{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:25:20Z","timestamp":1791267920461,"version":"4.1.0"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2002,6,1]]},"DOI":"10.1038\/sj.mp.4001031","type":"journal-article","created":{"date-parts":[[2002,9,3]],"date-time":"2002-09-03T21:08:27Z","timestamp":1031087307000},"page":"474-483","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs"],"prefix":"10.1038","volume":"7","author":[{"given":"K E","family":"Gabry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"Chrousos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K C","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Sternberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A B","family":"Negrao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E L","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P W","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,6,18]]},"reference":[{"key":"BF4001031_CR1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/138032a0","volume":"138","author":"H Selye","year":"1936","unstructured":"Selye H . A syndrome produced by diverse nocuous agents Nature 1936 138: 32\u201336","journal-title":"Nature"},{"key":"BF4001031_CR2","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1007\/s001340000724","volume":"26","author":"D Schilling","year":"2000","unstructured":"Schilling D et al. Low seroprevalence of Helicobacter pylori infection in patients with stress ulcer bleeding\u2014a prospective evaluation of patients on a cardiosurgical intensive care unit Intensive Care Med 2000 26: 1832\u20131836","journal-title":"Intensive Care Med"},{"key":"BF4001031_CR3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/00006842-199611000-00002","volume":"58","author":"H Weiner","year":"1996","unstructured":"Weiner H . Use of animal models in peptic ulcer disease Psychosom Med 1996 58: 524\u2013545","journal-title":"Psychosom Med"},{"key":"BF4001031_CR4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0016-5085(88)90231-4","volume":"94","author":"CL Williams","year":"1988","unstructured":"Williams CL, Villar RG, Peterson JM, Burks TF . Stress-induced changes in intestinal transit in the rat: a model for irritable bowel syndrome Gastroenterology 1988 94: 611\u2013621","journal-title":"Gastroenterology"},{"key":"BF4001031_CR5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/00365528509089674","volume":"20","author":"I Sjodin","year":"1985","unstructured":"Sjodin I, Svedlund J, Dotevall G, Gillberg R . Symptom profiles in chronic peptic ulcer disease. A detailed study of abdominal and mental symptoms Scand J Gastroenterol 1985 20: 419\u2013427","journal-title":"Scand J Gastroenterol"},{"key":"BF4001031_CR6","doi-asserted-by":"crossref","first-page":"65S","DOI":"10.1016\/S0002-9343(99)00082-0","volume":"107","author":"RB Lydiard","year":"1999","unstructured":"Lydiard RB, Falsetti SA . Experience with anxiety and depression treatment studies: implications for designing irritable bowel syndrome clinical trials Am J Med 1999 107: 65S\u201373S","journal-title":"Am J Med"},{"key":"BF4001031_CR7","first-page":"249","volume":"78","author":"MD De Bellis","year":"1994","unstructured":"De Bellis MD et al. Hypothalamic-pituitary-adrenal axis dysregulation in sexually abused girls J Clin Endocrinol Metab 1994 78: 249\u2013255","journal-title":"J Clin Endocrinol Metab"},{"key":"BF4001031_CR8","first-page":"185","volume":"33","author":"C Heim","year":"1997","unstructured":"Heim C, Owens MJ, Plotsky PM, Nemeroff CB . Persistent changes in corticotropin-releasing factor systems due to early life stress: relationship to the pathophysiology of major depression and post-traumatic stress disorder Psychopharmacol Bull 1997 33: 185\u2013192","journal-title":"Psychopharmacol Bull"},{"key":"BF4001031_CR9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.566471","volume":"201","author":"SH Ackerman","year":"1978","unstructured":"Ackerman SH, Hofer MA, Weiner H . Early maternal separation increases gastric ulcer risk in rats by producing a latent thermoregulatory disturbance Science 1978 201: 373\u2013376","journal-title":"Science"},{"key":"BF4001031_CR10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0095-4543(05)70342-0","volume":"23","author":"G Almounajed","year":"1996","unstructured":"Almounajed G, Drossman DA . Newer aspects of the irritable bowel syndrome Prim Care 1996 23: 