{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:38Z","timestamp":1790741978138,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T00:00:00Z","timestamp":1121904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T00:00:00Z","timestamp":1121904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2005,9,1]]},"DOI":"10.1038\/sj.leu.2403875","type":"journal-article","created":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T09:51:29Z","timestamp":1121939489000},"page":"1558-1566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Involvement of transforming growth factor-\u03b2 and thrombopoietin in the pathogenesis of myelodysplastic syndrome with myelofibrosis"],"prefix":"10.1038","volume":"19","author":[{"given":"T","family":"Akiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Terui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Miyanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Takimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kohda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Niitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,7,21]]},"reference":[{"key":"BF2403875_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/1097-0142(19920701)70:1<94::AID-CNCR2820700115>3.0.CO;2-D","volume":"70","author":"K Ohyashiki","year":"1992","unstructured":"Ohyashiki K, Sasao I, Ohyashiki JH, Murakami T, Tauchi T, Iwabuchi A et al. Cytogenetic and clinical findings of myelodysplastic syndromes with a poor prognosis. An experience with 97 cases. Cancer 1992; 70: 94\u201399.","journal-title":"Cancer"},{"key":"BF2403875_CR2","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0889-8588(18)30325-3","volume":"6","author":"P Kampmeier","year":"1992","unstructured":"Kampmeier P, Anastasi J, Vardiman JW . Issues in the pathology of the myelodysplastic syndromes. Hematol Oncol Clin North Am 1992; 6: 501\u2013522.","journal-title":"Hematol Oncol Clin North Am"},{"key":"BF2403875_CR3","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/j.1600-0609.1992.tb01587.x","volume":"48","author":"H Maschek","year":"1992","unstructured":"Maschek H, Georgii A, Kaloutsi V, Werner M, Bandecar K, Kressel MG et al. Myelofibrosis in primary myelodysplastic syndromes: a retrospective study of 352 patients. Eur J Haematol 1992; 48: 208\u2013214.","journal-title":"Eur J Haematol"},{"key":"BF2403875_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/BF01698371","volume":"63","author":"GE Verhoef","year":"1992","unstructured":"Verhoef GE, De Wolf-Peeters C, Ferrant A, Deprez S, Meeus P, Stul M et al. Myelodysplastic syndromes with bone marrow fibrosis: a myelodysplastic disorder with proliferative features. Ann Hematol 1992; 63: 235\u2013241.","journal-title":"Ann Hematol"},{"key":"BF2403875_CR5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/BF01695890","volume":"66","author":"G Lambertenghi-Deliliers","year":"1993","unstructured":"Lambertenghi-Deliliers G, Annaloro C, Oriani A, Soligo D, Pozzoli E, Polli EE . Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes. Ann Hematol 1993; 66: 85\u201391.","journal-title":"Ann Hematol"},{"key":"BF2403875_CR6","first-page":"87","volume":"57","author":"Y Yoshida","year":"1993","unstructured":"Yoshida Y, Stephenson J, Mufti GJ . Myelodysplastic syndromes: from morphology to molecular biology. Part I. Classification, natural history and cell biology of myelodysplasia. Int J Hematol 1993; 57: 87\u201397.","journal-title":"Int J Hematol"},{"key":"BF2403875_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0145-2126(92)90100-L","volume":"16","author":"M Imbert","year":"1992","unstructured":"Imbert M, Nguyen D, Sultan C . Myelodysplastic syndrome (MDS) and acute myeloid leukemias (AML) with myelofibrosis. Leuk Res 1992; 16: 51\u201354.","journal-title":"Leuk Res"},{"key":"BF2403875_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1365-2141.1981.tb07191.x","volume":"49","author":"C Sultan","year":"1981","unstructured":"Sultan C, Sigaux F, Imbert M, Reyes F . Acute myelodysplasia with myelofibrosis: a report of eight cases. Br J Haematol 1981; 49: 11\u201316.","journal-title":"Br J Haematol"},{"key":"BF2403875_CR9","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1365-2141.1991.tb04411.x","volume":"78","author":"G Lambertenghi-Deliliers","year":"1991","unstructured":"Lambertenghi-Deliliers G, Orazi A, Luksch R, Annaloro C, Soligo D . Myelodysplastic syndrome with increased marrow fibrosis: a distinct clinicopathological entity. Br J Haematol 1991; 78: 161\u2013166.","journal-title":"Br J Haematol"},{"key":"BF2403875_CR10","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.1182\/blood.V88.12.4534.bloodjournal88124534","volume":"88","author":"MC Le Bousse-Kerdiles","year":"1996","unstructured":"Le Bousse-Kerdiles MC, Chevillard S, Charpentier A, Romquin N, Clay D, Smadja-Joffe F et al. Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia. Blood 1996; 88: 4534\u20134546.","journal-title":"Blood"},{"key":"BF2403875_CR11","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/(SICI)1096-8652(199810)59:2<133::AID-AJH6>3.0.CO;2-Z","volume":"59","author":"P Rameshwar","year":"1998","unstructured":"Rameshwar P, Chang VT, Thacker UF, Gascon P . Systemic transforming growth factor-beta in patients with bone marrow fibrosis \u2013 pathophysiological implications. Am J Hematol 1998; 59: 133\u2013142.","journal-title":"Am J Hematol"},{"key":"BF2403875_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1365-2141.1994.tb04970.x","volume":"88","author":"MC Martyre","year":"1994","unstructured":"Martyre MC, Romquin N, Le Bousse-Kerdiles MC, Chevillard S, Benyahia B, Dupriez B et al. Transforming growth factor-beta and megakaryocytes in the pathogenesis of idiopathic myelofibrosis. Br J Haematol 1994; 88: 9\u201316.","journal-title":"Br J Haematol"},{"key":"BF2403875_CR13","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1182\/blood.V75.7.1540.1540","volume":"75","author":"T Terui","year":"1990","unstructured":"Terui T, Niitsu Y, Mahara K, Fujisaki Y, Urushizaki Y, Mogi Y et al. The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis. Blood 1990; 75: 1540\u20131548.","journal-title":"Blood"},{"key":"BF2403875_CR14","first-page":"129","volume":"12","author":"J Thiele","year":"2000","unstructured":"Thiele J, Kvasnicka HM, Beelen DW, Flucke U, Spoer C, Paperno S et al. Megakaryopoiesis and myelofibrosis in chronic myeloid leukemia after allogenic bone marrow transplantation: an immunohistochemical study of 127 patients. Mod Pathol 2000; 12: 129\u2013138.","journal-title":"Mod Pathol"},{"key":"BF2403875_CR15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3109\/10428199509054751","volume":"20","author":"MC Martyre","year":"1995","unstructured":"Martyre MC . TGF-beta and megakaryocytes in the pathogenesis of myelofibrosis in myeloproliferative disorders. Leuk Lymphoma 1995; 20: 39\u201344.","journal-title":"Leuk Lymphoma"},{"key":"BF2403875_CR16","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1046\/j.1365-2141.1997.292671.x","volume":"97","author":"MC Martyre","year":"1997","unstructured":"Martyre MC, Le Bousse-Kerdiles MC, Romquin N, Chevillard S, Praloran V, Demory JL et al. Elevated levels of basic fibroblast growth factor in megakaryocytes and platelets from patients with idiopathic myelofibrosis. Br J Haematol 1997; 97: 441\u2013448.","journal-title":"Br J Haematol"},{"key":"BF2403875_CR17","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1182\/blood.V92.1.46.413k44_46_52","volume":"92","author":"Y Hirayama","year":"1998","unstructured":"Hirayama Y, Sakamaki S, Matsunaga T, Kuga T, Kuroda H, Kusakabe T et al. Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells. Blood 1998; 92: 4652.","journal-title":"Blood"},{"key":"BF2403875_CR18","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1046\/j.1365-2141.2003.04755.x","volume":"124","author":"H Kuroda","year":"2004","unstructured":"Kuroda H, Matsunaga T, Terui T, Tanaka I, Takimoto R, Fujikawa K et al. Decrease of Smad4 gene expression in patients with essential thrombocythaemia may cause an escape from suppression of megakaryopoiesis by transforming growth factor-beta1. Br J Haematol 2004; 124: 211\u2013220.","journal-title":"Br J Haematol"},{"key":"BF2403875_CR19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","volume":"51","author":"JM Bennett","year":"1982","unstructured":"Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982; 51: 189\u2013199.","journal-title":"Br J Haematol"},{"key":"BF2403875_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1365-2141.1991.tb04444.x","volume":"78","author":"JM Bennett","year":"1991","unstructured":"Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-MO). Br J Haematol 1991; 78: 325\u2013329.","journal-title":"Br J Haematol"},{"key":"BF2403875_CR21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1365-2141.1979.tb03740.x","volume":"43","author":"A Manoharan","year":"1989","unstructured":"Manoharan A, Horsley R, Pitney WR . The reticulin content of bone marrow in acute leukaemia in adults. Br J Haematol 1989; 43: 185\u2013190.","journal-title":"Br J Haematol"},{"key":"BF2403875_CR22","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1182\/blood.V94.6.1961","volume":"94","author":"S Sakamaki","year":"1999","unstructured":"Sakamaki S, Hirayama Y, Matsunaga T, Kuroda H, Kusakabe T, Akiyama T et al. Transforming growth factor-beta1 (TGF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity. Blood 1999; 94: 1961\u20131970.","journal-title":"Blood"},{"key":"BF2403875_CR23","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1053\/gast.2001.27982","volume":"121","author":"K Miyanishi","year":"2001","unstructured":"Miyanishi K, Takayama T, Ohi M, Hayashi T, Nobuoka A, Nakajima T et al. Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis. Gastroenterology 2001; 121: 865\u2013874.","journal-title":"Gastroenterology"},{"key":"BF2403875_CR24","first-page":"4852","volume":"9","author":"H Hisai","year":"2003","unstructured":"Hisai H, Kato J, Kobune M, Murakami T, Miyanishi K, Takahashi M et al. Increased expression of angiogenin in hepatocellular carcinoma in correlation with tumor vascularity. Clin Cancer Res 2003; 9: 4852\u20134859.","journal-title":"Clin Cancer Res"},{"key":"BF2403875_CR25","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/32.2.6198355","volume":"32","author":"JL Cordel","year":"1984","unstructured":"Cordel JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, Mac Donald S et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase. J Histochem Cytochem 1984; 32: 219\u2013229.","journal-title":"J Histochem Cytochem"},{"key":"BF2403875_CR26","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1182\/blood.V66.6.1384.1384","volume":"66","author":"M Ogura","year":"1985","unstructured":"Ogura M, Morishima Y, Ohno R, Kato Y, Hirabayashi N, Nagura H et al. Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome. Blood 1985; 66: 1384\u20131392.","journal-title":"Blood"},{"key":"BF2403875_CR27","doi-asserted-by":"publisher","first-page":"14458","DOI":"10.1073\/pnas.241427398","volume":"98","author":"E Battinelli","year":"2001","unstructured":"Battinelli E, Willoughby SR, Foxall T, Valeri CR, Loscalzo J . Induction of platelet formation from megakaryocytoid cells by nitric oxide. Proc Natl Acad Sci USA 2001; 98: 14458\u201314463.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2403875_CR28","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood.V89.6.2079","volume":"89","author":"P Greenberg","year":"1997","unstructured":"Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997; 89: 2079\u20132088.","journal-title":"Blood"},{"key":"BF2403875_CR29","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1038\/sj.leu.2400846","volume":"11","author":"JC Wang","year":"1997","unstructured":"Wang JC, Chen C, Lou LH, Mora M . Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia. Leukemia 1997; 11: 1827\u20131832.","journal-title":"Leukemia"},{"key":"BF2403875_CR30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1182\/blood.V88.2.402.bloodjournal882402","volume":"88","author":"XQ Yan","year":"1996","unstructured":"Yan XQ, Lacey D, Hill D, Chen Y, Fletcher F, Hawley RG et al. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation. Blood 1996; 88: 402\u2013409.","journal-title":"Blood"},{"key":"BF2403875_CR31","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1182\/blood.V85.10.2720.bloodjournal85102720","volume":"85","author":"DJ Kuter","year":"1995","unstructured":"Kuter DJ, Rosenberg RD . The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995; 85: 2720\u20132730.","journal-title":"Blood"},{"key":"BF2403875_CR32","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1080\/1042819031000067927","volume":"44","author":"M Takabayashi","year":"2003","unstructured":"Takabayashi M, Sakai R, Kanamori H, Ishigatsubo Y . Successful treatment with intermediate dose cytosine arabinoside for myelodysplastic syndrome with acute myelofibrosis. Leuk Lymphoma 2003; 44: 891\u2013892.","journal-title":"Leuk Lymphoma"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2403875.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403875","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403875.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:58:14Z","timestamp":1648778294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2403875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,21]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9,1]]}},"alternative-id":["BF2403875"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2403875","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,21]]},"assertion":[{"value":"13 February 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}