{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:54:25Z","timestamp":1791276865004,"version":"4.1.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T00:00:00Z","timestamp":1145318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T00:00:00Z","timestamp":1145318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2006,6,1]]},"DOI":"10.1038\/sj.mp.4001824","type":"journal-article","created":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T11:16:54Z","timestamp":1145359014000},"page":"577-593","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes"],"prefix":"10.1038","volume":"11","author":[{"given":"T","family":"Kasahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Nabeshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,4,18]]},"reference":[{"key":"BF4001824_CR1","unstructured":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Text Revision (DSM-IV-TR), 2000."},{"key":"BF4001824_CR2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s11920-004-0004-1","volume":"6","author":"KR Merikangas","year":"2004","unstructured":"Merikangas KR, Low NC . The epidemiology of mood disorders. Curr Psychiatry Rep 2004; 6: 411\u2013421.","journal-title":"Curr Psychiatry Rep"},{"key":"BF4001824_CR3","volume-title":"Manic-Depressive Illness","author":"FK Goodwin","year":"1990","unstructured":"Goodwin FK, Jamison KR . Manic-Depressive Illness. Oxford University Press: New York, 1990."},{"key":"BF4001824_CR4","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1034\/j.1399-5618.2000.020305.x","volume":"2","author":"T Kato","year":"2000","unstructured":"Kato T, Kato N . Mitochondrial dysfunction in bipolar disorder. Bipolar Disord 2000; 2: 180\u2013190.","journal-title":"Bipolar Disord"},{"key":"BF4001824_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0165-0327(93)90097-4","volume":"27","author":"T Kato","year":"1993","unstructured":"Kato T, Takahashi S, Shioiri T, Inubushi T . Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo31P and 7Li magnetic resonance spectroscopy. J Affect Disord 1993; 27: 53\u201359.","journal-title":"J Affect Disord"},{"key":"BF4001824_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0165-0327(99)00173-1","volume":"62","author":"T Kato","year":"2001","unstructured":"Kato T, Kunugi H, Nanko S, Kato N . Mitochondrial DNA polymorphisms in bipolar disorder. J Affect Disord 2001; 62: 151\u2013164.","journal-title":"J Affect Disord"},{"key":"BF4001824_CR7","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.ygeno.2004.08.015","volume":"84","author":"K Munakata","year":"2004","unstructured":"Munakata K, Tanaka M, Mori K, Washizuka S, Yoneda M, Tajima O et al. Mitochondrial DNA 3644T \u2192 C mutation associated with bipolar disorder. Genomics 2004; 84: 1041\u20131050.","journal-title":"Genomics"},{"key":"BF4001824_CR8","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.biopsych.2004.11.041","volume":"57","author":"K Munakata","year":"2005","unstructured":"Munakata K, Iwamoto K, Bundo M, Kato T . Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. Biol Psychiatry 2005; 57: 525\u2013532.","journal-title":"Biol Psychiatry"},{"key":"BF4001824_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.biopsych.2004.07.004","volume":"56","author":"S Washizuka","year":"2004","unstructured":"Washizuka S, Iwamoto K, Kazuno A, Kakiuchi C, Mori K, Kametani M et al. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the NIMH pedigrees. Biol Psychiatry 2004; 56: 483\u2013489.","journal-title":"Biol Psychiatry"},{"key":"BF4001824_CR10","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1001\/archpsyc.61.3.300","volume":"61","author":"C Konradi","year":"2004","unstructured":"Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S et al. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry 2004; 61: 300\u2013308.","journal-title":"Arch Gen Psychiatry"},{"key":"BF4001824_CR11","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/hmg\/ddi022","volume":"14","author":"K Iwamoto","year":"2005","unstructured":"Iwamoto K, Bundo M, Kato T . Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 2005; 14: 241\u2013253.","journal-title":"Hum Mol Genet"},{"key":"BF4001824_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.psy.0000151489.36347.18","volume":"67","author":"KR Krishnan","year":"2005","unstructured":"Krishnan KR . Psychiatric and medical comorbidities of bipolar disorder. Psychosom Med 2005; 67: 1\u20138.","journal-title":"Psychosom Med"},{"key":"BF4001824_CR13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0960-8966(02)00221-3","volume":"13","author":"G Siciliano","year":"2003","unstructured":"Siciliano G, Tessa A, Petrini S, Mancuso M, Bruno C, Grieco GS et al. Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene. Neuromuscul Disord 2003; 13: 162\u2013165.","journal-title":"Neuromuscul Disord"},{"key":"BF4001824_CR14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.nmd.2004.12.004","volume":"15","author":"M Deschauer","year":"2005","unstructured":"Deschauer M, Hudson G, Muller T, Taylor RW, Chinnery PF, Zierz S et al. A novel ANT1 gene mutation with probable germline mosaicism in autosomal dominant progressive external ophthalmoplegia. Neuromuscul Disord 2005; 15: 311\u2013315.","journal-title":"Neuromuscul Disord"},{"key":"BF4001824_CR15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/90058","volume":"28","author":"JN Spelbrink","year":"2001","unstructured":"Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan Q-P, Tariq M et al. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet 2001; 28: 223\u2013231.","journal-title":"Nat Genet"},{"key":"BF4001824_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/90034","volume":"28","author":"G Van Goethem","year":"2001","unstructured":"Van Goethem G, Dermaut B, L\u00f6fgren A, Martin JJ, Van Broeckhoven C . Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Nat Genet 2001; 28: 211\u2013212.","journal-title":"Nat Genet"},{"key":"BF4001824_CR17","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1212\/WNL.62.2.316","volume":"62","author":"M Mancuso","year":"2004","unstructured":"Mancuso M, Filosto M, Bellan M, Liguori R, Montagna P, Baruzzi A et al. POLG mutations causing ophthalmoplegia, sensorimotor polyneuropathy, ataxia, and deafness. Neurology 2004; 62: 316\u2013318.","journal-title":"Neurology"},{"key":"BF4001824_CR18","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0140-6736(04)16983-3","volume":"364","author":"P Luoma","year":"2004","unstructured":"Luoma P, Melberg A, Rinne JO, Kaukonen JA, Nupponen NN, Chalmers RM et al. Parkinsonism, premature menopause, and mitochondrial DNA polymerase \u03b3 mutations: clinical and molecular genetic study. Lancet 2004; 364: 875\u2013882.","journal-title":"Lancet"},{"key":"BF4001824_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/humu.10246","volume":"22","author":"G Van Goethem","year":"2003","unstructured":"Van Goethem G, L\u00f6fgren A, Dermaut B, Ceuterick C, Martin J-J, Van Broeckhoven C et al. Digenic progressive external ophthalmoplegia in a sporadic patient: Recessive mutations in POLG and C10orf2\/Twinkle. Hum Mutat 2003; 22: 175\u2013176.","journal-title":"Hum Mutat"},{"key":"BF4001824_CR20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1172\/JCI115856","volume":"90","author":"A Suomalainen","year":"1992","unstructured":"Suomalainen A, Majander A, Haltia M, Somer H, Lonnqvist J, Savontaus ML et al. Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia. J Clin Invest 1992; 90: 61\u201366.","journal-title":"J Clin Invest"},{"key":"BF4001824_CR21","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1212\/01.WNL.0000140494.58732.83","volume":"63","author":"G Van Goethem","year":"2004","unstructured":"Van Goethem G, Luoma P, Rantamaki M, Al Memar A, Kaakkola S, Hackman P et al. POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement. Neurology 2004; 63: 1251\u20131257.","journal-title":"Neurology"},{"key":"BF4001824_CR22","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0006-3223(97)00012-7","volume":"42","author":"T Kato","year":"1997","unstructured":"Kato T, Stine OC, McMahon FJ, Crowe RR . Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder. Biol Psychiatry 1997; 42: 871\u2013875.","journal-title":"Biol Psychiatry"},{"key":"BF4001824_CR23","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0165-0327(94)90116-3","volume":"31","author":"T Kato","year":"1994","unstructured":"Kato T, Takahashi S, Shioiri T, Murashita J, Hamakawa H, Inubushi T et al. Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. J Affect Disord 1994; 31: 125\u2013133.","journal-title":"J Affect Disord"},{"key":"BF4001824_CR24","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1017\/S0033291799001439","volume":"30","author":"J Murashita","year":"2000","unstructured":"Murashita J, Kato T, Shioiri T, Inubushi T, Kato N . Altered brain energy metabolism in lithium-resistant bipolar disorder detected by photic stimulated 31P-MR spectroscopy. Psychol Med 2000; 30: 107\u2013115.","journal-title":"Psychol Med"},{"key":"BF4001824_CR25","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/jcbfm.1993.61","volume":"13","author":"B Barbiroli","year":"1993","unstructured":"Barbiroli B, Montagna P, Martinelli P, Lodi R, Iotti S, Cortelli P et al. Defective brain energy metabolism shown by in vivo31P MR spectroscopy in 28 patients with mitochondrial cytopathies. J Cereb Blood Flow Metab 1993; 13: 469\u2013474.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BF4001824_CR26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/00004647-200101000-00011","volume":"21","author":"M Rango","year":"2001","unstructured":"Rango M, Bozzali M, Prelle A, Scarlato G, Bresolin N . Brain activation in normal subjects and in patients affected by mitochondrial disease without clinical central nervous system involvement: a phosphorus magnetic resonance spectroscopy study. J Cereb Blood Flow Metab 2001; 21: 85\u201391.","journal-title":"J Cereb Blood Flow Metab"},{"key":"BF4001824_CR27","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1001\/archpsyc.61.5.450","volume":"61","author":"SR Dager","year":"2004","unstructured":"Dager SR, Friedman SD, Parow A, Demopulos C, Stoll AL, Lyoo IK et al. Brain metabolic alterations in medication-free patients with bipolar disorder. Arch Gen Psychiatry 2004; 61: 450\u2013458.","journal-title":"Arch Gen Psychiatry"},{"key":"BF4001824_CR28","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/sj.mp.4001711","volume":"10","author":"C Stork","year":"2005","unstructured":"Stork C, Renshaw PF . Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol Psychiatry 2005; 10: 900\u2013919.","journal-title":"Mol Psychiatry"},{"key":"BF4001824_CR29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1006\/geno.2000.6333","volume":"69","author":"D Zhang","year":"2000","unstructured":"Zhang D, Mott JL, Chang SW, Denniger G, Feng Z, Zassenhaus HP et al. Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis. Genomics 2000; 69: 151\u2013161.","journal-title":"Genomics"},{"key":"BF4001824_CR30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nature02517","volume":"429","author":"A Trifunovic","year":"2004","unstructured":"Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004; 429: 417\u2013423.","journal-title":"Nature"},{"key":"BF4001824_CR31","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.1112125","volume":"309","author":"GC Kujoth","year":"2005","unstructured":"Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005; 309: 481\u2013484.","journal-title":"Science"},{"key":"BF4001824_CR32","doi-asserted-by":"publisher","first-page":"13250","DOI":"10.1073\/pnas.93.23.13250","volume":"93","author":"M Mayford","year":"1996","unstructured":"Mayford M, Baranes D, Podsypanina K, Kandel ER . The 3\u2032-untranslated region of CaMKII\u03b1 is a cis-acting signal for the localization and translation of mRNA in dendrites. Proc Natl Acad Sci USA 1996; 93: 13250\u201313255.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4001824_CR33","unstructured":"World Health Organization. ICD 10: International Statistical Classification of Diseases and Related Health Problems (10 version). Geneva, Switzerland, 1992."},{"key":"BF4001824_CR34","first-page":"47","volume":"37","author":"H Einat","year":"2003","unstructured":"Einat H, Manji HK, Belmaker RH . New approaches to modeling bipolar disorder. Psychopharmacol Bull 2003; 37: 47\u201363.","journal-title":"Psychopharmacol Bull"},{"key":"BF4001824_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.pnpbp.2003.10.015","volume":"28","author":"R Machado-Vieira","year":"2004","unstructured":"Machado-Vieira R, Kapczinski F, Soares JC . Perspectives for the development of animal models of bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004; 28: 209\u2013224.