{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:45:36Z","timestamp":1790250336299,"version":"4.1.0"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2005,10,1]]},"DOI":"10.1038\/sj.mp.4001694","type":"journal-article","created":{"date-parts":[[2005,6,7]],"date-time":"2005-06-07T15:02:38Z","timestamp":1118156558000},"page":"961-971","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE"],"prefix":"10.1038","volume":"10","author":[{"given":"J S","family":"Wilcoxon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A G","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J F","family":"Disterhoft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E E","family":"Redei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"BF4001694_CR1","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1111\/j.1530-0277.1999.tb04227.x","volume":"23","author":"TM Roebuck","year":"1999","unstructured":"Roebuck TM, Mattson SN, Riley EP . Behavioral and psychosocial profiles of alcohol-exposed children. Alcohol Clin Exp Res 1999; 23: 1070\u20131076.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR2","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1111\/j.1530-0277.1999.tb04077.x","volume":"23","author":"SN Mattson","year":"1999","unstructured":"Mattson SN, Goodman AM, Caine C, Delis DC, Riley EP . Executive functioning in children with heavy prenatal alcohol exposure. Alcohol Clin Exp Res 1999; 23: 1808\u20131815.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/01.ALC.0000052703.38558.B2","volume":"27","author":"EP Riley","year":"2003","unstructured":"Riley EP, Mattson SN, Li TK, Jacobson SW, Coles CD, Kodituwakku PW et al. Neurobehavioral consequences of prenatal alcohol exposure: an international perspective. Alcohol Clin Exp Res 2003; 27: 362\u2013373.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1651-2227.1994.tb13379.x","volume":"404","author":"HL Spohr","year":"1994","unstructured":"Spohr HL, Willms J, Steinhausen HC . The fetal alcohol syndrome in adolescence. Acta Paediatr Suppl 1994; 404: 19\u201326.","journal-title":"Acta Paediatr Suppl"},{"key":"BF4001694_CR5","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1530-0277.1994.tb00904.x","volume":"18","author":"AP Streissguth","year":"1994","unstructured":"Streissguth AP, Sampson PD, Olson HC, Bookstein FL, Barr HM, Scott M et al. Maternal drinking during pregnancy: attention and short-term memory in 14-year-old offspring\u2014a longitudinal prospective study. Alcohol Clin Exp Res 1994; 18: 202\u2013218.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0166-4328(03)00028-7","volume":"143","author":"DA Hamilton","year":"2003","unstructured":"Hamilton DA, Kodituwakku P, Sutherland RJ, Savage DD . Children with fetal alcohol syndrome are impaired at place learning but not cued-navigation in a virtual Morris water task. Behav Brain Res 2003; 143: 85\u201394.","journal-title":"Behav Brain Res"},{"key":"BF4001694_CR7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.1530-0277.1997.tb03743.x","volume":"21","author":"CD Coles","year":"1997","unstructured":"Coles CD, Platzman KA, Raskind-Hood CL, Brown RT, Falek A, Smith IE . A comparison of children affected by prenatal alcohol exposure and attention deficit, hyperactivity disorder. Alcohol Clin Exp Res 1997; 21: 150\u2013161.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR8","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/j.1530-0277.1998.tb03657.x","volume":"22","author":"HC Steinhasusen","year":"1998","unstructured":"Steinhasusen HC, Sphor HL . Long-term outcome of children with fetal alcohol syndrome: psychopathology, behavior and intelligence. Alcohol Clin Exp Res 1998; 22: 334\u2013338.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR9","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1176\/ajp.155.4.552","volume":"155","author":"C Famy","year":"1998","unstructured":"Famy C, Streissguth AP, Unic AS . Mental illness in adults with fetal alcohol syndrome or fetal alcohol effects. Am J Psychiatry 1998; 155: 552\u2013554.","journal-title":"Am J Psychiatry"},{"key":"BF4001694_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0892-0362(90)90094-S","volume":"12","author":"CD Driscoll","year":"1990","unstructured":"Driscoll CD, Streissguth AP, Riley EP . Prenatal alcohol exposure: comparability of effects in humans and animal models. Neurotoxicol Teratol 1990; 