{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:32:07Z","timestamp":1773667927595,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2000,12,14]],"date-time":"2000-12-14T00:00:00Z","timestamp":976752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,12,14]],"date-time":"2000-12-14T00:00:00Z","timestamp":976752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2001,1,1]]},"DOI":"10.1038\/sj.mp.4000788","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T18:46:11Z","timestamp":1031165171000},"page":"59-65","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder"],"prefix":"10.1038","volume":"6","author":[{"given":"S P","family":"Hamilton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Slager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Helleby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G A","family":"Heiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D F","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S E","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Fyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2000,12,14]]},"reference":[{"key":"BF4000788_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1001\/archpsyc.1997.01830160021003","volume":"54","author":"MM Weissman","year":"1997","unstructured":"Weissman MM, Bland RC, Canino GJ, Faravelli C, Greenwald S, Hwu H-G et al. The cross-national epidemiology of panic disorder Arch Gen Psychiatry 1997 54: 305\u2013309","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000788_CR2","first-page":"pp 383","volume-title":"Review of Psychiatry","author":"JA Knowles","year":"1995","unstructured":"Knowles JA, Weissman MM . Panic disorder and agoraphobia. In: Oldham JM, Riba MB (eds) Review of Psychiatry Vol 14: American Psychiatric Press: Washington, DC 1995 pp 383\u2013404"},{"key":"BF4000788_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1001\/archpsyc.1997.01830150097014","volume":"54","author":"RB Goldstein","year":"1997","unstructured":"Goldstein RB, Wickramaratne PJ, Horwath E, Weissman MM . Familial aggregation and phenomenology of \u2018early-onset\u2019 (at or before age 20 years) panic disorder Arch Gen Psychiatry 1997 54: 271\u2013278","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000788_CR4","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/(SICI)1520-6394(1997)6:4<147::AID-DA3>3.0.CO;2-9","volume":"6","author":"E Horwath","year":"1997","unstructured":"Horwath E, Adams P, Wickramaratne P, Pine D, Weissman MM . Panic disorder with smothering symptoms: evidence for increased risk in first-degree relatives Depress Anxiety 1997 6: 147\u2013153","journal-title":"Depress Anxiety"},{"key":"BF4000788_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1017\/S003329170002849X","volume":"23","author":"KS Kendler","year":"1993","unstructured":"Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ . Panic disorder in women: a population-based twin study Psychol Med 1993 23: 397\u2013406","journal-title":"Psychol Med"},{"key":"BF4000788_CR6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/00041444-199322000-00001","volume":"3","author":"VJ Vieland","year":"1993","unstructured":"Vieland VJ, Hodge SE, Lish JD, Adams P, Weissman MM . Segregation analysis of panic disorder Psychiatr Genet 1993 3: 63\u201371","journal-title":"Psychiatr Genet"},{"key":"BF4000788_CR7","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/(SICI)1096-8628(19960409)67:2<147::AID-AJMG4>3.0.CO;2-P","volume":"67","author":"VJ Vieland","year":"1996","unstructured":"Vieland VJ, Goodman DW, Chapman T, Fyer AJ . New segregation analysis of panic disorder Am J Med Genet 1996 67: 147\u2013153","journal-title":"Am J Med Genet"},{"key":"BF4000788_CR8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/(SICI)1096-8628(19980328)81:2<139::AID-AJMG4>3.0.CO;2-R","volume":"81","author":"JA Knowles","year":"1998","unstructured":"Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA et al. Results of a genome-wide genetic screen for panic disorder Am J Med Genet (Neuropsychiatr Genet) 1998 81: 139\u2013147","journal-title":"Am J Med Genet (Neuropsychiatr Genet)"},{"key":"BF4000788_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/00041444-199700710-00008","volume":"7","author":"J Deckert","year":"1997","unstructured":"Deckert J, Catalano M, Heils A, Di Bella D, Friess F, Politi E et al. Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder Psychiatr Genet 1997 7: 45\u201347","journal-title":"Psychiatr Genet"},{"key":"BF4000788_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00041444-199903000-00001","volume":"9","author":"SP Hamilton","year":"1999","unstructured":"Hamilton SP, Heiman GA, Haghighi F, Mick S, Klein DF, Hodge SE et al. Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder Psychiatr Genet 1999 9: 1\u20136","journal-title":"Psychiatr Genet"},{"key":"BF4000788_CR11","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1440-1819.1997.tb03208.x","volume":"51","author":"H Ishiguro","year":"1997","unstructured":"Ishiguro H, Arinami T, Yamada K, Otsuka Y, Toru M, Shibuya H . An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population Psychiatr Clin Neurosci 1997 51: 333\u2013335","journal-title":"Psychiatr Clin Neurosci"},{"key":"BF4000788_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/(SICI)1096-8628(19960726)67:4<401::AID-AJMG14>3.0.CO;2-N","volume":"67","author":"T Kato","year":"1996","unstructured":"Kato T, Wang ZW, Zoega T, Crowe RR . Missense mutation of the cholecystokinin B receptor gene: lack of association with panic disorder Am J Med Genet 1996 67: 401\u2013405","journal-title":"Am J Med Genet"},{"key":"BF4000788_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0006-3223(95)00108-5","volume":"39","author":"K Ohara","year":"1996","unstructured":"Ohara K, Xie DW, Ishigaki T, Deng ZL, Nakamura Y, Suzuki Y et al. The genes encoding the 5HT1D alpha and 5HT1D beta receptors are unchanged in patients with panic disorder Biol Psychiatry 1996 39: 5\u201310","journal-title":"Biol Psychiatry"},{"key":"BF4000788_CR14","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S","volume":"81","author":"Z Wang","year":"1998","unstructured":"Wang Z, Valdes J, Noyes R, Zoega T, Crowe RR . Possible association of a cholecystokinin promotor polymorphism (CCK36CT with panic disorder Am J Med Genet (Neuropsychiatr Genet) 1998 81: 228\u2013234","journal-title":"Am J Med Genet (Neuropsychiatr Genet)"},{"key":"BF4000788_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0022-3999(97)00203-1","volume":"44","author":"M Bourin","year":"1998","unstructured":"Bourin M, Baker GB, Bradwejn J . Neurobiology of panic disorder J Psychosom Res 1998 44: 163\u2013180","journal-title":"J Psychosom Res"},{"key":"BF4000788_CR16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1001\/archpsyc.1989.01810060031006","volume":"46","author":"C de Montigny","year":"1989","unstructured":"de Montigny C . Cholecystokinin tetrapeptide induces panic-like attacks in healthy volunteers. Preliminary findings Arch Gen Psychiatry 1989 46: 511\u2013517","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000788_CR17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1177\/070674379003500115","volume":"35","author":"J Bradwejn","year":"1990","unstructured":"Bradwejn J, Koszycki D, Meterissian G . Cholecystokinin-tetrapeptide induces panic attacks in patients with panic disorder Can J Psychiatry 1990 35: 83\u201385","journal-title":"Can J Psychiatry"},{"key":"BF4000788_CR18","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1001\/archpsyc.1991.01810310021005","volume":"48","author":"J Bradwejn","year":"1991","unstructured":"Bradwejn J, Koszycki D, Shriqui C . Enhanced sensitivity to cholecystokinin tetrapeptide in panic disorder. Clinical and behavioral findings Arch Gen Psychiatry 1991 48: 603\u2013610","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000788_CR19","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0006-3223(94)91187-8","volume":"36","author":"JL Abelson","year":"1994","unstructured":"Abelson JL, Nesse RM . Pentagastrin infusions in patients with panic disorder. I. Symptoms and cardiovascular responses Biol Psychiatry 1994 36: 73\u201383","journal-title":"Biol Psychiatry"},{"key":"BF4000788_CR20","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1001\/archpsyc.1994.03950060050005","volume":"51","author":"J Bradwejn","year":"1994","unstructured":"Bradwejn J, Koszycki D, Couetoux du TA, van Megen H, den Boer J, Westenberg H . The panicogenic effects of cholecystokinin-tetrapeptide are antagonized by L-365,260, a central cholecystokinin receptor antagonist, in patients with panic disorder Arch Gen Psychiatry 1994 51: 486\u2013493","journal-title":"Arch Gen Psychiatry"},{"key":"BF4000788_CR21","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/0006-3223(96)00163-1","volume":"40","author":"DS Cowley","year":"1996","unstructured":"Cowley DS, Adams JB, Pyke RE, Cook J, Zaccharias P, Wingerson D et al. Effect of Cl-988, a cholecystokinin-B receptor antagonist, on lactate-induced panic Biol Psychiatry 1996 40: 550\u2013552","journal-title":"Biol Psychiatry"},{"key":"BF4000788_CR22","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/S0006-3223(99)00090-6","volume":"46","author":"AC Pande","year":"1999","unstructured":"Pande AC, Greiner M, Adams JB, Lydiard RB, Pierce MW . Placebo-controlled trial of the CCK-B antagonist, Cl-988, in panic disorder Biol Psychiatry 1999 46: 860\u2013862","journal-title":"Biol