477\u2013495","journal-title":"Prim Care"},{"key":"BF4001031_CR11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00004836-199912000-00009","volume":"29","author":"MW Russo","year":"1999","unstructured":"Russo MW, Gaynes BN, Drossman DA . A national survey of practice patterns of gastroenterologists with comparison to the past two decades J Clin Gastroenterol 1999 29: 339\u2013343","journal-title":"J Clin Gastroenterol"},{"key":"BF4001031_CR12","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/BF01303162","volume":"38","author":"DA Drossman","year":"1993","unstructured":"Drossman DA et al. US householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact Dig Dis Sci 1993 38: 1569\u20131580","journal-title":"Dig Dis Sci"},{"key":"BF4001031_CR13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0016-5085(19)34099-5","volume":"55","author":"DA Brodie","year":"1968","unstructured":"Brodie DA . Experimental peptic ulcer Gastroenterology 1968 55: 125\u2013134","journal-title":"Gastroenterology"},{"key":"BF4001031_CR14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/00365529209000071","volume":"27","author":"CH Cho","year":"1992","unstructured":"Cho CH, Koo MW, Garg GP, Ogle CW . Stress-induced gastric ulceration: its aetiology and clinical implications Scand J Gastroenterol 1992 27: 257\u2013262","journal-title":"Scand J Gastroenterol"},{"key":"BF4001031_CR15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0149-7634(86)90017-5","volume":"10","author":"WP Pare","year":"1986","unstructured":"Pare WP, Glavin GB . Restraint stress in biomedical research: a review Neurosci Biobehav Rev 1986 10: 339\u2013370","journal-title":"Neurosci Biobehav Rev"},{"key":"BF4001031_CR16","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1136\/bmj.316.7130.538","volume":"316","author":"S Levenstein","year":"1998","unstructured":"Levenstein S . Stress and peptic ulcer: life beyond Helicobacter BMJ 1998 316: 538\u2013541","journal-title":"BMJ"},{"key":"BF4001031_CR17","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0889-8529(05)70208-5","volume":"30","author":"KE Habib","year":"2001","unstructured":"Habib KE, Gold PW, Chrousos GP . Neuroendorinology of stress Endocrinol Metab Clin North Am 2001 30: 695\u2013728","journal-title":"Endocrinol Metab Clin North Am"},{"key":"BF4001031_CR18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0016-5085(83)80174-7","volume":"84","author":"MN Peters","year":"1983","unstructured":"Peters MN, Richardson CT . Stressful life events, acid hypersecretion, and ulcer disease Gastroenterology 1983 84: 114\u2013119","journal-title":"Gastroenterology"},{"key":"BF4001031_CR19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00004836-199309000-00006","volume":"17","author":"WH Bresnick","year":"1993","unstructured":"Bresnick WH, Rask-Madsen C, Hogan DL, Koss MA, Isenberg JI . The effect of acute emotional stress on gastric acid secretion in normal subjects and duodenal ulcer patients J Clin Gastroenterol 1993 17: 117\u2013122","journal-title":"J Clin Gastroenterol"},{"key":"BF4001031_CR20","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0031-9384(89)90203-5","volume":"46","author":"WP Pare","year":"1989","unstructured":"Pare WP . Stress ulcer susceptibility and depression in Wistar Kyoto (WKY) rats Physiol Behav 1989 46: 993\u2013998","journal-title":"Physiol Behav"},{"key":"BF4001031_CR21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0928-4257(93)90011-H","volume":"87","author":"GB Glavin","year":"1993","unstructured":"Glavin GB . Vulnerability to stress ulcerogenesis in rats differing in anxiety: a dopaminergic correlate J Physiol Paris 1993 87: 239\u2013243","journal-title":"J Physiol Paris"},{"key":"BF4001031_CR22","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/0016-5085(86)90189-7","volume":"91","author":"M Feldman","year":"1986","unstructured":"Feldman M, Walker P, Green JL, Weingarden K . Life events stress and psychosocial factors in men with peptic ulcer disease. A multidimensional case-controlled study Gastroenterology 1986 91: 1370\u20131379","journal-title":"Gastroenterology"},{"key":"BF4001031_CR23","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1001\/archinte.1984.00350150170037","volume":"144","author":"RK Ries","year":"1984","unstructured":"Ries RK, Gilbert DA, Katon W . Tricyclic antidepressant therapy for peptic ulcer disease Arch Intern Med 1984 144: 