{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:57:32Z","timestamp":1791262652506,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,1,3]],"date-time":"2006-01-03T00:00:00Z","timestamp":1136246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,1,3]],"date-time":"2006-01-03T00:00:00Z","timestamp":1136246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2006,4,1]]},"DOI":"10.1038\/sj.mp.4001786","type":"journal-article","created":{"date-parts":[[2006,1,3]],"date-time":"2006-01-03T10:11:04Z","timestamp":1136283064000},"page":"384-394","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia"],"prefix":"10.1038","volume":"11","author":[{"given":"S L","family":"Underwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Christoforou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P A","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N R","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tenesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Whittaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Le Hellard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S W","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D H R","family":"Blackwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W J","family":"Muir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Porteous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,1,3]]},"reference":[{"key":"BF4001786_CR1","first-page":"690","volume":"57","author":"N Craddock","year":"1995","unstructured":"Craddock N, Khodel V, Van Eerdewegh P, Reich T . Mathematical limits of multilocus models: the genetic transmission of bipolar disorder. Am J Hum Genet 1995; 57: 690\u2013702.","journal-title":"Am J Hum Genet"},{"key":"BF4001786_CR2","first-page":"415","volume":"28","author":"N Berry","year":"2003","unstructured":"Berry N, Jobanputra V, Pal H . Molecular genetics of schizophrenia: a critical review. J Psychiatry Neurosci 2003; 28: 415\u2013429.","journal-title":"J Psychiatry Neurosci"},{"key":"BF4001786_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0022-3956(03)00096-7","volume":"38","author":"MT Tsuang","year":"2004","unstructured":"Tsuang MT, Taylor L, Faraone SV . An overview of the genetics of psychotic mood disorders. J Psychiatr Res 2004; 38: 3\u201315.","journal-title":"J Psychiatr Res"},{"key":"BF4001786_CR4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/ng0496-427","volume":"12","author":"DH Blackwood","year":"1996","unstructured":"Blackwood DH, He L, Morris SW, McLean A, Whitton C, Thomson M et al. A locus for bipolar affective disorder on chromosome 4p. Nat Genet 1996; 12: 427\u2013430.","journal-title":"Nat Genet"},{"key":"BF4001786_CR5","unstructured":"Le Hellard S, Lee AJ, Underwood S, Thomson PA, Morris SW, Torrance HS et al. Haplotype analysis and a novel allele sharing method refines a chromosome 4p locus linked to bipolar disorder and schizophrenia. 2005 (submitted)."},{"key":"BF4001786_CR6","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/sj.mp.4000399","volume":"3","author":"P Asherson","year":"1998","unstructured":"Asherson P, Mant R, Williams N, Cardno A, Jones L, Murphy K et al. A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder. Mol Psychiatry 1998; 3: 310\u2013320.","journal-title":"Mol Psychiatry"},{"key":"BF4001786_CR7","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/sj.mp.4000420","volume":"3","author":"H Ewald","year":"1998","unstructured":"Ewald H, Degn B, Mors O, Kruse TA . Support for the possible locus on chromosome 4p16 for bipolar affective disorder. Mol Psychiatry 1998; 3: 442\u2013448.","journal-title":"Mol Psychiatry"},{"key":"BF4001786_CR8","doi-asserted-by":"publisher","first-page":"5604","DOI":"10.1073\/pnas.96.10.5604","volume":"96","author":"SD Detera-Wadleigh","year":"1999","unstructured":"Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G et al. A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 1999; 96: 5604\u20135609.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001786_CR9","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1093\/hmg\/8.9.1729","volume":"8","author":"NM Williams","year":"1999","unstructured":"Williams NM, Rees MI, Holmans P, Norton N, Cardno AG, Jones LA et al. A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. Hum Mol Genet 1999; 8: 1729\u20131739.","journal-title":"Hum Mol Genet"},{"key":"BF4001786_CR10","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/sj.mp.4001322","volume":"8","author":"B Lerer","year":"2003","unstructured":"Lerer B, Segman RH, Hamdan A, Kanyas K, Karni O, Kohn Y et al. Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24. Mol Psychiatry 2003; 8: 488\u2013498.","journal-title":"Mol Psychiatry"},{"key":"BF4001786_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/sj.mp.4001393","volume":"9","author":"TD Als","year":"2004","unstructured":"Als TD, Dahl HA, Flint TJ, Wang AG, Vang M, Mors O et al. Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands. Mol Psychiatry 2004; 9: 93\u201398.","journal-title":"Mol Psychiatry"},{"key":"BF4001786_CR12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1006\/geno.2000.6432","volume":"71","author":"KL Evans","year":"2001","unstructured":"Evans KL, Le Hellard S, Morris SW, Lawson D, Whitton C, Semple CA et al. A 6.9\u2009Mb high-resolution BAC\/PAC contig of human 4p153\u2013p161 a candidate region for bipolar affective disorder. Genomics 2001; 71: 315\u2013323.","journal-title":"Genomics"},{"key":"BF4001786_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S0022-3999(02)00426-9","volume":"53","author":"TD Gould","year":"2002","unstructured":"Gould TD, Manji HK . Signaling networks in the pathophysiology and treatment of mood disorders. J Psychosom Res 2002; 53: 687\u2013697.","journal-title":"J Psychosom Res"},{"key":"BF4001786_CR14","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/sj.mp.4001067","volume":"7","author":"J Gonzalez-Maeso","year":"2002","unstructured":"Gonzalez-Maeso J, Rodriguez-Puertas R, Meana JJ, Garcia-Sevilla JA, Guimon J . Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors. Mol Psychiatry 2002; 7: 755\u2013767.","journal-title":"Mol Psychiatry"},{"key":"BF4001786_CR15","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/sj.mp.4001593","volume":"10","author":"PA Thomson","year":"2005","unstructured":"Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A et al. Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Mol Psychiatry 2005; 10: 470\u2013478.","journal-title":"Mol Psychiatry"},{"key":"BF4001786_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0378-1119(01)00651-5","volume":"275","author":"DK Lee","year":"2001","unstructured":"Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O et al. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene 2001; 275: 83\u201391.","journal-title":"Gene"},{"key":"BF4001786_CR17","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0167-4781(99)00241-9","volume":"1490","author":"DK Lee","year":"2000","unstructured":"Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR et al. Cloning and characterization of additional members of the G protein-coupled receptor family. Biochim Biophys Acta 2000; 1490: 311\u2013323.","journal-title":"Biochim Biophys Acta"},{"key":"BF4001786_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1615\/CritRevNeurobiol.v10.i3-4.50","volume":"10","author":"JP Herman","year":"1996","unstructured":"Herman JP, Prewitt CM, Cullinan WE . Neuronal circuit regulation of the hypothalamo-pituitary-adrenocortical stress axis. Crit Rev Neurobiol 1996; 10: 371\u2013394.","journal-title":"Crit Rev Neurobiol"},{"key":"BF4001786_CR19","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S0022-3956(99)00014-X","volume":"33","author":"JK Rybakowski","year":"1999","unstructured":"Rybakowski JK, Twardowska K . The dexamethasone\/corticotropin-releasing hormone test in depression in bipolar and unipolar affective illness. J Psychiatr Res 1999; 33: 363\u2013370.","journal-title":"J Psychiatr Res"},{"key":"BF4001786_CR20","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0006-3223(00)01088-X","volume":"49","author":"CM Pariante","year":"2001","unstructured":"Pariante CM, Miller AH . Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 2001; 49: 391\u2013404.","journal-title":"Biol Psychiatry"},{"key":"BF4001786_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0924-977X(99)00017-6","volume":"10","author":"AC Altamura","year":"1999","unstructured":"Altamura AC, Boin F, Maes M . HPA axis and cytokines dysregulation in schizophrenia: potential implications for the antipsychotic treatment. Eur Neuropsychopharmacol 1999; 10: 1\u20134.","journal-title":"Eur Neuropsychopharmacol"},{"key":"BF4001786_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0149-7634(96)00014-0","volume":"21","author":"M Weinstock","year":"1997","unstructured":"Weinstock M . Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis? Neurosci Biobehav Rev 1997; 21: 1\u201310.","journal-title":"Neurosci Biobehav Rev"},{"key":"BF4001786_CR23","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0006-3223(99)00153-5","volume":"46","author":"EJ Bromet","year":"1999","unstructured":"Bromet EJ, Fennig S . Epidemiology and natural history of schizophrenia. Biol Psychiatry 1999; 46: 871\u2013881.","journal-title":"Biol Psychiatry"},{"key":"BF4001786_CR24","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1001\/archpsyc.1978.01770310043002","volume":"35","author":"J Endicott","year":"1978","unstructured":"Endicott J, Spitzer RL . A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 1978; 35: 837\u2013844.","journal-title":"Arch Gen Psychiatry"},{"key":"BF4001786_CR25","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"AP Association","year":"1994","unstructured":"Association AP . Diagnostic and Statistical Manual of Mental Disorders 4th edn. (DSM\u2013IV). APA: Washington, DC, 1994."