{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T12:32:11Z","timestamp":1774787531015,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2004,8,23]],"date-time":"2004-08-23T00:00:00Z","timestamp":1093219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,8,23]],"date-time":"2004-08-23T00:00:00Z","timestamp":1093219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2004,9,1]]},"DOI":"10.1038\/sj.leu.2403439","type":"journal-article","created":{"date-parts":[[2004,8,23]],"date-time":"2004-08-23T07:40:21Z","timestamp":1093246821000},"page":"1522-1530","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A diagnostic biochip for the comprehensive analysis of MLL translocations in acute leukemia"],"prefix":"10.1038","volume":"18","author":[{"given":"N","family":"Maroc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Morel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Beillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"de La Chapelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Fund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-J","family":"Mozziconacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-M","family":"Cayuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Gabert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Koki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Fert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Hermitte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,8,23]]},"reference":[{"key":"BF2403439_CR1","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/annurev.genet.32.1.495","volume":"32","author":"JD Rowley","year":"1998","unstructured":"Rowley JD . The critical role of chromosome translocations in human leukemias. Annu Rev Genet 1998; 32: 495\u2013519.","journal-title":"Annu Rev Genet"},{"key":"BF2403439_CR2","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1046\/j.1365-2141.1999.01439.x","volume":"106","author":"JF DiMartino","year":"1999","unstructured":"DiMartino JF, Cleary ML . MLL rearrangements in haematological malignancies: lessons from clinical and biological studies. Br J Haematol 1999; 106: 614\u2013626.","journal-title":"Br J Haematol"},{"key":"BF2403439_CR3","doi-asserted-by":"publisher","first-page":"10735","DOI":"10.1073\/pnas.88.23.10735","volume":"88","author":"S Ziemin-van der Poel","year":"1991","unstructured":"Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa III R, Patel Y, Harden A et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 1991; 88: 10735\u201310739.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2403439_CR4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/gcc.2870130202","volume":"13","author":"OA Bernard","year":"1995","unstructured":"Bernard OA, Berger R . Molecular basis of 11q23 rearrangements in haematopoietic malignant proliferations. Genes Chromosomes Cancer 1995; 13: 75\u201385.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403439_CR5","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S1471-4914(02)02397-3","volume":"8","author":"EC Collins","year":"2002","unstructured":"Collins EC, Rabbits TH . The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. Trends Mol Med 2002; 8: 436\u2013442.","journal-title":"Trends Mol Med"},{"key":"BF2403439_CR6","doi-asserted-by":"publisher","first-page":"4647","DOI":"10.1182\/blood-2002-03-0717","volume":"99","author":"S Hayette","year":"2002","unstructured":"Hayette S, Tigaud I, Maguer-Satta V, Bartholin L, Thomas X, Charrin C et al. Recurrent involvement of the MLL gene in adult T-lineage acute lymphoblastic leukemia. Blood 2002; 99: 4647\u20134649.","journal-title":"Blood"},{"key":"BF2403439_CR7","unstructured":"Huret JL Infobiogen. Atlas Genet Cytogenet Oncol Haematol. 11q23 rearrangements in leukaemia. http:\/\/www.infobiogen.fr\/services\/chromcancer\/Anomalies\/11q23ID1030.html (Accessed October 2003)."},{"key":"BF2403439_CR8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1182\/blood.V96.1.24","volume":"96","author":"A Biondi","year":"2000","unstructured":"Biondi A, Cimino G, Pieters R, Pui CH . Biological and therapeutic aspects of infant leukemia. Blood 2000; 96: 24\u201333.","journal-title":"Blood"},{"key":"BF2403439_CR9","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/gcc.10046","volume":"33","author":"CD Bloomfield","year":"2002","unstructured":"Bloomfield CD, Archer KJ, Mrozek K, Lillington DM, Kaneko Y, Head DR et al. 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop. Genes Chromosomes Cancer 2002; 33: 362\u2013378.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403439_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1046\/j.1365-2141.2000.01843.x","volume":"109","author":"CH Pui","year":"2000","unstructured":"Pui CH, Relling MV . Topoisomerase II inhibitor-related acute myeloid leukaemia. Br J Haematol 2000; 109: 13\u201323.","journal-title":"Br J Haematol"},{"key":"BF2403439_CR11","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/sj.leu.2401011","volume":"12","author":"LM Secker-Walker","year":"1998","unstructured":"Secker-Walker LM . General Report on the European Union Concerted Action Workshop on 11q23, London UK, May 1997. Leukemia 1998; 12: 776\u2013778.","journal-title":"Leukemia"},{"key":"BF2403439_CR12","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1073\/pnas.040569197","volume":"97","author":"PJ Kourlas","year":"2000","unstructured":"Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS et al. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. Proc Natl Acad Sci USA 2000; 97: 2145\u20132150.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2403439_CR13","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1073\/pnas.94.8.3899","volume":"94","author":"MA Caligiuri","year":"1997","unstructured":"Caligiuri MA, Strout MP, Oberkircher AR, Yu F, de la Chapelle A, Bloomfield CD . The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome. Proc Natl Acad Sci USA 1997; 94: 3899\u20133902.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2403439_CR14","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood.V92.7.2322","volume":"92","author":"D Grimwade","year":"1998","unstructured":"Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 1998; 92: 2322\u20132333.","journal-title":"Blood"},{"key":"BF2403439_CR15","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/00043426-199511000-00001","volume":"17","author":"JA Martinez-Climent","year":"1995","unstructured":"Martinez-Climent JA, Espinosa III R, Thirman MJ, Le Beau MM, Rowley JD . Abnormalities of chromosome band 11q23 and the MLL gene in pediatric myelomonocytic and monoblastic leukemias. Identification of the t(9;11) as an indicator of long survival. J Pediatr Hematol Oncol 1995; 17: 277\u2013283.","journal-title":"J Pediatr Hematol Oncol"},{"key":"BF2403439_CR16","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/ng765","volume":"30","author":"SA Armstrong","year":"2002","unstructured":"Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002; 30: 41\u201347.","journal-title":"Nat Genet"},{"key":"BF2403439_CR17","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.1038\/sj.onc.1204639","volume":"20","author":"PM Ayton","year":"2001","unstructured":"Ayton PM, Cleary ML . Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 2001; 20: 5695\u20135707.","journal-title":"Oncogene"},{"key":"BF2403439_CR18","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1016>3.0.CO;2-K","volume":"29","author":"G Cuthbert","year":"2000","unstructured":"Cuthbert G, Thompson K, Breese G, McCullough S, Bown N . Sensitivity of FISH in detection of MLL translocations. Genes Chromosomes Cancer 2000; 29: 180\u2013185.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403439_CR19","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1038\/sj.leu.2401512","volume":"13","author":"S Mathew","year":"1999","unstructured":"Mathew S, Behm F, Dalton J, Raimondi S . Comparison of cytogenetics, Southern blotting, and fluorescence in situ hybridization as methods for detecting MLL gene rearrangements in children with acute leukemia and with 11q23 abnormalities. Leukemia 1999; 13: 1713\u20131720.","journal-title":"Leukemia"},{"key":"BF2403439_CR20","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1038\/sj.leu.2401595","volume":"13","author":"M van der Burg","year":"1999","unstructured":"van der Burg M, Beverloo HB, Langerak AW, Wijsman J, van Drunen E, Slater R et al. Rapid and sensitive detection of all types of MLL gene translocations with a single FISH probe set. Leukemia 1999; 13: 2107\u20132113.","journal-title":"Leukemia"},{"key":"BF2403439_CR21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/(SICI)1098-2264(200005)28:1<14::AID-GCC2>3.0.CO;2-X","volume":"28","author":"A von Bergh","year":"2000","unstructured":"von Bergh A, Emanuel B, van Zelderen-Bhola S, Smetsers T, van Soest R, Stul M et al. A DNA probe combination for improved detection of MLL\/11q23 breakpoints by double-color interphase-FISH in acute leukemias. Genes Chromosomes Cancer 2000; 28: 14\u201322.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403439_CR22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/ajcp\/109.1.24","volume":"109","author":"MC Cox","year":"1998","unstructured":"Cox MC, Maffei L, Buffolino S, Del Poeta G, Venditti A, Cantonetti M et al. A comparative analysis of FISH, RT-PCR, and cytogenetics for the diagnosis of bcr-abl-positive leukemias. Am J Clin Pathol 1998; 109: 24\u201331.","journal-title":"Am J Clin Pathol"},{"key":"BF2403439_CR23","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1182\/blood.V92.2.574","volume":"92","author":"N Pallisgaard","year":"1998","unstructured":"Pallisgaard N, Hokland P, Riishoj DC, Pedersen B, Jorgensen P . Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia. Blood 1998; 92: 574\u2013588.","journal-title":"Blood"},{"key":"BF2403439_CR24","first-page":"210","volume":"9","author":"R Repp","year":"1995","unstructured":"Repp R, Borkhardt A, Haupt E, Kreuder J, Brettreich S, Hammermann J et al. Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia 1995; 9: 210\u2013215.","journal-title":"Leukemia"},{"key":"BF2403439_CR25","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1182\/blood.V97.3.805","volume":"97","author":"S Strehl","year":"2001","unstructured":"Strehl S, Konig M, Mann G, Haas OA . Multiplex reverse transcriptase-polymerase chain reaction screening in childhood acute myeloblastic leukemia. Blood 2001; 97: 805\u2013808.","journal-title":"Blood"},{"key":"BF2403439_CR26","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1373\/49.7.1066","volume":"49","author":"RZ Shi","year":"2003","unstructured":"Shi RZ, Morrissey JM, Rowley JD . Screening and quantification of multiple chromosome translocations in human leukemia. Clin Chem 2003; 49: 1066\u20131073.","journal-title":"Clin