{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:57:02Z","timestamp":1791493022676,"version":"4.3.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2006,11,1]]},"DOI":"10.1038\/sj.leu.2404385","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T12:20:25Z","timestamp":1158841225000},"page":"1937-1942","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Megakaryocytic dysfunction in myelodysplastic syndromes and idiopathic thrombocytopenic purpura is in part due to different forms of cell death"],"prefix":"10.1038","volume":"20","author":[{"given":"E J","family":"Houwerzijl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N R","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J L","family":"van der Want","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Vellenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J T M","family":"de Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,9,7]]},"reference":[{"key":"BF2404385_CR1","doi-asserted-by":"publisher","first-page":"3348","DOI":"10.1172\/JCI26891","volume":"115","author":"SR Patel","year":"2005","unstructured":"Patel SR, Hartwig JH, Italiano Jr JE . The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest 2005; 115: 3348\u20133354.","journal-title":"J Clin Invest"},{"key":"BF2404385_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1365-2141.1983.tb02022.x","volume":"53","author":"JM Radley","year":"1983","unstructured":"Radley JM, Haller CJ . Fate of senescent megakaryocytes in the bone marrow. Br J Haematol 1983; 53: 277\u2013287.","journal-title":"Br J Haematol"},{"key":"BF2404385_CR3","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1182\/blood.V90.6.2234","volume":"90","author":"G Zauli","year":"1997","unstructured":"Zauli G, Vitale M, Falcieri E, Gibellini D, Bassini A, Celeghini C et al. In vitro senescence and apoptotic cell death of human megakaryocytes. Blood 1997; 90: 2234\u20132243.","journal-title":"Blood"},{"key":"BF2404385_CR4","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1182\/blood-2002-03-0686","volume":"100","author":"S De Botton","year":"2002","unstructured":"De Botton S, Sabri S, Daugas E, Zermati Y, Guidotti JE, Hermine O et al. Platelet formation is the consequence of caspase activation within megakaryocytes. Blood 2002; 100: 1310\u20131317.","journal-title":"Blood"},{"key":"BF2404385_CR5","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.ceb.2004.09.011","volume":"16","author":"AL Edinger","year":"2004","unstructured":"Edinger AL, Thompson CB . Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 2004; 16: 663\u2013669.","journal-title":"Curr Opin Cell Biol"},{"key":"BF2404385_CR6","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/sj.cdd.4400526","volume":"6","author":"C Kitanaka","year":"1999","unstructured":"Kitanaka C, Kuchino Y . Caspase-independent programmed cell death with necrotic morphology. Cell Death Differ 1999; 6: 508\u2013515.","journal-title":"Cell Death Differ"},{"key":"BF2404385_CR7","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/35085008","volume":"2","author":"M Leist","year":"2001","unstructured":"Leist M, J\u00e4\u00e4ttel\u00e4 M . Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001; 2: 589\u2013598.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BF2404385_CR8","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1111\/j.1432-1033.2004.04084.x","volume":"271","author":"C Assun\u00e7\u00e3o Guimar\u00e3es","year":"2004","unstructured":"Assun\u00e7\u00e3o Guimar\u00e3es C, Linden R . Programmed cell deaths. Apoptosis and alternative deathstyles. Eur J Biochem 2004; 271: 1638\u20131650.","journal-title":"Eur J Biochem"},{"key":"BF2404385_CR9","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0079-6336(03)80002-5","volume":"38","author":"Y Otsuki","year":"2003","unstructured":"Otsuki Y, Li Z, Shibata MA . Apoptotic detection methods \u2013 from morphology to gene. Prog Histochem Cytochem 2003; 38: 275\u2013339.","journal-title":"Prog Histochem