{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:26:15Z","timestamp":1759580775527},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T00:00:00Z","timestamp":1100736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T00:00:00Z","timestamp":1100736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2005,2,1]]},"DOI":"10.1038\/sj.leu.2403596","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T12:11:12Z","timestamp":1100779872000},"page":"296-298","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Telomeres and telomerase in paediatric patients with T-cell acute lymphoblastic leukaemia (T-ALL)"],"prefix":"10.1038","volume":"19","author":[{"given":"E","family":"Kleideiter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Bangerter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Boukamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Koscielniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Klotz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Greil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,11,18]]},"reference":[{"key":"BF2403596_CR1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/S0167-7799(00)01541-9","volume":"19","author":"LK White","year":"2001","unstructured":"White LK, Wright WE, Shay JW . Telomerase inhibitors. Trends Biotechnol 2001; 19: 114\u2013120.","journal-title":"Trends Biotechnol"},{"key":"BF2403596_CR2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0304-3835(02)00709-7","volume":"194","author":"E Hiyama","year":"2003","unstructured":"Hiyama E, Hiyama K . Telomerase as tumor marker. Cancer Lett 2003; 194: 221\u2013233.","journal-title":"Cancer Lett"},{"key":"BF2403596_CR3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/0165-4608(92)90088-P","volume":"61","author":"DJ Adamson","year":"1992","unstructured":"Adamson DJ, King DJ, Haites NE . Significant telomere shortening in childhood leukemia. Cancer Genet Cytogenet 1992; 61: 204\u2013206.","journal-title":"Cancer Genet Cytogenet"},{"key":"BF2403596_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/sj.leu.2400889","volume":"12","author":"M Engelhardt","year":"1998","unstructured":"Engelhardt M, Ozkaynak MF, Drullinsky P, Sandoval C, Tugal O, Jayabose S et al. Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy. Leukemia 1998; 12: 13\u201324.","journal-title":"Leukemia"},{"key":"BF2403596_CR5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/sj.leu.2402815","volume":"17","author":"S Franco","year":"2003","unstructured":"Franco S, Ozkaynak MF, Sandoval C, Tugal O, Jayabose S, Engelhardt M et al. Telomere dynamics in childhood leukemia and solid tumors: a follow-up study. Leukemia 2003; 17: 401\u2013410.","journal-title":"Leukemia"},{"key":"BF2403596_CR6","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1006\/bcmd.2000.0332","volume":"26","author":"J Malaska","year":"2000","unstructured":"Malaska J, Sklenickova M, Krejci K, Fajkusova L, Bajer M, Hrstkova H et al. Telomerase activity and expression and telomere analysis in situ in the course of treatment of childhood leukemias. Blood Cells Mol Dis 2000; 26: 534\u2013539.","journal-title":"Blood Cells Mol Dis"},{"key":"BF2403596_CR7","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1002\/cncr.11313","volume":"97","author":"S Verstovsek","year":"2003","unstructured":"Verstovsek S, Manshouri T, Smith FO, Giles FJ, Cortes J, Estey E et al. Telomerase activity is prognostic in pediatric patients with acute myeloid leukemia: comparison with adult acute myeloid leukemia. Cancer 2003; 97: 2212\u20132217.","journal-title":"Cancer"},{"key":"BF2403596_CR8","first-page":"935","volume":"12","author":"D Januszkiewicz","year":"2003","unstructured":"Januszkiewicz D, Wysoki J, Lewandowski K, Pernak M, Nowicka K, Rembowska J et al. Lack of correlation between telomere length and telomerase activity and expression in leukemic cells. Int J Mol Med 2003; 12: 935\u2013938.","journal-title":"Int J Mol Med"},{"key":"BF2403596_CR9","first-page":"619","volume":"3","author":"JH Ohyashiki","year":"1997","unstructured":"Ohyashiki JH, Ohyashiki K, Iwama H, Hayashi S, Toyama K, Shay JW . Clinical implications of telomerase activity levels in acute leukemia. Clin Cancer Res 1997; 3: 619\u2013625.","journal-title":"Clin Cancer Res"},{"key":"BF2403596_CR10","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/mpo.2950250503","volume":"25","author":"H Schroeder","year":"1995","unstructured":"Schroeder H, Garwicz S, Kristinsson J, Siimes MA, Wesenberg F, Gustafsson G . Outcome after first relapse in children with acute lymphoblastic leukemia: a population-based study of 315 patients from the Nordic Society of Pediatric Hematology and Oncology (NOPHO). Med Pediatr Oncol 1995; 25: 372\u2013378.","journal-title":"Med Pediatr Oncol"},{"key":"BF2403596_CR11","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1203\/01.PDR.0000086901.29111.2A","volume":"54","author":"E Kleideiter","year":"2003","unstructured":"Kleideiter E, Schwab M, Friedrich U, Koscielniak E, Sch\u00e4fer BW, Klotz U . Telomerase activity in cell lines of pediatric soft tissue sarcomas. Pediatr Res 2003; 54: 718\u2013723.","journal-title":"Pediatr Res"},{"key":"BF2403596_CR12","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1056\/NEJMoa031197","volume":"351","author":"LA Wolfraim","year":"2004","unstructured":"Wolfraim LA, Fernandez TM, Mamura M, Fuller WL, Kumar R, Cole DE et al. Loss of Smad3 in acute T-cell lymphoblastic leukaemia. N Engl J Med 2004; 351: 552\u2013559.","journal-title":"N Engl J Med"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2403596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403596","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:14:08Z","timestamp":1648775648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2403596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,18]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2,1]]}},"alternative-id":["BF2403596"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2403596","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,18]]},"assertion":[{"value":"27 September 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}