{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:54:44Z","timestamp":1762160084785},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2003,9,29]],"date-time":"2003-09-29T00:00:00Z","timestamp":1064793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,9,29]],"date-time":"2003-09-29T00:00:00Z","timestamp":1064793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2003,10,1]]},"DOI":"10.1038\/sj.mp.4001389","type":"journal-article","created":{"date-parts":[[2003,9,29]],"date-time":"2003-09-29T13:49:47Z","timestamp":1064843387000},"page":"863-878","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes"],"prefix":"10.1038","volume":"8","author":[{"given":"Z K","family":"Mirnics","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Mirnics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Terrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Sisodia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N F","family":"Schor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,9,29]]},"reference":[{"key":"BF4001389_CR1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/34910","volume":"391","author":"B De Strooper","year":"1998","unstructured":"De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W et al. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 1998; 391: 387\u2013390.","journal-title":"Nature"},{"key":"BF4001389_CR2","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1073\/pnas.96.12.6959","volume":"96","author":"W Song","year":"1999","unstructured":"Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA . Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci USA 1999; 96: 6959\u20136963.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001389_CR3","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1126\/science.1065412","volume":"294","author":"CY Ni","year":"2001","unstructured":"Ni CY, Murphy MP, Golde TE, Carpenter G . gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 2001; 294: 2179\u20132181.","journal-title":"Science"},{"key":"BF4001389_CR4","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0166-2236(00)01987-1","volume":"24","author":"SS Sisodia","year":"2001","unstructured":"Sisodia SS, Annaert W, Kim SH, De Strooper B . Gamma-secretase: never more enigmatic. Trends Neurosci 2001; 24: S2\u2013S6.","journal-title":"Trends Neurosci"},{"key":"BF4001389_CR5","doi-asserted-by":"crossref","first-page":"11039","DOI":"10.1073\/pnas.211352598","volume":"98","author":"DJ Selkoe","year":"2001","unstructured":"Selkoe DJ . Presenilin, Notch, and the genesis and treatment of Alzheimer's disease. Proc Natl Acad Sci USA 2001; 98: 11039\u201311041.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001389_CR6","doi-asserted-by":"crossref","first-page":"49976","DOI":"10.1074\/jbc.M210179200","volume":"277","author":"DY Kim","year":"2002","unstructured":"Kim DY, Ingano LA, Kovacs DM . Nectin-1 alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin\/gamma-secretase-like cleavage. J Biol Chem 2002; 277: 49976\u201349981.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR7","doi-asserted-by":"crossref","first-page":"35113","DOI":"10.1074\/jbc.M204446200","volume":"277","author":"WT Kimberly","year":"2002","unstructured":"Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ . Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem 2002; 277: 35113\u201335117.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR8","doi-asserted-by":"crossref","first-page":"44754","DOI":"10.1074\/jbc.M206872200","volume":"277","author":"S Lammich","year":"2002","unstructured":"Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK et al. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem 2002; 277: 44754\u201344759.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR9","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/emboj\/21.8.1948","volume":"21","author":"P Marambaud","year":"2002","unstructured":"Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V et al. A presenilin-1\/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J 2002; 21: 1948\u20131956.","journal-title":"EMBO J"},{"key":"BF4001389_CR10","doi-asserted-by":"crossref","first-page":"18736","DOI":"10.1074\/jbc.M201979200","volume":"277","author":"P May","year":"2002","unstructured":"May P, Reddy YK, Herz J . Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem 2002; 277: 18736\u201318743.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrn785","volume":"3","author":"SS Sisodia","year":"2002","unstructured":"Sisodia SS, St George-Hyslop PH . Gamma-secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci 2002; 3: 281\u2013290.","journal-title":"Nat Rev Neurosci"},{"key":"BF4001389_CR12","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1074\/jbc.C200711200","volume":"278","author":"T Ikeuchi","year":"2003","unstructured":"Ikeuchi T, Sisodia SS . The Notch ligands, delta1 and Jagged2, are substrates for presenilin-dependent \u2018gamma-secretase\u2019 cleavage. J Biol Chem 2003; 278: 7751\u20137754.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR13","doi-asserted-by":"crossref","first-page":"11223","DOI":"10.1021\/bi991080q","volume":"38","author":"MS Wolfe","year":"1999","unstructured":"Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ . Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry 1999; 38: 11223\u201311230.","journal-title":"Biochemistry"},{"key":"BF4001389_CR14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1021\/bi026888g","volume":"42","author":"WT Kimberly","year":"2003","unstructured":"Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T et al. Notch and the amyloid precursor protein are cleaved by similar gamma- secretase(s). Biochemistry 2003; 42: 137\u2013144.","journal-title":"Biochemistry"},{"key":"BF4001389_CR15","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","volume":"2","author":"D Scheuner","year":"1996","unstructured":"Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996; 2: 864\u2013870.","journal-title":"Nat Med"},{"key":"BF4001389_CR16","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","volume":"17","author":"DR Borchelt","year":"1996","unstructured":"Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42\/1-40 ratio in vitro and in vivo. Neuron 1996; 17: 1005\u20131013.","journal-title":"Neuron"},{"key":"BF4001389_CR17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.neuro.21.1.479","volume":"21","author":"DL Price","year":"1998","unstructured":"Price DL, Sisodia SS . Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci 1998; 21: 479\u2013505.","journal-title":"Annu Rev Neurosci"},{"key":"BF4001389_CR18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/nbdi.1998.0183","volume":"5","author":"M Citron","year":"1998","unstructured":"Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W et al. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiol Dis 1998; 5: 107\u2013116.","journal-title":"Neurobiol Dis"},{"key":"BF4001389_CR19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0092-8674(00)80244-5","volume":"89","author":"J Shen","year":"1997","unstructured":"Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S . Skeletal and CNS defects in presenilin-1-deficient mice. Cell 1997; 89: 629\u2013639.","journal-title":"Cell"},{"key":"BF4001389_CR20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/387288a0","volume":"387","author":"PC Wong","year":"1997","unstructured":"Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME et al. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 1997; 387: 288\u2013292.","journal-title":"Nature"},{"key":"BF4001389_CR21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4615-4869-0_9","volume":"446","author":"PC Wong","year":"1998","unstructured":"Wong PC, Borchelt DR, Lee MK, Pardo CA, Thinakaran G, Martin LJ et al. Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models. Adv Exp Med Biol 1998; 446: 145\u2013159.","journal-title":"Transgenic models. Adv Exp Med Biol"},{"key":"BF4001389_CR22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0896-6273(00)80998-8","volume":"20","author":"JA Davis","year":"1998","unstructured":"Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL et al. