{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:23:25Z","timestamp":1790619805432,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2006,7,1]]},"DOI":"10.1038\/sj.leu.2404238","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T11:28:29Z","timestamp":1146137309000},"page":"1231-1237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)"],"prefix":"10.1038","volume":"20","author":[{"given":"I","family":"Del Giudice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Matutes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Osuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Parry-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Morilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Brito-Babapulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Oscier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,4,27]]},"reference":[{"key":"BF2404238_CR1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S0140-6736(73)93135-8","volume":"2","author":"D Catovsky","year":"1973","unstructured":"Catovsky D, Galetto J, Okos A, Galton DA, Wiltshaw E, Stathopoulos G . Prolymphocytic leukaemia of B and T cell type. Lancet 1973; 2: 232\u2013234.","journal-title":"Lancet"},{"key":"BF2404238_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1365-2141.1974.tb06769.x","volume":"27","author":"DA Galton","year":"1974","unstructured":"Galton DA, Goldman JM, Wiltshaw E, Catovsky D, Henry K, Goldenberg GJ . Prolymphocytic leukaemia. Br J Haematol 1974; 27: 7\u201323.","journal-title":"Br J Haematol"},{"key":"BF2404238_CR3","first-page":"131","volume-title":"Tumours of Hematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumours","author":"D Catovsky","year":"2001","unstructured":"Catovsky D, Montserrat E, Harris NL, Muller-Hermelink HK . B-Prolymphocytic leukemia. In: Jaffe ES, Harris N, Stein H, Vardiman JW (eds). Tumours of Hematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumours. IARC Press: Lyon, France, 2001, pp 131\u2013132."},{"key":"BF2404238_CR4","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1182\/blood.V89.6.2015","volume":"89","author":"D Lens","year":"1997","unstructured":"Lens D, De Schouwer PJ, Hamoudi RA, Abdul-Rauf M, Farahat N, Matutes E et al. p53 abnormalities in B-cell prolymphocytic leukemia. Blood 1997; 89: 2015\u20132023.","journal-title":"Blood"},{"key":"BF2404238_CR5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/sj.leu.2401644","volume":"14","author":"D Lens","year":"2000","unstructured":"Lens D, Matutes E, Catovsky D, Coignet LJA . Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL). Leukemia 2000; 14: 427\u2013430.","journal-title":"Leukemia"},{"key":"BF2404238_CR6","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/j.1365-2141.2004.04913.x","volume":"125","author":"R Ruchlemer","year":"2004","unstructured":"Ruchlemer R, Parry-Jones N, Brito-Bapapulle V, Attolico I, Wotherspoon AC, Matutes E et al. B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia. Br J Haematol 2004; 125: 330\u2013336.","journal-title":"Br J Haematol"},{"key":"BF2404238_CR7","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1182\/blood.V88.10.3953.bloodjournal88103953","volume":"88","author":"F Davi","year":"1996","unstructured":"Davi F, Maloum K, Michel A, Pritsch O, Magnac C, Macintyre E et al. High frequency of somatic mutations in the VH genes expressed in prolymphocytic leukemia. Blood 1996; 88: 3953\u20133961.","journal-title":"Blood"},{"key":"BF2404238_CR8","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","volume":"94","author":"TJ Hamblin","year":"1999","unstructured":"Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK . Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848\u20131854.","journal-title":"Blood"},{"key":"BF2404238_CR9","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1056\/NEJMoa023143","volume":"348","author":"M Crespo","year":"2003","unstructured":"Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348: 1764\u20131775.","journal-title":"N Engl J Med"},{"key":"BF2404238_CR10","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1002\/cncr.21437","volume":"104","author":"I Del Giudice","year":"2005","unstructured":"Del Giudice I, Morilla A, Osuji N, Matutes E, Morilla R, Burford A et al. Zeta-Chain associated protein 70 and CD38 combined predict the time to first treatment in patients with chronic lymphocytic leukemia. Cancer 2005; 104: 2124\u20132132.","journal-title":"Cancer"},{"key":"BF2404238_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/sj.thj.6200360","volume":"5","author":"PD Thornton","year":"2004","unstructured":"Thornton PD, Fernandez C, Giustolisi GM, Morilla R, Atkinson S, A\u2019Hern RP et al. CD38 expression as a prognostic indicator in chronic lymphocytic leukaemia. Hematol J 2004; 5: 145\u2013151.","journal-title":"Hematol J"},{"key":"BF2404238_CR12","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1182\/blood.V83.12.3647.3647","volume":"83","author":"SD Wagner","year":"1994","unstructured":"Wagner SD, Martinelli V, Luzzatto L . Similar patterns of V kappa gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma. Blood 1994; 83: 3647\u20133653.","journal-title":"Blood"},{"key":"BF2404238_CR13","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","volume":"94","author":"RN Damle","year":"1999","unstructured":"Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840\u20131847.","journal-title":"Blood"},{"key":"BF2404238_CR14","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0140-6736(03)15260-9","volume":"363","author":"JA Orchard","year":"2004","unstructured":"Orchard JA, Ibbotson RE, Davis Z, Wiestner A, Rosenwald A, Thomas PW et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia. Lancet 2004; 363: 105\u2013111.","journal-title":"Lancet"},{"key":"BF2404238_CR15","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1056\/NEJMoa040857","volume":"351","author":"LZ Rassenti","year":"2004","unstructured":"Rassenti LZ, Huynh L, Toy TL, Chen L, Keating MJ, Gribben JG et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004; 351: 893\u2013901.","journal-title":"N Engl J Med"},{"key":"BF2404238_CR16","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1038\/sj.leu.2403147","volume":"17","author":"J Durig","year":"2003","unstructured":"Durig J, Nuckel H, Cremer M, Fuhrer A, Halfmeyer K, Fandrey J et al. ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia. Leukemia 2003; 17: 2426\u20132434.","journal-title":"Leukemia"},{"key":"BF2404238_CR17","doi-asserted-by":"publisher","first-page":"4944","DOI":"10.1182\/blood-2002-10-3306","volume":"101","author":"A Wiestner","year":"2003","unstructured":"Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, Henrickson SE et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 2003; 101: 4944\u20134951.","journal-title":"Blood"},{"key":"BF2404238_CR18","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1182\/blood-2003-05-1383","volume":"102","author":"D Kienle","year":"2003","unstructured":"Kienle D, Krober A, Katzenberger T, Ott G, Leupolt E, Barth TF et al. VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberra'tions, clinical characteristics, and outcome. Blood 2003; 102: 3003\u20133009.","journal-title":"Blood"},{"key":"BF2404238_CR19","doi-asserted-by":"publisher","first-page":"4975","DOI":"10.1182\/blood-2002-06-1864","volume":"101","author":"J Orchard","year":"2003","unstructured":"Orchard J, Garand R, Davis Z, Babbage G, Sahota S, Matutes E et al. A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease. Blood 2003; 101: 4975\u20134981.","journal-title":"Blood"},{"key":"BF2404238_CR20","doi-asserted-by":"publisher","first-page":"4042","DOI":"10.1182\/blood-2002-11-3456","volume":"101","author":"FI Camacho","year":"2003","unstructured":"Camacho FI, Algara P, Rodriguez A, Ruiz-Ballesteros E, Mollejo M, Martinez N et al. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations. Blood 2003; 101: 4042\u20134046.","journal-title":"Blood"},{"key":"BF2404238_CR21","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1182\/blood-2002-11-3479","volume":"101","author":"SH Walsh","year":"2003","unstructured":"Walsh SH, Thorselius M, Johnson A, Soderberg O, Jerkeman M, Bjorck E et al. Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood 2003; 101: 4047\u20134054.","journal-title":"Blood"},{"key":"BF2404238_CR22","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1182\/blood.V99.4.1299","volume":"99","author":"P Algara","year":"2002","unstructured":"Algara P, Mateo MS, Sanchez-Beato M, Mollejo M, Navas IC, Romero L et al. Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course. Blood 2002; 99: 1299\u20131304.","journal-title":"Blood"},{"key":"BF2404238_CR23","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1182\/blood-2004-01-0132","volume":"104","author":"G Tobin","year":"2004","unstructured":"Tobin G, Thunberg U, Karlsson K, Murray F, Laurell A, Willander K et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 2004; 104: 2879\u20132885.","journal-title":"Blood"},{"key":"BF2404238_CR24","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1182\/blood-2004-07-2606","volume":"105","author":"P Ghia","year":"2005","unstructured":"Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stella S, Guida G et al. Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood 2005; 105: 1678\u20131685.","journal-title":"Blood"},{"key":"BF2404238_CR25","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1182\/blood.V98.9.2633","volume":"98","author":"G Del Poeta","year":"2001","unstructured":"Del Poeta G, Maurillo L, Venditti A, Buccisano F, Epiceno AM, Capelli G et al. Clinical significance of CD38 expression in chronic lymphocytic leukemia. Blood 2001; 98: 2633\u20132639.","journal-title":"Blood"},{"key":"BF2404238_CR26","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1182\/blood.V98.1.181","volume":"98","author":"S Ibrahim","year":"2001","unstructured":"Ibrahim S, Keating M, Do KA, O\u2019Brien S, Huh YO, Jilani I et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001; 98: 181\u2013186.","journal-title":"Blood"},{"key":"BF2404238_CR27","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1038\/sj.leu.2403504","volume":"18","author":"P Ghia","year":"2004","unstructured":"Ghia P, Guida G, Scielzo C, Geuna M, Caligaris-Cappio F . CD38 modifications in chronic lymphocytic leukemia: are they relevant? Leukemia 2004; 18: 1733\u20131735.","journal-title":"Leukemia"},{"key":"BF2404238_CR28","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1309\/WVQPVDF8UF7AV21X","volume":"122","author":"SJ Sup","year":"2004","unstructured":"Sup SJ, Domiati-Saad R, Kelley TW, Steinle R, Zhao X, Hsi ED . ZAP-70 expression in B-cell hematologic malignancy is not limited to CLL\/SLL. Am J Clin Pathol 2004; 122: 582\u2013587.","journal-title":"Am J Clin Pathol"},{"key":"BF2404238_CR29","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1080\/10428190410001723331","volume":"45","author":"E Matutes","year":"2004","unstructured":"Matutes E, Parry-Jones N, Brito-Babapulle V, Wotherspoon A, Morilla R, Atkinson S et al. The leukemic presentation of mantle-cell lymphoma: disease features and prognostic factors in 58 patients. Leuk Lymphoma 2004; 45: 2007\u20132015.","journal-title":"Leuk Lymphoma"},{"key":"BF2404238_CR30","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/sj.thj.6200111","volume":"2","author":"E Vizcarra","year":"2001","unstructured":"Vizcarra E, Martinez-Climent JA, Benet I, Marugan I, Terol MJ, Prosper F et al. Identification of two subgroups of mantle cell leukemia with distinct clinical and biological features. Hematol J 2001; 2: 234\u2013241.","journal-title":"Hematol J"},{"key":"BF2404238_CR31","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1182\/blood-2004-10-3898","volume":"106","author":"E Ruiz-Ballesteros","year":"2005","unstructured":"Ruiz-Ballesteros E, Mollejo M, Rodriguez A, Camacho FI, Algara P, Martinez N et al. Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers after tissue and cDNA microarray analysis. Blood 2005; 106: 1831\u20131838.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2404238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404238","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:31:37Z","timestamp":1648780297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2404238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,27]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7,1]]}},"alternative-id":["BF2404238"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2404238","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,27]]},"assertion":[{"value":"18 November 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}