{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:37:49Z","timestamp":1778877469980,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2005,4,19]],"date-time":"2005-04-19T00:00:00Z","timestamp":1113868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,4,19]],"date-time":"2005-04-19T00:00:00Z","timestamp":1113868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2005,9,1]]},"DOI":"10.1038\/sj.mp.4001670","type":"journal-article","created":{"date-parts":[[2005,4,19]],"date-time":"2005-04-19T09:26:00Z","timestamp":1113902760000},"page":"851-860","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, Harm avoidance and minimum body mass index"],"prefix":"10.1038","volume":"10","author":[{"given":"M","family":"Ribases","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gratacos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Badia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Solano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Vallejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Fernandez-Aranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Estivill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,4,19]]},"reference":[{"key":"BF4001670_CR1","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/0140-6736(93)90768-C","volume":"341","author":"DM Garner","year":"1993","unstructured":"Garner DM . Pathogenesis of anorexia nervosa. Lancet 1993; 341: 1631\u20131635.","journal-title":"Lancet"},{"key":"BF4001670_CR2","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/nn1073","volume":"6","author":"B Xu","year":"2003","unstructured":"Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones RK et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003; 6: 736\u2013742.","journal-title":"Nat Neurosci"},{"key":"BF4001670_CR3","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1093\/emboj\/19.6.1290","volume":"19","author":"SG Kernie","year":"2000","unstructured":"Kernie SG, Liebl DJ, Parada LF . BDNF regulates eating behavior and locomotor activity in mice. EMBO J 2000; 19: 1290\u20131300.","journal-title":"EMBO J"},{"key":"BF4001670_CR4","doi-asserted-by":"publisher","first-page":"15239","DOI":"10.1073\/pnas.96.26.15239","volume":"96","author":"WE Lyons","year":"1999","unstructured":"Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci USA 1999; 96: 15239\u201315244.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001670_CR5","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1210\/mend.15.10.0706","volume":"15","author":"M Rios","year":"2001","unstructured":"Rios M, Fan G, Fekete C, Kelly J, Bates B, Kuehn R et al. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 2001; 15: 1748\u20131757.","journal-title":"Mol Endocrinol"},{"key":"BF4001670_CR6","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/sj.mp.4001281","volume":"8","author":"M Ribases","year":"2003","unstructured":"Ribases M, Gratacos M, Armengol L, de Cid R, Badia A, Jimenez L et al. Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry 2003; 8: 745\u2013751.","journal-title":"Mol Psychiatry"},{"key":"BF4001670_CR7","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/hmg\/ddh137","volume":"13","author":"M Ribases","year":"2004","unstructured":"Ribases M, Gratacos M, Fernandez-Aranda F, Bellodi L, Boni C, Anderluh M et al. Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum Mol Genet 2004; 13: 1205\u20131212.","journal-title":"Hum Mol Genet"},{"key":"BF4001670_CR8","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/sj.ejhg.5201351","volume":"13","author":"M Ribases","year":"2005","unstructured":"Ribases M, Gratacos M, Fernandez-Aranda F, Bellodi L, Boni C, Anderluh M et al. Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Eur J Hum Genet 2005; 13: 428\u2013434.","journal-title":"Eur J Hum Genet"},{"key":"BF4001670_CR9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/ajmg.b.20153","volume":"127B","author":"H Koizumi","year":"2004","unstructured":"Koizumi H, Hashimoto K, Itoh K, Nakazato M, Shimizu E, Ohgake S et al. Association between the brain-derived neurotrophic factor 196G\/A polymorphism and eating disorders. Am J Med Genet 2004; 127B: 125\u2013127.","journal-title":"Am J Med Genet"},{"key":"BF4001670_CR10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/ajmg.b.20085","volume":"124B","author":"M Gabrovsek","year":"2004","unstructured":"Gabrovsek M, Brecelj-Anderluh M, Bellodi L, Cellini E, Di Bella D, Estivill X et al. Combined family trio and case\u2013control analysis of the COMT Val158Met polymorphism in European patients with anorexia nervosa. Am J Med Genet 2004; 124B: 68\u201372.","journal-title":"Am J Med Genet"},{"key":"BF4001670_CR11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/sj.mp.4000938","volume":"7","author":"P Gorwood","year":"2002","unstructured":"Gorwood P, Ades J, Bellodi L, Cellini E, Collier DA, Di Bella D et al. The 5-HT(2A) -1438G\/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres. Mol Psychiatry 2002; 7: 90\u201394.","journal-title":"Mol Psychiatry"},{"key":"BF4001670_CR12","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1086\/379378","volume":"73","author":"M Stephens","year":"2003","unstructured":"Stephens M, Donnelly P . A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73: 1162\u20131169.","journal-title":"Am J Hum