{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:29:45Z","timestamp":1791174585638,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T00:00:00Z","timestamp":1192060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T00:00:00Z","timestamp":1192060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Leukemia"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1038\/sj.leu.2404957","type":"journal-article","created":{"date-parts":[[2007,10,11]],"date-time":"2007-10-11T09:49:55Z","timestamp":1192096195000},"page":"124-131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences"],"prefix":"10.1038","volume":"22","author":[{"given":"M","family":"van Grotel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P P","family":"Meijerink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E R","family":"van Wering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A W","family":"Langerak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H B","family":"Beverloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G C A M","family":"Buijs-Gladdines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N B","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Passier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M","family":"van Lieshout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W A","family":"Kamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J P","family":"Veerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"van Noesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,10,11]]},"reference":[{"key":"BF2404957_CR1","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1056\/NEJMra023001","volume":"350","author":"CH Pui","year":"2004","unstructured":"Pui CH, Relling MV, Downing JR . Acute lymphoblastic leukemia. N Engl J Med 2004; 350: 1535\u20131548.","journal-title":"N Engl J Med"},{"key":"BF2404957_CR2","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1182\/blood.V73.5.1247.1247","volume":"73","author":"E Thiel","year":"1989","unstructured":"Thiel E, Kranz BR, Raghavachar A, Bartram CR, Loffler H, Messerer D et al. Prethymic phenotype and genotype of pre-T (CD7+\/ER\u2212)-cell leukemia and its clinical significance within adult acute lymphoblastic leukemia. Blood 1989; 73: 1247\u20131258.","journal-title":"Blood"},{"key":"BF2404957_CR3","first-page":"1116","volume":"90","author":"K De Keersmaecker","year":"2005","unstructured":"De Keersmaecker K, Marynen P, Cools J . Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia. Haematologica 2005; 90: 1116\u20131127.","journal-title":"Haematologica"},{"key":"BF2404957_CR4","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1182\/blood.V81.9.2237.2237","volume":"81","author":"SC Raimondi","year":"1993","unstructured":"Raimondi SC . Current status of cytogenetic research in childhood acute lymphoblastic leukemia. Blood 1993; 81: 2237\u20132251.","journal-title":"Blood"},{"key":"BF2404957_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00043426-199801000-00001","volume":"20","author":"JE Rubnitz","year":"1998","unstructured":"Rubnitz JE, Look AT . Molecular genetics of childhood leukemias. J Pediatr Hematol Oncol 1998; 20: 1\u201311.","journal-title":"J Pediatr Hematol Oncol"},{"key":"BF2404957_CR6","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/sj.leu.2404243","volume":"20","author":"B Cauwelier","year":"2006","unstructured":"Cauwelier B, Dastugue N, Cools J, Poppe B, Herens C, De Paepe A et al. Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes. Leukemia 2006; 20: 1238\u20131244.","journal-title":"Leukemia"},{"key":"BF2404957_CR7","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1182\/blood-2006-12-064683","volume":"110","author":"E Clappier","year":"2007","unstructured":"Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela JM, Dik WA et al. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood 2007; 110: 1251\u20131261.","journal-title":"Blood"},{"key":"BF2404957_CR8","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1182\/blood-2002-09-2913","volume":"102","author":"V Asnafi","year":"2003","unstructured":"Asnafi V, Radford-Weiss I, Dastugue N, Bayle C, Leboeuf D, Charrin C et al. CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage. Blood 2003; 102: 1000\u20131006.","journal-title":"Blood"},{"key":"BF2404957_CR9","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/ng1425","volume":"36","author":"C Graux","year":"2004","unstructured":"Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R et al. Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet 2004; 36: 1084\u20131089.","journal-title":"Nat Genet"},{"key":"BF2404957_CR10","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/ng2025","volume":"39","author":"I Lahortiga","year":"2007","unstructured":"Lahortiga I, De Keersmaecker K, Van Vlierberghe P, Graux C, Cauwelier B, Lambert F et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nat Genet 2007; 39: 593\u2013595.","journal-title":"Nat Genet"},{"key":"BF2404957_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","volume":"306","author":"AP Weng","year":"2004","unstructured":"Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269\u2013271.","journal-title":"Science"},{"key":"BF2404957_CR12","first-page":"1212","volume":"91","author":"M van Grotel","year":"2006","unstructured":"van Grotel M, Meijerink JP, Beverloo HB, Langerak AW, Buys-Gladdines JG, Schneider P et al. The outcome of molecular-cytogenetic subgroups in pediatric T-cell acute lymphoblastic leukemia: a retrospective study of patients treated according to DCOG or COALL protocols. Haematologica 2006; 91: 1212\u20131221.","journal-title":"Haematologica"},{"key":"BF2404957_CR13","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1182\/blood-2001-11-0093","volume":"100","author":"P Ballerini","year":"2002","unstructured":"Ballerini P, Blaise A, Busson-Le Coniat M, Su XY, Zucman-Rossi J, Adam M et al. HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis. Blood 2002; 100: 991\u2013997.","journal-title":"Blood"},{"key":"BF2404957_CR14","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1182\/blood-2003-05-1495","volume":"103","author":"H Cave","year":"2004","unstructured":"Cave H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A et al. Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951. Blood 2004; 103: 442\u2013450.","journal-title":"Blood"},{"key":"BF2404957_CR15","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/S0037-1963(03)00195-1","volume":"40","author":"AA Ferrando","year":"2003","unstructured":"Ferrando AA, Look AT . Gene expression profiling in T-cell acute lymphoblastic leukemia. Semin Hematol 2003; 40: 274\u2013280.","journal-title":"Semin Hematol"},{"key":"BF2404957_CR16","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/sj.leu.2403834","volume":"19","author":"NG Gottardo","year":"2005","unstructured":"Gottardo NG, Jacoby PA, Sather HN, Reaman GH, Baker DL, Kees UR . Significance of HOX11L2\/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on children's cancer group protocols. Leukemia 2005; 19: 1705\u20131708.","journal-title":"Leukemia"},{"key":"BF2404957_CR17","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1038\/sj.leu.2402709","volume":"16","author":"L Mauvieux","year":"2002","unstructured":"Mauvieux L, Leymarie V, Helias C, Perrusson N, Falkenrodt A, Lioure B et al. High incidence of Hox11L2 expression in children with T-ALL. Leukemia 2002; 16: 2417\u20132422.","journal-title":"Leukemia"},{"key":"BF2404957_CR18","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0140-6736(04)15542-6","volume":"363","author":"AA Ferrando","year":"2004","unstructured":"Ferrando AA, Neuberg DS, Dodge RK, Paietta E, Larson RA, Wiernik PH et al. Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. Lancet 2004; 363: 535\u2013536.","journal-title":"Lancet"},{"key":"BF2404957_CR19","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/sj.leu.2402892","volume":"17","author":"UR Kees","year":"2003","unstructured":"Kees UR, Heerema NA, Kumar R, Watt PM, Baker DL, La MK et al. Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG). Leukemia 2003; 17: 887\u2013893.","journal-title":"Leukemia"},{"key":"BF2404957_CR20","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1182\/blood.V96.7.2543","volume":"96","author":"NR Schneider","year":"2000","unstructured":"Schneider NR, Carroll AJ, Shuster JJ, Pullen DJ, Link MP, Borowitz MJ et al. New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases. Blood 2000; 96: 2543\u20132549.","journal-title":"Blood"},{"key":"BF2404957_CR21","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1182\/blood-2005-12-4956","volume":"108","author":"S Breit","year":"2006","unstructured":"Breit S, Stanulla M, Flohr T, Schrappe M, Ludwig WD, Tolle G et al. Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood 2006; 108: 1151\u20131157.","journal-title":"Blood"},{"key":"BF2404957_CR22","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1126\/science.3535067","volume":"234","author":"MF Greaves","year":"1986","unstructured":"Greaves MF . Differentiation-linked leukemogenesis in lymphocytes. Science 1986; 234: 697\u2013704.","journal-title":"Science"},{"key":"BF2404957_CR23","doi-asserted-by":"publisher","first-page":"4173","DOI":"10.1182\/blood-2003-11-3944","volume":"104","author":"V Asnafi","year":"2004","unstructured":"Asnafi V, Beldjord K, Libura M, Villarese P, Millien C, Ballerini P et al. Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy. Blood 2004; 104: 4173\u20134180.","journal-title":"Blood"},{"key":"BF2404957_CR24","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1084\/jem.177.4.965","volume":"177","author":"TM Breit","year":"1993","unstructured":"Breit TM, Mol EJ, Wolvers-Tettero IL, Ludwig WD, van Wering ER, van Dongen JJ . Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha\/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes. J Exp Med 1993; 177: 965\u2013977.","journal-title":"J Exp Med"},{"key":"BF2404957_CR25","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1182\/blood.V80.6.1511.1511","volume":"80","author":"EA Macintyre","year":"1992","unstructured":"Macintyre EA, Smit L, Ritz J, Kirsch IR, Strominger JL . Disruption of the SCL locus in T-lymphoid malignancies correlates with commitment to the T-cell receptor alpha beta lineage. Blood 1992; 80: 1511\u20131520.","journal-title":"Blood"},{"key":"BF2404957_CR26","first-page":"1783","volume":"9","author":"MC Bene","year":"1995","unstructured":"Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia 1995; 9: 1783\u20131786.","journal-title":"Leukemia"},{"key":"BF2404957_CR27","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1182\/blood.V72.6.1891.1891","volume":"72","author":"WM Crist","year":"1988","unstructured":"Crist WM, Shuster JJ, Falletta J, Pullen DJ, Berard CW, Vietti TJ et al. Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a pediatric oncology group study. Blood 1988; 72: 1891\u20131897.","journal-title":"Blood"},{"key":"BF2404957_CR28","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/978-3-642-84895-7_24","volume":"131","author":"WD Ludwig","year":"1993","unstructured":"Ludwig WD, Harbott J, Bartram CR, Komischke B, Sperling C, Teichmann JV et al. Incidence and prognostic significance of immunophenotypic subgroups in childhood acute lymphoblastic leukemia: experience of the BFM study 86. Recent Results Cancer Res 1993; 131: 269\u2013282.","journal-title":"Recent Results Cancer Res"},{"key":"BF2404957_CR29","first-page":"161","volume":"7","author":"R Garand","year":"1993","unstructured":"Garand R, Voisin S, Papin S, Praloran V, Lenormand B, Favre M et al. Characteristics of pro-T ALL subgroups: comparison with late T-ALL. The Groupe d'Etude Immunologique des Leucemies. Leukemia 1993; 7: 161\u2013167.","journal-title":"Leukemia"},{"key":"BF2404957_CR30","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1182\/blood-2005-04-1754","volume":"107","author":"A Vitale","year":"2006","unstructured":"Vitale A, Guarini A, Ariola C, Mancini M, Mecucci C, Cuneo A et al. Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol. Blood 2006; 107: 473\u2013479.","journal-title":"Blood"},{"key":"BF2404957_CR31","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1182\/blood-2004-09-3666","volume":"105","author":"V Asnafi","year":"2005","unstructured":"Asnafi V, Buzyn A, Thomas X, Huguet F, Vey N, Boiron JM et al. Impact of TCR status and genotype on outcome in adult T-cell acute lymphoblastic leukemia: a LALA-94 study. Blood 2005; 105: 3072\u20133078.","journal-title":"Blood"},{"key":"BF2404957_CR32","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/sj.leu.2401382","volume":"13","author":"T Niehues","year":"1999","unstructured":"Niehues T, Kapaun P, Harms DO, Burdach S, Kramm C, Korholz D et al. A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies. Leukemia 1999; 13: 614\u2013617.","journal-title":"Leukemia"},{"key":"BF2404957_CR33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1182\/blood.V82.2.343.343","volume":"82","author":"CH Pui","year":"1993","unstructured":"Pui CH, Behm FG, Crist WM . Clinical and biologic relevance of immunologic marker studies in childhood acute lymphoblastic leukemia. Blood 1993; 82: 343\u2013362.","journal-title":"Blood"},{"key":"BF2404957_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1535-6108(02)00018-1","volume":"1","author":"AA Ferrando","year":"2002","unstructured":"Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002; 1: 75\u201387.","journal-title":"Cancer Cell"},{"key":"BF2404957_CR35","first-page":"1226","volume":"94","author":"WA Kamps","year":"1999","unstructured":"Kamps WA, Bokkerink JP, Hahlen K, Hermans J, Riehm H, Gadner H et al. Intensive treatment of children with acute lymphoblastic leukemia according to ALL-BFM-86 without cranial radiotherapy: results of Dutch childhood leukemia study group protocol ALL-7 (1988\u20131991). Blood 1999; 94: 1226\u20131236.","journal-title":"Blood"},{"key":"BF2404957_CR36","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/sj.leu.2402489","volume":"16","author":"WA Kamps","year":"2002","unstructured":"Kamps WA, Bokkerink JP, Hakvoort-Cammel FG, Veerman AJ, Weening RS, van Wering ER et al. BFM-oriented treatment for children with acute lymphoblastic leukemia without cranial irradiation and treatment reduction for standard risk patients: results of DCLSG protocol ALL-8 (1991\u20131996). Leukemia 2002; 16: 1099\u20131111.","journal-title":"Leukemia"},{"key":"BF2404957_CR37","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1182\/blood-2002-05-1600","volume":"101","author":"RW Stam","year":"2003","unstructured":"Stam RW, den Boer ML, Meijerink JP, Ebus ME, Peters GJ, Noordhuis P et al. Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood 2003; 101: 1270\u20131276.","journal-title":"Blood"},{"key":"BF2404957_CR38","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S1525-1578(10)60652-6","volume":"3","author":"J Meijerink","year":"2001","unstructured":"Meijerink J, Mandigers C, van de Locht L, Tonnissen E, Goodsaid F, Raemaekers J . A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR. J Mol Diagn 2001; 3: 55\u201361.","journal-title":"J Mol Diagn"},{"key":"BF2404957_CR39","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","volume":"17","author":"J Gabert","year":"2003","unstructured":"Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N et al. Standardization and quality control studies of \u2018real-time\u2019 quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia\u2014a Europe against cancer program. Leukemia 2003; 17: 2318\u20132357.","journal-title":"Leukemia"},{"key":"BF2404957_CR40","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/gcc.2870080406","volume":"8","author":"A Hagemeijer","year":"1993","unstructured":"Hagemeijer A, Buijs A, Smit E, Janssen B, Creemers GJ, Van der Plas D et al. Translocation of BCR to chromosome 9: a new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia. Genes Chromosomes Cancer 1993; 8: 237\u2013245.","journal-title":"Genes Chromosomes Cancer"},{"key":"BF2404957_CR41","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/sj.leu.2403340","volume":"18","author":"M van der Burg","year":"2004","unstructured":"van der Burg M, Poulsen TS, Hunger SP, Beverloo HB, Smit EM, Vang-Nielsen K et al. Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia. Leukemia 2004; 18: 895\u2013908.","journal-title":"Leukemia"},{"key":"BF2404957_CR42","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1046\/j.1365-2141.2000.02143.x","volume":"110","author":"ER van Wering","year":"2000","unstructured":"van Wering ER, van der Linden-Schrever BE, Szczepanski T, Willemse MJ, Baars EA, van Wijngaarde-Schmitz HM et al. Regenerating normal B-cell precursors during and after treatment of acute lymphoblastic leukaemia: implications for monitoring of minimal residual disease. Br J Haematol 2000; 110: 139\u2013146.","journal-title":"Br J Haematol"},{"key":"BF2404957_CR43","doi-asserted-by":"publisher","first-page":"3520","DOI":"10.1182\/blood-2006-04-019927","volume":"108","author":"P Van Vlierberghe","year":"2006","unstructured":"Van Vlierberghe P, van Grotel M, Beverloo HB, Lee C, Helgason T, Buijs-Gladdines J et al. The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia. Blood 2006; 108: 3520\u20133529.","journal-title":"Blood"},{"key":"BF2404957_CR44","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1182\/blood-2003-07-2577","volume":"103","author":"AA Ferrando","year":"2004","unstructured":"Ferrando AA, Herblot S, Palomero T, Hansen M, Hoang T, Fox EA et al. Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Blood 2004; 103: 1909\u20131911.","journal-title":"Blood"},{"key":"BF2404957_CR45","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/77819","volume":"1","author":"S Herblot","year":"2000","unstructured":"Herblot S, Steff AM, Hugo P, Aplan PD, Hoang T . SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression. Nat Immunol 2000; 1: 138\u2013144.","journal-title":"Nat Immunol"},{"key":"BF2404957_CR46","doi-asserted-by":"publisher","first-page":"4594","DOI":"10.1093\/emboj\/17.16.4594","volume":"17","author":"GG Grutz","year":"1998","unstructured":"Grutz GG, Bucher K, Lavenir I, Larson T, Larson R, Rabbitts TH . The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. EMBO J 1998; 17: 4594\u20134605.","journal-title":"EMBO J"},{"key":"BF2404957_CR47","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1073\/pnas.91.8.3181","volume":"91","author":"HL Hsu","year":"1994","unstructured":"Hsu HL, Wadman I, Baer R . Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc Natl Acad Sci USA 1994; 91: 3181\u20133185.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF2404957_CR48","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1093\/emboj\/16.11.3145","volume":"16","author":"IA Wadman","year":"1997","unstructured":"Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1\/NLI proteins. EMBO J 1997; 16: 3145\u20133157.","journal-title":"EMBO J"}],"container-title":["Leukemia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/2404957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404957","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/2404957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:51:42Z","timestamp":1648781502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/2404957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,11]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["BF2404957"],"URL":"https:\/\/doi.org\/10.1038\/sj.leu.2404957","relation":{},"ISSN":["0887-6924","1476-5551"],"issn-type":[{"value":"0887-6924","type":"print"},{"value":"1476-5551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,11]]},"assertion":[{"value":"4 July 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}