},{"key":"BF4001786_CR26","unstructured":"World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. WHO: Geneva, 1992."},{"key":"BF4001786_CR27","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/35015718","volume":"405","author":"NJ Risch","year":"2000","unstructured":"Risch NJ . Searching for genetic determinants in the new millennium. Nature 2000; 405: 847\u2013856.","journal-title":"Nature"},{"key":"BF4001786_CR28","first-page":"365","volume":"132","author":"S Rozen","year":"2000","unstructured":"Rozen S, Skaletsky H . Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000; 132: 365\u2013386.","journal-title":"Methods Mol Biol"},{"key":"BF4001786_CR29","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1101\/gr.8.3.195","volume":"8","author":"D Gordon","year":"1998","unstructured":"Gordon D, Abajian C, Green P . Consed: a graphical tool for sequence finishing. Genome Res 1998; 8: 195\u2013202.","journal-title":"Genome Res"},{"key":"BF4001786_CR30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ . Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263\u2013265.","journal-title":"Bioinformatics"},{"key":"BF4001786_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1375\/twin.8.2.87","volume":"8","author":"NR Wray","year":"2005","unstructured":"Wray NR . Allele frequencies and the r2 measure of linkage disequilibrium: impact on design and interpretation of association studies. Twin Res Hum Genet 2005; 8: 87\u201394.","journal-title":"Twin Res Hum Genet"},{"key":"BF4001786_CR32","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nrg1123","volume":"4","author":"JD Wall","year":"2003","unstructured":"Wall JD, Pritchard JK . Haplotype blocks and linkage disequilibrium in the human genome. Nat Rev Genet 2003; 4: 587\u2013597.","journal-title":"Nat Rev Genet"},{"key":"BF4001786_CR33","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/ajmg.c.20014","volume":"123","author":"W Berrettini","year":"2003","unstructured":"Berrettini W . Evidence for shared susceptibility in bipolar disorder and schizophrenia. Am J Med Genet C 2003; 123: 59\u201364.","journal-title":"Am J Med Genet C"},{"key":"BF4001786_CR34","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1136\/jmg.2005.030718","volume":"42","author":"N Craddock","year":"2005","unstructured":"Craddock N, O'Donovan MC, Owen MJ . The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet 2005; 42: 193\u2013204.","journal-title":"J Med Genet"},{"key":"BF4001786_CR35","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1126\/science.308.5728.1574","volume":"308","author":"C Holden","year":"2005","unstructured":"Holden C . Sex and the suffering brain. Science 2005; 308: 1574.","journal-title":"Science"},{"key":"BF4001786_CR36","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/sj.mp.4001354","volume":"8","author":"GS Zubenko","year":"2003","unstructured":"Zubenko GS, Hughes III HB, Stiffler JS, Brechbiel A, Zubenko WN, Maher BS et al. Sequence variations in CREB1 cosegregate with depressive disorders in women. Mol Psychiatry 2003; 8: 611\u2013618.","journal-title":"Mol Psychiatry"},{"key":"BF4001786_CR37","volume-title":"Essential Medical Statistics","author":"BR Kirkwood","year":"2003","unstructured":"Kirkwood BR, Sterne JAC . Essential Medical Statistics, 2nd edn. Blackwell Science Ltd: Malden, MA, 2003."},{"key":"BF4001786_CR38","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1086\/338007","volume":"70","author":"HJ Cordell","year":"2002","unstructured":"Cordell HJ, Clayton DG . A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case\/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet 2002; 70: 124\u2013141.","journal-title":"Am J Hum Genet"},{"key":"BF4001786_CR39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/gepi.10252","volume":"25","author":"F Dudbridge","year":"2003","unstructured":"Dudbridge F . Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003; 25: 115\u2013121.","journal-title":"Genet Epidemiol"},{"key":"BF4001786_CR40","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ . Basic local alignment search tool. J Mol Biol 1990; 215: 403\u2013410.","journal-title":"J Mol Biol"},{"key":"BF4001786_CR41","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1093\/nar\/gkg509","volume":"31","author":"PC Ng","year":"2003","unstructured":"Ng PC, Henikoff S . SIFT: predicting amino acid changes that affect protein function. Nucleic Acids Res 2003; 31: 3812\u20133814.","journal-title":"Nucleic Acids Res"},{"key":"BF4001786_CR42","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1093\/protein\/15.9.745","volume":"15","author":"M Cserzo","year":"2002","unstructured":"Cserzo M, Eisenhaber F, Eisenhaber B, Simon I . On filtering false positive transmembrane protein predictions. Protein Eng 2002; 15: 745\u2013752.","journal-title":"Protein Eng"},{"key":"BF4001786_CR43","doi-asserted-by":"publisher","first-page":"D134","DOI":"10.1093\/nar\/gkh044","volume":"32","author":"N Hulo","year":"2004","unstructured":"Hulo N, Sigrist CJ, Le Saux V, Langendijk-Genevaux PS, Bordoli L, Gattiker A et al. Recent improvements to the PROSITE database. Nucleic Acids Res 2004; 32: D134\u2013D137.","journal-title":"Nucleic Acids Res"},{"key":"BF4001786_CR44","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1006\/jmbi.1999.3310","volume":"294","author":"N Blom","year":"1999","unstructured":"Blom N, Gammeltoft S, Brunak S . Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 1999; 294: 1351\u20131362.","journal-title":"J Mol Biol"},{"key":"BF4001786_CR45","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1101\/gr.1933104","volume":"14","author":"M Blanchette","year":"2004","unstructured":"Blanchette M, Kent WJ, Riemer C, Elnitski L, Smit AF, Roskin KM et al. Aligning multiple genomic sequences with the threaded blockset aligner. Genome Res 2004; 14: 708\u2013715.","journal-title":"Genome Res"},{"key":"BF4001786_CR46","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1089\/1066527041410472","volume":"11","author":"A Siepel","year":"2004","unstructured":"Siepel A, Haussler D . Combining phylogenetic and hidden Markov models in biosequence analysis. J Comput Biol 2004; 11: 413\u2013428.","journal-title":"J Comput Biol"},{"key":"BF4001786_CR47","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gr.229102","volume":"12","author":"WJ Kent","year":"2002","unstructured":"Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM et al. The human genome browser at UCSC. Genome Res 2002; 12: 996\u20131006.","journal-title":"Genome Res"},{"key":"BF4001786_CR48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/nar\/gkg129","volume":"31","author":"D Karolchik","year":"2003","unstructured":"Karolchik D, Baertsch R, Diekhans M, Furey TS, Hinrichs A, Lu YT et al. The UCSC Genome Browser Database. Nucleic Acids Res 2003; 31: 51\u201354.","journal-title":"Nucleic Acids Res"},{"key":"BF4001786_CR49","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1093\/nar\/gkg585","volume":"31","author":"AE Kel","year":"2003","unstructured":"Kel AE, Gossling E, Reuter I, Cheremushkin E, Kel-Margoulis OV, Wingender E . MATCH: a tool for searching transcription factor binding sites in DNA sequences. Nucleic Acids Res 2003; 31: 3576\u20133579.","journal-title":"Nucleic Acids Res"},{"key":"BF4001786_CR50","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/nar\/29.1.281","volume":"29","author":"E Wingender","year":"2001","unstructured":"Wingender E, Chen X, Fricke E, Geffers R, Hehl R, Liebich I et al. The TRANSFAC system on gene expression regulation. Nucleic Acids Res 2001; 29: 281\u2013283.","journal-title":"Nucleic Acids Res"},{"key":"BF4001786_CR51","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","volume":"18","author":"TIH Consortium","year":"2003","unstructured":"Consortium TIH . The international HapMap project. Nature 2003; 18: 789\u2013796.","journal-title":"Nature"},{"key":"BF4001786_CR52","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/sj.ejhg.5200619","volume":"9","author":"J Akey","year":"2001","unstructured":"Akey J, Jin L, Xiong M . Haplotypes vs single marker linkage disequilibrium tests: what do we gain? Eur J Hum Genet 2001; 9: 291\u2013300.","journal-title":"Eur J Hum Genet"},{"key":"BF4001786_CR53","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/sj.ejhg.5201146","volume":"12","author":"A Jawaid","year":"2004","unstructured":"Jawaid A, Sham PC, Makoff AJ, Asherson PJ . Is haplotype tagging the panacea to association mapping studies? Eur J Hum Genet 2004; 12: 259\u2013262.","journal-title":"Eur J Hum Genet"},{"key":"BF4001786_CR54","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1086\/324471","volume":"69","author":"HH Goring","year":"2001","unstructured":"Goring HH, Terwilliger JD, Blangero J . Large upward bias in estimation of locus-specific effects from genomewide scans. Am J Hum Genet 2001; 69: 1357\u20131369.","journal-title":"Am J Hum Genet"},{"key":"BF4001786_CR55","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrg1522","volume":"6","author":"WY Wang","year":"2005","unstructured":"Wang WY, Barratt BJ, Clayton DG, Todd JA . Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet 2005; 6: 109\u2013118.","journal-title":"Nat Rev Genet"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4001786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001786","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001786.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:07:11Z","timestamp":1648782431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4001786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,3]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4,1]]}},"alternative-id":["BF4001786"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4001786","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,3]]},"assertion":[{"value":"22 August 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}