Genet"},{"key":"BF4001670_CR13","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1086\/319501","volume":"68","author":"M Stephens","year":"2001","unstructured":"Stephens M, Smith NJ, Donnelly P . A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68: 978\u2013989.","journal-title":"Am J Hum Genet"},{"key":"BF4001670_CR14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/(SICI)1098-108X(199709)22:2<195::AID-EAT12>3.0.CO;2-0","volume":"22","author":"CM Bulik","year":"1997","unstructured":"Bulik CM, Sullivan PF, Carter FA, Joyce PR . Initial manifestations of disordered eating behavior: dieting versus binging. Int J Eat Disord 1997; 22: 195\u2013201.","journal-title":"Int J Eat Disord"},{"key":"BF4001670_CR15","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1176\/appi.ajp.157.6.886","volume":"157","author":"CM Bulik","year":"2000","unstructured":"Bulik CM, Sullivan PF, Kendler KS . An empirical study of the classification of eating disorders. Am J Psychiatry 2000; 157: 886\u2013895.","journal-title":"Am J Psychiatry"},{"key":"BF4001670_CR16","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/(SICI)1098-108X(199812)24:4<371::AID-EAT4>3.0.CO;2-U","volume":"24","author":"KA Gendall","year":"1998","unstructured":"Gendall KA, Joyce PR, Sullivan PF, Bulik CM . Personality and dimensions of dietary restraint. Int J Eat Disord 1998; 24: 371\u2013379.","journal-title":"Int J Eat Disord"},{"key":"BF4001670_CR17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1086\/338446","volume":"70","author":"T Niu","year":"2002","unstructured":"Niu T, Qin ZS, Xu X, Liu JS . Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. Am J Hum Genet 2002; 70: 157\u2013169.","journal-title":"Am J Hum Genet"},{"key":"BF4001670_CR18","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0193-953X(05)70221-5","volume":"24","author":"S Wonderlich","year":"2001","unstructured":"Wonderlich S, Mitchell JE . The role of personality in the onset of eating disorders and treatment implications. Psychiatr Clin N Am 2001; 24: 249\u2013258.","journal-title":"Psychiatr Clin N Am"},{"key":"BF4001670_CR19","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1001\/archpsyc.1993.01820240059008","volume":"50","author":"CR Cloninger","year":"1993","unstructured":"Cloninger CR, Svrakic DM, Przybeck TR . A psychobiological model of temperament and character. Arch Gen Psychiatry 1993; 50: 975\u2013990.","journal-title":"Arch Gen Psychiatry"},{"key":"BF4001670_CR20","doi-asserted-by":"publisher","first-page":"6337","DOI":"10.1093\/emboj\/17.21.6337","volume":"17","author":"M Gallegos","year":"1998","unstructured":"Gallegos M, Ahringer J, Crittenden S, Kimble J . Repression by the 3\u2032 UTR of fem-3, a sex-determining gene, relies on a ubiquitous mog-dependent control in Caenorhabditis elegans. EMBO J 1998; 17: 6337\u20136347.","journal-title":"EMBO J"},{"key":"BF4001670_CR21","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/ng1047","volume":"32","author":"K Ozaki","year":"2002","unstructured":"Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 2002; 32: 650\u2013654.","journal-title":"Nat Genet"},{"key":"BF4001670_CR22","doi-asserted-by":"publisher","first-page":"16798","DOI":"10.1074\/jbc.273.27.16798","volume":"273","author":"KH Surinya","year":"1998","unstructured":"Surinya KH, Cox TC, May BK . Identification and characterization of a conserved erythroid-specific enhancer located in intron 8 of the human 5-aminolevulinate synthase 2 gene. J Biol Chem 1998; 273: 16798\u201316809.","journal-title":"J Biol Chem"},{"key":"BF4001670_CR23","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/ng1267","volume":"35","author":"S Tokuhiro","year":"2003","unstructured":"Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T et al. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet 2003; 35: 341\u2013348.","journal-title":"Nat Genet"},{"key":"BF4001670_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/1098-108X(200009)28:2<139::AID-EAT2>3.0.CO;2-G","volume":"28","author":"CM Bulik","year":"2000","unstructured":"Bulik CM, Sullivan PF, Fear JL, Pickering A . Outcome of anorexia nervosa: eating attitudes, personality, and parental bonding. Int J Eat Disord 2000; 28: 139\u2013147.","journal-title":"Int J Eat Disord"},{"key":"BF4001670_CR25","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/eat.10099","volume":"32","author":"S Fassino","year":"2002","unstructured":"Fassino S, Abbate-Daga G, Amianto F, Leombruni P, Boggio S, Rovera GG . Temperament and character profile of eating disorders: a controlled study with the Temperament and Character Inventory. Int J Eat Disord 2002; 32: 412\u2013425.","journal-title":"Int J Eat Disord"},{"key":"BF4001670_CR26","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0022-3999(01)00280-X","volume":"51","author":"S Fassino","year":"2001","unstructured":"Fassino S, Daga GA, Piero A, Leombruni P, Rovera GG . Anger and personality in eating disorders. J Psychosom Res 2001; 51: 757\u2013764.","journal-title":"J Psychosom Res"},{"key":"BF4001670_CR27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/00005053-200009000-00001","volume":"188","author":"KL Klump","year":"2000","unstructured":"Klump KL, Bulik CM, Pollice C, Halmi KA, Fichter MM, Berrettini WH et al. Temperament and character in women with anorexia nervosa. J Nerv Ment Dis 2000; 188: 559\u2013567.","journal-title":"J Nerv Ment