosis, delays S phase progression and associates with replication foci Oncogene 1999 18: 5063\u20135075","journal-title":"Oncogene"},{"key":"BF2402707_CR38","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1097\/00000478-200006000-00010","volume":"24","author":"A Dogan","year":"2000","unstructured":"Dogan A, Bagdi E, Munson P, Isaacson PG . CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas Am J Surg Pathol 2000 24: 846\u2013852","journal-title":"Am J Surg Pathol"},{"key":"BF2402707_CR39","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1097\/00000478-200008000-00004","volume":"24","author":"MD Kraus","year":"2000","unstructured":"Kraus MD, Haley J . Lymphocyte predominance Hodgkin's disease: the use of bcl-6 and CD57 in diagnosis and differential diagnosis Am J Surg Pathol 2000 24: 1068\u20131078","journal-title":"Am J Surg Pathol"},{"key":"BF2402707_CR40","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1046\/j.1365-2141.1997.2703087.x","volume":"98","author":"J Dierlamm","year":"1997","unstructured":"Dierlamm J, Pittaluga S, Stul M, Wlodarska I, Michaux L, Thomas J, Verhoef G, Verhest A, Depardieu C, Cassiman JJ, Hagemeijer A, De Wolf-Peeters C, Van den Berghe H . BCL6 gene rearrangements also occur in marginal zone B-cell lymphoma Br J Haematol 1997 98: 719\u2013725","journal-title":"Br J Haematol"},{"key":"BF2402707_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/(SICI)1099-1069(200003)18:1<1::AID-HON647>3.0.CO;2-G","volume":"18","author":"J Dierlamm","year":"2000","unstructured":"Dierlamm J, Wlodarska I, Michaux L, Stefanova M, Hinz K, Van Den Berghe H, Hagemeijer A, Hossfeld DK . Genetic abnormalities in marginal zone B-cell lymphoma Hematol Oncol 2000 18: 1\u201313","journal-title":"Hematol Oncol"},{"key":"BF2402707_CR42","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1309\/X559-FDJB-LJGD-YG7E","volume":"114","author":"A Abou-Elella","year":"2000","unstructured":"Abou-Elella A, Shafer MT, Wan XY, Velanker M, Weisenburger DD, Nathwani BN, Gascoyne RD, Greiner TC, Chan WC . Lymphomas with follicular and monocytoid B-cell components. Evidence for a common clonal origin from follicle center cells Am J Clin Pathol 2000 114: 516\u2013522","journal-title":"Am J Clin Pathol"},{"key":"BF2402707_CR43","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0046-8177(99)90003-5","volume":"30","author":"BN Nathwani","year":"1999","unstructured":"Nathwani BN, Anderson JR, Armitage JO, Cavalli F, Diebold J, Drachenberg MR, Harris NL, MacLennan KA, Muller-Hermelink HK, Ullrich FA, Weisenburger DD . Clinical significance of follicular lymphoma with monocytoid B cells. Non-Hodgkin's Lymphoma Classification Project Hum Pathol 1999 30: 263\u2013268","journal-title":"Hum Pathol"},{"key":"BF2402707_CR44","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1182\/blood.V98.3.781","volume":"98","author":"A Conconi","year":"2001","unstructured":"Conconi A, Bertoni F, Pedrinis E, Motta T, Roggero E, Luminari S, Capella C, Bonato M, Cavalli F, Zucca E . Nodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes Blood 2001 98: 781\u2013786","journal-title":"Blood"},{"key":"BF2402707_CR45","doi-asserted-by":"publisher","first-page":"830","DOI":"10.4049\/jimmunol.165.2.830","volume":"165","author":"H Zan","year":"2000","unstructured":"Zan H, Li Z, Yamaji K, Dramitinos P, Cerutti A, Casali P . B cell receptor engagement and T cell contact induce Bcl-6 somatic hypermutation in human B cells: identity with Ig hypermutation J Immunol 2000 165: 830\u2013839","journal-title":"J Immunol"},{"key":"BF2402707_CR46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1182\/blood.V79.1.229.229","volume":"79","author":"S Tanaka","year":"1992","unstructured":"Tanaka S, Louie DC, Kant JA, Reed JC . Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas Blood 1992 79: 229\u2013237","journal-title":"Blood"},{"key":"BF2402707_CR47","doi-asserted-by":"publisher","first-page":"4031","DOI":"10.1128\/MCB.15.8.4031","volume":"15","author":"AT Hoang","year":"1995","unstructured":"Hoang AT, Lutterbach B, Lewis BC, Yano T, Chou TY, Barrett JF, Raffeld M, Hann SR, Dang CV . A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain Mol Cell Biol 1995 15: 4031\u20134042","journal-title":"Mol Cell Biol"},{"key":"BF2402707_CR48","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/S0167-5699(00)01650-9","volume":"21","author":"K Stamatopoulos","year":"2000","unstructured":"Stamatopoulos K, Kosmas C, Belessi C, Stavroyianni N, Kyriazopoulos P, Papadaki T . Molecular insights into the immunopathogenesis of follicular lymphoma Immunol Today 2000 21: 298\u2013305","journal-title":"Immunol Today"},{"key":"BF2402707_CR49","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1182\/blood.V91.11.4292","volume":"91","author":"CH Ottensmeier","year":"1998","unstructured":"Ottensmeier CH, Thompsett AR, Zhu D, Wilkins BS, Sweetenham JW, Stevenson FK . Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression Blood 1998 91: 4292\u20134299","journal-title":"Blood"},{"key":"BF2402707_CR50","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1182\/blood.V99.2.716","volume":"99","author":"JA Fenton","year":"2002","unstructured":"Fenton JA, Vaandrager JW, Aarts WM, Bende RJ, Heering K, van Dijk M, Morgan G, van Noesel CJ, Schuuring E, Kluin PM . Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells Blood 2002 99: 716\u2013718","journal-title":"Blood"},{"key":"BF2402707_CR51","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/bjc.1992.16","volume":"65","author":"F Pezzella","year":"1992","unstructured":"Pezzella F, Jones M, Ralfkiaer E, Ersboll J, Gatter KC, Mason DY . Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma Br J Cancer 1992 65: 87\u201389","journal-title":"Br J Cancer"},{"key":"BF2402707_CR52","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1182\/blood.V93.9.3081","volume":"93","author":"A Lopez-Guillermo","year":"1999","unstructured":"Lopez-Guillermo A, Cabanillas F, McDonnell TI, McLaughlin P, Smith T, Pugh W, Hagemeister F, Rodriguez MA, Romaguera JE, Younes A, Sarris AH, Preti HA, Lee MS . Correlation of bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma Blood 1999 93: 3081\u20133087","journal-title":"Blood"},{"key":"BF2402707_CR53","first-page":"574a","volume":"96 (Suppl. 1)","author":"LHG Shen","year":"2000","unstructured":"Shen LHG, Connors JM, Klasa JM, Horsman DE . Comparison of t(14;18) positive and t(14;18) negative follicular lymphomas: clinical characteristics, outcome and cytogenetics Blood 2000 96 (Suppl. 1): Abstr 574a","journal-title":"Blood"},{"key":"BF2402707_CR54","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/ajcp\/103.4.472","volume":"103","author":"DE Horsman","year":"1995","unstructured":"Horsman DE, Gascoyne RD, Coupland RW, Coldman AJ, Adomat SA . Comparison of cytogenetic analysis, southern analysis, and polymerase chain reaction for the detection of t(14;18) in follicular lymphoma Am J Clin Pathol 1995 103: 472\u2013478","journal-title":"Am J Clin Pathol"},{"key":"BF2402707_CR55","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1038\/sj.leu.2401889","volume":"14","author":"G Buchonnet","year":"2000","unstructured":"Buchonnet G, Lenain P, Ruminy P, Lepretre S, Stamatoullas A, Parmentier F, Jardin F, Duval C, Tilly H, Bastard C . Characterisation of BCL2-JH rearrangements in follicular lymphoma: PCR detection of 3\u2019 BCL2 breakpoints and evidence of a new cluster Leukemia 2000 14: 1563\u20131569","journal-title":"Leukemia"},{"key":"BF2402707_CR56","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1182\/blood.V92.9.3152","volume":"92","author":"MH Kramer","year":"1998","unstructured":"Kramer MH, Hermans J, Wijburg E, Philippo K, Geelen E, van Krieken JH, de Jong D, Maartense E, Schuuring E, Kluin PM . Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma Blood 1998 92: 3152\u20133162","journal-title":"Blood"},{"key":"BF2402707_CR57","first-page":"161","volume":"20","author":"M Jerkeman","year":"2002","unstructured":"Jerkeman M, Aman P, Cavallin-Stahl E, Torlakovic E, Akerman M, Mitelman F, Fioretos T . Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma \u2013 a Nordic Lymphoma Group study Int J Oncol 2002 20: 161\u2013165","journal-title":"Int J Oncol"},{"key":"BF2402707_CR58","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/35000501","volume":"403","author":"AA Alizadeh","year":"2000","unstructured":"Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J Jr, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Levy R, Wilson W, Grevers M, Byrd J, Bolstein D, Brown P, Staudt LM . Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling Nature 2000 403: 503\u2013511","journal-title":"Nature"},{"key":"BF2402707_CR59","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1182\/blood.V98.4.945","volume":"98","author":"IS Lossos","year":"2001","unstructured":"Lossos IS, Jones CD, Warnke R, Natkunam Y, Kaizer H, Zehnder JL, Tibshirani R, Levy R . Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma Blood 2001 98: 945\u2013951","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2402707.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402707","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2402707.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:28:10Z","timestamp":1648762090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2402707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,28]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11,1]]}},"alternative-id":["BF2402707"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2402707","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,28]]},"assertion":[{"value":"12 September 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2002","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}