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron 1998; 20: 603\u2013609.","journal-title":"Neuron"},{"key":"BF4001389_CR23","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0960-9822(99)80331-5","volume":"9","author":"D Hartmann","year":"1999","unstructured":"Hartmann D, De Strooper B, Saftig P . Presenilin-1 deficiency leads to loss of Cajal\u2013Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly. Curr Biol 1999; 9: 719\u2013727.","journal-title":"Curr Biol"},{"key":"BF4001389_CR24","doi-asserted-by":"crossref","first-page":"11872","DOI":"10.1073\/pnas.96.21.11872","volume":"96","author":"A Herreman","year":"1999","unstructured":"Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci USA 1999; 96: 11872\u201311877.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001389_CR25","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1242\/dev.127.12.2593","volume":"127","author":"M Handler","year":"2000","unstructured":"Handler M, Yang X, Shen J . Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 2000; 127: 2593\u20132606.","journal-title":"Development"},{"key":"BF4001389_CR26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/35017105","volume":"2","author":"A Herreman","year":"2000","unstructured":"Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B . Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. Nat Cell Biol 2000; 2: 461\u2013462.","journal-title":"Nat Cell Biol"},{"key":"BF4001389_CR27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s004060050099","volume":"249","author":"P Saftig","year":"1999","unstructured":"Saftig P, Hartmann D, De Strooper B . The function of presenilin-1 in amyloid beta-peptide generation and brain development. Eur Arch Psychiatry Clin Neurosci 1999; 249: 271\u2013279.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"BF4001389_CR28","doi-asserted-by":"crossref","first-page":"7932","DOI":"10.1073\/pnas.96.14.7932","volume":"96","author":"AL Schwarzman","year":"1999","unstructured":"Schwarzman AL, Singh N, Tsiper M, Gregori L, Dranovsky A, Vitek MP et al. Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix. Proc Natl Acad Sci USA 1999; 96: 7932\u20137937.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001389_CR29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(99)01664-6","volume":"465","author":"AA Johnsingh","year":"2000","unstructured":"Johnsingh AA, Johnston JM, Merz G, Xu J, Kotula L, Jacobsen JS et al. Altered binding of mutated presenilin with cytoskeleton-interacting proteins. FEBS Lett 2000; 465: 53\u201358.","journal-title":"FEBS Lett"},{"key":"BF4001389_CR30","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/excr.2001.5329","volume":"269","author":"L Benussi","year":"2001","unstructured":"Benussi L, Alberici A, Mayhaus M, Langer U, Ghidoni R, Mazzoli F et al. Detection of the presenilin 1 COOH-terminal fragment in the extracellular compartment: a release enhanced by apoptosis. Exp Cell Res 2001; 269: 256\u2013265.","journal-title":"Exp Cell Res"},{"key":"BF4001389_CR31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3940(01)02399-0","volume":"316","author":"O Wirths","year":"2001","unstructured":"Wirths O, Multhaup G, Czech C, Blanchard V, Tremp G, Pradier L et al. Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett 2001; 316: 145\u2013148.","journal-title":"Neurosci Lett"},{"key":"BF4001389_CR32","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1046\/j.1471-4159.2002.01182.x","volume":"83","author":"C Song","year":"2002","unstructured":"Song C, Perides G, Wang D, Liu YF . Beta-amyloid peptide induces formation of actin stress fibers through p38 mitogen-activated protein kinase. J Neurochem 2002; 83: 828\u2013836.","journal-title":"J Neurochem"},{"key":"BF4001389_CR33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0169-328X(02)00491-6","volume":"109","author":"J Liauw","year":"2002","unstructured":"Liauw J, Nguyen V, Huang J, St George-Hyslop P, Rozmahel R . Differential display analysis of presenilin 1-deficient mouse brains. Brain Res Mol Brain Res 2002; 109: 56\u201362.","journal-title":"Brain Res Mol Brain Res"},{"key":"BF4001389_CR34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/4447","volume":"21","author":"RJ Lipshutz","year":"1999","unstructured":"Lipshutz RJ, Fodor SP, Gingeras TR, Lockhart DJ . High density synthetic oligonucleotide arrays. Nat Genet 