{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:39:20Z","timestamp":1791383960638,"version":"4.3.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2001,7,1]]},"DOI":"10.1038\/sj.mp.4000911","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T21:18:58Z","timestamp":1032470338000},"page":"367-372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["MAO-A and COMT polymorphisms and gene effects in narcolepsy"],"prefix":"10.1038","volume":"6","author":[{"given":"Y","family":"Dauvilliers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Neidhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lecendreux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Billiard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tafti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,7,9]]},"reference":[{"key":"BF4000911_CR1","first-page":"34","volume":"42 (suppl 6)","author":"MS Aldrich","year":"1992","unstructured":"Aldrich MS . Narcolepsy Neurology 1992 42 (suppl 6): 34\u201343","journal-title":"Neurology"},{"key":"BF4000911_CR2","first-page":"626","volume":"53","author":"JBE Gelineau","year":"1880","unstructured":"Gelineau JBE . De la narcolepsie Gazette des H\u00f4pitaux (Paris) 1880 53: 626\u2013628","journal-title":"Gazette des H\u00f4pitaux (Paris)"},{"key":"BF4000911_CR3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","volume":"98","author":"L Lin","year":"1999","unstructured":"Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin W et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene Cell 1999 98: 365\u2013376","journal-title":"Cell"},{"key":"BF4000911_CR4","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","volume":"98","author":"RM Chemelli","year":"1999","unstructured":"Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation Cell 1999 98: 437\u2013451","journal-title":"Cell"},{"key":"BF4000911_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0960-5428(94)00043-N","volume":"5","author":"E Mignot","year":"1995","unstructured":"Mignot E, Tafti M, Dement WC, Grumet FC . Narcolepsy and immunity Adv Neuroimmunol 1995 5: 23\u201337","journal-title":"Adv Neuroimmunol"},{"key":"BF4000911_CR6","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1212\/WNL.48.6.1550","volume":"48","author":"AE Rogers","year":"1997","unstructured":"Rogers AE, Meehan J, Guilleminault C, Grumet FC, Mignot E . HLA DR15 (DR2) and DQB1*0602 typing studies in 188 narcoleptic patients with cataplexy Neurology 1997 48: 1550\u20131556","journal-title":"Neurology"},{"key":"BF4000911_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0198-8859(86)90068-6","volume":"17","author":"C Guilleminault","year":"1986","unstructured":"Guilleminault C, Grumet C . HLA DR2 and narcolepsy: not all narcoleptic-cataplectic patients are DR2 Hum Immunol 1986 17: 1\u20132","journal-title":"Hum Immunol"},{"key":"BF4000911_CR8","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1212\/WNL.50.2_Suppl_1.S16","volume":"50 (suppl 1)","author":"E Mignot","year":"1998","unstructured":"Mignot E . Genetic and familial aspects of narcolepsy Neurology 1998 50 (suppl 1): S16\u2013S22","journal-title":"Neurology"},{"key":"BF4000911_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","volume":"355","author":"S Nishino","year":"2000","unstructured":"Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E . Hypocretin (orexin) deficiency in human narcolepsy Lancet 2000 355: 39\u201340","journal-title":"Lancet"},{"key":"BF4000911_CR10","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/79690","volume":"6","author":"C Peyron","year":"2000","unstructured":"Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Nat Med 2000 6: 991\u2013997","journal-title":"Nat Med"},{"key":"BF4000911_CR11","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","volume":"27","author":"TC Thannickal","year":"2000","unstructured":"Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M et al. Reduced number of hypocretin neurons in human narcolepsy Neuron 2000 27: 469\u2013474","journal-title":"Neuron"},{"key":"BF4000911_CR12","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0140-6736(98)05831-0","volume":"353","author":"H Koch","year":"1999","unstructured":"Koch H, Craig I, Dahlitz M, Denney R, Parkes D . Analysis of the monoamine oxidase genes and the Norrie disease gene locus in narcolepsy Lancet 1999 353: 645\u2013646","journal-title":"Lancet"},{"key":"BF4000911_CR13","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1034\/j.1399-0039.1999.540204.x","volume":"54","author":"H Hohjoh","year":"1999","unstructured":"Hohjoh H, Nakayama T, Ohashi J, Miyagawa T, Tanaka H, Akaza T et al. Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy Tissue Antigens 1999 54: 138\u2013145","journal-title":"Tissue Antigens"},{"key":"BF4000911_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/0006-8993(89)90450-2","volume":"490","author":"E Mignot","year":"1989","unstructured":"Mignot E, Guilleminault C, Bowersox S, Frusthofer B, Nishino S, Maddaluno J et al. Central alpha 1 adrenoreceptor subtypes in narcolepsy-cataplexy: a disorder of REM sleep Brain Res 1989 490: 186\u2013191","journal-title":"Brain Res"},{"key":"BF4000911_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1212\/WNL.42.1.229","volume":"42","author":"SJ Kish","year":"1992","unstructured":"Kish SJ, Mamelak M, Slimovitch C, Dixon LM, Lewis A, Shannak K et al. Brain neurotransmitter changes in human narcolepsy Neurology 1992 42: 229\u2013234","journal-title":"Neurology"},{"key":"BF4000911_CR16","first-page":"598","volume":"17","author":"MS Aldrich","year":"1994","unstructured":"Aldrich MS, Prokopowicz G, Ockert K, Hollingsworth Z, Penney JB, Albin RL . Neurochemical studies of human