Dis"},{"key":"BF4001670_CR28","first-page":"87","volume":"49","author":"M Tomotake","year":"2002","unstructured":"Tomotake M, Ohmori T . Personality profiles in patients with eating disorders. J Med Invest 2002; 49: 87\u201396.","journal-title":"J Med Invest"},{"key":"BF4001670_CR29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0306-4522(97)00526-5","volume":"84","author":"WJ Friedman","year":"1998","unstructured":"Friedman WJ, Black IB, Kaplan DR . Distribution of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4\/5 in the postnatal rat brain: an immunocytochemical study. Neuroscience 1998; 84: 101\u2013114.","journal-title":"Neuroscience"},{"key":"BF4001670_CR30","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/0092-8674(91)90628-C","volume":"66","author":"R Klein","year":"1991","unstructured":"Klein R, Nanduri V, Jing SA, Lamballe F, Tapley P, Bryant S et al. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 1991; 66: 395\u2013403.","journal-title":"Cell"},{"key":"BF4001670_CR31","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1086\/342288","volume":"71","author":"M Neves-Pereira","year":"2002","unstructured":"Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy JL . The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 2002; 71: 651\u2013655.","journal-title":"Am J Hum Genet"},{"key":"BF4001670_CR32","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/sj.mp.4001058","volume":"7","author":"P Sklar","year":"2002","unstructured":"Sklar P, Gabriel SB, McInnis MG, Bennett P, Lim YM, Tsan G et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry 2002; 7: 579\u2013593.","journal-title":"Mol Psychiatry"},{"key":"BF4001670_CR33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S0006-3223(03)00181-1","volume":"54","author":"E Shimizu","year":"2003","unstructured":"Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003; 54: 70\u201375.","journal-title":"Biol Psychiatry"},{"key":"BF4001670_CR34","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1086\/377003","volume":"73","author":"D Hall","year":"2003","unstructured":"Hall D, Dhilla A, Charalambous A, Gogos JA, Karayiorgou M . Sequence variants of the Brain-Derived Neurotrophic Factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am J Hum Genet 2003; 73: 370\u2013376.","journal-title":"Am J Hum Genet"},{"key":"BF4001670_CR35","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1001\/archpsyc.1991.01810300068010","volume":"48","author":"WH Kaye","year":"1991","unstructured":"Kaye WH, Gwirtsman HE, George DT, Ebert MH . Altered serotonin activity in anorexia nervosa after long-term weight restoration. Does elevated cerebrospinal fluid 5-hydroxyindoleacetic acid level correlate with rigid and obsessive behavior? Arch Gen Psychiatry 1991; 48: 556\u2013562.","journal-title":"Arch Gen Psychiatry"},{"key":"BF4001670_CR36","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1093\/ajhp\/54.18.2059","volume":"54","author":"KA Bever","year":"1997","unstructured":"Bever KA, Perry PJ . Dexfenfluramine hydrochloride: an anorexigenic agent. Am J Health Syst Pharm 1997; 54: 2059\u20132072.","journal-title":"Am J Health Syst Pharm"},{"key":"BF4001670_CR37","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1177\/070674378603100813","volume":"31","author":"W Cole","year":"1986","unstructured":"Cole W, Lapierre YD . The use of tryptophan in normal-weight bulimia. Can J Psychiatry 1986; 31: 755\u2013756.","journal-title":"Can J Psychiatry"},{"key":"BF4001670_CR38","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1001\/archpsyc.1992.01820020052007","volume":"49","author":"DC Jimerson","year":"1992","unstructured":"Jimerson DC, Lesem MD, Kaye WH, Brewerton TD . Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes. Arch Gen Psychiatry 1992; 49: 132\u2013138.","journal-title":"Arch Gen Psychiatry"},{"key":"BF4001670_CR39","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1001\/archpsyc.55.10.927","volume":"55","author":"WH Kaye","year":"1998","unstructured":"Kaye WH, Greeno CG, Moss H, Fernstrom J, Fernstrom M, Lilenfeld LR et al. Alterations in serotonin activity and psychiatric symptoms after recovery from bulimia nervosa. Arch Gen Psychiatry 1998; 55: 927\u2013935.","journal-title":"Arch Gen Psychiatry"},{"key":"BF4001670_CR40","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s002130100716","volume":"155","author":"JT Kuikka","year":"2001","unstructured":"Kuikka JT, Tammela L, Karhunen L, Rissanen A, Bergstrom KA, Naukkarinen H et al. Reduced serotonin transporter binding in binge eating women. Psychopharmacology (Berl) 2001; 155: 310\u2013314.","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4001670.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001670","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001670.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:46:59Z","timestamp":1648784819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4001670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,19]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9,1]]}},"alternative-id":["BF4001670"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4001670","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,19]]},"assertion":[{"value":"17 March 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2005","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}