566\u2013569","journal-title":"Arch Intern Med"},{"key":"BF4001031_CR24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archinte.1982.00340150073014","volume":"142","author":"JC Mangla","year":"1982","unstructured":"Mangla JC, Pereira M . Tricyclic antidepressants in the treatment of peptic ulcer disease Arch Intern Med 1982 142: 273\u2013275","journal-title":"Arch Intern Med"},{"key":"BF4001031_CR25","first-page":"616","volume":"20","author":"RK Shrivastava","year":"1984","unstructured":"Shrivastava RK, Siegel H . The role of tricyclics and benzodiazepine compounds in the treatment of irritable gut syndrome and peptic ulcer disease Psychopharmacol Bull 1984 20: 616\u2013621","journal-title":"Psychopharmacol Bull"},{"key":"BF4001031_CR26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0033-3182(85)72859-9","volume":"26","author":"JJ Haggerty Jr","year":"1985","unstructured":"Haggerty JJ Jr, Drossman DA . Use of psychotropic drugs in patients with peptic ulcer Psychosomatics 1985 26: 277\u2013280 283\u2013284","journal-title":"Psychosomatics"},{"key":"BF4001031_CR27","first-page":"181","volume":"7","author":"RK Shrivastava","year":"1985","unstructured":"Shrivastava RK, Shah BK, Siegal H . Doxepin and cimetidine in the treatment of duodenal ulcer: a double-blind comparative study Clin Ther 1985 7: 181\u2013189","journal-title":"Clin Ther"},{"key":"BF4001031_CR28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1254\/jjp.61.115","volume":"61","author":"N Ogawa","year":"1993","unstructured":"Ogawa N, Hara C, Takaki S . Anxiolytic activity of SC-48274 compared with those of buspirone and diazepam in experimental anxiety models Jpn J Pharmacol 1993 61: 115\u2013121","journal-title":"Jpn J Pharmacol"},{"key":"BF4001031_CR29","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpcell.1987.253.6.C866","volume":"253","author":"CL Williams","year":"1987","unstructured":"Williams CL, Peterson JM, Villar RG, Burks TF . Corticotropin-releasing factor directly mediates colonic responses to stress Am J Physiol 1987 253: G582\u2013G586","journal-title":"Am J Physiol"},{"key":"BF4001031_CR30","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/S0016-5085(88)80070-2","volume":"95","author":"HJ Lenz","year":"1988","unstructured":"Lenz HJ, Raedler A, Greten H, Vale WW, Rivier JE . Stress-induced gastrointestinal secretory and motor responses in rats are mediated by endogenous corticotropin-releasing factor Gastroenterology 1988 95: 1510\u20131517","journal-title":"Gastroenterology"},{"key":"BF4001031_CR31","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1749-6632.1998.tb09602.x","volume":"840","author":"C Pothoulakis","year":"1998","unstructured":"Pothoulakis C, Castagliuolo I, Leeman SE . Neuroimmune mechanisms of intestinal responses to stress. Role of corticotropin-releasing factor and neurotensin Ann N Y Acad Sci 1998 840: 635\u2013648","journal-title":"Ann N Y Acad Sci"},{"key":"BF4001031_CR32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0006-8993(93)90089-6","volume":"624","author":"A Ray","year":"1993","unstructured":"Ray A, Henke PG, Gulati K, Sen P . The amygdaloid complex, corticotropin releasing factor and stress-induced gastric ulcerogenesis in rats Brain Res 1993 624: 286\u2013290","journal-title":"Brain Res"},{"key":"BF4001031_CR33","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0024-3205(85)90238-3","volume":"36","author":"T Nakane","year":"1985","unstructured":"Nakane T, Kanie N, Audhya T, Hollander CS . The effects of centrally administered neuropeptides on the development of gastric lesions in the rat Life Sci 1985 36: 1197\u20131203","journal-title":"Life Sci"},{"key":"BF4001031_CR34","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6267699","volume":"213","author":"W Vale","year":"1981","unstructured":"Vale W, Spiess J, Rivier C, Rivier J . Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin Science 1981 213: 1394\u20131397","journal-title":"Science"},{"key":"BF4001031_CR35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/297331a0","volume":"297","author":"RE Sutton","year":"1982","unstructured":"Sutton RE, Koob GF, Le Moal M, Rivier J, Vale W . Corticotropin releasing factor produces behavioural activation in rats Nature 1982 297: 331\u2013333","journal-title":"Nature"},{"key":"BF4001031_CR36","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1073\/pnas.97.11.6079","volume":"97","author":"KE Habib","year":"2000","unstructured":"Habib KE et al. Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates Proc Natl Acad Sci U S A 2000 97: 6079\u20136084","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BF4001031_CR37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1126\/science.6415815","volume":"222","author":"Y Tache","year":"1983","unstructured":"Tache Y et al. Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor Science 1983 222: 935\u2013937","journal-title":"Science"},{"key":"BF4001031_CR38","first-page":"754","volume":"280","author":"V Martinez","year":"1997","unstructured":"Martinez V, Rivier J, Wang L, Tache Y . Central injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks CRF- and stress-related alterations of gastric and colonic motor function J Pharmacol Exp Ther 1997 280: 754\u2013760","journal-title":"J Pharmacol Exp Ther"},{"key":"BF4001031_CR39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4088\/JCP.v58n1104","volume":"58","author":"RB Lydiard","year":"1997","unstructured":"Lydiard RB . Anxiety and the irritable bowel syndrome: psychiatric, medical, or both? J Clin Psychiatry 1997 58: 51\u201358 discussion 59\u201361","journal-title":"J Clin Psychiatry"},{"key":"BF4001031_CR40","first-page":"S119","volume":"23(S2)","author":"KE Habib","year":"2000","unstructured":"Habib KE et al. CRH type-1 receptor antagonism attenuates behavioral, endocrine and autonomic responses to stress in primates Neuropsychopharmacology 2000 23(S2): S119","journal-title":"Neuropsychopharmacology"},{"key":"BF4001031_CR41","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1056\/NEJM198808183190706","volume":"319","author":"PW Gold","year":"1988","unstructured":"Gold PW, Goodwin FK, Chrousos GP . Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (2) N Engl J Med 1988 319: 413\u2013420","journal-title":"N Engl J Med"},{"key":"BF4001031_CR42","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/jm960861b","volume":"40","author":"YL Chen","year":"1997","unstructured":"Chen YL et al. Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: a centrally active corticotropin-releasing factor1 receptor antagonist J Med Chem 1997 40: 1749\u20131754","journal-title":"J Med Chem"},{"key":"BF4001031_CR43","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1053\/gast.2000.20251","volume":"119","author":"C Maillot","year":"2000","unstructured":"Maillot C, Million M, Wei JY, Gauthier A, Tache Y . Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats Gastroenterology 2000 119: 1569\u20131579","journal-title":"Gastroenterology"},{"key":"BF4001031_CR44","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1021\/jm990590f","volume":"43","author":"PJ Gilligan","year":"2000","unstructured":"Gilligan PJ, Robertson DW, Zaczek R . Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents J Med Chem 2000 43: 1641\u20131660","journal-title":"J Med Chem"},{"key":"BF4001031_CR45","first-page":"61","volume":"5 Suppl 3","author":"G Beaumont","year":"1990","unstructured":"Beaumont G . Adverse effects of antidepressants Int Clin Psychopharmacol 1990 5 Suppl 3: 61\u201366","journal-title":"Int Clin Psychopharmacol"},{"key":"BF4001031_CR46","first-page":"G884","volume":"271","author":"I Castagliuolo","year":"1996","unstructured":"Castagliuolo I et al. Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells Am J Physiol 1996 271: G884\u2013G892","journal-title":"Am J Physiol"},{"key":"BF4001031_CR47","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1037\/h0071444","volume":"18","author":"CS Hall","year":"1934","unstructured":"Hall CS . Emotional behavior in the rat J Comp Psychol 1934 18: 385\u2013403","journal-title":"J Comp Psychol"},{"key":"BF4001031_CR48","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1210\/endo.137.12.8940412","volume":"137","author":"EL Webster","year":"1996","unstructured":"Webster EL et al. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation Endocrinology 1996 137: 5747\u20135750","journal-title":"Endocrinology"},{"key":"BF4001031_CR49","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/BF02412124","volume":"89","author":"I Ushijima","year":"1986","unstructured":"Ushijima I et al. The role of adenosinergic, GABAergic and benzodiazepine systems in hyperemotionality and ulcer formation in stressed rats Psychopharmacology 1986 89: 472\u2013476","journal-title":"Psychopharmacology"},{"key":"BF4001031_CR50","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/0024-3205(85)90606-X","volume":"37","author":"Y Ida","year":"1985","unstructured":"Ida Y, Tanaka M, Tsuda A, Tsujimaru S, Nagasaki N . Attenuating effect of diazepam on stress-induced increases in noradrenaline turnover in specific brain regions of rats: antagonism by Ro 15\u20131788 Life Sci 1985 37: 2491\u20132498","journal-title":"Life Sci"},{"key":"BF4001031_CR51","first-page":"229","volume":"24","author":"SF de Boer","year":"1990","unstructured":"de Boer SF, Slangen JL, van der Gugten J . Effects of chlordiazepoxide and buspirone on plasma catecholamine and corticosterone levels in rats under basal and stress conditions Endocrinol Exp 1990 24: 229\u2013239","journal-title":"Endocrinol Exp"},{"key":"BF4001031_CR52","first-page":"127","volume":"215","author":"BR Cooper","year":"1980","unstructured":"Cooper BR, Hester TJ, Maxwell RA . Behavioral and biochemical effects of the antidepressant bupropion (Wellbutrin): evidence for selective blockade of dopamine uptake in vivo J Pharmacol Exp Ther 1980 215: 127\u2013134","journal-title":"J Pharmacol Exp Ther"},{"key":"BF4001031_CR53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0028-3908(92)90066-X","volume":"31","author":"S Caccia","year":"1992","unstructured":"Caccia S, Fracasso C, Garattini S, Guiso G, Sarati S . Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain Neuropharmacology 1992 31: 343\u2013347","journal-title":"Neuropharmacology"},{"key":"BF4001031_CR54","first-page":"318","volume":"21","author":"RF Weichert 3rd","year":"1970","unstructured":"Weichert RF 3rd, Ellison JP, Woolverton WC, Drapanas T . Postvagotomy serotonin depletion in mucosal mast cells of the rat stomach Surg Forum 1970 21: 318\u2013320","journal-title":"Surg Forum"},{"key":"BF4001031_CR55","first-page":"G0783","volume":"116","author":"KE Habib","year":"1999","unstructured":"Habib KE, Negro PJ, Sciullo D, Dib A, Gold PW . Protective role of the sympathoadrenal system against stress-induced gastric mucosal injury in the rat Gastroenterology 1999 116: G0783","journal-title":"Gastroenterology"},{"key":"BF4001031_CR56","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0024-3205(89)90205-1","volume":"45","author":"HK Bakke","year":"1989","unstructured":"Bakke HK, Murison R . Plasma corticosterone and restraint induced gastric pathology: age-related differences after administration of corticotropin releasing factor Life Sci 1989 45: 907\u2013916","journal-title":"Life Sci"},{"key":"BF4001031_CR57","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0165-0173(91)90012-W","volume":"16","author":"GB Glavin","year":"1991","unstructured":"Glavin GB et al. The neurobiology of stress ulcers Brain Res Brain Res Rev 1991 16: 301\u2013343","journal-title":"Brain Res Brain Res Rev"},{"key":"BF4001031_CR58","volume-title":"Role of brain-adrenal-gastric axis in modulating gastric responses to stress in albino rats","author":"KE Habib","year":"1994","unstructured":"Habib KE . Role of brain-adrenal-gastric axis in modulating gastric responses to stress in albino rats MSc, Minia University 1994"},{"key":"BF4001031_CR59","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/0016-5085(88)90229-6","volume":"94","author":"HJ Lenz","year":"1988","unstructured":"Lenz HJ, Burlage M, Raedler A, Greten H . Central nervous system effects of corticotropin-releasing factor on gastrointestinal transit in the rat Gastroenterology 1988 94: 598\u2013602","journal-title":"Gastroenterology"},{"key":"BF4001031_CR60","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/0016-5085(86)90690-6","volume":"91","author":"L Bueno","year":"1986","unstructured":"Bueno L et al. Effects of corticotropin-releasing factor on plasma motilin and somatostatin levels and gastrointestinal motility in dogs Gastroenterology 1986 91: 884\u2013889","journal-title":"Gastroenterology"},{"key":"BF4001031_CR61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1749-6632.1990.tb16159.x","volume":"597","author":"R Murison","year":"1990","unstructured":"Murison R, Bakke HK . The role of corticotropin-releasing factor in rat gastric ulcerogenesis Ann N Y Acad Sci 1990 597: 71\u201380","journal-title":"Ann N Y Acad Sci"},{"key":"BF4001031_CR62","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/07420528709078504","volume":"4","author":"Y