1999; 21: 20\u201324.","journal-title":"Nat Genet"},{"key":"BF4001389_CR35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/nar\/gkg121","volume":"31","author":"G Liu","year":"2003","unstructured":"Liu G, Loraine AE, Shigeta R, Cline M, Cheng J, Valmeekam V et al. NetAffx: Affymetrix probesets and annotations. Nucleic Acids Res 2003; 31: 82\u201386.","journal-title":"Nucleic Acids Res"},{"key":"BF4001389_CR36","first-page":"75","volume":"8","author":"A Califano","year":"2000","unstructured":"Califano A, Stolovitzky G, Tu Y . Analysis of gene expression microarrays for phenotype classification. Proc Int Conf Intell Syst Mol Biol 2000; 8: 75\u201385.","journal-title":"Proc Int Conf Intell Syst Mol Biol"},{"key":"BF4001389_CR37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0896-6273(00)00085-4","volume":"28","author":"K Mirnics","year":"2000","unstructured":"Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P . Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 2000; 28: 53\u201367.","journal-title":"Neuron"},{"key":"BF4001389_CR38","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0166-2236(00)01862-2","volume":"24","author":"K Mirnics","year":"2001","unstructured":"Mirnics K, Middleton FA, Lewis DA, Levitt P . Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci 2001; 24: 479\u2013486.","journal-title":"Trends Neurosci"},{"key":"BF4001389_CR39","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1176\/appi.ajp.158.9.1384","volume":"158","author":"K Mirnics","year":"2001","unstructured":"Mirnics K, Middleton FA, Lewis DA, Levitt P . The human genome: gene expression profiling and schizophrenia. Am J Psychiatry 2001; 158: 1384.","journal-title":"Am J Psychiatry"},{"key":"BF4001389_CR40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S1471-4914(01)02067-6","volume":"7","author":"K Mirnics","year":"2001","unstructured":"Mirnics K, Lewis DA . Genes and subtypes of schizophrenia. Trends Mol Med 2001; 7: 281\u2013283.","journal-title":"Trends Mol Med"},{"key":"BF4001389_CR41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0301-0082(96)00038-X","volume":"50","author":"E Masliah","year":"1996","unstructured":"Masliah E, Mallory M, Veinbergs I, Miller A, Samuel W . Alterations in apolipoprotein E expression during aging and neurodegeneration. Prog Neurobiol 1996; 50: 493\u2013503.","journal-title":"Prog Neurobiol"},{"key":"BF4001389_CR42","first-page":"484","volume":"153","author":"DL Price","year":"1997","unstructured":"Price DL, Wong PC, Borchelt DR, Pardo CA, Thinakaran G, Doan AP et al. Amyotrophic lateral sclerosis and Alzheimer disease. Les-sons from model systems. Rev Neurol (Paris) 1997; 153: 484\u2013495.","journal-title":"Rev Neurol (Paris)"},{"key":"BF4001389_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(00)00550-9","volume":"103","author":"WK Dowjat","year":"2001","unstructured":"Dowjat WK, Wisniewski H, Wisniewski T . Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments. Neuroscience 2001; 103: 1\u20138.","journal-title":"Neuroscience"},{"key":"BF4001389_CR44","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/jnr.10351","volume":"70","author":"V Colangelo","year":"2002","unstructured":"Colangelo V, Schurr J, Ball MJ, Pelaez RP, Bazan NG, Lukiw WJ . Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J Neurosci Res 2002; 70: 462\u2013473.","journal-title":"J Neurosci Res"},{"key":"BF4001389_CR45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1385\/NMM:2:2:089","volume":"2","author":"G Morfini","year":"2002","unstructured":"Morfini G, Pigino G, Beffert U, Busciglio J, Brady ST . Fast axonal transport misregulation and Alzheimer's disease. Neuromolecular Med 2002; 2: 89\u201399.","journal-title":"Neuromolecular Med"},{"key":"BF4001389_CR46","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S1357-2725(97)89968-2","volume":"29","author":"R Kageyama","year":"1997","unstructured":"Kageyama R, Ishibashi M, Takebayashi K, Tomita K . bHLH transcription factors and mammalian neuronal differentiation. Int J Biochem Cell Biol 1997; 29: 1389\u20131399.","journal-title":"Int J Biochem Cell Biol"},{"key":"BF4001389_CR47","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0006-2952(98)00209-3","volume":"56","author":"C Lambert de Rouvroit","year":"1998","unstructured":"Lambert de Rouvroit C, Goffinet AM . A new view of early cortical development. Biochem Pharmacol 1998; 56: 1403\u20131409.","journal-title":"Biochem Pharmacol"},{"key":"BF4001389_CR48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0378-1119(00)00290-0","volume":"254","author":"M Ueno","year":"2000","unstructured":"Ueno M, Kimura N, Nakashima K, Saito-Ohara F, Inazawa J, Taga T . Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1. Gene 2000; 254: 29\u201335.","journal-title":"Gene"},{"key":"BF4001389_CR49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3727\/000000001783992597","volume":"9","author":"H Zhou","year":"2001","unstructured":"Zhou H, Hughes DE, Major ML, Yoo K, Pesold C, Costa RH . Atypical mouse cerebellar development is caused by ectopic expression of the forkhead box transcription factor HNF-3beta. Gene Express 2001; 9: 217\u2013236.","journal-title":"Gene Express"},{"key":"BF4001389_CR50","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/35005118","volume":"404","author":"YP Hsueh","year":"2000","unstructured":"Hsueh YP, Wang TF, Yang FC, Sheng M . Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK\/LIN-2. Nature 2000; 404: 298\u2013302.","journal-title":"Nature"},{"key":"BF4001389_CR51","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0896-6273(00)80861-2","volume":"24","author":"T Hiesberger","year":"1999","unstructured":"Hiesberger T, Trommsdorff M, Howell BW, Goffinet A, Mumby MC, Cooper JA et al. Direct binding of reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 1999; 24: 481\u2013489.","journal-title":"Neuron"},{"key":"BF4001389_CR52","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/emboj\/18.8.2196","volume":"18","author":"T Ohtsuka","year":"1999","unstructured":"Ohtsuka T, Ishibashi M, Gradwohl G, Nakanishi S, Guillemot F, Kageyama R . Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J 1999; 18: 2196\u20132207.","journal-title":"EMBO J"},{"key":"BF4001389_CR53","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.cr.7290016","volume":"9","author":"R Kageyama","year":"1999","unstructured":"Kageyama R, Ohtsuka T . The Notch-Hes pathway in mammalian neural development. Cell Res 1999; 9: 179\u2013188.","journal-title":"Cell Res"},{"key":"BF4001389_CR54","doi-asserted-by":"crossref","first-page":"8763","DOI":"10.1074\/jbc.C100758200","volume":"277","author":"P Kabos","year":"2002","unstructured":"Kabos P, Kabosova A, Neuman T . Blocking HES1 expression initiates GABAergic differentiation and induces the expression of p21(CIP1\/WAF1) in human neural stem cells. J Biol Chem 2002; 277: 8763\u20138766.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR55","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0092-8674(00)00032-5","volume":"102","author":"M Bothwell","year":"2000","unstructured":"Bothwell M, Giniger E . Alzheimer's disease: neurodevelopment converges with neurodegeneration. Cell 2000; 102: 271\u2013273.","journal-title":"Cell"},{"key":"BF4001389_CR56","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0079-6123(02)36024-2","volume":"136","author":"A Fairen","year":"2002","unstructured":"Fairen A, Morante-Oria J, Frassoni C . The surface of the developing cerebral cortex: still special cells one century later. Prog Brain Res 2002; 136: 281\u2013291.","journal-title":"Prog Brain Res"},{"key":"BF4001389_CR57","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0736-5748(02)00040-0","volume":"20","author":"MM Sobeih","year":"2002","unstructured":"Sobeih MM, Corfas G . Extracellular factors that regulate neuronal migration in the central nervous system. Int J Dev Neurosci 2002; 20: 349\u2013357.","journal-title":"Int J Dev Neurosci"},{"key":"BF4001389_CR58","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1523\/JNEUROSCI.22-14-06029.2002","volume":"22","author":"W Halfter","year":"2002","unstructured":"Halfter W, Dong S, Yip YP, Willem M, Mayer U . A critical function of the pial basement membrane in cortical histogenesis. J Neurosci 2002; 22: 6029\u20136040.","journal-title":"J