Cytochem"},{"key":"BF2404385_CR10","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/sj.cdd.4401724","volume":"12","author":"G Kroemer","year":"2005","unstructured":"Kroemer G, El-Deiry WS, Golstein P, Peter ME, Vaux D, Vandenabeele P et al. Nomenclature committee on cell death. Classification of cell death: recommendations of the nomenclature committee on cell death. Cell Death Differ 2005; 12: 1463\u20131467.","journal-title":"Cell Death Differ"},{"key":"BF2404385_CR11","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nrc1738","volume":"5","author":"G Kroemer","year":"2005","unstructured":"Kroemer G, J\u00e4\u00e4ttel\u00e4 M . Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005; 5: 886\u2013897.","journal-title":"Nat Rev Cancer"},{"key":"BF2404385_CR12","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1172\/JCI26390","volume":"115","author":"B Levine","year":"2005","unstructured":"Levine B, Yuan J . Autophagy in cell death: an innocent convict? J Clin Invest 2005; 115: 2679\u20132688.","journal-title":"J Clin Invest"},{"key":"BF2404385_CR13","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1172\/JCI26321","volume":"115","author":"DR Green","year":"2005","unstructured":"Green DR, Kroemer G . Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest 2005; 115: 2610\u20132617.","journal-title":"J Clin Invest"},{"key":"BF2404385_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1159\/000074488","volume":"111","author":"JE Parker","year":"2004","unstructured":"Parker JE, Mufti GJ . The myelodysplastic syndromes: a matter of life or death. Acta Haematol 2004; 111: 78\u201399.","journal-title":"Acta Haematol"},{"key":"BF2404385_CR15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1634\/stemcells.22-4-590","volume":"22","author":"JL Liesveld","year":"2004","unstructured":"Liesveld JL, Jordan CT, Phillips II GL . The hematopoietic stem cell in myelodysplasia. Stem Cells 2004; 22: 590\u2013599.","journal-title":"Stem Cells"},{"key":"BF2404385_CR16","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0145-2126(99)00094-6","volume":"23","author":"Y Yoshida","year":"1999","unstructured":"Yoshida Y, Mufti GJ . Apoptosis and its significance in MDS: controversies revisited. Leuk Res 1999; 23: 777\u2013785.","journal-title":"Leuk Res"},{"key":"BF2404385_CR17","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.arcmed.2003.09.001","volume":"34","author":"SD Mundle","year":"2003","unstructured":"Mundle SD . Lingering biologic dilemmas about the status of the progenitor cells in myelodysplasia. Arch Med Res 2003; 34: 515\u2013519.","journal-title":"Arch Med Res"},{"key":"BF2404385_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.4065\/81.1.104","volume":"81","author":"DP Steensma","year":"2006","unstructured":"Steensma DP, Bennett JM . The myelodysplastic syndromes: diagnosis and treatment. Mayo Clin Proc 2006; 81: 104\u2013130.","journal-title":"Mayo Clin Proc"},{"key":"BF2404385_CR19","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.1182\/blood-2004-06-2108","volume":"105","author":"EJ Houwerzijl","year":"2005","unstructured":"Houwerzijl EJ, Blom NR, van der Want JJ, Louwes H, Esselink MT, Smit JW et al. Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients. Blood 2005; 105: 3472\u20133479.","journal-title":"Blood"},{"key":"BF2404385_CR20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.7326\/0003-4819-103-1-58","volume":"103","author":"DB Cines","year":"1985","unstructured":"Cines DB, Cassileth PA, Kiss JE . Danazol therapy in myelodysplasia. Ann Intern Med 1985; 103: 58\u201360.","journal-title":"Ann Intern Med"},{"key":"BF2404385_CR21","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/sj.leu.2402129","volume":"15","author":"E Bourgeois","year":"2001","unstructured":"Bourgeois E, Caulier MT, Rose C, Dupriez B, Bauters F, Fenaux P . Role of splenectomy in the treatment of myelodysplastic syndromes with peripheral thrombocytopenia: a report on six cases. Leukemia 2001; 15: 