{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:15:02Z","timestamp":1792440902374,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T00:00:00Z","timestamp":1112832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T00:00:00Z","timestamp":1112832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1038\/sj.leu.2403738","type":"journal-article","created":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T11:20:25Z","timestamp":1112872825000},"page":"1058-1063","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances"],"prefix":"10.1038","volume":"19","author":[{"given":"Y","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Karube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Suzumiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G-S","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,4,7]]},"reference":[{"key":"BF2403738_CR1","doi-asserted-by":"crossref","unstructured":"The Non-Hodgkin's lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. Blood 1997; 89: 3909\u20133918.","DOI":"10.1182\/blood.V89.11.3909"},{"key":"BF2403738_CR2","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","volume":"84","author":"NL Harris","year":"1994","unstructured":"Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML et al. A revised European\u2013American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361\u20131392.","journal-title":"Blood"},{"key":"BF2403738_CR3","volume-title":"WHO Classification: Tumors of Hematopoietic and Lymphoid Tissues","author":"ES Jaffe","year":"2001","unstructured":"Jaffe ES, Harris NL, Stein H, Vardiman JW . WHO Classification: Tumors of Hematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001."},{"key":"BF2403738_CR4","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0140-6736(88)90367-4","volume":"1","author":"AG Stansfeld","year":"1988","unstructured":"Stansfeld AG, Diebold J, Noel H, Kapanci Y, Rilke F, Kelenyi G et al. Updated Kiel classification for lymphomas. Lancet 1988; 1: 292\u2013293.","journal-title":"Lancet"},{"key":"BF2403738_CR5","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.1182\/blood.V99.12.4265","volume":"99","author":"JJ Biagi","year":"2002","unstructured":"Biagi JJ, Seymour JF . Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation. Blood 2002; 99: 4265\u20134275.","journal-title":"Blood"},{"key":"BF2403738_CR6","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/ajcp\/103.4.472","volume":"103","author":"DE Horsman","year":"1995","unstructured":"Horsman DE, Gascoyne RD, Coupland RW, Coldman AJ, Adomat SA . Comparison of cytogenetic analysis, southern analysis, and polymerase chain reaction for the detection of t (14;18) in follicular lymphoma. Am J Clin Pathol 1995; 103: 472\u2013478.","journal-title":"Am J Clin Pathol"},{"key":"BF2403738_CR7","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1182\/blood.V99.10.3806","volume":"99","author":"G Ott","year":"2002","unstructured":"Ott G, Katzenberger T, Lohr A, Kindelberger S, Rudiger T, Wilhelm M et al. Cytomorphologic, immunohistochemical, and cytogenetic profiles of follicular lymphoma: 2 types of follicular lymphoma grade 3. Blood 2002; 99: 3806\u20133812.","journal-title":"Blood"},{"key":"BF2403738_CR8","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1053\/hupa.2001.27118","volume":"32","author":"HJ Ree","year":"2001","unstructured":"Ree HJ, Yang WI, Kim CW, Huh J, Lee SS, Cho EY et al. Coexpression of Bcl-6 and CD10 in diffuse large B-cell lymphomas: significance of Bcl-6 expression patterns in identifying germinal center B-cell lymphoma. Hum Pathol 2001; 32: 954\u2013962.","journal-title":"Hum Pathol"},{"key":"BF2403738_CR9","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1038\/sj.leu.2402707","volume":"16","author":"F Jardin","year":"2002","unstructured":"Jardin F, Gaulard P, Buchonnet G, Contentin N, Lepretre S, Lenain P et al. Follicular lymphoma without t (14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics. Leukemia 2002; 16: 2309\u20132317.","journal-title":"Leukemia"},{"key":"BF2403738_CR10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/(SICI)1096-9896(199606)179:2<145::AID-PATH565>3.0.CO;2-1","volume":"179","author":"S Pittaluga","year":"1996","unstructured":"Pittaluga S, Ayoubi TA, Wlodarska I, Stul M, Cassiman JJ, Mecucci C et al. BCL-6 expression in reactive lymphoid tissue and in B-cell non-Hodgkin's lymphomas. J Pathol 1996; 179: 145\u2013150.","journal-title":"J