12: 231\u2013237.","journal-title":"Neurotoxicol Teratol"},{"key":"BF4001694_CR11","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0166-4328(90)90060-R","volume":"36","author":"C Gianoulakis","year":"1990","unstructured":"Gianoulakis C . Rats exposed prenatally to alcohol exhibit impairment in spatial-navigation test. Behav Brain Res 1990; 36: 217\u2013228.","journal-title":"Behav Brain Res"},{"key":"BF4001694_CR12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0031-9384(89)90319-3","volume":"46","author":"E Reyes","year":"1989","unstructured":"Reyes E, Wolfe J, Savage DD . The effects of prenatal alcohol exposure on radial arm maze performance in adult rats. Physiol Behav 1989; 46: 45\u201348.","journal-title":"Physiol Behav"},{"key":"BF4001694_CR13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0166-4328(05)80039-7","volume":"42","author":"B Zimmerberg","year":"1991","unstructured":"Zimmerberg B, Sukel HL, Stekler JD . Spatial learning of adult rats with fetal alcohol exposure: deficits are sex-dependent. Behav Brain Res 1991; 42: 49\u201356.","journal-title":"Behav Brain Res"},{"key":"BF4001694_CR14","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1037\/0735-7044.111.5.985","volume":"111","author":"CK Kim","year":"1997","unstructured":"Kim CK, Kalynchuk LE, Kornecook TJ, Mumby DG, Dadgar NA, Pinel JP et al. Object-recognition and spatial learning and memory in rats prenatally exposed to ethanol. Behav Neurosci 1997; 111: 985\u2013995.","journal-title":"Behav Neurosci"},{"key":"BF4001694_CR15","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/BF00443410","volume":"97","author":"HC Becker","year":"1989","unstructured":"Becker HC, Randall CL . Effects of prenatal ethanol exposure in C57BL mice on locomotor activity and passive avoidance behavior. Psychopharmacology 1989; 97: 40\u201344.","journal-title":"Psychopharmacology"},{"key":"BF4001694_CR16","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0741-8329(85)90059-X","volume":"2","author":"CD Driscoll","year":"1985","unstructured":"Driscoll CD, Riley EP, Meyer LS . Delayed taste aversion learning in pre-weaning rats exposed to alcohol prenatally. Alcohol 1985; 2: 277\u2013280.","journal-title":"Alcohol"},{"key":"BF4001694_CR17","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/tera.1420370206","volume":"37","author":"GD Gentry","year":"1988","unstructured":"Gentry GD, Middaugh LD . Prenatal ethanol weakens the efficacy of reinforcers for adult mice. Teratology 1988; 37: 135\u2013144.","journal-title":"Teratology"},{"key":"BF4001694_CR18","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1111\/j.1530-0277.2001.tb02362.x","volume":"25","author":"ML Schneider","year":"2001","unstructured":"Schneider ML, Moore CF, Kraemer GW . Moderate alcohol during pregnancy: learning and behavior in adolescent rhesus monkeys. Alcohol Clin Exp Res 2001; 25: 1383\u20131392.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR19","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0892-0362(01)00186-6","volume":"24","author":"JL Slone","year":"2002","unstructured":"Slone JL, Redei EE . Maternal alcohol and adrenalectomy: asynchrony of stress response and forced swim behavior. Neurotoxicol Teratol 2002; 24: 173\u2013178.","journal-title":"Neurotoxicol Teratol"},{"key":"BF4001694_CR20","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre M . Depression: a new animal model sensitive to antidepressant treatments. Nature 1977; 266: 730\u2013732.","journal-title":"Nature"},{"key":"BF4001694_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1053\/scnp.2001.20882","volume":"6","author":"EE Redei","year":"19200","unstructured":"Redei EE, Ahmadiyeh N, Baum AE, Sasso DA, Slone JL, Solberg LC et al. Novel animal models of affective disorders. Semin Clin Neuropsychiatry 200; 6: 43\u201367.","journal-title":"Semin Clin Neuropsychiatry"},{"key":"BF4001694_CR22","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1046\/j.1365-2265.1999.00639.x","volume":"50","author":"VJ Pop","year":"1999","unstructured":"Pop VJ, Kuijpens JL, van Baar AL, Verkerk G, van Son MM, de Vijlder JJ et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol 1999; 50: 155\u2013159.","journal-title":"Clin Endocrinol"},{"key":"BF4001694_CR23","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1056\/NEJM199908193410801","volume":"341","author":"JE Haddow","year":"1999","unstructured":"Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999; 341: 549\u2013555.","journal-title":"N Engl J Med"},{"key":"BF4001694_CR24","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1046\/j.1365-2265.2003.01822.x","volume":"59","author":"VJ Pop","year":"2003","unstructured":"Pop VJ, Brouwers EP, Vader HL, Vulsma T, van Baar AL, de Vijlder JJ . Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin Endocrinol (Oxf) 2003; 59: 282\u2013288.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BF4001694_CR25","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/j.1365-2826.2004.01243.x","volume":"16","author":"RT Zoeller","year":"2004","unstructured":"Zoeller RT, Rovet J . Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J Neuroendocrinol 2004; 16: 809\u2013818.","journal-title":"J Neuroendocrinol"},{"key":"BF4001694_CR26","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1017\/S1461145700001863","volume":"3","author":"AJ Friedhoff","year":"2000","unstructured":"Friedhoff AJ, Miller JC, Armour M, Schweitzer JW, Mohan S . Role of maternal biochemistry in fetal brain development: effect of maternal thyroidectomy on behaviour and biogenic amine metabolism in rat progeny. Int J Neuropsychopharmacol 2000; 3: 89\u201397.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BF4001694_CR27","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1172\/JCI200316262","volume":"111","author":"R Lavado-Autric","year":"2003","unstructured":"Lavado-Autric R, Auso E, Garcia-Velasco JV, Arufe Mdel C, Escobar del Rey F, Berbel P et al. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. J Clin Invest 2003; 111: 1073\u20131082.","journal-title":"J Clin Invest"},{"key":"BF4001694_CR28","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.1210\/en.2004-0274","volume":"145","author":"E Auso","year":"2004","unstructured":"Auso E, Lavado-Autric R, Cuevas E, Del Rey FE, Morreale De Escobar G, Berbel P . A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology 2004; 145: 4037\u20134047.","journal-title":"Endocrinology"},{"key":"BF4001694_CR29","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0885-4505(92)90072-7","volume":"48","author":"JT Hernandez","year":"1992","unstructured":"Hernandez JT, Hoffman L, Weavil S, Cvejin S, Prange AJJ . The effect of drug exposure on thyroid hormone levels of newborns. Biochem Med Metab Biol 1992; 48: 255\u2013262.","journal-title":"Biochem Med Metab Biol"},{"key":"BF4001694_CR30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/0304-3940(90)90535-H","volume":"109","author":"Z Gottesfeld","year":"1990","unstructured":"Gottesfeld Z, Silverman PB . Developmental delays associated with prenatal alcohol exposure are reversed by thyroid hormone treatment. Neurosci Lett 1990; 109: 42\u201347.","journal-title":"Neurosci Lett"},{"key":"BF4001694_CR31","doi-asserted-by":"publisher","first-page":"E318","DOI":"10.1152\/ajpendo.00022.2004","volume":"287","author":"JS Wilcoxon","year":"2004","unstructured":"Wilcoxon JS, Redei EE . Prenatal programming of adult thyroid function by alcohol and thyroid hormones. Am J Physiol Endocrinol Metab 2004; 287: E318\u2013E326.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BF4001694_CR32","doi-asserted-by":"publisher","first-page":"7657","DOI":"10.1073\/pnas.97.13.7657","volume":"97","author":"A Routtenberg","year":"2000","unstructured":"Routtenberg A, Cantallops I, Zaffuto S, Serrano P, Namgung U . Enhanced learning after genetic overexpression of a brain growth protein. Proc Natl Acad Sci USA 2000; 97: 7657\u20137662.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001694_CR33","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0006-8993(00)02021-7","volume":"860","author":"EA Young","year":"2000","unstructured":"Young EA, Owen EH, Meiri KF, Wehner JM . Alterations in hippocampal GAP-43 phosphorylation and protein level following contextual fear conditioning. Brain Res 2000; 860: 95\u2013103.","journal-title":"Brain Res"},{"key":"BF4001694_CR34","doi-asserted-by":"publisher","first-page":"11668","DOI":"10.1073\/pnas.191388398","volume":"98","author":"A Quattrone","year":"2001","unstructured":"Quattrone A, Pascale A, Nogues X, Zhao W, Gusev P, Pacini A et al. Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins. Proc Natl Acad Sci USA\n 2001; 98: 11668\u201311673.