Tache","year":"1987","unstructured":"Tache Y . The peptidergic brain-gut axis: influence on gastric ulcer formation Chronobiol Int 1987 4: 11\u201317","journal-title":"Chronobiol Int"},{"key":"BF4001031_CR63","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1056\/NEJM199505183322008","volume":"332","author":"GP Chrousos","year":"1995","unstructured":"Chrousos GP . The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation N Engl J Med 1995 332: 1351\u20131362","journal-title":"N Engl J Med"},{"key":"BF4001031_CR64","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-2999(76)90319-8","volume":"35","author":"CH Cho","year":"1976","unstructured":"Cho CH, Ogle CW, Dai S . Acute gastric ulcer formation in response to electrical vagal stimulation in rats Eur J Pharmacol 1976 35: 215\u2013219","journal-title":"Eur J Pharmacol"},{"key":"BF4001031_CR65","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0024-3205(86)90646-6","volume":"39","author":"DE Hernandez","year":"1986","unstructured":"Hernandez DE . Neuroendocrine mechanisms of stress ulceration: focus on thyrotropin-releasing hormone (TRH) Life Sci 1986 39: 279\u2013296","journal-title":"Life Sci"},{"key":"BF4001031_CR66","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00006842-199109000-00002","volume":"53","author":"H Weiner","year":"1991","unstructured":"Weiner H . From simplicity to complexity (1950\u20131990): the case of peptic ulceration\u2013II. Animal studies Psychosom Med 1991 53: 491\u2013516","journal-title":"Psychosom Med"},{"key":"BF4001031_CR67","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1749-6632.1990.tb16169.x","volume":"597","author":"CV Grijalva","year":"1990","unstructured":"Grijalva CV, Novin D . The role of the hypothalamus and dorsal vagal complex in gastrointestinal function and pathophysiology Ann N Y Acad Sci 1990 597: 207\u2013222","journal-title":"Ann N Y Acad Sci"},{"key":"BF4001031_CR68","first-page":"G0782","volume":"116","author":"KE Habib","year":"1999","unstructured":"Habib KE, Negro PJ, Negro PP, Gold PW . Endogenous opioids contribute to gastric ulcerogenesis during immobilization stress in male Sprague\u2013Dawley rats. Recognition of \u03b2-endorphin immunoreactivity in the gastric mucosa Gastroenterology 1999 116: G0782","journal-title":"Gastroenterology"},{"key":"BF4001031_CR69","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1136\/gut.42.6.845","volume":"42","author":"S Fukudo","year":"1998","unstructured":"Fukudo S, Nomura T, Hongo M . Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome Gut 1998 42: 845\u2013849","journal-title":"Gut"},{"key":"BF4001031_CR70","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0196-9781(84)90266-3","volume":"5","author":"P Petrusz","year":"1984","unstructured":"Petrusz P et al. Corticotropin-releasing factor (CRF)-like immunoreactivity in the gastro-entero-pancreatic endocrine system Peptides 1984 5: 71\u201378","journal-title":"Peptides"},{"key":"BF4001031_CR71","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0006-291X(84)90486-8","volume":"122","author":"HJ Wolter","year":"1984","unstructured":"Wolter HJ . Corticotropin-releasing factor is contained within perikarya and nerve fibres of rat duodenum Biochem Biophys Res Commun 1984 122: 381\u2013387","journal-title":"Biochem Biophys Res Commun"},{"key":"BF4001031_CR72","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0016-5085(94)90743-9","volume":"106","author":"Y Kawahito","year":"1994","unstructured":"Kawahito Y et al. Local secretion of corticotropin-releasing hormone by enterochromaffin cells in human colon Gastroenterology 1994 106: 859\u2013865","journal-title":"Gastroenterology"},{"key":"BF4001031_CR73","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/gut.37.4.544","volume":"37","author":"Y Kawahito","year":"1995","unstructured":"Kawahito Y et al. Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis Gut 1995 37: 544\u2013551","journal-title":"Gut"},{"key":"BF4001031_CR74","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0024-3205(97)00014-3","volume":"60","author":"Y Iwakiri","year":"1997","unstructured":"Iwakiri Y, Chijiiwa Y, Motomura Y, Osame M, Nawata H . Presence of functional receptors for corticotropin releasing hormone in caecal circular smooth muscle cells of guinea pig Life Sci 1997 60: 857\u2013864","journal-title":"Life Sci"},{"key":"BF4001031_CR75","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-2999(92)90256-4","volume":"211","author":"M Hanani","year":"1992","unstructured":"Hanani M, Wood JD . Corticotropin-releasing hormone excites myenteric neurons in the guinea-pig small intestine Eur J Pharmacol 1992 211: 23\u201327","journal-title":"Eur J Pharmacol"},{"key":"BF4001031_CR76","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1365-2680.1998.1860319.x","volume":"18","author":"R Mancinelli","year":"1998","unstructured":"Mancinelli R, Azzena GB, Diana M, Forgione A, Fratta W . In vitro excitatory actions of corticotropin-releasing factor on rat colonic motility J Auton Pharmacol 1998 18: 319\u2013324","journal-title":"J Auton Pharmacol"},{"key":"BF4001031_CR77","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0304-3940(99)00349-3","volume":"267","author":"S Harada","year":"1999","unstructured":"Harada S et al. Urocortin mRNA is expressed in the enteric nervous system of the rat Neurosci Lett 1999 267: 125\u2013128","journal-title":"Neurosci Lett"},{"key":"BF4001031_CR78","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0196-9781(00)00335-1","volume":"21","author":"Y Muramatsu","year":"2000","unstructured":"Muramatsu Y et al. Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa Peptides 2000 21: 1799\u20131809","journal-title":"Peptides"},{"key":"BF4001031_CR79","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1096-9861(20000221)417:4<399::AID-CNE2>3.0.CO;2-W","volume":"417","author":"RJ Valentino","year":"2000","unstructured":"Valentino RJ, Kosboth M, Colflesh M, Miselis RR . Transneuronal labeling from the rat distal colon: anatomic evidence for regulation of distal colon function by a pontine corticotropin-releasing factor system J Comp Neurol 2000 417: 399\u2013414","journal-title":"J Comp Neurol"},{"key":"BF4001031_CR80","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1023\/A:1018820315549","volume":"42","author":"WE Whitehead","year":"1997","unstructured":"Whitehead WE, Crowell MD, Davidoff AL, Palsson OS, Schuster MM . Pain from rectal distension in women with irritable bowel syndrome: relationship to sexual abuse Dig Dis Sci 1997 42: 796\u2013804","journal-title":"Dig Dis Sci"},{"key":"BF4001031_CR81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2982.1996.tb00237.x","volume":"8","author":"T Lembo","year":"1996","unstructured":"Lembo T et al. Effects of the corticotropin-releasing factor (CRF) on rectal afferent nerves in humans Neurogastroenterol Motil 1996 8: 9\u201318","journal-title":"Neurogastroenterol Motil"},{"key":"BF4001031_CR82","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0006-8993(97)00116-9","volume":"756","author":"SM Lechner","year":"1997","unstructured":"Lechner SM, Curtis AL, Brons R, Valentino RJ . Locus coeruleus activation by colon distention: role of corticotropin-releasing factor and excitatory amino acids Brain Res 1997 756: 114\u2013124","journal-title":"Brain Res"},{"key":"BF4001031_CR83","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0006-8993(94)90352-2","volume":"644","author":"H Monnikes","year":"1994","unstructured":"Monnikes H, Schmidt BG, Tebbe J, Bauer C, Tache Y . Microinfusion of corticotropin releasing factor into the locus coeruleus\/subcoeruleus nuclei stimulates colonic motor function in rats Brain Res 1994 644: 101\u2013108","journal-title":"Brain Res"},{"key":"BF4001031_CR84","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1749-6632.1995.tb44668.x","volume":"771","author":"AE Calogero","year":"1995","unstructured":"Calogero AE . Neurotransmitter regulation of the hypothalamic corticotropin-releasing hormone neuron Ann N Y Acad Sci 1995 771: 31\u201340","journal-title":"Ann N Y Acad Sci"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4001031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001031","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:42:18Z","timestamp":1648784538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4001031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,1]]},"references-count":84,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,6,1]]}},"alternative-id":["BF4001031"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4001031","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,1]]},"assertion":[{"value":"22 May 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2002","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}