narcolepsy: alpha-adrenergic receptor autoradiography of human narcoleptic brain and brainstem Sleep 1994 17: 598\u2013608","journal-title":"Sleep"},{"key":"BF4000911_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0301-0082(96)00070-6","volume":"52","author":"S Nishino","year":"1997","unstructured":"Nishino S, Mignot E . Pharmacological aspects of human and canine narcolepsy Prog Neurobiol 1997 52: 27\u201378","journal-title":"Prog Neurobiol"},{"key":"BF4000911_CR18","first-page":"383","volume":"49","author":"GS Hotamisligil","year":"1991","unstructured":"Hotamisligil GS, Breakefield XO . Human monoamine oxydase A gene determines levels of enzyme activity Am J Hum Genet 1991 49: 383\u2013392","journal-title":"Am J Hum Genet"},{"key":"BF4000911_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0165-1781(80)90022-0","volume":"2","author":"XO Breakefield","year":"1980","unstructured":"Breakefield XO, Giller EL, Nurnberger JI, Castiglione CM, Buchsbaum MS, Gershon ES . Monoamine oxidase type A in fibroblasts from patients with bipolar depressive illness Psychiat Res 1980 2: 307\u2013314","journal-title":"Psychiat Res"},{"key":"BF4000911_CR20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/ajmg.1320600413","volume":"60","author":"LC Lim","year":"1995","unstructured":"Lim LC, Powell J, Sham P, Castle D, Hunt N, Murray R et al. Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder Am J Med Genet 1995 60: 325\u2013331","journal-title":"Am J Med Genet"},{"key":"BF4000911_CR21","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1093\/hmg\/8.4.621","volume":"8","author":"J Deckert","year":"1999","unstructured":"Deckert J, Catalano M, Syagailo YV, Bosi M, Okladnova O, Di Bella D et al. Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder Hum Mol Genet 1999 8: 621\u2013624","journal-title":"Hum Mol Genet"},{"key":"BF4000911_CR22","first-page":"235","volume":"7","author":"JC Shih","year":"1999","unstructured":"Shih JC, Chen K . MAO-A and -B gene knock-out mice exhibit distinctly different behavior Neurobiology (Bp) 1999 7: 235\u2013246","journal-title":"Neurobiology (Bp)"},{"key":"BF4000911_CR23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/00008571-199606000-00007","volume":"6","author":"HM Lachman","year":"1996","unstructured":"Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM . Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders Pharmacogenetics 1996 6: 243\u2013250","journal-title":"Pharmacogenetics"},{"key":"BF4000911_CR24","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/S0006-3223(98)00319-9","volume":"45","author":"M Karayiorgou","year":"1999","unstructured":"Karayiorgou M, Sobin C, Blundell ML, Galke BL, Malinova L, Goldberg P et al. Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder Biol Psychiatry 1999 45: 1178\u20131189","journal-title":"Biol Psychiatry"},{"key":"BF4000911_CR25","doi-asserted-by":"publisher","first-page":"9991","DOI":"10.1073\/pnas.95.17.9991","volume":"95","author":"JA Gogos","year":"1998","unstructured":"Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D et al. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in cathecholamine levels and behaviour Proc Natl Acad Sci USA 1998 95: 9991\u20139996","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4000911_CR26","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1365-2869.1992.tb00046.x","volume":"1","author":"M Tafti","year":"1992","unstructured":"Tafti M, Carlander B, Besset A, Billiard M . Sleep onset REM episodes in narcolepsy: REM sleep pressure or nonREM-REM sleep dysregulation J Sleep Res 1992 1: 245\u2013250","journal-title":"J Sleep Res"},{"key":"BF4000911_CR27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1126\/science.7939668","volume":"266","author":"C Chen","year":"1994","unstructured":"Chen C, Rainnie DG, Greene RW, Tonegawa S . Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmoduline kinase II Science 1994 266: 291\u2013294","journal-title":"Science"},{"key":"BF4000911_CR28","doi-asserted-by":"publisher","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","volume":"18","author":"C Peyron","year":"1998","unstructured":"Peyron C, Tighe DK, van den Pol AN, De Lecea L, Heller HC, Sutcliffe G et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems J Neurosci 1998 18: 9996\u201310015","journal-title":"J Neurosci"},{"key":"BF4000911_CR29","first-page":"359","volume":"23","author":"TS Kilduff","year":"2000","unstructured":"Kilduff TS, Peyron C . The hypocretin\/orexin ligand-receptor system: implications for sleep and sleep disorders TINS 2000 23: 359\u2013364","journal-title":"TINS"},{"key":"BF4000911_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1006\/geno.2000.6143","volume":"65","author":"J Nakayama","year":"2000","unstructured":"Nakayama J, Miura M, Honda M, Miki T, Honda Y, Arinami T . Linkage of human narcolepsy with HLA association to chromosome 4p13\u2013q21 Genomics 2000 65: 84\u201386","journal-title":"Genomics"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4000911.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4000911","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4000911.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:47:18Z","timestamp":1648784838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4000911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,1]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,7,1]]}},"alternative-id":["BF4000911"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4000911","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,1]]},"assertion":[{"value":"2 February 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2001","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}