Psychiatry"},{"key":"BF4000788_CR23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s002130050186","volume":"129","author":"HJ van Megen","year":"1997","unstructured":"van Megen HJ, Westenberg HG, den Boer JA, Slaap B, Es-Radhakishun F, Pande AC . The cholecystokinin-B receptor antagonist Cl-988 failed to affect CCK-4 induced symptoms in panic disorder patients Psychopharmacology (Berl) 1997 129: 243\u2013248","journal-title":"Psychopharmacology (Berl)"},{"key":"BF4000788_CR24","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1176\/ajp.151.2.261","volume":"151","author":"J Bradwejn","year":"1994","unstructured":"Bradwejn J, Koszycki D . Imipramine antagonism of the panicogenic effects of cholecystokinin tetrapeptide in panic disorder patients Am J Psychiatry 1994 151: 261\u2013263","journal-title":"Am J Psychiatry"},{"key":"BF4000788_CR25","first-page":"332","volume":"22","author":"J Shlik","year":"1997","unstructured":"Shlik J, Aluoja A, Vasar V, Vasar E, Podar T, Bradwejn J . Effects of citalopram treatment on behavioural, cardiovascular and neuroendocrine response to cholecystokinin tetrapeptide challenge in patients with panic disorder J Psychiatry Neurosci 1997 22: 332\u2013340","journal-title":"J Psychiatry Neurosci"},{"key":"BF4000788_CR26","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s002130050201","volume":"129","author":"HJ van Megen","year":"1997","unstructured":"van Megen HJ, Westenberg HG, den Boer JA, Slaap B, Scheepmakers A . Effect of the selective serotonin reuptake inhibitor fluvoxamine on CCK-4 induced panic attacks Psychopharmacology (Berl) 1997 129: 357\u2013364","journal-title":"Psychopharmacology (Berl)"},{"key":"BF4000788_CR27","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/sj.mp.4000507","volume":"4","author":"JL Kennedy","year":"1999","unstructured":"Kennedy JL, Bradwejn J, Koszycki D, King N, Crowe R, Vincent J et al. Investigation of cholecystokinin system genes in panic disorder Mol Psychiatry 1999 4: 284\u2013285","journal-title":"Mol Psychiatry"},{"key":"BF4000788_CR28","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0022-3956(86)90034-8","volume":"20","author":"S Mannuzza","year":"1986","unstructured":"Mannuzza S, Fyer AJ, Klein DF, Endicott J . Schedule For Affective Disorders and Schizophrenia\u2013Lifetime Version Modified for the Study of Anxiety Disorders (SADS-LA): Rationale and Conceptual Development J Psychiat Res 1986 20: 317\u2013325","journal-title":"J Psychiat Res"},{"key":"BF4000788_CR29","volume-title":"Family Informant Schedule and Criteria","author":"S Mannuzza","year":"1985","unstructured":"Mannuzza S, Fyer AJ, Endicott J, Klein DF . Family Informant Schedule and Criteria Anxiety Disorders Clinic, New York State Psychiatric Institute 1985"},{"key":"BF4000788_CR30","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/(SICI)1096-8628(19990416)88:2<173::AID-AJMG15>3.0.CO;2-#","volume":"88","author":"AJ Fyer","year":"1999","unstructured":"Fyer AJ, Weissman MM . Genetic linkage study of panic: clinical methodology and description of pedigrees Am J Med Genet (Neuropsychiatr Genet) 1999 88: 173\u2013181","journal-title":"Am J Med Genet (Neuropsychiatr Genet)"},{"key":"BF4000788_CR31","first-page":"2081","volume":"3","author":"B Glaser","year":"1994","unstructured":"Glaser B, Anker R, Chiu KC, Donis-Keller H, Permutt MA . Dinucleotide repeat polymorphism at the human CCKBR locus Hum Mol Genet 1994 3: 2081","journal-title":"Hum Mol Genet"},{"key":"BF4000788_CR32","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1101\/gr.9.5.492","volume":"9","author":"X Chen","year":"1999","unstructured":"Chen X, Levine L, Kwok PY . Fluorescence polarization in homogeneous nucleic acid analysis Genome Res 1999 9: 492\u2013498","journal-title":"Genome Res"},{"key":"BF4000788_CR33","first-page":"252","volume":"53","author":"Jr Cottingham RW","year":"1993","unstructured":"Cottingham RW Jr, Idury RM, Schaffer AA . Faster sequential genetic linkage computations Am J Hum Genet 1993 53: 252\u2013263","journal-title":"Am J Hum Genet"},{"key":"BF4000788_CR34","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1159\/000154222","volume":"44","author":"AA Schaffer","year":"1994","unstructured":"Schaffer AA, Gupta SK, Shriram K, Cottingham RW Jr . Avoiding recomputation in linkage analysis Hum Hered 1994 44: 225\u2013237","journal-title":"Hum Hered"},{"key":"BF4000788_CR35","doi-asserted-by":"crossref","DOI":"10.56021\/9780801861406","volume-title":"Analysis of Human Genetic Linkage, 3rd edn","author":"J Ott","year":"1999","unstructured":"Ott J . Analysis of Human Genetic Linkage, 3rd edn Johns Hopkins University Press: Baltimore 1999"},{"key":"BF4000788_CR36","volume-title":"The available possibilities to analyze data of polygenic disease statistically","author":"JD Terwilliger","year":"1994","unstructured":"Terwilliger JD . The available possibilities to analyze data of polygenic disease statistically Abstract to IVth Workshop of the Nordic Genome Initiative, Helsinki 1994"},{"key":"BF4000788_CR37","first-page":"506","volume":"52","author":"RS Spielman","year":"1993","unstructured":"Spielman RS, McGinnis RE, Ewens WJ . Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am J Hum Genet 1993 52: 506\u2013516","journal-title":"Am J Hum Genet"},{"key":"BF4000788_CR38","first-page":"777","volume":"56","author":"JD Terwilliger","year":"1995","unstructured":"Terwilliger JD . A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci Am J Hum Genet 1995 56: 777\u2013787","journal-title":"Am J Hum Genet"},{"key":"BF4000788_CR39","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1159\/000154096","volume":"42","author":"JD Terwilliger","year":"1992","unstructured":"Terwilliger JD, Ott J . A haplotype-based \u2018haplotype relative risk\u2019 approach to detecting allelic associations Hum Hered 1992 42: 337\u2013346","journal-title":"Hum Hered"},{"key":"BF4000788_CR40","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.2307\/2533457","volume":"50","author":"K Jin","year":"1994","unstructured":"Jin K, Speed TP, Klitz W, Thomson G . Testing for segregation distortion in the HLA complex Biometrics 1994 50: 1189\u20131198","journal-title":"Biometrics"},{"key":"BF4000788_CR41","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1469-1809.1995.tb01608.x","volume":"59","author":"PC Sham","year":"1995","unstructured":"Sham PC, Curtis D . Monte Carlo tests for associations between disease and alleles at highly polymorphic loci Ann Hum Genet 1995 59: 97\u2013105","journal-title":"Ann Hum Genet"},{"key":"BF4000788_CR42","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1089\/dna.1996.15.53","volume":"15","author":"FC Nielsen","year":"1996","unstructured":"Nielsen FC, Pedersen K, Hansen TV, Rourke IJ, Rehfeld JF . Transcriptional regulation of the human cholecystokinin gene: composite action of upstream stimulatory factor, Sp1, and members of the CREB\/ATF-AP-1 family of transcription factors DNA Cell Biol 1996 15: 53\u201363","journal-title":"DNA Cell Biol"},{"key":"BF4000788_CR43","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/S0006-8993(99)01242-1","volume":"824","author":"L Giardino","year":"1999","unstructured":"Giardino L, Bettelli C, Pozza M, Calza L . Regulation of CCK mRNA expression in the rat brain by stress and treatment with sertraline, a selective serotonin re-uptake inhibitor Brain Res 1999 824: 304\u2013307","journal-title":"Brain Res"},{"key":"BF4000788_CR44","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/sj.mp.4000293","volume":"3","author":"T Bowen","year":"1998","unstructured":"Bowen T, Norton N, Jacobsen NJ, Guy C, Daniels JK, Sanders RD et al. Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder Mol Psychiatry 1998 3: 67\u201371","journal-title":"Mol Psychiatry"},{"key":"BF4000788_CR45","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0165-1781(98)00127-9","volume":"85","author":"H Ishiguro","year":"1999","unstructured":"Ishiguro H, Saito T, Shibuya H, Toru M, Arinami T . No association between C-45T polymorphism in the Sp1 binding site of the promoter region of the cholecystokinin gene and alcoholism Psychiatry Res 1999 85: 209\u2013213","journal-title":"Psychiatry Res"},{"key":"BF4000788_CR46","doi-asserted-by":"publisher","first-page":"11S","DOI":"10.1111\/j.1530-0277.1999.tb04525.x","volume":"23","author":"T Okubo","year":"1999","unstructured":"Okubo T, Harada S, Higuchi S, Matsushita S . Genetic association between alcohol withdrawal symptoms and polymorphism of CCK gene promoter Alcohol Clin Exp Res 1999 23: (4 Suppl) 11S\u201312S","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4000788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4000788","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4000788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:09:27Z","timestamp":1682035767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4000788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,14]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1,1]]}},"alternative-id":["BF4000788"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4000788","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12,14]]},"assertion":[{"value":"11 February 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2000","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2000","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2000","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}