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001694_CR35","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1046\/j.1460-9568.1998.00381.x","volume":"10","author":"MS Oitzl","year":"1998","unstructured":"Oitzl MS, Fluttert M, Sutanto W, de Kloet ER . Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats. Eur J Neurosci 1998; 10: 3759\u20133766.","journal-title":"Eur J Neurosci"},{"key":"BF4001694_CR36","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0014-2999(96)00064-7","volume":"301","author":"SM Korte","year":"1996","unstructured":"Korte SM, De Kloet ER, Buwalda B, Bouman SD, Bohus B . Antisense to the glucocorticoid receptor in hippocampal dentate gyrus reduces immobility in forced swim test. Eur J Pharmacol 1996; 301: 19\u201325.","journal-title":"Eur J Pharmacol"},{"key":"BF4001694_CR37","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1046\/j.1460-9568.2000.00958.x","volume":"12","author":"LA Welberg","year":"2000","unstructured":"Welberg LA, Seckl JR, Holmes MC . Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Eur J Neurosci 2000; 12: 1047\u20131054.","journal-title":"Eur J Neurosci"},{"key":"BF4001694_CR38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0306-4522(01)00065-3","volume":"104","author":"LA Welberg","year":"2001","unstructured":"Welberg LA, Seckl JR, Holmes MC . Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience 2001; 104: 71\u201379.","journal-title":"Neuroscience"},{"key":"BF4001694_CR39","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/12703","volume":"23","author":"F Tronche","year":"1999","unstructured":"Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 1999; 23: 99\u2013103.","journal-title":"Nat Genet"},{"key":"BF4001694_CR40","doi-asserted-by":"publisher","first-page":"4792","DOI":"10.1210\/endo.138.11.5477","volume":"138","author":"P Sinha","year":"1997","unstructured":"Sinha P, Halasz I, Choi JF, McGivern RF, Redei E . Maternal adrenalectomy eliminates a surge of plasma dehydroepiandrosterone in the mother and attenuates the prenatal testosterone surge in the male fetus. Endocrinology 1997; 138: 4792\u20134797.","journal-title":"Endocrinology"},{"key":"BF4001694_CR41","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/978-1-4899-2064-5_25","volume":"245","author":"AN Taylor","year":"1988","unstructured":"Taylor AN, Branch BJ, Van Zuylen JE, Redei E . Maternal alcohol consumption and stress responsiveness in offspring. Adv Exp Med Biol 1988; 245: 311\u2013317.","journal-title":"Adv Exp Med Biol"},{"key":"BF4001694_CR42","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0031-9384(99)00077-3","volume":"67","author":"R Hernandez-Tristan","year":"1999","unstructured":"Hernandez-Tristan R, Arevalo C, Canals S . Effect of prenatal uterine position on male and female rats sexual behavior. Physiol Behav 1999; 67: 401\u2013408.","journal-title":"Physiol Behav"},{"key":"BF4001694_CR43","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0165-3806(02)00282-1","volume":"133","author":"ES Mitchell","year":"2002","unstructured":"Mitchell ES, Keller Jr RW, Synder-Keller A . Immediate-early gene expression in concurrent prenatal ethanol-and\/or cocaine-exposed rat pups: intrauterine differences in cocaine levels of Fos expression. Brain Res Dev Brain Res 2002; 133: 141\u2013149.","journal-title":"Brain Res Dev Brain Res"},{"key":"BF4001694_CR44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0166-4328(94)00166-D","volume":"68","author":"S Darbra","year":"1995","unstructured":"Darbra S, Balada F, Garau A, Gatell P, Sala J, Marti-Carbonell MA . Perinatal alterations of thyroid hormones and behaviour in adult rats. Behav Brain Res 1995; 68: 159\u2013164.","journal-title":"Behav Brain Res"},{"key":"BF4001694_CR45","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/sj.mp.4001255","volume":"8","author":"LC Solberg","year":"2003","unstructured":"Solberg LC, Ahmadiyeh N, Baum AE, Vitaterna MH, Takahashi JS, Turek FW et al. Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto \u00d7 Fisher 344 cross. Mol Psychiatry 2003; 8: 423\u2013433.","journal-title":"Mol Psychiatry"},{"key":"BF4001694_CR46","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/BF02245592","volume":"121","author":"MJ Detke","year":"1995","unstructured":"Detke MJ, Rickels M, Lucki I . Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology 1995; 121: 66\u201372.","journal-title":"Psychopharmacology"},{"key":"BF4001694_CR47","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/j.1530-0277.1996.tb01054.x","volume":"20","author":"J Weinberg","year":"1996","unstructured":"Weinberg J, Taylor AN, Gianoulakis C . Fetal ethanol exposure: hypothalamic\u2013pituitary\u2013adrenal and beta-endorphin responses to repeated stress. Alcohol Clin Exp Res 1996; 20: 122\u2013131.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR48","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/j.1530-0277.1986.tb05112.x","volume":"10","author":"LR Nelson","year":"1986","unstructured":"Nelson LR, Taylor AN, Lewis JW, Poland RE, Redei E, Branch BJ . Pituitary-adrenal responses to morphine and footshock stress are enhanced following prenatal alcohol exposure. Alcohol Clin Exp Res 1986; 10: 397\u2013402.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR49","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"1997","unstructured":"Paxinos G, Watson C . The Rat Brain in Stereotaxic Coordinates, 3rd edn. Academic Press: San Diego, CA, 1997."},{"key":"BF4001694_CR50","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1210\/endo.133.2.8344191","volume":"133","author":"E Redei","year":"1993","unstructured":"Redei E, Halasz I, Li LF, Prystowsky MB . Maternal adrenalectomy alters the immune and endocrine functions of fetal alcohol-exposed male offspring. Endocrinology 1993; 133: 452\u2013460.","journal-title":"Endocrinology"},{"key":"BF4001694_CR51","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/0003-2697(83)90418-9","volume":"132","author":"AP Feinberg","year":"1983","unstructured":"Feinberg AP, Vogelstein B . A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 1983; 132: 6\u201313.","journal-title":"Anal Biochem"},{"key":"BF4001694_CR52","first-page":"321","volume":"42","author":"I Kiyosawa","year":"1993","unstructured":"Kiyosawa I, Aoki M, Imamura T, Naito J, Saito TR, Takahashi KW . Possibility of detecting visual functional disturbance in rats by the open-field test. Jikken Dobutsu 1993; 42: 321\u2013325.","journal-title":"Jikken Dobutsu"},{"key":"BF4001694_CR53","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0892-0362(87)90010-9","volume":"9","author":"BA Blanchard","year":"1987","unstructured":"Blanchard BA, Riley EP, Hannigan JH . Deficits on a spatial-navigation task following prenatal exposure to ethanol. Neurotoxicol Teratol 1987; 9: 253\u2013258.","journal-title":"Neurotoxicol Teratol"},{"key":"BF4001694_CR54","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3758\/BF03327214","volume":"18","author":"BA Blanchard","year":"1990","unstructured":"Blanchard BA, Pilati ML, Hannigan JH . The role of stress and age in spatial-navigation deficits following prenatal exposure to ethanol. Psychobiology 1990; 18: 48\u201354.","journal-title":"Psychobiology"},{"key":"BF4001694_CR55","first-page":"697","volume":"7","author":"EA Lochry","year":"1985","unstructured":"Lochry EA, Hoberman AM, Christian MS . Detection of prenatal effects on learning as a function of differential criteria. Neurobehav Toxicol Teratol 1985; 7: 697\u2013701.","journal-title":"Neurobehav Toxicol Teratol"},{"key":"BF4001694_CR56","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/0091-3057(79)90097-2","volume":"10","author":"EP Riley","year":"1979","unstructured":"Riley EP, Lochry EA, Shapiro NR, Baldwin J . Response perseveration in rats exposed to alcohol prenatally. Pharmacol Biochem Behav 1979; 10: 255\u2013259.","journal-title":"Pharmacol Biochem Behav"},{"key":"BF4001694_CR57","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1006\/enrs.1993.1133","volume":"63","author":"M Omoto","year":"1993","unstructured":"Omoto M, Seki K, Imai T, Nomura R . The effects of ethanol exposure on radial arm maze learning and behavior of offspring rats. Environ Res 1993; 63: 109\u2013121.","journal-title":"Environ Res"},{"key":"BF4001694_CR58","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0091-3057(89)90246-3","volume":"32","author":"B Zimmerberg","year":"1989","unstructured":"Zimmerberg B, Mattson S, Riley EP . Impaired alternation test performance in adult rats following prenatal alcohol exposure. Pharmacol Biochem Behav 1989; 32: 293\u2013299.","journal-title":"Pharmacol Biochem Behav"},{"key":"BF4001694_CR59","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.bbr.2004.05.008","volume":"156","author":"K Kanari","year":"2005","unstructured":"Kanari