Chem"},{"key":"BF2403439_CR27","first-page":"363","volume":"87","author":"T Nasedkina","year":"2002","unstructured":"Nasedkina T, Domer P, Zharinov V, Hoberg J, Lysov Y, Mirabekov A . Identification of chromosomal translocations in leukemias by hybridization with oligonucleotide microarrays. Haematologica 2002; 87: 363\u2013372.","journal-title":"Haematologica"},{"key":"BF2403439_CR28","first-page":"1766","volume":"56","author":"D Rasio","year":"1996","unstructured":"Rasio D, Schichman SA, Negrini M, Canaani E, Croce CM . Complete exon structure of the ALL1 gene. Cancer Res 1996; 56: 1766\u20131769.","journal-title":"Cancer Res"},{"key":"BF2403439_CR29","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1182\/blood-2002-04-1199","volume":"100","author":"JW Vardiman","year":"2002","unstructured":"Vardiman JW, Harris NL, Brunning RD . The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 2002; 100: 2292\u20132302.","journal-title":"Blood"},{"key":"BF2403439_CR30","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/(SICI)1098-2264(199604)15:4<206::AID-GCC2>3.0.CO;2-5","volume":"15","author":"S Tanabe","year":"1996","unstructured":"Tanabe S, Zeleznik-Le NJ, Kobayashi H, Vignon C, Espinosa III R, LeBeau MM et al. Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line. Genes Chromosomes Cancer 1996; 15: 206\u2013216.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403439_CR31","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/gcc.10284","volume":"38","author":"C Scholl","year":"2003","unstructured":"Scholl C, Breitinger H, Schlenk RF, D\u00f6hner H, Fr\u00f6hling S, D\u00f6hner K . AML Study Group Ulm. Development of a real-time RT-PCR assay for the quantification of the most frequent MLL\/AF9 fusion types resulting from translocation t(9;11)(p22;q23) in acute leukemia. Genes Chromosomes Cancer 2003; 38: 274\u2013280.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2403439_CR32","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","volume":"17","author":"J Gabert","year":"2003","unstructured":"Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N et al. Standardization and quality control studies of \u2018real-time\u2019 quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia \u2013 a Europe Against Cancer Program. Leukemia 2003; 17: 2318\u20132357.","journal-title":"Leukemia"},{"key":"BF2403439_CR33","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0378-1119(97)00640-9","volume":"208","author":"C Caldas","year":"1998","unstructured":"Caldas C, So CW, MacGregor A, Ford AM, McDonald B, Chan LC et al. Exon scrambling of MLL transcripts occur commonly and mimic partial genomic duplication of the gene. Gene 1998; 208: 167\u2013176.","journal-title":"Gene"},{"key":"BF2403439_CR34","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0378-1119(96)00364-2","volume":"178","author":"DK Nam","year":"1996","unstructured":"Nam DK, Honoki K, Yu M, Yunis JJ . Alternative RNA splicing of the MLL gene in normal and malignant cells. Gene 1996; 178: 169\u2013175.","journal-title":"Gene"},{"key":"BF2403439_CR35","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0037-1963(00)90013-1","volume":"37","author":"A Gozzetti","year":"2000","unstructured":"Gozzetti A, Le Beau MM . Fluorescence in situ hybridizations: uses and limitations. Semin Hematol 2000; 37: 320\u2013333.","journal-title":"Semin Hematol"},{"key":"BF2403439_CR36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/clinchem\/45.2.297","volume":"45","author":"KA Kreuzer","year":"1999","unstructured":"Kreuzer KA, Lass U, Landt O, Nitsche A, Laser J, Ellbrock H et al. Highly sensitive and specific fluorescence reverse transcription PCR assay for the pseudogene-free detection of beta-actin transcripts as quantitative reference. Clin Chem 1999; 45: 297\u2013300.","journal-title":"Clin Chem"},{"key":"BF2403439_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/00001622-200001000-00002","volume":"12","author":"CH Pui","year":"2000","unstructured":"Pui CH . Acute lymphoblastic leukemia in children. Curr Opin Oncol 2000; 12: 3\u201312.","journal-title":"Curr Opin Oncol"},{"key":"BF2403439_CR38","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1200\/JCO.2002.08.023","volume":"20","author":"JE Rubnitz","year":"2002","unstructured":"Rubnitz JE, Raimondi SC, Tong X, Srivastava DK, Razzouk BI, Shurtleff SA et al. Favorable impact of the t(9;11) in childhood acute myeloid leukemia. J Clin Oncol 2002; 20: 2302\u20132309.","journal-title":"J Clin Oncol"},{"key":"BF2403439_CR39","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nm0403-383","volume":"9","author":"TH Rabbitts","year":"2003","unstructured":"Rabbitts TH, Stocks MR . Chromosomal translocation products engender new intracellular therapeutic technologies. Nat Med 2003; 9: 383\u2013386.","journal-title":"Nat Med"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2403439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403439","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:47:32Z","timestamp":1648777652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2403439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,23]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9,1]]}},"alternative-id":["BF2403439"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2403439","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,23]]},"assertion":[{"value":"28 January 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}