950\u2013953.","journal-title":"Leukemia"},{"key":"BF2404385_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3109\/10428190009060315","volume":"38","author":"WK Hofmann","year":"2000","unstructured":"Hofmann WK, Kalina U, Koschmieder S, Seipelt G, Hoelzer D, Ottmann OG . Defective megakaryocytic development in myelodysplastic syndromes. Leuk Lymphoma 2000; 38: 13\u201319.","journal-title":"Leuk Lymphoma"},{"key":"BF2404385_CR23","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<332::AID-GCC4>3.0.CO;2-4","volume":"25","author":"K van Lom","year":"1999","unstructured":"van Lom K, Houtsmuller AB, van Putten WL, Slater RM, L\u00f6wenberg B . Cytogenetic clonality analysis of megakaryocytes in myelodysplastic syndrome by dual-color fluorescence in situ hybridization and confocal laser scanning microscopy. Genes Chromosomes Cancer 1999; 25: 332\u2013338.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2404385_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1046\/j.1365-2141.1997.3543166.x","volume":"99","author":"JA Adams","year":"1997","unstructured":"Adams JA, Liu Yin JA, Brereton ML, Briggs M, Burgess R, Hyde K . The in vitro effect of pegylated recombinant human megakaryocyte growth and development factor (PEG rHuMGDF) on megakaryopoiesis in normal subjects and patients with myelodysplasia and acute myeloid leukaemia. Br J Haematol 1997; 99: 139\u2013146.","journal-title":"Br J Haematol"},{"key":"BF2404385_CR25","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/S0301-472X(00)00527-0","volume":"28","author":"U Kalina","year":"2000","unstructured":"Kalina U, Hofmann WK, Koschmieder S, Wagner S, Kauschat D, Hoelzer D et al. Alteration of c-mpl-mediated signal transduction in CD34(+) cells from patients with myelodysplastic syndromes. Exp Hematol 2000; 28: 1158\u20131163.","journal-title":"Exp Hematol"},{"key":"BF2404385_CR26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/sj.leu.2400901","volume":"12","author":"H Zwierzina","year":"1998","unstructured":"Zwierzina H, Rollinger-Holzinger I, Nuessler V, Herold M, Meng YG . Endogenous serum thrombopoietin concentrations in patients with myelodysplastic syndromes. Leukemia 1998; 12: 59\u201364.","journal-title":"Leukemia"},{"key":"BF2404385_CR27","first-page":"87","volume":"6","author":"SJ Hatfill","year":"1992","unstructured":"Hatfill SJ, Fester ED, Steytler JG . Apoptotic megakaryocyte dysplasia in the myelodysplastic syndromes. Hematol Pathol 1992; 6: 87\u201393.","journal-title":"Hematol Pathol"},{"key":"BF2404385_CR28","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/sj.leu.2400640","volume":"11","author":"AD Bogdanovic","year":"1997","unstructured":"Bogdanovic AD, Trpinac DP, Jankovic GM, Bumbasirevic VZ, Obradovic M, Colovic MD . Incidence and role of apoptosis in myelodysplastic syndrome: morphological and ultrastructural assessment. Leukemia 1997; 11: 656\u2013659.","journal-title":"Leukemia"},{"key":"BF2404385_CR29","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1182\/blood.V96.4.1388","volume":"96","author":"V Shetty","year":"2000","unstructured":"Shetty V, Hussaini S, Broady-Robinson L, Allampallam K, Mundle S, Borok R et al. Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: apoptotic cells recovered from high-density fraction of bone marrow aspirates. Blood 2000; 96: 1388\u20131392.","journal-title":"Blood"},{"key":"BF2404385_CR30","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1046\/j.0007-1048.2002.03366.x","volume":"116","author":"V Shetty","year":"2002","unstructured":"Shetty V, Hussaini S, Alvi S, Joshi L, Shaher A, Dangerfield B et al. Excessive apoptosis, increased phagocytosis, nuclear inclusion bodies and cylindrical confronting cisternae in bone marrow biopsies of myelodysplastic syndrome patients. Br J Haematol 2002; 116: 817\u2013825.","journal-title":"Br J Haematol"},{"key":"BF2404385_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000040984","volume":"102","author":"H Kurotaki","year":"2000","unstructured":"Kurotaki