K, Kikusui T, Takeuchi Y, Mori Y . Multidimensional structure of anxiety-related behavior in early-weaned rats. Behav Brain Res 2005; 156: 45\u201352.","journal-title":"Behav Brain Res"},{"key":"BF4001694_CR60","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1023\/A:1026131130686","volume":"33","author":"A Ramos","year":"2003","unstructured":"Ramos A, Correia EC, Izidio GS, Bruske GR . Genetic selection of two new rat lines displaying different levels of anxiety-related behaviors. Behav Genet 2003; 33: 657\u2013668.","journal-title":"Behav Genet"},{"key":"BF4001694_CR61","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/hipo.1092","volume":"11","author":"T Miyakawa","year":"2001","unstructured":"Miyakawa T, Yared E, Pak JH, Huang FL, Huang KP, Crawley JN . Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components. Hippocampus 2001; 11: 763\u2013775.","journal-title":"Hippocampus"},{"key":"BF4001694_CR62","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1046\/j.1471-4159.1998.71052104.x","volume":"71","author":"NI Perrone-Bizzozero","year":"1998","unstructured":"Perrone-Bizzozero NI, Isaacson TV, Keidan GM, Eriqat C, Meiri KF, Savage DD et al. Prenatal ethanol exposure decreases GAP-43 phosphorylation and protein kinase C activity in the hippocampus of adult rat offspring. J Neurochem 1998; 71: 2104\u20132111.","journal-title":"J Neurochem"},{"key":"BF4001694_CR63","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/01.ALC.0000106308.50817.B3","volume":"28","author":"DC Tanner","year":"2004","unstructured":"Tanner DC, Githinji AW, Young EA, Meiri K, Savage DD, Perrone-Bizzozero ND . Fetal alcohol exposure alters GAP-43 phosphorylation and protein kinase C responses to contextual fear conditioning in the hippocampus of adult rat offspring. Alcohol Clin Exp Res 2004; 28: 113\u2013122.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR64","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1046\/j.1460-9568.2002.02026.x","volume":"15","author":"S Hulo","year":"2002","unstructured":"Hulo S, Alberi S, Laux T, Muller D, Caroni P . A point mutant of GAP-43 induces enhanced short-term and long-term hippocampal plasticity. Eur J Neurosci 2002; 15: 1976\u20131982.","journal-title":"Eur J Neurosci"},{"key":"BF4001694_CR65","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0169-328X(91)90114-D","volume":"11","author":"RH Lustig","year":"1991","unstructured":"Lustig RH, Sudol M, Pfaff DW, Federoff HJ . Estrogenic regulation and sex dimorphism of growth-associated protein 43\u2009kDa (GAP-43) messenger RNA in the rat. Brain Res Mol Brain Res 1991; 11: 125\u2013132.","journal-title":"Brain Res Mol Brain Res"},{"key":"BF4001694_CR66","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/cne.903400204","volume":"340","author":"PJ Shughrue","year":"1994","unstructured":"Shughrue PJ, Dorsa DM . The ontogeny of GAP-43 (neuromodulin) mRNA in postnatal rat brain: evidence for a sex dimorphism. J Comp Neurol 1994; 340: 174\u2013184.","journal-title":"J Comp Neurol"},{"key":"BF4001694_CR67","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1006\/nlme.1995.1046","volume":"64","author":"CA Frye","year":"1995","unstructured":"Frye CA, Sturgis JD . Neurosteroids affect spatial\/reference, working, and long-term memory of female rats. Neurobiol Learn Memory 1995; 64: 83\u201396.","journal-title":"Neurobiol Learn Memory"},{"key":"BF4001694_CR68","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1093\/cercor\/6.2.311","volume":"6","author":"RP Kesner","year":"1996","unstructured":"Kesner RP, Hunt ME, Williams JM, Long JM . Prefrontal cortex and working memory for spatial response, spatial location, and visual object information in the rat. Cerebral Cortex 1996; 6: 311\u2013318.","journal-title":"Cerebral Cortex"},{"key":"BF4001694_CR69","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0028-3908(99)00157-4","volume":"39","author":"RH Wang","year":"2000","unstructured":"Wang RH, Bejar C, Weinstock M . Gender differences in the effect of rivastigmine on brain cholinesterase activity and cognitive function in rats. Neuropharmacology 2000; 39: 497\u2013506.","journal-title":"Neuropharmacology"},{"key":"BF4001694_CR70","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1523\/JNEUROSCI.10-04-01286.1990","volume":"10","author":"E Gould","year":"1990","unstructured":"Gould E, Woolley CS, Frankfurt M, McEwen BS . Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci 1990; 10: 1286\u20131291.","journal-title":"J Neurosci"},{"key":"BF4001694_CR71","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1523\/JNEUROSCI.12-07-02549.1992","volume":"12","author":"CS Woolley","year":"1992","unstructured":"Woolley CS, McEwen BS . Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci 1992; 12: 2549\u20132554.","journal-title":"J Neurosci"},{"key":"BF4001694_CR72","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1037\/0735-7044.111.2.259","volume":"111","author":"SG Warren","year":"1997","unstructured":"Warren SG, Juraska JM . Spatial and nonspatial learning across the rat estrous cycle. Behav Neurosci 1997; 111: 259\u2013266.","journal-title":"Behav Neurosci"},{"key":"BF4001694_CR73","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1006\/hbeh.1998.1464","volume":"34","author":"MG Packard","year":"1998","unstructured":"Packard MG . Posttraining estrogen and memory modulation. Horm Behav 1998; 34: 126\u2013139.","journal-title":"Horm Behav"},{"key":"BF4001694_CR74","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1097\/00001756-199709290-00004","volume":"8","author":"MG Packard","year":"1997","unstructured":"Packard MG, Teather LA . Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats. Neuroreport 1997; 8: 3009\u20133013.","journal-title":"Neuroreport"},{"key":"BF4001694_CR75","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3109\/10253899909001120","volume":"3","author":"TJ Shors","year":"1999","unstructured":"Shors TJ, Pickett J, Wood G, Paczynski M . Acute stress persistently enhances estrogen levels in the female rat. Stress 1999; 3: 163\u2013171.","journal-title":"Stress"},{"key":"BF4001694_CR76","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1023\/A:1020767917795","volume":"22","author":"M Ferrini","year":"2002","unstructured":"Ferrini M, Bisagno V, Piroll G, Grillo C, Deniselle MC, De Nicola AF . Effects of estrogen on choline-acetyltransferase immunoreactivity and GAP-43 mRNA in the forebrain of young and aging male rats. Cell Mol Neurobiol 2002; 22: 289\u2013301.","journal-title":"Cell Mol Neurobiol"},{"key":"BF4001694_CR77","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S0169-328X(97)00050-8","volume":"47","author":"Y Li","year":"1997","unstructured":"Li Y, McGivern RF, Nagahara AH, Handa RJ . Alterations in the estrogen sensitivity of hypothalamic proenkephalin mRNA expression with age and prenatal exposure to alcohol. Mol Brain Res 1997; 47: 215\u2013222.","journal-title":"Mol Brain Res"},{"key":"BF4001694_CR78","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1530-0277.1995.tb01526.x","volume":"19","author":"RF McGivern","year":"1995","unstructured":"McGivern RF, McGeary J, Robeck S, Cohen S, Handa RJ . Loss of reproductive competence at an earlier age in female rats exposed prenatally to ethanol. Alcohol Clin Exp Res 1995; 19: 427\u2013433.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF4001694_CR79","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1006\/mcne.1994.1048","volume":"5","author":"SJ Yi","year":"1994","unstructured":"Yi SJ, Masters JN, Baram TZ . GR-mRNA ontogeny in the fetal and postnatal rat forebrain. Mol Cell Neurosci 1994; 5: 385\u2013393.","journal-title":"Mol Cell Neurosci"},{"key":"BF4001694_CR80","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0306-4530(99)00058-X","volume":"25","author":"B Roozendaal","year":"2000","unstructured":"Roozendaal B . Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology 2000; 25: 213\u2013238.","journal-title":"Psychoneuroendocrinology"},{"key":"BF4001694_CR81","first-page":"758","volume":"238","author":"GE Duncan","year":"1986","unstructured":"Duncan GE, Breese GR, Criswell H, Stumpf WE, Mueller RA, Covey JB . Effects of antidepressant drugs injected into the amygdala on behavioral responses of rats in the forced swim test. J Pharmacol Exp Ther 1986; 238: 758\u2013762.","journal-title":"J Pharmacol Exp Ther"},{"key":"BF4001694_CR82","doi-asserted-by":"publisher","first-page":"R1899","DOI":"10.1152\/ajpregu.2000.279.5.R1899","volume":"279","author":"T Brabham","year":"2000","unstructured":"Brabham T, Phelka A, Zimmer C, Nash A, Lopez JF, Vazquez DM . Effects of prenatal dexamethasone on spatial learning and response to stress is influenced by maternal factors. Am J Physiol Regul Integr Comp Physiol 2000; 279: R1899\u2013R1909.