{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:05:36Z","timestamp":1790888736587,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T00:00:00Z","timestamp":1131580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T00:00:00Z","timestamp":1131580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2006,1,1]]},"DOI":"10.1038\/sj.leu.2404022","type":"journal-article","created":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T11:32:10Z","timestamp":1131622330000},"page":"122-127","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fatty acids, inhibitors for the DNA binding of c-Myc\/Max dimer, suppress proliferation and induce apoptosis of differentiated HL-60 human leukemia cell"],"prefix":"10.1038","volume":"20","author":[{"given":"K C","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y H","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H S","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H-K","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,11,10]]},"reference":[{"key":"BF2404022_CR1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0065-230X(08)60353-X","volume":"68","author":"M Henriksson","year":"1996","unstructured":"Henriksson M, Luscher B . Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res 1996; 68: 109\u2013182.","journal-title":"Adv Cancer Res"},{"key":"BF2404022_CR2","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1096\/fasebj.12.9.633","volume":"12","author":"LM Facchini","year":"1998","unstructured":"Facchini LM, Penn LZ . The molecular role of Myc in growth and transformation: recent discoveries lead to new insights. FASEB J 1998; 12: 633\u2013651.","journal-title":"FASEB J"},{"key":"BF2404022_CR3","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1038\/sj.onc.1202727","volume":"18","author":"GC Prendergast","year":"1999","unstructured":"Prendergast GC . Mechanisms of apoptosis by c-Myc. Oncogene 1999; 18: 2967\u20132987.","journal-title":"Oncogene"},{"key":"BF2404022_CR4","doi-asserted-by":"publisher","first-page":"13180","DOI":"10.1073\/pnas.96.23.13180","volume":"96","author":"BM Iritani","year":"1999","unstructured":"Iritani BM, Eisenman RN . c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc Natl Acad Sci USA 1999; 96: 13180\u201313185.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2404022_CR5","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1126\/science.2006410","volume":"251","author":"EM Blackwood","year":"1991","unstructured":"Blackwood EM, Eisenman RN . Max: a helix\u2013loop\u2013helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 1991; 251: 1211\u20131217.","journal-title":"Science"},{"key":"BF2404022_CR6","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/0092-8674(91)90457-A","volume":"65","author":"GC Prendergast","year":"1991","unstructured":"Prendergast GC, Lawe D, Ziff EB . Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation. Cell 1991; 65: 395\u2013407.","journal-title":"Cell"},{"key":"BF2404022_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1101\/gad.6.1.71","volume":"6","author":"EM Blackwood","year":"1992","unstructured":"Blackwood EM, Luscher B, Eisenman RN . Myc and Max associate in vivo. Genes Dev 1992; 6: 71\u201380.","journal-title":"Genes Dev"},{"key":"BF2404022_CR8","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1002\/j.1460-2075.1991.tb04938.x","volume":"10","author":"A Wenzel","year":"1991","unstructured":"Wenzel A, Cziepluch C, Hamann U, Schurmann J, Schwab M . The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20\/22) in human neuroblastoma cells. EMBO J 1991; 10: 3703\u20133712.","journal-title":"EMBO J"},{"key":"BF2404022_CR9","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1126\/science.2251503","volume":"250","author":"TK Blackwell","year":"1990","unstructured":"Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H . Sequence-specific DNA binding by the c-Myc protein. Science 1990; 250: 1149\u20131151.","journal-title":"Science"},{"key":"BF2404022_CR10","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1073\/pnas.88.10.4323","volume":"88","author":"E Kerkhoff","year":"1991","unstructured":"Kerkhoff E, Bister K, Klempnauer KH . Sequence-specific DNA binding by Myc proteins. Proc Natl Acad Sci USA 1991; 88: 4323\u20134327.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2404022_CR11","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1006\/excr.1999.4686","volume":"253","author":"CV Dang","year":"1999","unstructured":"Dang CV, Resar LM, Emison E, Kim S, Li Q, Prescott JE et al. Function of the c-Myc oncogenic transcription factor. Exp Cell Res 1999; 253: 63\u201377.","journal-title":"Exp Cell Res"},{"key":"BF2404022_CR12","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1002\/j.1460-2075.1993.tb06202.x","volume":"12","author":"B Amati","year":"1993","unstructured":"Amati B, Littlewood TD, Evan GI, Land H . The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J 1993; 12: 5083\u20135087.","journal-title":"EMBO J"},{"key":"BF2404022_CR13","first-page":"21","volume":"3","author":"M Guerin","year":"1988","unstructured":"Guerin M, Barrois M, Terrier MJ, Spielmann M, Riou G . Overexpression of either c-myc or c-erbB-2\/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis. Oncogene Res 1988; 3: 21\u201331.","journal-title":"Oncogene Res"},{"key":"BF2404022_CR14","first-page":"199","volume":"48","author":"R Mariani-Costantini","year":"1988","unstructured":"Mariani-Costantini R, Escot C, Theillet C, Gentile A, Merlo G, Lidereau R et al. In situ c-myc expression and genomic status of the c-myc locus in infiltrating ductal carcinomas of the breast. Cancer Res 1988; 48: 199\u2013205.","journal-title":"Cancer Res"},{"key":"BF2404022_CR15","first-page":"821","volume":"9","author":"DA Spandidos","year":"1989","unstructured":"Spandidos DA, Field JK, Agnantis NJ, Evan GI, Moore JP . High levels of c-myc protein in human breast tumours determined by a sensitive ELISA technique. Anticancer Res 1989; 9: 821\u2013826.","journal-title":"Anticancer Res"},{"key":"BF2404022_CR16","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/306760a0","volume":"306","author":"TH Rabbitts","year":"1983","unstructured":"Rabbitts TH, Hamlyn PH, Baer R . Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. Nature 1983; 306: 760\u2013765.","journal-title":"Nature"},{"key":"BF2404022_CR17","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1038\/sj.onc.1202746","volume":"18","author":"CE Nesbit","year":"1999","unstructured":"Nesbit CE, Tersak JM, Prochownik EV . MYC oncogenes and human neoplastic disease. Oncogene 1999; 18: 3004\u20133016.","journal-title":"Oncogene"},{"key":"BF2404022_CR18","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.7878464","volume":"267","author":"CB Thompson","year":"1995","unstructured":"Thompson CB . Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456\u20131462.","journal-title":"Science"},{"key":"BF2404022_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0165-6147(98)01277-2","volume":"20","author":"RA Kinloch","year":"1999","unstructured":"Kinloch RA, Treherne JM, Furness LM, Hajimohamadreza I . The pharmacology of apoptosis. Trends Pharmacol Sci 1999; 20: 35\u201342.","journal-title":"Trends Pharmacol Sci"},{"key":"BF2404022_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/sj.leu.2402337","volume":"16","author":"VM Dirsch","year":"2002","unstructured":"Dirsch VM, Antlsperger DS, Hentze H, Vollmar AM . Ajoene, an experimental anti-leukemic drug: mechanism of cell death. Leukemia 2002; 16: 74\u201383.","journal-title":"Leukemia"},{"key":"BF2404022_CR21","first-page":"1426","volume":"60","author":"L Gamet-Payrastre","year":"2000","unstructured":"Gamet-Payrastre L, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 2000; 60: 1426\u20131433.","journal-title":"Cancer Res"},{"key":"BF2404022_CR22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0014-5793(96)01307-5","volume":"400","author":"J Klucar","year":"1997","unstructured":"Klucar J, Al-Rubeai M . G2 cell cycle arrest and apoptosis are induced in Burkitt's lymphoma cells by the anticancer agent oracin. FEBS Lett 1997; 400: 127\u2013130.","journal-title":"FEBS Lett"},{"key":"BF2404022_CR23","first-page":"915","volume":"10","author":"R Bieker","year":"2003","unstructured":"Bieker R, Lerchenmuller C, Wehmeyer J, Serve HL, Mesters RM, Buchner T et al. Phase I study of liposomal daunorubicin in relapsed and refractory acute myeloid leukemia. Oncol Rep 2003; 10: 915\u2013920.","journal-title":"Oncol Rep"},{"key":"BF2404022_CR24","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.bbrc.2005.06.088","volume":"334","author":"KC Jung","year":"2005","unstructured":"Jung KC, Rhee HS, Park CH, Yang CH . Determination of the dissociation constants for recombinant c-Myc, Max, and DNA complexes: the inhibitory effect of linoleic acid on the DNA-binding step. Biochem Biophys Res Commun 2005; 334: 269\u2013275.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF2404022_CR25","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1073\/pnas.75.5.2458","volume":"75","author":"SJ Collins","year":"1978","unstructured":"Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC . Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Natl Acad Sci USA 1978; 75: 2458\u20132462.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2404022_CR26","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1177\/0148607104028005308","volume":"28","author":"RC Gillis","year":"2004","unstructured":"Gillis RC, Daley BJ, Enderson BL, Karlstad MD . Inhibition of 5-lipoxygenase induces cell death in anti-inflammatory fatty acid-treated HL-60 cells. JPEN J Parenter Enteral Nutr 2004; 28: 308\u2013314.","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"BF2404022_CR27","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S0167-4889(96)00148-6","volume":"1355","author":"Y Liu","year":"1997","unstructured":"Liu Y, Levy R . Phospholipase A2 has a role in proliferation but not in differentiation of HL-60 cells. Biochim Biophys Acta 1997; 1355: 270\u2013280.","journal-title":"Biochim Biophys Acta"},{"key":"BF2404022_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0022-4804(02)96496-6","volume":"107","author":"RC Gillis","year":"2002","unstructured":"Gillis RC, Daley BJ, Enderson BL, Karlstad MD . Eicosapentaenoic acid and gamma-linolenic acid induce apoptosis in HL-60 cells. J Surg Res 2002; 107: 145\u2013153.","journal-title":"J Surg Res"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2404022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404022","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:11:20Z","timestamp":1648775480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2404022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,10]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1,1]]}},"alternative-id":["BF2404022"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2404022","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,10]]},"assertion":[{"value":"29 August 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2005","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2005","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}