Pathol"},{"key":"BF2403738_CR11","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1097\/00000478-200006000-00010","volume":"24","author":"A Dogan","year":"2000","unstructured":"Dogan A, Bagdi E, Munson P, Isaacson PG . CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. Am J Surg Pathol 2000; 24: 846\u2013852.","journal-title":"Am J Surg Pathol"},{"key":"BF2403738_CR12","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1093\/ajcp\/105.5.538","volume":"105","author":"PL Nguyen","year":"1996","unstructured":"Nguyen PL, Zukerberg LR, Benedict WF, Harris NL . Immunohistochemical detection of p53, bcl-2, and retinoblastoma proteins in follicular lymphoma. Am J Clin Pathol 1996; 105: 538\u2013543.","journal-title":"Am J Clin Pathol"},{"key":"BF2403738_CR13","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1309\/B6MK-J7NF-A6JP-X56K","volume":"115","author":"C Eshoa","year":"2001","unstructured":"Eshoa C, Perkins S, Kampalath B, Shidham V, Juckett M, Chang CC . Decreased CD10 expression in grade III and in interfollicular infiltrates of follicular lymphomas. Am J Clin Pathol 2001; 115: 862\u2013867.","journal-title":"Am J Clin Pathol"},{"key":"BF2403738_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1349-7006.2004.tb03249.x","volume":"95","author":"M Seto","year":"2004","unstructured":"Seto M . Genetic and epigenetic factors involved in B cell lymphomagenesis. Cancer Sci 2004; 95: 1\u20137.","journal-title":"Cancer Sci"},{"key":"BF2403738_CR15","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1006\/bbrc.2001.4820","volume":"283","author":"Y Hosokawa","year":"2001","unstructured":"Hosokawa Y, Maeda Y, Seto M . Target genes downregulated by the BCL-6\/LAZ3 oncoprotein in mouse Ba\/F3 cells. Biochem Biophys Res Commun 2001; 283: 563\u2013568.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF2403738_CR16","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1046\/j.1365-2559.2001.01196.x","volume":"39","author":"K Ohshima","year":"2001","unstructured":"Ohshima K, Kawasaki C, Muta H, Muta K, Deyev V, Haraoka S et al. CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis. Histopathology 2001; 39: 156\u2013162.","journal-title":"Histopathology"},{"key":"BF2403738_CR17","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/S0002-9440(10)65399-0","volume":"154","author":"JY Li","year":"1999","unstructured":"Li JY, Gaillard F, Moreau A, Harousseau JL, Laboisse C, Milpied N et al. Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescence in situ hybridization. Am J Pathol 1999; 154: 1449\u20131452.","journal-title":"Am J Pathol"},{"key":"BF2403738_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1349-7006.2004.tb03162.x","volume":"95","author":"X Zhang","year":"2004","unstructured":"Zhang X, Karnan S, Tagawa H, Suzuki R, Tsuzuki S, Hosokawa Y et al. Comparison of genetic aberrations in CD10+ diffused large B-cell lymphoma and follicular lymphoma by comparative genomic hybridization and tissue-fluorescence in situ hybridization. Cancer Sci 2004; 95: 1\u20136.","journal-title":"Cancer Sci"},{"key":"BF2403738_CR19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/sj.bjc.6601006","volume":"89","author":"I Chau","year":"2003","unstructured":"Chau I, Jones R, Cunningham D, Wotherspoon A, Maisey N, Norman AR et al. Outcome of follicular lymphoma grade 3: is anthracycline necessary as front-line therapy? Br J Cancer 2003; 89: 36\u201342.","journal-title":"Br J Cancer"},{"key":"BF2403738_CR20","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/BF02982692","volume":"76","author":"H Miyazato","year":"2002","unstructured":"Miyazato H, Nakatsuka S, Miyanaga I, Hanamoto H, Tatsumi Y, Matsuda M et al. Follicular lymphoma in Osaka, Japan: histological features and chronological change. Int J Hematol 2002; 76: 333\u2013337.","journal-title":"Int J Hematol"},{"key":"BF2403738_CR21","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/S0002-9440(10)64905-X","volume":"160","author":"A Albinger-Hegyi","year":"2002","unstructured":"Albinger-Hegyi A, Hochreutener B, Abdou MT, Hegyi I, Dours-Zimmermann MT, Kurrer MO et al. High frequency of t(14;18)-translocation breakpoints outside of major breakpoint and minor cluster regions in follicular lymphomas: improved polymerase chain reaction protocols for their detection. Am J Pathol 2002; 160: 823\u2013832.","journal-title":"Am J Pathol"},{"key":"BF2403738_CR22","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0002-9440(10)64897-3","volume":"160","author":"JC Aster","year":"2002","unstructured":"Aster JC, Longtine JA . Detection of BCL2 rearrangements in follicular lymphoma. Am J Pathol 2002; 160: 759\u2013763.","journal-title":"Am J Pathol"},{"key":"BF2403738_CR23","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1182\/blood.V101.3.1149","volume":"101","author":"AG Bosga-Bouwer","year":"2003","unstructured":"Bosga-Bouwer AG, van Imhoff GW, Boonstra R, van der Veen A, Haralambieva E, van den Berg A et al. Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive. Blood 2003; 101: 1149\u20131154.","journal-title":"Blood"},{"key":"BF2403738_CR24","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood.V83.9.2423.2423","volume":"83","author":"C Bastard","year":"1994","unstructured":"Bastard C, Deweindt C, Kerckaert JP, Lenormand B, Rossi A, Pezzella F et al. LAZ3 rearrangements in non-Hodgkin's lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 1994; 83: 2423\u20132427.","journal-title":"Blood"},{"key":"BF2403738_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1056\/NEJM199407143310202","volume":"331","author":"K Offit","year":"1994","unstructured":"Offit K, Lo Coco F, Louie DC, Parsa NZ, Leung D, Portlock C et al. Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. N Engl J Med 1994; 331: 74\u201380.","journal-title":"N Engl J Med"},{"key":"BF2403738_CR26","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1182\/blood.V83.7.1757.1757","volume":"83","author":"F Lo Coco","year":"1994","unstructured":"Lo Coco F, Ye BH, Lista F, Corradini P, Offit K, Knowles DM et al. Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 1994; 83: 1757\u20131759.","journal-title":"Blood"},{"key":"BF2403738_CR27","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1046\/j.1365-2141.1996.d01-1728.x","volume":"93","author":"M Muramatsu","year":"1996","unstructured":"Muramatsu M, Akasaka T, Kadowaki N, Ohno H, Yamabe H, Edamura S et al. Rearrangement of the BCL6 gene in B-cell lymphoid neoplasms: comparison with lymphomas associated with BCL2 rearrangement. Br J Haematol 1996; 93: 911\u2013920.","journal-title":"Br J Haematol"},{"key":"BF2403738_CR28","first-page":"864","volume":"11","author":"R Lai","year":"1998","unstructured":"Lai R, Arber DA, Chang KL, Wilson CS, Weiss LM . Frequency of bcl-2 expression in non-Hodgkin's lymphoma: a study of 778 cases with comparison of marginal zone lymphoma and monocytoid B-cell hyperplasia. Mod Pathol 1998; 11: 864\u2013869.","journal-title":"Mod Pathol"},{"key":"BF2403738_CR29","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1182\/blood-2002-07-2009","volume":"101","author":"M Sanchez-Beato","year":"2003","unstructured":"Sanchez-Beato M, Sanchez-Aguilera A, Piris MA . Cell cycle deregulation in B-cell lymphomas. Blood 2003; 101: 1220\u20131235, [E-pub 2002 September 12].","journal-title":"Blood"},{"key":"BF2403738_CR30","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S0046-8177(99)90141-7","volume":"30","author":"BF Skinnider","year":"1999","unstructured":"Skinnider BF, Horsman DE, Dupuis B, Gascoyne RD . Bcl-6 an Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities. Hum Pathol 1999; 30: 803\u2013808.","journal-title":"Hum Pathol"},{"key":"BF2403738_CR31","first-page":"405","volume":"147","author":"L Flenghi","year":"1995","unstructured":"Flenghi L, Ye BH, Fizzotti M, Bigerna B, Cattoretti G, Venturi S et al. A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells. Am J Pathol 1995; 147: 405\u2013411.","journal-title":"Am J Pathol"},{"key":"BF2403738_CR32","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0165-4608(00)00383-6","volume":"126","author":"AN Mohamed","year":"2001","unstructured":"Mohamed AN, Palutke M, Eisenberg L, Al-Katib A . Chromosomal analyses of 52 cases of follicular lymphoma with t(14;18), including blastic\/blastoid variant. Cancer Genet Cytogenet 2001; 126: 45\u201351.","journal-title":"Cancer Genet Cytogenet"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2403738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403738","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:32:23Z","timestamp":1648776743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2403738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,7]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6,1]]}},"alternative-id":["BF2403738"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2403738","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,7]]},"assertion":[{"value":"15 December 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}