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BF4001694_CR83","doi-asserted-by":"publisher","first-page":"12790","DOI":"10.1073\/pnas.231313998","volume":"98","author":"MS Oitzl","year":"2001","unstructured":"Oitzl MS, Reichardt HM, Joels M, de Kloet ER . Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proc Natl Acad Sci USA 2001; 98: 12790\u201312795.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001694_CR84","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1097\/00001756-199703030-00007","volume":"8","author":"I Rousse","year":"1997","unstructured":"Rousse I, Beaulieu S, Rowe W, Meaney MJ, Barden N, Rochford J . Spatial memory in transgenic mice with impaired glucocorticoid receptor function. Neuroreport 1997; 8: 841\u2013845.","journal-title":"Neuroreport"},{"key":"BF4001694_CR85","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S0306-4530(99)00015-3","volume":"24","author":"CK Kim","year":"1999","unstructured":"Kim CK, Yu W, Edin G, Ellis L, Osborn JA, Weinberg J . Chronic intermittent stress does not differentially alter brain corticosteroid receptor densities in rats prenatally exposed to ethanol. Psychoneuroendocrinology 1999; 24: 585\u2013611.","journal-title":"Psychoneuroendocrinology"},{"key":"BF4001694_CR86","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1037\/0735-7044.110.5.1074","volume":"110","author":"B Roozendaal","year":"1996","unstructured":"Roozendaal B, Portillo-Marquez G, McGaugh JL . Basolateral amygdala lesions block glucocorticoid-induced modulation of memory for spatial learning. Behav Neurosci 1996; 110: 1074\u20131083.","journal-title":"Behav Neurosci"},{"key":"BF4001694_CR87","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1006\/exmp.1999.2283","volume":"67","author":"EJ Nathaniel","year":"1999","unstructured":"Nathaniel EJ, Hassard T, Burton L, Novak C . Effect of exogenous thyroxine on the development of the Purkinje cell in fetal alcohol effects in the rat. Exp Mol Pathol 1999; 67: 175\u2013191.","journal-title":"Exp Mol Pathol"},{"key":"BF4001694_CR88","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/0169-328X(93)90010-M","volume":"17","author":"BC Figueiredo","year":"1993","unstructured":"Figueiredo BC, Almazan G, Ma Y, Tetzlaff W, Miller FD, Cuello AC . Gene expression in the developing cerebellum during perinatal hypo- and hyperthyroidism. Brain Res Mol Brain Res 1993; 17: 258\u2013268.","journal-title":"Brain Res Mol Brain Res"},{"key":"BF4001694_CR89","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/BF02740632","volume":"15","author":"DD Gerendasy","year":"1997","unstructured":"Gerendasy DD, Sutcliffe JG . RC3\/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes. Mol Neurobiol 1997; 15: 131\u2013163.","journal-title":"Mol Neurobiol"},{"key":"BF4001694_CR90","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0169-328X(00)00190-X","volume":"82","author":"AL Dowling","year":"2000","unstructured":"Dowling AL, Zoeller RT . Thyroid hormone of maternal origin regulates the expression of RC3\/neurogranin mRNA in the fetal rat brain. Brain Res Mol Brain Res 2000; 82: 126\u2013132.","journal-title":"Brain Res Mol Brain Res"},{"key":"BF4001694_CR91","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1172\/JCI115894","volume":"90","author":"MA Iniguez","year":"1992","unstructured":"Iniguez MA, Rodriguez-Pena A, Ibarrola N, Morreale de Escobar G, Bernal J . Adult rat brain is sensitive to thyroid hormone. Regulation of RC3\/neurogranin mRNA. J Clin Invest 1992; 90: 554\u2013558.","journal-title":"J Clin Invest"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4001694.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001694","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001694.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T05:11:04Z","timestamp":1649913064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4001694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,31]]},"references-count":91,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,10,1]]}},"alternative-id":["BF4001694"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4001694","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,31]]},"assertion":[{"value":"5 January 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2005","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}