{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:26Z","timestamp":1791229466538,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2004,6,10]],"date-time":"2004-06-10T00:00:00Z","timestamp":1086825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,6,10]],"date-time":"2004-06-10T00:00:00Z","timestamp":1086825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2004,8,1]]},"DOI":"10.1038\/sj.leu.2403399","type":"journal-article","created":{"date-parts":[[2004,6,10]],"date-time":"2004-06-10T09:28:17Z","timestamp":1086859697000},"page":"1340-1346","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia"],"prefix":"10.1038","volume":"18","author":[{"given":"C","family":"Terre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Eclache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rousselot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Imbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Charrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gervais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Mozziconacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Maarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Mossafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Auger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Dastugue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Talmant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Van den Akker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F N'Guyen","family":"Khac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Mugneret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Vigui\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lafage-Pochitaloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J N","family":"Bastie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G L","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Maloisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Vey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Recher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vigier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yacouben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Giraudier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Vernant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Salles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Roussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Castaigne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Leymarie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Flandrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lessard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of France Intergroupe pour la Leucemie Myeloide Chronique (FILMC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,6,10]]},"reference":[{"key":"BF2403399_CR1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1182\/blood.V65.5.1039.1039","volume":"65","author":"RE Champlin","year":"1985","unstructured":"Champlin RE, Golde DW . Chronic myelogenous leukemia: recent advances. Blood 1985; 65: 1039\u20131047.","journal-title":"Blood"},{"key":"BF2403399_CR2","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/315550a0","volume":"315","author":"E Shtivelman","year":"1985","unstructured":"Shtivelman E, Lifshitz B, Gale RP, Canaani E . Fused transcript of ABL and BCR genes in chronic myelogenous leukemia. Nature 1985; 315: 550\u2013554.","journal-title":"Nature"},{"key":"BF2403399_CR3","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1056\/NEJMoa011573","volume":"346","author":"H Kantarjian","year":"2002","unstructured":"Kantarjian H, Sawyers C, Hochlaus A, Guilhot F, Schiffer C, Gambacorti-Passerini C et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002; 346: 645\u2013652.","journal-title":"N Engl J Med"},{"key":"BF2403399_CR4","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1056\/NEJMoa022457","volume":"348","author":"SG O'Brien","year":"2003","unstructured":"O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F et al. IRIS Investigators. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994\u20131004.","journal-title":"N Engl J Med"},{"key":"BF2403399_CR5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/gcc.2870040314","volume":"4","author":"M Casali","year":"1992","unstructured":"Casali M, Truglio F, Milone G, Di Raimondo F, Parinello G, Maserati E et al. Trisomy 8 in Philadelphia chromosome (Ph 1)-negative cells in the course of Ph1-positive chronic myelocytic leukemia. Genes Chromosomes Cancer 1992; 4: 269\u2013270.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403399_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/gcc.2870060414","volume":"4","author":"C Bilhou-Nabera","year":"1993","unstructured":"Bilhou-Nabera C, Marit G, Devianne I, Viard F, Salzes S, Montastruc M et al. A second case of trisomy 8 in Philadelphia chromosome (Ph)-negative cells during the course of Ph-positive chronic myelocytic leukemia. Genes Chromosomes Cancer 1993; 4: 255\u2013256.