{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:27:11Z","timestamp":1790515631851,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T00:00:00Z","timestamp":1143504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T00:00:00Z","timestamp":1143504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2006,7,1]]},"DOI":"10.1038\/sj.mp.4001822","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T10:46:39Z","timestamp":1143542799000},"page":"695-703","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity"],"prefix":"10.1038","volume":"11","author":[{"given":"T","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Numakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kosuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tatsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kamijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kunugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,3,28]]},"reference":[{"key":"BF4001822_CR1","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/0896-6273(90)90089-X","volume":"5","author":"PC Maisonpierre","year":"1990","unstructured":"Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME et al. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 1990; 5: 501\u2013509.","journal-title":"Neuron"},{"key":"BF4001822_CR2","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1126\/science.270.5236.593","volume":"270","author":"H Thoenen","year":"1995","unstructured":"Thoenen H . Neurotrophins and neuronal plasticity. Science 1995; 270: 593\u2013598.","journal-title":"Science"},{"issue":"Suppl 1","key":"BF4001822_CR3","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1038\/sj.mp.4001016","volume":"7","author":"RS Duman","year":"2002","unstructured":"Duman RS . Synaptic plasticity and mood disorders. Mol Psychiatry 2002; 7(Suppl 1): S29\u2013S34.","journal-title":"Mol Psychiatry"},{"key":"BF4001822_CR4","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/sj.mp.4001471","volume":"9","author":"MB Knable","year":"2004","unstructured":"Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, Torrey EF . Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 2004; 9: 609\u2013620.","journal-title":"Mol Psychiatry"},{"key":"BF4001822_CR5","doi-asserted-by":"publisher","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","volume":"15","author":"M Nibuya","year":"1995","unstructured":"Nibuya M, Morinobu S, Duman RS . Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995; 15: 7539\u20137547.","journal-title":"J Neurosci"},{"key":"BF4001822_CR6","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/S0028-3908(02)00217-4","volume":"43","author":"R Hashimoto","year":"2002","unstructured":"Hashimoto R, Takei N, Shimazu K, Christ L, Lu B, Chuang DM . Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology 2002; 43: 1173\u20131179.","journal-title":"Neuropharmacology"},{"key":"BF4001822_CR7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s11920-003-0086-1","volume":"5","author":"E Green","year":"2003","unstructured":"Green E, Craddock N . Brain-derived neurotrophic factor as a potential risk locus for bipolar disorder: evidence, limitations, and implications. Curr Psychiatry Rep 2003; 5: 469\u2013476.","journal-title":"Curr Psychiatry Rep"},{"key":"BF4001822_CR8","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1086\/342288","volume":"71","author":"M Neves-Pereira","year":"2002","unstructured":"Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy JL . The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 2002; 71: 651\u2013655.","journal-title":"Am J Hum Genet"},{"key":"BF4001822_CR9","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/sj.mp.4001058","volume":"7","author":"P Sklar","year":"2002","unstructured":"Sklar P, Gabriel SB, McInnis MG, Bennett P, Lim YM, Tsan G et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Mol Psychiatry 2002; 7: 579\u2013593.","journal-title":"Mol Psychiatry"},{"key":"BF4001822_CR10","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1176\/appi.ajp.161.9.1698","volume":"161","author":"B Geller","year":"2004","unstructured":"Geller B, Badner JA, Tillman R, Christian SL, Bolhofner K, Cook Jr EH . Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 2004; 161: 1698\u20131700.","journal-title":"Am J Psychiatry"},{"key":"BF4001822_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/ajmg.b.30056","volume":"129B","author":"P Oswald","year":"2004","unstructured":"Oswald P, Del-Favero J, Massat I, Souery D, Claes S, Van Broeckhoven C et al. Non-replication of the brain-derived neurotrophic factor (BDNF) association in bipolar affective disorder: a Belgian patient-control study. Am J Med Genet 2004; 129B: 34\u201335.","journal-title":"Am J Med Genet"},{"key":"BF4001822_CR12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/15622970410029936","volume":"5","author":"M Skibinska","year":"2004","unstructured":"Skibinska M, Hauser J, Czerski PM, Leszczynska-Rodziewicz A, Kosmowska M, Kapelski P et al. Association analysis of brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism in schizophrenia and bipolar affective disorder. World J Biol Psychiatry 2004; 5: 215\u2013220.","journal-title":"World J Biol Psychiatry"},{"key":"BF4001822_CR13","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/sj.mp.4001575","volume":"10","author":"M Neves-Pereira","year":"2005","unstructured":"Neves-Pereira M, Cheung JK, Pasdar A, Zhang F, Breen G, Yates P et al. BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 2005; 10: 208\u2013212.","journal-title":"Mol Psychiatry"},{"key":"BF4001822_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000074636","volume":"48","author":"CJ Hong","year":"2003","unstructured":"Hong CJ, Huo SJ, Yen FC, Tung CL, Pan GM, Tsai SJ . Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 2003; 48: 186\u2013189.","journal-title":"Neuropsychobiology"},{"key":"BF4001822_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0304-3940(02)01292-2","volume":"337","author":"K Nakata","year":"2003","unstructured":"Nakata K, Ujike H, Sakai A, Uchida N, Nomura A, Imamura T et al. Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder. Neurosci Lett 2003; 337: 17\u201320.","journal-title":"Neurosci Lett"},{"key":"BF4001822_CR16","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.biopsych.2004.06.017","volume":"56","author":"H Kunugi","year":"2004","unstructured":"Kunugi H, Iijima Y, Tatsumi M, Yoshida M, Hashimoto R, Kato T et al. No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study. Biol Psychiatry 2004; 56: 376\u2013378.","journal-title":"Biol Psychiatry"},{"key":"BF4001822_CR17","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/hmg\/1.5.353-a","volume":"1","author":"M Pr\u00f6schel","year":"1992","unstructured":"Pr\u00f6schel M, Saunders A, Roses AD, Muller CR . Dinucleotide repeat polymorphism at the human gene for the brain-derived neurotrophic factor (BDNF). Hum Mol Genet 1992; 1: 353.","journal-title":"Hum Mol Genet"},{"key":"BF4001822_CR18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/ajmg.b.30041","volume":"131B","author":"J Strauss","year":"2004","unstructured":"Strauss J, Barr CL, George CJ, King N, Shaikh S, Devlin B et al. Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorder. Am J Med Genet 2004; 131B: 16\u201319.","journal-title":"Am J Med Genet"},{"key":"BF4001822_CR19","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/sj.mp.4000749","volume":"5","author":"MO Krebs","year":"2000","unstructured":"Krebs MO, Guillin O, Bourdell MC, Schwartz JC, Olie JP, Poirier MF et al. Brain derived neurotrophic factor (BDNF) gene variants association with age at onset and therapeutic response in schizophrenia. Mol Psychiatry 2000; 5: 558\u2013562.","journal-title":"Mol Psychiatry"},{"key":"BF4001822_CR20","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/sj.mp.4001221","volume":"8","author":"P Muglia","year":"2003","unstructured":"Muglia P, Vicente AM, Verga M, King N, Macciardi F, Kennedy JL . Association between the BDNF gene and schizophrenia. Mol Psychiatry 2003; 8: 146\u2013147.","journal-title":"Mol Psychiatry"},{"key":"BF4001822_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/sj.mp.4000289","volume":"3","author":"DE Comings","year":"1998","unstructured":"Comings DE . Polygenic inheritance and micro\/minisatellites. Mol Psychiatry 1998; 3: 21\u201331.","journal-title":"Mol Psychiatry"},{"key":"BF4001822_CR22","unstructured":"American Psychiatric Association. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington DC, 1994."},{"key":"BF4001822_CR23","doi-asserted-by":"publisher","first-page":"6520","DOI":"10.1074\/jbc.M109139200","volume":"277","author":"T Numakawa","year":"2002","unstructured":"Numakawa T, Yamagishi S, Adachi N, Matsumoto T, Yokomaku D, Yamada M et al. Brain-derived neurotrophic factor-induced potentiation of Ca(2+) oscillations in developing cortical neurons. J Biol Chem 2002; 277: 6520\u20136529.","journal-title":"J Biol Chem"},{"key":"BF4001822_CR24","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1159\/000079971","volume":"50","author":"K Tadokoro","year":"2004","unstructured":"Tadokoro K, Hashimoto R, Tatsumi M, Kamijima K, Kunugi H . Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. Neuropsychobiology 2004; 50: 206\u2013210.","journal-title":"Neuropsychobiology"},{"key":"BF4001822_CR25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0304-3835(00)00715-1","volume":"164","author":"M Aoyama","year":"2001","unstructured":"Aoyama M, Asai K, Shishikura T, Kawamoto T, Miyachi T, Yokoi T et al. Human neuroblastomas with unfavorable biologies express high levels of brain-derived neurotrophic factor mRNA and a variety of its variants. Cancer Lett 2001; 164: 51\u201360.","journal-title":"Cancer Lett"},{"key":"BF4001822_CR26","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1046\/j.1471-4159.2002.01030.x","volume":"82","author":"D Garzon","year":"2002","unstructured":"Garzon D, Yu G, Fahnestock M . A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. J Neurochem 2002; 82: 1058\u20131064.","journal-title":"J Neurochem"},{"key":"BF4001822_CR27","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/ajmg.b.30169","volume":"135","author":"H Koizumi","year":"2005","unstructured":"Koizumi H, Hashimoto K, Shimizu E, Iyo M, Mashimo Y, Hata A . Further analysis of microsatellite marker in the BDNF gene. Am J Med Genet 2005; 135: 103.","journal-title":"Am J Med Genet"},{"key":"BF4001822_CR28","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","volume":"112","author":"MF Egan","year":"2003","unstructured":"Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112: 257\u2013269.","journal-title":"Cell"},{"key":"BF4001822_CR29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/ajmg.b.30150","volume":"134","author":"E Dempster","year":"2005","unstructured":"Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F et al. Association between BDNF val66 met genotype and episodic memory. Am J Med Genet 2005; 134: 73\u201375.","journal-title":"Am J Med Genet"},{"key":"BF4001822_CR30","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/S0006-3223(00)00910-0","volume":"48","author":"JA Sweeney","year":"2000","unstructured":"Sweeney JA, Kmiec JA, Kupfer DJ . Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery. Biol Psychiatry 2000; 48:674\u2013684.","journal-title":"Biol Psychiatry"},{"key":"BF4001822_CR31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1399-5618.2004.00118.x","volume":"6","author":"T Deckersbach","year":"2004","unstructured":"Deckersbach T, Savage CR, Reilly-Harrington N, Clark L, Sachs G, Rauch SL . Episodic memory impairment in bipolar disorder and obsessive-compulsive disorder: the role of memory strategies. Bipolar Disord 2004; 6: 233\u2013244.","journal-title":"Bipolar Disord"},{"key":"BF4001822_CR32","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/(SICI)1096-8628(19970725)74:4<443::AID-AJMG17>3.0.CO;2-I","volume":"74","author":"T Sasaki","year":"1997","unstructured":"Sasaki T, Dai XY, Kuwata S, Fukuda R, Kunugi H, Hattori M et al. Brain-derived neurotrophic factor gene and schizophrenia in Japanese subjects. Am J Med Genet 1997; 74: 443\u2013444.","journal-title":"Am J Med Genet"},{"key":"BF4001822_CR33","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0165-1781(98)00076-6","volume":"81","author":"Z Hawi","year":"1998","unstructured":"Hawi Z, Straub RE, O'Neill A, Kendler KS, Walsh D, Gill M . No linkage or linkage disequilibrium between brain-derived neurotrophic factor (BDNF) dinucleotide repeat polymorphism and schizophrenia in Irish families. Psychiatry Res 1998; 81: 111\u2013116.","journal-title":"Psychiatry Res"},{"key":"BF4001822_CR34","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<724::AID-AJMG25>3.0.CO;2-7","volume":"88","author":"TH Wassink","year":"1999","unstructured":"Wassink TH, Nelson JJ, Crowe RR, Andreasen NC . Heritability of BDNF alleles and their effect on brain morphology in schizophrenia. Am J Med Genet 1999; 88: 724\u2013728.","journal-title":"Am J Med Genet"},{"key":"BF4001822_CR35","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0920-9964(00)00106-7","volume":"49","author":"C Virgos","year":"2001","unstructured":"Virgos C, Martorell L, Valero J, Figuera L, Civeira F, Joven J et al. Association study of schizophrenia with polymorphisms at six candidate genes. Schizophr Res 2001; 49: 65\u201371.","journal-title":"Schizophr Res"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4001822.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001822","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001822.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:16:05Z","timestamp":1648782965000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4001822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,28]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7,1]]}},"alternative-id":["BF4001822"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4001822","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,28]]},"assertion":[{"value":"8 November 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}