{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:36:35Z","timestamp":1790670995372,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:00:00Z","timestamp":1174521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:00:00Z","timestamp":1174521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1038\/sj.leu.2404662","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T08:03:17Z","timestamp":1174550597000},"page":"1183-1188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma"],"prefix":"10.1038","volume":"21","author":[{"given":"G","family":"Metzgeroth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Walz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Score","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Schnittger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Popp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Haferlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Erben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Beneke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Del Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W E","family":"Aulitzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Wittkowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"M\u00fcller-Hermelink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Diecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"D\u00f6hner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Schuld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hehlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hochhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N C P","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,3,22]]},"reference":[{"key":"BF2404662_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1046\/j.1365-2141.2003.04458.x","volume":"122","author":"BJ Bain","year":"2003","unstructured":"Bain BJ . Cytogenetic and molecular genetic aspects of eosinophilic leukaemias. Br J Haematol 2003; 122: 173\u2013179.","journal-title":"Br J Haematol"},{"key":"BF2404662_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","volume":"54","author":"MJ Chusid","year":"1975","unstructured":"Chusid MJ, Dale DC, West BC, Wolff SM . The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 1975; 54: 1\u201327.","journal-title":"Medicine (Baltimore)"},{"key":"BF2404662_CR3","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V83.10.2759.2759","volume":"83","author":"PF Weller","year":"1994","unstructured":"Weller PF, Bubley GJ . The idiopathic hypereosinophilic syndrome. Blood 1994; 83: 2759\u20132779.","journal-title":"Blood"},{"key":"BF2404662_CR4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000039744","volume":"104","author":"J Kuroda","year":"2000","unstructured":"Kuroda J, Kimura S, Akaogi T, Hayashi H, Yamano T, Sasai Y et al. Myelodysplastic syndrome with clonal eosinophilia accompanied by eosinophilic pulmonary interstitial infiltration. Acta Haematol 2000; 104: 119\u2013123.","journal-title":"Acta Haematol"},{"key":"BF2404662_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1159\/000046639","volume":"107","author":"D Macdonald","year":"2002","unstructured":"Macdonald D, Reiter A, Cross NC . The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. Acta Haematol 2002; 107: 101\u2013107.","journal-title":"Acta Haematol"},{"key":"BF2404662_CR6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000046641","volume":"107","author":"EJ Steer","year":"2002","unstructured":"Steer EJ, Cross NC . Myeloproliferative disorders with translocations of chromosome 5q31\u201335: role of the platelet-derived growth factor receptor beta. Acta Haematol 2002; 107: 113\u2013122.","journal-title":"Acta Haematol"},{"key":"BF2404662_CR7","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1056\/NEJMoa025217","volume":"348","author":"J Cools","year":"2003","unstructured":"Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003; 348: 1201\u20131214.","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"BF2404662_CR8","doi-asserted-by":"publisher","first-page":"S133","DOI":"10.1038\/sj.thj.6200439","volume":"5","author":"G Gilliland","year":"2004","unstructured":"Gilliland G, Cools J, Stover EH, Wlodarska I, Marynen P . FIP1L1-PDGFRalpha in hypereosinophilic syndrome and mastocytosis. Hematol J 2004; 5 (Suppl 3): S133\u2013S137.","journal-title":"Hematol J"},{"key":"BF2404662_CR9","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.1182\/blood-2003-05-1627","volume":"102","author":"A Pardanani","year":"2003","unstructured":"Pardanani A, Ketterling RP, Brockman SR, Flynn HC, Paternoster SF, Shearer BM et al. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood 2003; 102: 3093\u20133096.","journal-title":"Blood"},{"key":"BF2404662_CR10","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1182\/blood-2002-10-3103","volume":"101","author":"A Pardanani","year":"2003","unstructured":"Pardanani A, Reeder T, Porrata LF, Li CY, Tazelaar HD, Baxter EJ et al. Imatinib therapy for hypereosinophilic syndrome and other eosinophilic disorders. Blood 2003; 101: 3391\u20133397.","journal-title":"Blood"},{"key":"BF2404662_CR11","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1159\/000085562","volume":"114","author":"A Tefferi","year":"2005","unstructured":"Tefferi A . Modern diagnosis and treatment of primary eosinophilia. Acta Haematol 2005; 114: 52\u201360.","journal-title":"Acta Haematol"},{"key":"BF2404662_CR12","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.leukres.2005.11.011","volume":"30","author":"A Pardanani","year":"2006","unstructured":"Pardanani A, Ketterling RP, Li CY, Patnaik MM, Wolanskyj AP, Elliott MA et al. FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature. Leuk Res 2006; 30: 965\u2013970.","journal-title":"Leuk Res"},{"key":"BF2404662_CR13","first-page":"177","volume":"125","author":"J Cools","year":"2006","unstructured":"Cools J, Stover EH, Gilliland DG . Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia. Methods Mol Med 2006; 125: 177\u2013187.","journal-title":"Methods Mol Med"},{"key":"BF2404662_CR14","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1365-2141.2005.05863.x","volume":"132","author":"J Robyn","year":"2006","unstructured":"Robyn J, Lemery S, McCoy JP, Kubofcik J, Kim YJ, Pack S et al. Multilineage involvement of the fusion gene in patients with FIP1L1\/PDGFRA-positive hypereosinophilic syndrome. Br J Haematol 2006; 132: 286\u2013292.","journal-title":"Br J Haematol"},{"key":"BF2404662_CR15","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/sj.leu.2401695","volume":"14","author":"M Nakao","year":"2000","unstructured":"Nakao M, Janssen JW, Erz D, Seriu T, Bartram CR . Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia: a marker for the monitoring of minimal residual disease. Leukemia 2000; 14: 522\u2013524.","journal-title":"Leukemia"},{"key":"BF2404662_CR16","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/sj.leu.2401773","volume":"14","author":"S Schnittger","year":"2000","unstructured":"Schnittger S, Kinkelin U, Schoch C, Heinecke A, Haase D, Haferlach T et al. Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML. Leukemia 2000; 14: 796\u2013804.","journal-title":"Leukemia"},{"key":"BF2404662_CR17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood.V100.1.59","volume":"100","author":"S Schnittger","year":"2002","unstructured":"Schnittger S, Schoch C, Dugas M, Kern W, Staib P, Wuchter C et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 2002; 100: 59\u201366.","journal-title":"Blood"},{"key":"BF2404662_CR18","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1182\/blood-2005-06-2248","volume":"106","author":"S Schnittger","year":"2005","unstructured":"Schnittger S, Schoch C, Kern W, Mecucci C, Tschulik C, Martelli MF et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood 2005; 106: 3733\u20133739.","journal-title":"Blood"},{"key":"BF2404662_CR19","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/sj.leu.2401645","volume":"14","author":"M Nakao","year":"2000","unstructured":"Nakao M, Janssen JW, Seriu T, Bartram CR . Rapid and reliable detection of N-ras mutations in acute lymphoblastic leukemia by melting curve analysis using LightCycler technology. Leukemia 2000; 14: 312\u2013315.","journal-title":"Leukemia"},{"key":"BF2404662_CR20","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1093\/nar\/23.14.2762","volume":"23","author":"H Miyoshi","year":"1995","unstructured":"Miyoshi H, Ohira M, Shimizu K, Mitani K, Hirai H, Imai T et al. Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. Nucleic Acids Res 1995; 23: 2762\u20132769.","journal-title":"Nucleic Acids Res"},{"key":"BF2404662_CR21","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/sj.leu.2404154","volume":"20","author":"J Score","year":"2006","unstructured":"Score J, Curtis C, Waghorn K, Stalder M, Jotterand M, Grand FH et al. Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia. Leukemia 2006; 20: 827\u2013832.","journal-title":"Leukemia"},{"key":"BF2404662_CR22","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/S1470-2045(05)70213-8","volume":"6","author":"PP Piccaluga","year":"2005","unstructured":"Piccaluga PP, Agostinelli C, Zinzani PL, Baccarani M, Dalla FR, Pileri SA . Expression of platelet-derived growth factor receptor alpha in peripheral T-cell lymphoma not otherwise specified. Lancet Oncol 2005; 6: 440.","journal-title":"Lancet Oncol"},{"key":"BF2404662_CR23","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/sj.leu.2402556","volume":"16","author":"NC Cross","year":"2002","unstructured":"Cross NC, Reiter A . Tyrosine kinase fusion genes in chronic myeloproliferative diseases. Leukemia 2002; 16: 1207\u20131212.","journal-title":"Leukemia"},{"key":"BF2404662_CR24","doi-asserted-by":"publisher","first-page":"615","DOI":"10.2174\/156652405774641115","volume":"5","author":"FJ Giles","year":"2005","unstructured":"Giles FJ, Cortes JE, Kantarjian HM . Targeting the kinase activity of the BCR-ABL fusion protein in patients with chronic myeloid leukemia. Curr Mol Med 2005; 5: 615\u2013623.","journal-title":"Curr Mol Med"},{"key":"BF2404662_CR25","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/sj.leu.2403600","volume":"19","author":"N von Bubnoff","year":"2005","unstructured":"von Bubnoff N, Sandherr M, Schlimok G, Andreesen R, Peschel C, Duyster J . Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFR alpha-positive chronic myeloproliferative disease with prominent eosinophilia. Leukemia 2005; 19: 286\u2013287.","journal-title":"Leukemia"},{"key":"BF2404662_CR26","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/sj.leu.2403313","volume":"18","author":"P Vandenberghe","year":"2004","unstructured":"Vandenberghe P, Wlodarska I, Michaux L, Zachee P, Boogaerts M, Vanstraelen D et al. Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias. Leukemia 2004; 18: 734\u2013742.","journal-title":"Leukemia"},{"key":"BF2404662_CR27","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1182\/blood-2006-06-001149","volume":"109","author":"K Mrozek","year":"2007","unstructured":"Mrozek K, Marcucci G, Paschka P, Whitman SP, Bloomfield CD . Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood 2007; 109: 431\u2013448.","journal-title":"Blood"},{"key":"BF2404662_CR28","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/sj.leu.2404186","volume":"20","author":"M Suzuki","year":"2006","unstructured":"Suzuki M, Abe A, Kiyoi H, Murata M, Ito Y, Shimada K et al. Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation. Leukemia 2006; 20: 1168\u20131169.","journal-title":"Leukemia"},{"key":"BF2404662_CR29","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1158\/0008-5472.CAN-04-4263","volume":"65","author":"A Reiter","year":"2005","unstructured":"Reiter A, Walz C, Watmore A, Schoch C, Blau I, Schlegelberger B et al. The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer Res 2005; 65: 2662\u20132667.","journal-title":"Cancer Res"},{"key":"BF2404662_CR30","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/sj.leu.2403722","volume":"19","author":"C Roche-Lestienne","year":"2005","unstructured":"Roche-Lestienne C, Lepers S, Soenen-Cornu V, Kahn JE, Lai JL, Hachulla E et al. Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics. Leukemia 2005; 19: 792\u2013798.","journal-title":"Leukemia"},{"key":"BF2404662_CR31","first-page":"1628","volume":"9","author":"D Macdonald","year":"1995","unstructured":"Macdonald D, Aguiar RC, Mason PJ, Goldman JM, Cross NC . A new myeloproliferative disorder associated with chromosomal translocations involving 8p11: a review. Leukemia 1995; 9: 1628\u20131630.","journal-title":"Leukemia"},{"key":"BF2404662_CR32","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1535-6108(03)00108-9","volume":"3","author":"J Cools","year":"2003","unstructured":"Cools J, Stover EH, Boulton CL, Gotlib J, Legare RD, Amaral SM et al. PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRalpha-induced myeloproliferative disease. Cancer Cell 2003; 3: 459\u2013469.","journal-title":"Cancer Cell"},{"key":"BF2404662_CR33","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1182\/blood-2006-02-004457","volume":"108","author":"E Lierman","year":"2006","unstructured":"Lierman E, Folens C, Stover EH, Mentens N, Van Miegroet H, Scheers W et al. Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib-resistant FIP1L1-PDGFRalpha T674I mutant. Blood 2006; 108: 1374\u20131376.","journal-title":"Blood"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2404662.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404662","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404662.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:34:33Z","timestamp":1648780473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2404662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,22]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["BF2404662"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2404662","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,22]]},"assertion":[{"value":"5 December 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}