H, Tsushima Y, Nagai K, Yagihashi S . Apoptosis, bcl-2 expression and p53 accumulation in myelodysplastic syndrome, myelodysplastic-syndrome-derived acute myelogenous leukemia and de novo acute myelogenous leukemia. Acta Haematol 2000; 102: 115\u2013123.","journal-title":"Acta Haematol"},{"key":"BF2404385_CR32","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/sj.leu.2400654","volume":"11","author":"D Bouscary","year":"1997","unstructured":"Bouscary D, De Vos J, Guesnu M, Jondeau K, Viguier F, Melle J et al. Fas\/Apo-1 (CD95) expression and apoptosis in patients with myelodysplastic syndromes. Leukemia 1997; 11: 839\u2013845.","journal-title":"Leukemia"},{"key":"BF2404385_CR33","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.leukres.2004.01.001","volume":"28","author":"SJ Brada","year":"2004","unstructured":"Brada SJ, van de Loosdrecht AA, Koudstaal J, de Wolf JT, Vellenga E . Limited numbers of apoptotic cells in fresh paraffin embedded bone marrow samples of patients with myelodysplastic syndrome. Leuk Res 2004; 28: 921\u2013925.","journal-title":"Leuk Res"},{"key":"BF2404385_CR34","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/10428190400013126","volume":"46","author":"X Li","year":"2005","unstructured":"Li X, Pu Q . Megakaryocytopoiesis and apoptosis in patients with myelodysplastic syndromes. Leuk Lymphoma 2005; 46: 387\u2013391.","journal-title":"Leuk Lymphoma"},{"key":"BF2404385_CR35","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/sj.leu.2400980","volume":"12","author":"M Kitagawa","year":"1998","unstructured":"Kitagawa M, Yamaguchi S, Takahashi M, Tanizawa T, Hirokawa K, Kamiyama R . Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia. Leukemia 1998; 12: 486\u2013492.","journal-title":"Leukemia"},{"key":"BF2404385_CR36","doi-asserted-by":"publisher","first-page":"7925","DOI":"10.1074\/jbc.M307807200","volume":"279","author":"T Vanden Berghe","year":"2004","unstructured":"Vanden Berghe T, van Loo G, Saelens X, Van Gurp M, Brouckaert G, Kalai M et al. Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD. J Biol Chem 2004; 279: 7925\u20137933.","journal-title":"J Biol Chem"},{"key":"BF2404385_CR37","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1182\/blood.V101.3.1172","volume":"101","author":"GM Fuhler","year":"2003","unstructured":"Fuhler GM, Drayer AL, Vellenga E . Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia. Blood 2003; 101: 1172\u20131180.","journal-title":"Blood"},{"key":"BF2404385_CR38","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1365-2141.1970.tb01605.x","volume":"19","author":"LA Harker","year":"1970","unstructured":"Harker LA . Thrombokinetics in idiopathic thrombocytopenic purpura. Br J Haematol 1970; 19: 95\u2013104.","journal-title":"Br J Haematol"},{"key":"BF2404385_CR39","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1182\/blood.V3.10.1090.1090","volume":"3","author":"LW Diggs","year":"1948","unstructured":"Diggs LW, Hewlett JB . A study of the bone marrow from thirty-six patients with idiopathic hemorrhagic (thrombopenic) purpura. Blood 1948; 3: 1090\u20131104.","journal-title":"Blood"},{"key":"BF2404385_CR40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1172\/JCI113060","volume":"80","author":"PJ Ballem","year":"1987","unstructured":"Ballem PJ, Segal GM, Stratton JR, Gernsheimer T, Adamson JW, Slichter SJ . Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest 1987; 80: 33\u201340.","journal-title":"J Clin Invest"},{"key":"BF2404385_CR41","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/S0002-9343(99)00054-6","volume":"106","author":"H Louwes","year":"1999","unstructured":"Louwes H, Zeinali Lathori OA, Vellenga E, de Wolf JT . Platelet kinetic studies in patients with idiopathic thrombocytopenic purpura. Am J Med 1999; 106: 430\u2013434.","journal-title":"Am J Med"},{"key":"BF2404385_CR42","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1182\/blood.V8.8.703.703","volume":"8","author":"AV Pisciotta","year":"1953","unstructured":"Pisciotta AV, Stefanini M, Dameshek W . Studies on platelets. X. Morphologic characteristics of megakaryocytes by phase contrast microscopy in normals and in patients with idiopathic thrombocytopenic purpura. Blood 1953; 8: 703\u2013723.","journal-title":"Blood"},{"key":"BF2404385_CR43","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1182\/blood-2003-01-0275","volume":"103","author":"EJ Houwerzijl","year":"2004","unstructured":"Houwerzijl EJ, Blom NR, van der Want JJ, Esselink MT, Koornstra JJ, Smit JW et al. Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood 2004; 103: 500\u2013506.","journal-title":"Blood"},{"key":"BF2404385_CR44","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1182\/blood-2004-01-0193","volume":"104","author":"L Centurione","year":"2004","unstructured":"Centurione L, Di Baldassarre A, Zingariello M, Bosco D, Gatta V, Rana RA et al. Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice. Blood 2004; 104: 3573\u20133580.","journal-title":"Blood"},{"key":"BF2404385_CR45","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000203671","volume":"97","author":"J Thiele","year":"1997","unstructured":"Thiele J, Lorenzen J, Manich B, Kvasnicka HM, Zirbes TK, Fischer R . Apoptosis (programmed cell death) in idiopathic (primary) osteo-\/myelofibrosis: naked nuclei in megakaryopoiesis reveal features of para-apoptosis. Acta Haematol 1997; 97: 137\u2013143.","journal-title":"Acta Haematol"},{"key":"BF2404385_CR46","first-page":"906","volume":"45","author":"CG Craddock Jr","year":"1955","unstructured":"Craddock Jr CG, Adams WS, Perry S, Lawrence JS . The dynamics of platelet production as studied by a depletion technique in normal and irradiated dogs. J Lab Clin Med 1955; 45: 906\u2013919.","journal-title":"J Lab Clin Med"},{"key":"BF2404385_CR47","first-page":"1295","volume":"134","author":"D Zucker-Franklin","year":"1989","unstructured":"Zucker-Franklin D, Termin CS, Cooper MC . Structural changes in the megakaryocytes of patients infected with the human immune deficiency virus (HIV-1). Am J Pathol 1989; 134: 1295\u20131303.","journal-title":"Am J Pathol"},{"key":"BF2404385_CR48","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1034\/j.1600-0609.2003.00069.x","volume":"70","author":"C Ucar","year":"2003","unstructured":"Ucar C, Oren H, Irken G, Ates H, Atabay B, Turker M et al. Investigation of megakaryocyte apoptosis in children with acute and chronic idiopathic thrombocytopenic purpura. Eur J Haematol 2003; 70: 347\u2013352.","journal-title":"Eur J Haematol"},{"key":"BF2404385_CR49","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1182\/blood-2003-08-2672","volume":"103","author":"R McMillan","year":"2004","unstructured":"McMillan R, Wang L, Tomer A, Nichol J, Pistillo J . Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 2004; 103: 1364\u20131369.","journal-title":"Blood"},{"key":"BF2404385_CR50","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1080\/1042819031000083037","volume":"44","author":"K Ohshima","year":"2003","unstructured":"Ohshima K, Karube K, Shimazaki K, Kamma H, Suzumiya J, Hamasaki M et al. Imbalance between apoptosis and telomerase activity in myelodysplastic syndromes: possible role in ineffective hemopoiesis. Leuk Lymphoma 2003; 44: 1339\u20131346.","journal-title":"Leuk Lymphoma"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2404385.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404385","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404385.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:22:54Z","timestamp":1648779774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2404385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,7]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11,1]]}},"alternative-id":["BF2404385"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2404385","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,7]]},"assertion":[{"value":"17 February 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}