{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:50:38Z","timestamp":1789527038994,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2004,6,1]]},"DOI":"10.1038\/sj.leu.2403357","type":"journal-article","created":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T10:17:55Z","timestamp":1080814675000},"page":"1153-1156","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Amplification of the ABL gene in T-cell acute lymphoblastic leukemia"],"prefix":"10.1038","volume":"18","author":[{"given":"K E","family":"Barber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Martineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Harewood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Strefford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Rutherford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T D","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z J","family":"Broadfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R L","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G R","family":"Jalali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A V","family":"Moorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,4,1]]},"reference":[{"key":"BF2403357_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1046\/j.1365-2141.2001.02643.x","volume":"113","author":"CJ Harrison","year":"2001","unstructured":"Harrison CJ, Martineau M, Secker-Walker LM . The Leukaemia Research Fund\/United Kingdom Cancer Cytogenetics Group Karyotype Database in acute lymphoblastic leukaemia: a valuable resource for patient management. Br J Haematol 2001; 113: 3\u201310.","journal-title":"Br J Haematol"},{"key":"BF2403357_CR2","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S0165-4608(98)00260-X","volume":"112","author":"PE Crossen","year":"1999","unstructured":"Crossen PE, Savage LM, Heaton DC, Morrison MJ . Characterization of the C-MYC amplicon in a case of acute myeloid leukemia with double minute chromosomes. Cancer Genet Cytogenet 1999; 112: 144\u2013148.","journal-title":"Cancer Genet Cytogenet"},{"key":"BF2403357_CR3","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1038\/sj.leu.2401919","volume":"14","author":"G Cuthbert","year":"2000","unstructured":"Cuthbert G, Thompson K, McCullough S, Watmore A, Dickinson H, Telford N et al MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Study Group (UKCCG) study. Leukemia 2000; 14: 1885\u20131891.","journal-title":"Leukemia"},{"key":"BF2403357_CR4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/gcc.10038","volume":"34","author":"SN Sait","year":"2002","unstructured":"Sait SN, Qadir MU, Conroy JM, Matsui S, Nowak NJ, Baer MR . Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping. Genes Chromosomes Cancer 2002; 34: 42\u201347.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403357_CR5","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/sj.leu.2402849","volume":"17","author":"L Harewood","year":"2003","unstructured":"Harewood L, Robinson H, Harris R, Jabbar Al-Obaidi MS, Jalali GR, Martineau M et al Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases. Leukemia 2003; 17: 547\u2013553.","journal-title":"Leukemia"},{"key":"BF2403357_CR6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S0165-4608(02)00615-5","volume":"139","author":"LJ Campbell","year":"2002","unstructured":"Campbell LJ, Patsouris C, Rayeroux KC, Somana K, Januszewicz EH, Szer J . BCR\/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration. Cancer Genet Cytogenet 2002; 139: 30\u201333.","journal-title":"Cancer Genet Cytogenet"},{"key":"BF2403357_CR7","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1034\/j.1600-0609.2003.00046.x","volume":"70","author":"F Morel","year":"2003","unstructured":"Morel F, Bris MJ, Herry A, Calvez GL, Marion V, Abgrall JF et al Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib. Eur J Haematol 2003; 70: 235\u2013239.","journal-title":"Eur J Haematol"},{"key":"BF2403357_CR8","doi-asserted-by":"publisher","first-page":"4813","DOI":"10.1073\/pnas.80.15.4813","volume":"80","author":"SJ Collins","year":"1983","unstructured":"Collins SJ, Groudine MT . Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562. Proc Natl Acad Sci USA 1983; 80: 4813\u20134817.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2403357_CR9","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s004280050337","volume":"434","author":"L Kenner","year":"1999","unstructured":"Kenner L, Beham-Schmid C, Kerbl R, Schmidt HH, Sill H, Hoefler G . ABL amplification in a patient with lymphoid blast crisis of chronic myelogenous leukaemia. Virchows Arch 1999; 434: 255\u2013257.","journal-title":"Virchows Arch"},{"key":"BF2403357_CR10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1182\/blood.V89.2.596","volume":"89","author":"K Tanaka","year":"1997","unstructured":"Tanaka K, Arif M, Eguchi M, Kyo T, Dohy H, Kamada N . Frequent jumping translocations of chromosomal segments involving the ABL oncogene alone or in combination with CD3-MLL genes in secondary leukemias. Blood 1997; 89: 596\u2013600.","journal-title":"Blood"},{"key":"BF2403357_CR11","unstructured":"ISCN. An International System for Human Cytogenetic Nomenclature, 1st edn. Basel: S Karger, 1995."},{"key":"BF2403357_CR12","doi-asserted-by":"publisher","first-page":"7124","DOI":"10.1038\/sj.onc.1203202","volume":"18","author":"F Vaillant","year":"1999","unstructured":"Vaillant F, Blyth K, Terry A, Bell M, Cameron ER, Neil J et al. A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc. Oncogene 1999; 18: 7124\u20137134.","journal-title":"Oncogene"},{"key":"BF2403357_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/gcc.10104","volume":"35","author":"X Mao","year":"2002","unstructured":"Mao X, Lillington D, Child F, Russell-Jones R, Young B, Whittaker S . Comparative genomic hybridization analysis of primary cutaneous B-cell lymphomas: identification of common genomic alterations in disease pathogenesis. Genes Chromosomes Cancer 2002; 35: 144\u2013155.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403357_CR14","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1046\/j.1523-1747.2003.12406.x","volume":"121","author":"X Mao","year":"2003","unstructured":"Mao X, Onadim Z, Price EA, Child F, Lillington DM, Russell-Jones R et al Genomic alterations in blastic natural killer\/extranodal natural killer-like T cell lymphoma with cutaneous involvement. J Invest Dermatol 2003; 121: 618\u2013627.","journal-title":"J Invest Dermatol"},{"key":"BF2403357_CR15","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/gcc.10184","volume":"37","author":"X Mao","year":"2003","unstructured":"Mao X, Orchard G, Lillington DM, Russell-Jones R, Young BD, Whittaker S . Genetic alterations in primary cutaneous CD30+ anaplastic large cell lymphoma. Genes Chromosomes Cancer 2003; 37: 176\u2013185.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403357_CR16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000132340","volume":"44","author":"EM Jack","year":"1987","unstructured":"Jack EM, Harrison CJ, Allen TD, Harris R . A scanning electron microscope study of double minutes from a human tumour cell line. Cytogenet Cell Genet 1987; 44: 49\u201352.","journal-title":"Cytogenet Cell Genet"},{"key":"BF2403357_CR17","doi-asserted-by":"publisher","first-page":"4804","DOI":"10.1073\/pnas.85.13.4804","volume":"85","author":"DD Von Hoff","year":"1988","unstructured":"Von Hoff DD, Needham-VanDevanter DR, Yucel J, Windle BE, Wahl GM . Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci USA 1988; 85: 4804\u20134808.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2403357_CR18","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/327434a0","volume":"327","author":"BJ Maurer","year":"1987","unstructured":"Maurer BJ, Lai E, Hamkalo BA, Hood L, Attardi G . Novel submicroscopic extrachromosomal elements containing amplified genes in human cells. Nature 1987; 327: 434\u2013437.","journal-title":"Nature"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2403357.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403357","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403357.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:43:28Z","timestamp":1648777408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2403357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,1]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6,1]]}},"alternative-id":["BF2403357"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2403357","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,1]]},"assertion":[{"value":"5 June 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}