Neurosci"},{"key":"BF4001389_CR59","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/S0022-2275(20)31967-2","volume":"41","author":"T Helledie","year":"2000","unstructured":"Helledie T, Antonius M, Sorensen RV, Hertzel AV, Bernlohr DA, Kolvraa S et al. Lipid-binding proteins modulate ligand-dependent trans-activation by peroxisome proliferator-activated receptors and localize to the nucleus as well as the cytoplasm. J Lipid Res 2000; 41: 1740\u20131751.","journal-title":"J Lipid Res"},{"key":"BF4001389_CR60","doi-asserted-by":"crossref","first-page":"294S","DOI":"10.1093\/jn\/130.2.294S","volume":"130","author":"J Knudsen","year":"2000","unstructured":"Knudsen J, Neergaard TB, Gaigg B, Jensen MV, Hansen JK . Role of acyl-CoA binding protein in acyl-CoA metabolism and acyl-CoA-mediated cell signaling. J Nutr 2000; 130: 294S\u2013298S.","journal-title":"J Nutr"},{"key":"BF4001389_CR61","doi-asserted-by":"crossref","first-page":"22514","DOI":"10.1074\/jbc.271.37.22514","volume":"271","author":"CK Schjerling","year":"1996","unstructured":"Schjerling CK, Hummel R, Hansen JK, Borsting C, Mikkelsen JM, Kristiansen K et al. Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae. J Biol Chem 1996; 271: 22514\u201322521.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR62","doi-asserted-by":"crossref","first-page":"34317","DOI":"10.1074\/jbc.274.48.34317","volume":"274","author":"MC Hunt","year":"1999","unstructured":"Hunt MC, Nousiainen SE, Huttunen MK, Orii KE, Svensson LT, Alexson SE . Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. J Biol Chem 1999; 274: 34317\u201334326.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR63","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1073\/pnas.051619898","volume":"98","author":"C Wolfrum","year":"2001","unstructured":"Wolfrum C, Borrmann CM, Borchers T, Spener F . Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha- and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus. Proc Natl Acad Sci USA 2001; 98: 2323\u20132328.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001389_CR64","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1096\/fasebj.7.2.8440409","volume":"7","author":"AC Ross","year":"1993","unstructured":"Ross AC . Cellular metabolism and activation of retinoids: roles of cellular retinoid-binding proteins. FASEB J 1993; 7: 317\u2013327.","journal-title":"FASEB J"},{"key":"BF4001389_CR65","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1194\/jlr.M200376-JLR200","volume":"44","author":"K Hellemans","year":"2003","unstructured":"Hellemans K, Rombouts K, Quartier E, Dittie AS, Knorr A, Michalik L et al. PPAR{beta} regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. J Lipid Res 2003; 44: 280\u2013295.","journal-title":"J Lipid Res"},{"key":"BF4001389_CR66","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1388-1981(00)00155-4","volume":"1529","author":"J Nimpf","year":"2000","unstructured":"Nimpf J, Schneider WJ . From cholesterol transport to signal transduction: low density lipoprotein receptor, very low density lipoprotein receptor, and apolipoprotein E receptor-2. Biochim Biophys Acta 2000; 1529: 287\u2013298.","journal-title":"Biochim Biophys Acta"},{"key":"BF4001389_CR67","doi-asserted-by":"crossref","first-page":"11420","DOI":"10.1074\/jbc.M008782200","volume":"276","author":"T Fujino","year":"2001","unstructured":"Fujino T, Kondo J, Ishikawa M, Morikawa K, Yamamoto TT . Acetyl\u2013CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J Biol Chem 2001; 276: 11420\u201311426.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR68","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0022-2275(20)30266-2","volume":"42","author":"S Santamarina-Fojo","year":"2001","unstructured":"Santamarina-Fojo S, Remaley AT, Neufeld EB, Brewer Jr HB . Regulation and intracellular trafficking of the ABCA1 transporter. J Lipid Res 2001; 42: 1339\u20131345.","journal-title":"J Lipid Res"},{"key":"BF4001389_CR69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0952-3278(02)00261-2","volume":"68","author":"M Miyazaki","year":"2003","unstructured":"Miyazaki M, Ntambi JM . Role of stearoyl-coenzyme A desaturase in lipid metabolism. Prostaglandins Leukot Essent Fatty Acids 2003; 68: 113\u2013121.