{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:37:04Z","timestamp":1792701424421,"version":"4.5.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T00:00:00Z","timestamp":1122508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T00:00:00Z","timestamp":1122508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2005,9,1]]},"DOI":"10.1038\/sj.leu.2403876","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T15:07:44Z","timestamp":1122563264000},"page":"1567-1572","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Having a higher blast percentage in circulation than bone marrow: clinical implications in myelodysplastic syndrome and acute lymphoid and myeloid leukemias"],"prefix":"10.1038","volume":"19","author":[{"given":"H M","family":"Amin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E H","family":"Estey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F J","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"Kantarjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Jilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Albitar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,7,28]]},"reference":[{"key":"BF2403876_CR1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1365-2141.1976.tb03563.x","volume":"33","author":"JM Bennett","year":"1976","unstructured":"Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposals for the classification of acute leukaemias. French\u2013American\u2013British (FAB) cooperative group. Br J Haematol 1976; 33: 451\u2013458.","journal-title":"Br J Haematol"},{"key":"BF2403876_CR2","doi-asserted-by":"publisher","first-page":"620","DOI":"10.7326\/0003-4819-103-4-620","volume":"103","author":"JM Bennett","year":"1985","unstructured":"Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French\u2013American\u2013British Cooperative Group. Ann Intern Med 1985; 103: 620\u2013625.","journal-title":"Ann Intern Med"},{"key":"BF2403876_CR3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","volume":"51","author":"JM Bennett","year":"1982","unstructured":"Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982; 51: 189\u2013199.","journal-title":"Br J Haematol"},{"key":"BF2403876_CR4","first-page":"63","volume-title":"World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues","author":"RD Brunning","year":"2001","unstructured":"Brunning RD, Bennett JM, Flandrin G, Flandrin G, Matutes E, Head D et al. Myelodysplastic syndromes: introduction. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds). World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press, 2001, pp 63\u201367."},{"key":"BF2403876_CR5","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/sj.leu.2401768","volume":"14","author":"TC Griffin","year":"2000","unstructured":"Griffin TC, Shuster JJ, Buchanan GR, Murphy SB, Camitta BM, Amylon MD . Slow disappearance of peripheral blood blasts is an adverse prognostic factor in childhood T cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia 2000; 14: 792\u2013795.","journal-title":"Leukemia"},{"key":"BF2403876_CR6","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0145-2126(01)00064-9","volume":"25","author":"K Vehmeyer","year":"2001","unstructured":"Vehmeyer K, Haase D, Alves F . Increased peripheral stem cell pool in MDS: an indicator of disease progression? Leuk Res 2001; 25: 955\u2013959.","journal-title":"Leuk Res"},{"key":"BF2403876_CR7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00277-003-0619-z","volume":"82","author":"A Berer","year":"2003","unstructured":"Berer A, Jager E, Sagaster V, Streubel B, Wizamal F, Sperr WR et al. Circulating myeloid colony-forming cells predict survival in myelodysplastic syndromes. Ann Hematol 2003; 82: 271\u2013277.","journal-title":"Ann Hematol"},{"key":"BF2403876_CR8","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1046\/j.1365-2141.2001.02921.x","volume":"114","author":"S Verstovsek","year":"2001","unstructured":"Verstovsek S, Kantarjian H, Aguayo A, Manshouri T, Freireich E, Keating M et al. Significance of angiogenin plasma concentrations in patients with acute myeloid leukaemia and advanced myelodysplastic syndrome. Br J Haematol 2001; 114: 290\u2013295.","journal-title":"Br J Haematol"},{"key":"BF2403876_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1080\/1024533021000037207","volume":"7","author":"S Aref","year":"2002","unstructured":"Aref S, Mabed M, Sakrana M, Goda M, El-Sherbiny M . Soluble hepatocyte growth factor (sHGF) and vascular endothelial growth factor (sVEGF) in adult acute myeloid leukemia: relationship to disease characteristics. Hematology 2002; 7: 273\u2013279.","journal-title":"Hematology"},{"key":"BF2403876_CR10","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1158\/0008-5472.CAN-03-3005","volume":"64","author":"C Recher","year":"2004","unstructured":"Recher C, Ysebaert L, Beyne-Rauzy O, Mansat-De Mas V, Ruidavets JB, Cariven P et al. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res 2004; 64: 3191\u20133197.","journal-title":"Cancer Res"},{"key":"BF2403876_CR11","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/S0145-2126(98)00103-9","volume":"22","author":"X Thomas","year":"1998","unstructured":"Thomas X, Anglaret B, Bailly M, Maritaz O, Magaud JP, Archimbaud E . Differential adhesiveness between blood and marrow leukemic cells having similar pattern of VLA adhesion molecule expression. Leuk Res 1998; 22: 953\u2013960.","journal-title":"Leuk Res"},{"key":"BF2403876_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10428199509064917","volume":"18","author":"KF Bradstock","year":"1995","unstructured":"Bradstock KF, Gottlieb DJ . Interaction of acute leukemia cells with the bone marrow microenvironment: implications for control of minimal residual disease. Lymphoma 1995; 18: 1\u201316.","journal-title":"Lymphoma"},{"key":"BF2403876_CR13","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/sj.leu.2402431","volume":"16","author":"C Voermans","year":"2002","unstructured":"Voermans C, van Heese WP, de Jong I, Gerritsen WR, van Der Schoot CE . Migratory behavior of leukemic cells from acute myeloid leukemia patients. Leukemia 2002; 16: 650\u2013657.","journal-title":"Leukemia"},{"key":"BF2403876_CR14","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1200\/JCO.2000.18.19.3447","volume":"18","author":"P Greenberg","year":"2000","unstructured":"Greenberg P, Anderson J, de Witte T, Estey E, Fenaux P, Gupta P et al. Problematic WHO reclassification of myelodysplastic syndromes. Members of the International MDS Study Group. J Clin Oncol 2000; 18: 3447\u20133452.","journal-title":"J Clin Oncol"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2403876.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403876","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2403876.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:58:16Z","timestamp":1648778296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2403876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,28]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9,1]]}},"alternative-id":["BF2403876"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2403876","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,28]]},"assertion":[{"value":"7 March 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}