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403399_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/0165-4608(94)00197-9","volume":"81","author":"T Ariyama","year":"1995","unstructured":"Ariyama T, Inazawa J, Uemura Y, Kakazu N, Maekawa T, Urase FK et al. Clonal origin of Philadelphia chromosome negative cells with trisomy 8 appearing during the course of \u03b1-interferon therapy for Ph positive chronic myelocytic leukemia. Cancer Genet Cytogenet 1995; 81: 20\u201323.","journal-title":"Cancer Genet Cytogenet"},{"key":"BF2403399_CR8","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/j.1365-2141.1995.tb05223.x","volume":"90","author":"E Ohtuska","year":"1995","unstructured":"Ohtuska E, Kikuchi H, Abe Y, Moriyama K, Ohno E, Hirota K et al. Acute myeloblastic leukemia without Philadelphia chromosome developing after interferon therapy for chronic myelocytic leukemia with Philadelphia chromosome. Br J Haematol 1995; 90: 951\u2013953.","journal-title":"Br J Haematol"},{"key":"BF2403399_CR9","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0925-5710(96)00469-0","volume":"64","author":"T Izumi","year":"1996","unstructured":"Izumi T, Imagawa S, Hatatake H, Miura Y, Ariyama T, Inazawa J et al. Philadelphia chromosome-negative cells with trisomy 8 after busulfan and interferon treatment of Ph1-positive chronic myelogenous leukemia. Int J Hematol 1996; 64: 73\u201377.","journal-title":"Int J Hematol"},{"key":"BF2403399_CR10","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/sj.leu.2400642","volume":"11","author":"L Fayad","year":"1997","unstructured":"Fayad L, Kantarjian H, O'Brien S, Seong D, Keating M, Talpaz M . Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases. Leukemia 1997; 11: 767\u2013771.","journal-title":"Leukemia"},{"key":"BF2403399_CR11","first-page":"617a","volume":"98","author":"S Marktel","year":"2001","unstructured":"Marktel S, Bua M, Marin D, Chase A, Udom C, Armstrong L et al. Emergence of additional chromosomal abnormalities following treatment with STI571 (Imatinib Mesylate) for Philadelphia positive chronic myeloid leukemia in chronic phase. Blood 2001; 98: 617a (abstr.).","journal-title":"Blood"},{"key":"BF2403399_CR12","doi-asserted-by":"publisher","first-page":"257b","DOI":"10.1182\/blood.V98.2.257","volume":"98","author":"C Gambarcoti-Passeri","year":"2001","unstructured":"Gambarcoti-Passeri C, Giudici G, le Coutre P, Bungaro S, Pogliani EM, Kreuzer KA et al. Non random chromosomal abnormalities in Ph-negative bone marrow (BM) cells from CML patients achieving major cytogenetic response (MCR) with STI571 (GleevecTM). Blood 2001; 98: 257b (abstr.).","journal-title":"Blood"},{"key":"BF2403399_CR13","first-page":"263b","volume":"98","author":"V Meunier","year":"2001","unstructured":"Meunier V, Giraudier S, Van den Akker J, Perot C, Jouault H, Caron-Servan B et al. Treatment with STI571 (Novartis) in chronic myeloid leukemia (CML): unexpected hematological findings in a series of 26 patients. Blood 2001; 98: 263b (abstr.).","journal-title":"Blood"},{"key":"BF2403399_CR14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1182\/blood.V100.2.435","volume":"100","author":"R Braziel","year":"2002","unstructured":"Braziel R, Launder M, Druker B, Olson S, Magenis E, Mauro M et al. Hematopathologic and cytogenetic findings in imatinib mesylate-treated chronic myelogenous leukemia patients: 14 months experience. Blood 2002; 100: 435\u2013441.","journal-title":"Blood"},{"key":"BF2403399_CR15","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1038\/sj.leu.2402634","volume":"16","author":"MK Andersen","year":"2002","unstructured":"Andersen MK, Pedersen-Bjergaard J, Kjeldsen L, Dufva IH, Brondum-Nielsen K . Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8. Leukemia 2002; 16: 1390\u20131393.","journal-title":"Leukemia"},{"key":"BF2403399_CR16","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1182\/blood-2002-07-2053","volume":"101","author":"T Bumm","year":"2003","unstructured":"Bumm T, M\u00fcller C, Al-Ali HF, Krohn K, Shepherd P, Schmidt E et al. Emergence of clonal cytogenetic abnormalities in Ph-negative cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003; 101: 1941\u20131949.","journal-title":"Blood"},{"key":"BF2403399_CR17","first-page":"2299","volume":"100","author":"E Feldman","year":"2002","unstructured":"Feldman E, Najfeld V, Schuster M, Roboz G, Chadburn A, Goodman O et al. The emergence of Philadelphia chromosome (Ph) negative trisomy 8 cells in patients treated with imatinib mesylate: clinical evidence for a multistep pathogenesis. Blood 2002; 100: 2299 (abstr.).","journal-title":"Blood"},{"key":"BF2403399_CR18","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/sj.leu.2402791","volume":"17","author":"P Meeus","year":"2003","unstructured":"Meeus P, Demuynck H, Martiat P, Michaux L, Wouters E, Hagemeijer A . Sustained, clonal karyotype abnormalities in the Philadelphia chromosome negative cells of CML patients successfully treated with Imatinib. Leukemia 2003; 17: 465\u2013467.","journal-title":"Leukemia"},{"key":"BF2403399_CR19","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/sj.leu.2402813","volume":"17","author":"C Schoch","year":"2003","unstructured":"Schoch C, Haferlach T, Kern W, Schnittgers S, Berger U, Hehlmann R et al. Occurence of additional chromosome aberrations in chronic myeloid leukemia patients treated with imatinib mesylate. Leukemia 2003; 17: 461\u2013463.","journal-title":"Leukemia"},{"key":"BF2403399_CR20","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/sj.leu.2402848","volume":"17","author":"M O'Dwyer","year":"2003","unstructured":"O'Dwyer M, Gatter K, Loriaux M, Druker B, Olson S, Magenis E et al. Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate. Leukemia 2003; 17: 481\u2013487.","journal-title":"Leukemia"},{"key":"BF2403399_CR21","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1182\/blood-2003-06-1943","volume":"102","author":"M McMullin","year":"2003","unstructured":"McMullin M, Humphreys M, Byrne J, Russel N, Cuthbert R, O'Dwyer M . Chromosomal abnormalities in Ph\u2212 cells of patients on imatinib. Blood 2003; 102: 2700\u20132701.","journal-title":"Blood"},{"key":"BF2403399_CR22","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1002\/cncr.11729","volume":"98","author":"J Medina","year":"2003","unstructured":"Medina J, Kantarajian H, Talpaz M, O'Brien S, Garcia-Manero G, Giles F et al. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during Imatinib Mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Cancer 2003; 98: 1905\u20131911.","journal-title":"Cancer"},{"key":"BF2403399_CR23","first-page":"55","volume":"21","author":"J Sehested","year":"1975","unstructured":"Sehested J . A simple method for R-banding of human chromosomes, showing a pH-dependent connection between R and G bands. Humangentik 1975; 21: 55\u201358.","journal-title":"Humangentik"},{"key":"BF2403399_CR24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/(SICI)1098-2264(200001)27:1<11::AID-GCC2>3.0.CO;2-I","volume":"27","author":"A Wiktor","year":"2000","unstructured":"Wiktor A, Rybicki B, Prao Z, Shurafa M, Barthel B, Maeda K et al. Clinical significance of Y chromosome loss in hematologic disease. Genes Chromosomes Cancer 2000; 27: 11\u201316.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403399_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/gcc.1214","volume":"33","author":"E Maserati","year":"2002","unstructured":"Maserati E, Aprili F, Vinante F, Locatelli F, Amendola G, Zatterale A et al. Trisomy 8 in myelodysplasia and acute leukaemia is constitutional in 15\u201320% of cases. Genes Chromosomes Cancer 2002; 33: 93\u201397.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403399_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF00329123","volume":"55","author":"AC Chandley","year":"1980","unstructured":"Chandley AC, Hargreave TB, Fletcher JM, Soos M, Axworthy D, Price WH . Trisomy 8. Report of a mosaic human male with near-normal phenotype and normal IQ, ascertained through infertility. Hum Genet 1980; 55: 31\u201338.","journal-title":"Hum Genet"},{"key":"BF2403399_CR27","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/387516a0","volume":"387","author":"R Baskaran","year":"1997","unstructured":"Baskaran R, Wood LD, Whitaker LL, Canman CE, Morgan SE, Xu Y et al. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 1997; 387: 516\u2013519.","journal-title":"Nature"},{"key":"BF2403399_CR28","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/386732a0","volume":"386","author":"S Kharbanda","year":"1997","unstructured":"Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan ZM et al. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 1997; 386: 732\u2013735.","journal-title":"Nature"},{"key":"BF2403399_CR29","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/387520a0","volume":"387","author":"T Shafman","year":"1997","unstructured":"Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T et al. Interaction between ATM protein and c-Abl in response to DNA damage. Nature 1997; 387: 520\u2013523.","journal-title":"Nature"},{"key":"BF2403399_CR30","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1074\/jbc.273.7.3799","volume":"273","author":"ZM Yuan","year":"1998","unstructured":"Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kharbanda S et al. Regulation of Rad51 function by c-Abl in response to DNA damage. J Biol Chem 1998; 273: 3799\u20133802.","journal-title":"J Biol Chem"},{"key":"BF2403399_CR31","doi-asserted-by":"publisher","first-page":"12748","DOI":"10.1074\/jbc.274.18.12748","volume":"274","author":"G Chen","year":"1999","unstructured":"Chen G, Yuan SS, Liu W, Xu Y, Trujillo K, Song B et al. Radiation-induced assembly of Rad21 and rad52 combination complex requires ATM and c-Abl. J Biol Chem 1999; 274: 12748\u201312752.","journal-title":"J Biol Chem"},{"key":"BF2403399_CR32","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/21690","volume":"399","author":"JG Gong","year":"1999","unstructured":"Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin WG, Levrero M et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999; 399: 806\u2013809.","journal-title":"Nature"},{"key":"BF2403399_CR33","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/21704","volume":"399","author":"ZM Yuan","year":"1999","unstructured":"Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 1999; 399: 814\u2013817.","journal-title":"Nature"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2403399.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403399","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403399.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:46:01Z","timestamp":1648777561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2403399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,10]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8,1]]}},"alternative-id":["BF2403399"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2403399","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,10]]},"assertion":[{"value":"24 November 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}