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BF4001824_CR36","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1523\/JNEUROSCI.22-06-02335.2002","volume":"22","author":"Y Miyamoto","year":"2002","unstructured":"Miyamoto Y, Yamada K, Noda Y, Mori H, Mishina M, Nabeshima T et al. Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor \u025b4 subunit. J Neurosci 2002; 22: 2335\u20132342.","journal-title":"J Neurosci"},{"key":"BF4001824_CR37","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1076\/brhm.30.2.178.1422","volume":"30","author":"T Ruf","year":"1999","unstructured":"Ruf T . The Lomb-Scargle periodogram in biological rhythm: analysis of incomplete and unequally spaced time-series. Biol Rhythm Res 1999; 30: 178\u2013201.","journal-title":"Biol Rhythm Res"},{"key":"BF4001824_CR38","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1046\/j.1399-5618.2003.00067.x","volume":"5","author":"JF Goldberg","year":"2003","unstructured":"Goldberg JF, Truman CJ . Antidepressant-induced mania: an overview of current controversies. Bipolar Disord 2003; 5: 407\u2013420.","journal-title":"Bipolar Disord"},{"key":"BF4001824_CR39","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0091-3057(85)90494-0","volume":"22","author":"LH Storlien","year":"1985","unstructured":"Storlien LH, Higson FM, Gleeson RM, Smythe GA, Atrens DM . Effects of chronic lithium, amitriptyline and mianserin on glucoregulation, corticosterone and energy balance in the rat. Pharmacol Biochem Behav 1985; 22: 119\u2013125.","journal-title":"Pharmacol Biochem Behav"},{"key":"BF4001824_CR40","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1095\/biolreprod27.2.327","volume":"27","author":"JF Nelson","year":"1982","unstructured":"Nelson JF, Felicio LS, Randall PK, Sims C, Finch CE . A longitudinal study of estrous cyclicity in aging C57BL\/6J mice: I Cycle frequency, length and vaginal cytology. Biol Reprod 1982; 27: 327\u2013339.","journal-title":"Biol Reprod"},{"issue":"Suppl 426","key":"BF4001824_CR41","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1600-0447.2005.00521.x","volume":"111","author":"SM Carney","year":"2005","unstructured":"Carney SM, Goodwin GM . Lithium \u2013 a continuing story in the treatment of bipolar disorder. Acta Psychiatr Scand 2005; 111 (Suppl 426): 7\u201312.","journal-title":"Acta Psychiatr Scand"},{"issue":"Suppl 3","key":"BF4001824_CR42","first-page":"S230","volume":"36","author":"T Bschor","year":"2003","unstructured":"Bschor T, Lewitzka U, Sasse J, Adli M, Koberle U, Bauer M et al. Lithium augmentation in treatment-resistant depression: clinical evidence, serotonergic and endocrine mechanisms. Pharmacopsychiatry 2003; 36 (Suppl 3): S230\u2013S234.","journal-title":"Pharmacopsychiatry"},{"key":"BF4001824_CR43","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1901\/jeab.1997.67-337","volume":"67","author":"TW Belke","year":"1997","unstructured":"Belke TW . Running and responding reinforced by the opportunity to run: effect of reinforcer duration. J Exp Anal Behav 1997; 67: 337\u2013351.","journal-title":"J Exp Anal Behav"},{"key":"BF4001824_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1006\/anbe.1998.0836","volume":"56","author":"CM Sherwin","year":"1998","unstructured":"Sherwin CM . Voluntary wheel running: a review and novel interpretation. Anim Behav 1998; 56: 11\u201327.","journal-title":"Anim Behav"},{"key":"BF4001824_CR45","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0165-0327(92)90015-X","volume":"26","author":"K Daimon","year":"1992","unstructured":"Daimon K, Yamada N, Tsujimoto T, Takahashi S . Circadian rhythm abnormalities of deep body temperature in depressive disorders. J Affect Disord 1992; 26: 191\u2013198.","journal-title":"J Affect Disord"},{"issue":"Suppl 6","key":"BF4001824_CR46","first-page":"4","volume":"61","author":"RM Hirschfeld","year":"2000","unstructured":"Hirschfeld RM . History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry 2000; 61 (Suppl 6): 4\u20136.","journal-title":"J Clin Psychiatry"},{"issue":"Suppl 14","key":"BF4001824_CR47","first-page":"11","volume":"59","author":"DS Charney","year":"1998","unstructured":"Charney DS . Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry 1998; 59 (Suppl 14): 11\u201314.","journal-title":"J Clin Psychiatry"},{"key":"BF4001824_CR48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0006-3223(94)91201-7","volume":"35","author":"LT Young","year":"1994","unstructured":"Young LT, Warsh JJ, Kish SJ, Shannak K, Hornykeiwicz O . Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder. Biol Psychiatry 1994; 35: 121\u2013127.","journal-title":"Biol Psychiatry"},{"key":"BF4001824_CR49","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1034\/j.1399-5618.2002.01217.x","volume":"4","author":"S Sobczak","year":"2002","unstructured":"Sobczak S, Honig A, van Duinen MA, Riedel WJ . Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies. Bipolar Disord 2002; 4: 347\u2013356.","journal-title":"Bipolar Disord"},{"key":"BF4001824_CR50","first-page":"239","volume":"34","author":"MC Blehar","year":"1998","unstructured":"Blehar MC, DePaulo Jr JR, Gershon ES, Reich T, Simpson SG, Nurnberger Jr JI et al. Women with bipolar disorder: findings from the NIMH Genetics Initiative sample. Psychopharmacol Bull 1998; 34: 239\u2013243.","journal-title":"Psychopharmacol Bull"},{"key":"BF4001824_CR51","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jpsychires.2004.05.006","volume":"39","author":"N Rasgon","year":"2005","unstructured":"Rasgon N, Bauer M, Grof P, Gyulai L, Elman S, Glenn T et al. Sex-specific self-reported mood changes by patients with bipolar disorder. J Psychiatr Res 2005; 39: 77\u201383.","journal-title":"J Psychiatr Res"},{"key":"BF4001824_CR52","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1600-0447.1980.tb00569.x","volume":"61","author":"M Steiner","year":"1980","unstructured":"Steiner M, Haskett RF, Osmun JN, Carroll BJ . Treatment of premenstrual tension with lithium carbonate. A pilot study. Acta Psychiatr Scand 1980; 61: 96\u2013102.","journal-title":"Acta Psychiatr Scand"},{"key":"BF4001824_CR53","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1399-5618.2004.00112.x","volume":"6","author":"F Karadag","year":"2004","unstructured":"Karadag F, Akdeniz F, Erten E, Pirildar S, Yucel B, Polat A et al. Menstrually related symptom changes in women with treatment-responsive bipolar disorder. Bipolar Disord 2004; 6: 253\u2013259.","journal-title":"Bipolar Disord"},{"key":"BF4001824_CR54","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S0006-3223(01)01184-2","volume":"50","author":"W Perry","year":"2001","unstructured":"Perry W, Minassian A, Feifel D, Braff DL . Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biol Psychiatry 2001; 50: 418\u2013424.","journal-title":"Biol Psychiatry"},{"key":"BF4001824_CR55","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/j.1399-5618.2005.00183.x","volume":"7","author":"BA Rich","year":"2005","unstructured":"Rich BA, Vinton D, Grillon C, Bhangoo RK, Leibenluft E . An investigation of prepulse inhibition in pediatric bipolar disorder. Bipolar Disord 2005; 7: 198\u2013203.","journal-title":"Bipolar Disord"},{"key":"BF4001824_CR56","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1017\/S0033291705005702","volume":"35","author":"SL Barrett","year":"2005","unstructured":"Barrett SL, Kelly C, Watson DR, Bell R, King DJ . Normal levels of prepulse inhibition in the euthymic phase of bipolar disorder. Psychol Med 2005; 35: 1737\u20131746.","journal-title":"Psychol Med"},{"key":"BF4001824_CR57","first-page":"37","volume":"30","author":"S Ludewig","year":"2005","unstructured":"Ludewig S, Geyer MA, Ramseier M, Vollenweider FX, Rechsteiner E, Cattapan-Ludewig K et al. Information-processing deficits and cognitive dysfunction in panic disorder. J Psychiatry Neurosci 2005; 30: 37\u201343.","journal-title":"J Psychiatry Neurosci"},{"key":"BF4001824_CR58","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1176\/appi.ajp.161.12.2222","volume":"161","author":"NM Simon","year":"2004","unstructured":"Simon NM, Otto MW, Wisniewski SR, Fossey M, Sagduyu K, Frank E et al. Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry 2004; 161: 2222\u20132229.","journal-title":"Am J Psychiatry"},{"key":"BF4001824_CR59","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/nsmb805","volume":"11","author":"MA Graziewicz","year":"2004","unstructured":"Graziewicz MA, Longley MJ, Bienstock RJ, Zeviani M, Copeland WC . Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia. Nat Struct Mol Biol 2004; 11: 770\u2013776.","journal-title":"Nat Struct Mol Biol"},{"key":"BF4001824_CR60","doi-asserted-by":"publisher","first-page":"24818","DOI":"10.1074\/jbc.M000559200","volume":"275","author":"JN Spelbrink","year":"2000","unstructured":"Spelbrink JN, Toivonen JM, Hakkaart GA, Kurkela JM, Cooper HM, Lehtinen SK et al. In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells. J Biol Chem 2000; 275: 24818\u201324828.","journal-title":"J Biol Chem"},{"key":"BF4001824_CR61","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/S0140-6736(04)16983-3","volume":"364","author":"P Luoma","year":"2004","unstructured":"Luoma P, Melberg A, Rinne JO, Kaukonen JA, Nupponen NN, Chalmers RM et al. Parkinsonism, premature menopause, and mitochondrial DNA polymerase \u03b3 mutations: clinical and molecular genetic study. Lancet 2004; 364: 875\u2013882.","journal-title":"Lancet"},{"key":"BF4001824_CR62","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1212\/01.WNL.0000140494.58732.83","volume":"63","author":"G Van Goethem","year":"2004","unstructured":"Van Goethem G, Luoma P, Rantamaki M, Al Memar A, Kaakkola S, Hackman P et al. POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement. Neurology 2004; 63: 1251\u20131257.","journal-title":"Neurology"},{"key":"BF4001824_CR63","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1086\/444548","volume":"77","author":"AH Hakonen","year":"2005","unstructured":"Hakonen AH, Heiskanen S, Juvonen V, Lappalainen I, Luoma PT, Rantamaki M et al. Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin. Am J Hum Genet 2005; 77: 430\u2013441.","journal-title":"Am J Hum Genet"},{"key":"BF4001824_CR64","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/humu.9203","volume":"22","author":"A Di Fonzo","year":"2003","unstructured":"Di Fonzo A, Bordoni A, Crimi M, Sara G, Del Bo R, Bresolin N et al. POLG mutations in sporadic mitochondrial disorders with multiple mtDNA deletions. Hum Mutat 2003; 22: 498\u2013499.","journal-title":"Hum Mutat"},{"key":"BF4001824_CR65","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1054\/ceca.2000.0166","volume":"28","author":"T Pozzan","year":"2000","unstructured":"Pozzan T, Magalhaes P, Rizzuto R . The comeback of mitochondria to calcium signalling. Cell Calcium 2000; 28: 279\u2013283.","journal-title":"Cell Calcium"},{"key":"BF4001824_CR66","first-page":"685","volume":"33","author":"JC Soares","year":"1997","unstructured":"Soares JC, Mallinger AG . Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients. Psychopharmacol Bull 1997; 33: 685\u2013691.","journal-title":"Psychopharmacol Bull"},{"key":"BF4001824_CR67","first-page":"321","volume":"21","author":"S Yamawaki","year":"1996","unstructured":"Yamawaki S, Kagaya A, Okamoto Y, Shimizu M, Nishida A, Uchitoni Y . Enhanced calcium response to serotonin in platelets from patients with affective disorders. J Psychiatry Neurosci 1996; 21: 321\u2013324.","journal-title":"J Psychiatry Neurosci"},{"key":"BF4001824_CR68","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1176\/appi.ajp.162.3.616","volume":"162","author":"C-G Hahn","year":"2005","unstructured":"Hahn C-G, Gomez G, Restrepo D, Friedman E, Josiassen R, Pribitkin EA et al. Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder. Am J Psychiatry 2005; 162: 616\u2013618.","journal-title":"Am J Psychiatry"},{"key":"BF4001824_CR69","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1073\/pnas.68.9.2252","volume":"68","author":"H Kasamatsu","year":"1971","unstructured":"Kasamatsu H, Robberson DL, Vinograd J . A novel closed-circular mitochondrial DNA with properties of a replicating intermediate. Proc Natl Acad Sci USA 1971; 68: 2252\u20132257.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4001824.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001824","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4001824.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T03:11:42Z","timestamp":1648782702000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4001824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,18]]},"references-count":69,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6,1]]}},"alternative-id":["BF4001824"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4001824","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,18]]},"assertion":[{"value":"10 November 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}