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"BF4001389_CR70","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00041433-200302000-00007","volume":"14","author":"ME Brousseau","year":"2003","unstructured":"Brousseau ME . ATP-binding cassette transporter A1, fatty acids, and cholesterol absorption. Curr Opin Lipidol 2003; 14: 35\u201340.","journal-title":"Curr Opin Lipidol"},{"key":"BF4001389_CR71","first-page":"2","volume":"2","author":"C Joyce","year":"2003","unstructured":"Joyce C, Freeman L, Brewer Jr HB, Santamarina-Fojo S . Study of ABCA1 function in transgenic mice. Arterioscler Thromb Vasc Biol 2003; 2: 2.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BF4001389_CR72","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1074\/jbc.M208288200","volume":"278","author":"K Fujimori","year":"2003","unstructured":"Fujimori K, Fujitani Y, Kadoyama K, Kumanogoh H, Ishikawa K, Urade Y . Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells. J Biol Chem 2003; 278: 6018\u20136026.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR73","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1097\/00001756-199412000-00019","volume":"5","author":"T Kainu","year":"1994","unstructured":"Kainu T, Wikstrom AC, Gustafsson JA, Pelto-Huikko M . Localization of the peroxisome proliferator-activated receptor in the brain. Neuroreport 1994; 5: 2481\u20132485.","journal-title":"Neuroreport"},{"key":"BF4001389_CR74","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1006\/bbrc.1995.2871","volume":"217","author":"G Xing","year":"1995","unstructured":"Xing G, Zhang L, Heynen T, Yoshikawa T, Smith M, Weiss S et al. Rat PPAR delta contains a CGG triplet repeat and is prominently expressed in the thalamic nuclei. Biochem Biophys Res Commun 1995; 217: 1015\u20131025.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF4001389_CR75","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0300-9084(97)81506-4","volume":"79","author":"FJ Gonzalez","year":"1997","unstructured":"Gonzalez FJ . Recent update on the PPAR alpha-null mouse. Biochimie 1997; 79: 139\u2013144.","journal-title":"Biochimie"},{"key":"BF4001389_CR76","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0024-3205(01)01221-8","volume":"69","author":"MC Hung","year":"2001","unstructured":"Hung MC, Hayase K, Yoshida R, Sato M, Imaizumi K . Cerebral protein kinase C and its mRNA level in apolipoprotein E-deficient mice. Life Sci 2001; 69: 1419\u20131427.","journal-title":"Life Sci"},{"key":"BF4001389_CR77","doi-asserted-by":"crossref","first-page":"29729","DOI":"10.1074\/jbc.272.47.29729","volume":"272","author":"C Garces","year":"1997","unstructured":"Garces C, Ruiz-Hidalgo MJ, de Mora JF, Park C, Miele L, Goldstein J et al. Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J Biol Chem 1997; 272: 29729\u201329734.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR78","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/sj.cdd.4401036","volume":"9","author":"BJ Nickoloff","year":"2002","unstructured":"Nickoloff BJ, Qin JZ, Chaturvedi V, Denning MF, Bonish B, Miele L . Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ 2002; 9: 842\u2013855.","journal-title":"Cell Death Differ"},{"key":"BF4001389_CR79","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0959-4388(91)90067-H","volume":"1","author":"M Goedert","year":"1991","unstructured":"Goedert M, Sisodia SS, Price DL . Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease. Curr Opin Neurobiol 1991; 1: 441\u2013447.","journal-title":"Curr Opin Neurobiol"},{"key":"BF4001389_CR80","first-page":"59","volume":"5","author":"SS Sisodia","year":"1995","unstructured":"Sisodia SS, Martin LJ, Walker LC, Borchelt DR, Price DL . Cellular and molecular biology of Alzheimer's disease and animal models. Neuroimaging Clin N Am 1995; 5: 59\u201368.","journal-title":"Neuroimaging Clin N Am"},{"key":"BF4001389_CR81","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.143.3.777","volume":"143","author":"A Ebneth","year":"1998","unstructured":"Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B, Mandelkow E . Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. J Cell Biol 1998; 143: 777\u2013794.","journal-title":"J Cell Biol"},{"key":"BF4001389_CR82","first-page":"383","volume":"6","author":"MD Neely","year":"2002","unstructured":"Neely MD, Montine TJ . Csf lipoproteins and Alzheimer s disease. J Nutr Health Aging 2002; 6: 383\u2013391.","journal-title":"J Nutr Health Aging"},{"key":"BF4001389_CR83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.2002.8017","volume":"178","author":"RS Chung","year":"2002","unstructured":"Chung RS, Vickers JC, Chuah MI, Eckhardt BL, West AK . Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting. Exp Neurol 2002; 178: 1\u201312.","journal-title":"Exp Neurol"},{"key":"BF4001389_CR84","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0168-0102(02)00057-3","volume":"43","author":"I Miyazaki","year":"2002","unstructured":"Miyazaki I, Asanuma M, Higashi Y, Sogawa CA, Tanaka K, Ogawa N . Age-related changes in expression of metallothionein-III in rat brain. Neurosci Res 2002; 43: 323\u2013333.","journal-title":"Neurosci Res"},{"key":"BF4001389_CR85","doi-asserted-by":"crossref","first-page":"32353","DOI":"10.1074\/jbc.M111263200","volume":"277","author":"Y Uchida","year":"2002","unstructured":"Uchida Y, Gomi F, Masumizu T, Miura Y . Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. J Biol Chem 2002; 277: 32353\u201332359.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR86","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1073\/pnas.98.4.1930","volume":"98","author":"CH Jiang","year":"2001","unstructured":"Jiang CH, Tsien JZ, Schultz PG, Hu Y . The effects of aging on gene expression in the hypothalamus and cortex of mice. Proc Natl Acad Sci USA 2001; 98: 1930\u20131934.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001389_CR87","first-page":"22","volume":"22","author":"RP Koldamova","year":"2003","unstructured":"Koldamova RP, Lefterov IM, Ikonomovic MD, Skoko J, Lefterov PI, Isanski BA et al. 22R-Hydroxycholesterol and 9-cis-retinoic acid induce ABCA1 transporter expression and cholesterol efflux in brain cells and decrease Abeta secretion. J Biol Chem 2003; 22: 22.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR88","doi-asserted-by":"crossref","first-page":"6998","DOI":"10.1074\/jbc.273.12.6998","volume":"273","author":"P Milev","year":"1998","unstructured":"Milev P, Chiba A, Haring M, Rauvala H, Schachner M, Ranscht B et al. High affinity binding and overlapping localization of neurocan and phosphacan\/protein-tyrosine phosphatase-zeta\/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule. J Biol Chem 1998; 273: 6998\u20137005.","journal-title":"J Biol Chem"},{"key":"BF4001389_CR89","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1679\/aohc.65.27","volume":"65","author":"H Yanase","year":"2002","unstructured":"Yanase H, Shimizu H, Yamada K, Iwanaga T . Cellular localization of the diazepam binding inhibitor in glial cells with special reference to its coexistence with brain-type fatty acid binding protein. Arch Histol Cytol 2002; 65: 27\u201336.","journal-title":"Arch Histol Cytol"},{"key":"BF4001389_CR90","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jcp.10208","volume":"194","author":"T Iso","year":"2003","unstructured":"Iso T, Kedes L, Hamamori Y . HES and HERP families: multiple effectors of the notch signaling pathway. J Cell Physiol 2003; 194: 237\u2013255.","journal-title":"J Cell Physiol"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4001389.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001389","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001389.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T02:58:19Z","timestamp":1648781899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4001389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,29]]},"references-count":90,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10,1]]}},"alternative-id":["BF4001389"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4001389","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,29]]},"assertion":[{"value":"28 March 2003","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2003","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}