{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:32:17Z","timestamp":1792805537902,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T00:00:00Z","timestamp":1147305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T00:00:00Z","timestamp":1147305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2006,7,1]]},"DOI":"10.1038\/sj.leu.2404258","type":"journal-article","created":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T11:50:47Z","timestamp":1147348247000},"page":"1279-1287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to \u03b3-secretase inhibitors"],"prefix":"10.1038","volume":"20","author":[{"given":"T","family":"Palomero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K C","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Real","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Glade Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Sulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V V","family":"Murty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A I","family":"Colovai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Balbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Ferrando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,5,11]]},"reference":[{"key":"BF2404258_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","volume":"306","author":"AP Weng","year":"2004","unstructured":"Weng AP, Ferrando AA, Lee W, Morris JPT, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269\u2013271.","journal-title":"Science"},{"key":"BF2404258_CR2","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/ni1164","volume":"6","author":"AW Duncan","year":"2005","unstructured":"Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 2005; 6: 314\u2013322.","journal-title":"Nat Immunol"},{"key":"BF2404258_CR3","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1084\/jem.194.7.991","volume":"194","author":"AC Jaleco","year":"2001","unstructured":"Jaleco AC, Neves H, Hooijberg E, Gameiro P, Clode N, Haury M et al. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med 2001; 194: 991\u20131002.","journal-title":"J Exp Med"},{"key":"BF2404258_CR4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S1044-5323(03)00003-4","volume":"15","author":"WS Pear","year":"2003","unstructured":"Pear WS, Radtke F . Notch signaling in lymphopoiesis. Semin Immunol 2003; 15: 69\u201379.","journal-title":"Semin Immunol"},{"key":"BF2404258_CR5","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S1074-7613(00)80105-3","volume":"11","author":"JC Pui","year":"1999","unstructured":"Pui JC, Allman D, Xu L, DeRocco S, Karnell FG, Bakkour S et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 1999; 11: 299\u2013308.","journal-title":"Immunity"},{"key":"BF2404258_CR6","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-0","volume":"10","author":"F Radtke","year":"1999","unstructured":"Radtke F, Wilson A, Stark G, Bauer M, van Meerwijk J, MacDonald HR et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 1999; 10: 547\u2013558.","journal-title":"Immunity"},{"key":"BF2404258_CR7","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/01.moh.0000143965.90813.70","volume":"11","author":"WS Pear","year":"2004","unstructured":"Pear WS, Aster JC . T cell acute lymphoblastic leukemia\/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. Curr Opin Hematol 2004; 11: 426\u2013433.","journal-title":"Curr Opin Hematol"},{"key":"BF2404258_CR8","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1084\/jem.20040394","volume":"200","author":"TM Schmitt","year":"2004","unstructured":"Schmitt TM, Ciofani M, Petrie HT, Zuniga-Pflucker JC . Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. J Exp Med 2004; 200: 469\u2013479.","journal-title":"J Exp Med"},{"key":"BF2404258_CR9","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S1074-7613(02)00330-8","volume":"16","author":"A Wolfer","year":"2002","unstructured":"Wolfer A, Wilson A, Nemir M, MacDonald HR, Radtke F . Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity 2002; 16: 869\u2013879.","journal-title":"Immunity"},{"key":"BF2404258_CR10","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/S0092-8674(00)81929-7","volume":"88","author":"T Washburn","year":"1997","unstructured":"Washburn T, Schweighoffer E, Gridley T, Chang D, Fowlkes BJ, Cado D et al. Notch activity influences the alphabeta versus gammadelta T cell lineage decision. Cell 1997; 88: 833\u2013843.","journal-title":"Cell"},{"key":"BF2404258_CR11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/S0952-7915(99)00067-9","volume":"12","author":"ML Deftos","year":"2000","unstructured":"Deftos ML, Bevan MJ . Notch signaling in T cell development. Curr Opin Immunol 2000; 12: 166\u2013172.","journal-title":"Curr Opin Immunol"},{"key":"BF2404258_CR12","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.4049\/jimmunol.169.4.1817","volume":"169","author":"BJ Fowlkes","year":"2002","unstructured":"Fowlkes BJ, Robey EA . A reassessment of the effect of activated Notch1 on CD4 and CD8\u2009T cell development. J Immunol 2002; 169: 1817\u20131821.","journal-title":"J Immunol"},{"key":"BF2404258_CR13","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1074-7613(01)00107-8","volume":"14","author":"DJ Izon","year":"2001","unstructured":"Izon DJ, Punt JA, Xu L, Karnell FG, Allman D, Myung PS et al. Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity 2001; 14: 253\u2013264.","journal-title":"Immunity"},{"key":"BF2404258_CR14","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/S0092-8674(00)81368-9","volume":"87","author":"E Robey","year":"1996","unstructured":"Robey E, Chang D, Itano A, Cado D, Alexander H, Lans D et al. An activated form of Notch influences the choice between CD4 and CD8T cell lineages. Cell 1996; 87: 483\u2013492.","journal-title":"Cell"},{"key":"BF2404258_CR15","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.molcel.2004.10.014","volume":"16","author":"CJ Fryer","year":"2004","unstructured":"Fryer CJ, White JB, Jones KA . Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell 2004; 16: 509\u2013520.","journal-title":"Mol Cell"},{"key":"BF2404258_CR16","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0092-8674(91)90111-B","volume":"66","author":"LW Ellisen","year":"1991","unstructured":"Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66: 649\u2013661.","journal-title":"Cell"},{"key":"BF2404258_CR17","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1182\/blood-2005-06-2553","volume":"107","author":"J O'Neil","year":"2006","unstructured":"O'Neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH et al. Activating Notch1 mutations in mouse models of T-ALL. Blood 2006; 107: 781\u2013785.","journal-title":"Blood"},{"key":"BF2404258_CR18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1056\/NEJM198407263110405","volume":"311","author":"AT Look","year":"1984","unstructured":"Look AT, Hayes FA, Nitschke R, McWilliams NB, Green AA . Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma. N Engl J Med 1984; 311: 231\u2013235.","journal-title":"N Engl J Med"},{"key":"BF2404258_CR19","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1242\/dev.127.11.2421","volume":"127","author":"MH Lin","year":"2000","unstructured":"Lin MH, Leimeister C, Gessler M, Kopan R . Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers. Development 2000; 127: 2421\u20132432.","journal-title":"Development"},{"key":"BF2404258_CR20","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0037-1963(00)90018-0","volume":"37","author":"AA Ferrando","year":"2000","unstructured":"Ferrando AA, Look AT . Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. Semin Hematol 2000; 37: 381\u2013395.","journal-title":"Semin Hematol"},{"key":"BF2404258_CR21","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1056\/NEJMra023001","volume":"350","author":"CH Pui","year":"2004","unstructured":"Pui CH, Relling MV, Downing JR . Acute lymphoblastic leukemia. N Engl J Med 2004; 350: 1535\u20131548.","journal-title":"N Engl J Med"},{"key":"BF2404258_CR22","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1056\/NEJM199411103311902","volume":"331","author":"AJ Barrett","year":"1994","unstructured":"Barrett AJ, Horowitz MM, Pollock BH, Zhang MJ, Bortin MM, Buchanan GR et al. Bone marrow transplants from HLA-identical siblings as compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission. N Engl J Med 1994; 331: 1253\u20131258.","journal-title":"N Engl J Med"},{"key":"BF2404258_CR23","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1182\/blood.V80.4.1090.1090","volume":"80","author":"JC Biggs","year":"1992","unstructured":"Biggs JC, Horowitz MM, Gale RP, Ash RC, Atkinson K, Helbig W et al. Bone marrow transplants may cure patients with acute leukemia never achieving remission with chemotherapy. Blood 1992; 80: 1090\u20131093.","journal-title":"Blood"},{"key":"BF2404258_CR24","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1182\/blood.V78.10.2780.2780","volume":"78","author":"R Dopfer","year":"1991","unstructured":"Dopfer R, Henze G, Bender-Gotze C, Ebell W, Ehninger G, Friedrich W et al. Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission after intensive primary and relapse therapy according to the BFM- and CoALL-protocols: results of the German Cooperative Study. Blood 1991; 78: 2780\u20132784.","journal-title":"Blood"},{"key":"BF2404258_CR25","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1200\/JCO.1991.9.9.1570","volume":"9","author":"SJ Forman","year":"1991","unstructured":"Forman SJ, Schmidt GM, Nademanee AP, Amylon MD, Chao NJ, Fahey JL et al. Allogeneic bone marrow transplantation as therapy for primary induction failure for patients with acute leukemia. J Clin Oncol 1991; 9: 1570\u20131574.","journal-title":"J Clin Oncol"},{"key":"BF2404258_CR26","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/sj.bmt.1701617","volume":"23","author":"H Schroeder","year":"1999","unstructured":"Schroeder H, Gustafsson G, Saarinen-Pihkala UM, Glomstein A, Jonmundsson G, Nysom K et al. Allogeneic bone marrow transplantation in second remission of childhood acute lymphoblastic leukemia: a population-based case control study from the Nordic countries. Bone Marrow Transplant 1999; 23: 555\u2013560.","journal-title":"Bone Marrow Transplant"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2404258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404258","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404258.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:29:18Z","timestamp":1648780158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2404258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,11]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7,1]]}},"alternative-id":["BF2404258"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2404258","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,11]]},"assertion":[{"value":"9 March 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}