{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:36:41Z","timestamp":1791117401214,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1038\/sj.mp.4002001","type":"journal-article","created":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T10:23:21Z","timestamp":1178015001000},"page":"429-441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins"],"prefix":"10.1038","volume":"13","author":[{"given":"G","family":"Kuratomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Kusumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"BF4002001_CR1","volume-title":"Manic-Depressive Illness","author":"FK Goodwin","year":"1990","unstructured":"Goodwin FK, Jamison KR . Manic-Depressive Illness. Oxford University Press: New York, 1990."},{"key":"BF4002001_CR2","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/sj.mp.4000750","volume":"5","author":"A Petronis","year":"2000","unstructured":"Petronis A, Gottesman II, Crow TJ, DeLisi LE, Klar AJ, Macciardi F et al. Psychiatric epigenetics: a new focus for the new century. Mol Psychiatry 2000; 5: 342\u2013346.","journal-title":"Mol Psychiatry"},{"key":"BF4002001_CR3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/35102186","volume":"414","author":"MA Surani","year":"2001","unstructured":"Surani MA . Reprogramming of genome function through epigenetic inheritance. Nature 2001; 414: 122\u2013128.","journal-title":"Nature"},{"key":"BF4002001_CR4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nature02625","volume":"429","author":"G Egger","year":"2004","unstructured":"Egger G, Liang G, Aparicio A, Jones PA . Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004; 429: 457\u2013463.","journal-title":"Nature"},{"key":"BF4002001_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"A Bird","year":"2002","unstructured":"Bird A . DNA methylation patterns and epigenetic memory. Genes Dev 2002; 16: 6\u201321.","journal-title":"Genes Dev"},{"key":"BF4002001_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/ajmg.c.20015","volume":"123","author":"A Petronis","year":"2003","unstructured":"Petronis A . Epigenetics and bipolar disorder: new opportunities and challenges. Am J Med Genet C Semin Med Genet 2003; 123: 65\u201375.","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"BF4002001_CR7","doi-asserted-by":"publisher","first-page":"36734","DOI":"10.1074\/jbc.M101287200","volume":"276","author":"CJ Phiel","year":"2001","unstructured":"Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS . Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 2001; 276: 36734\u201336741.","journal-title":"J Biol Chem"},{"key":"BF4002001_CR8","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1192\/bjp.150.5.724","volume":"150","author":"MW Carney","year":"1987","unstructured":"Carney MW, Chary TK, Bottiglieri T, Reynolds EH, Toone BK . Switch mechanism in affective illness and oral S-adenosylmethionine (SAM). Br J Psychiatry 1987; 150: 724\u2013725.","journal-title":"Br J Psychiatry"},{"key":"BF4002001_CR9","doi-asserted-by":"publisher","first-page":"20812","DOI":"10.1074\/jbc.M211813200","volume":"278","author":"N Detich","year":"2003","unstructured":"Detich N, Hamm S, Just G, Knox JD, Szyf M . The methyl donor S-adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-adenosylmethionine. J Biol Chem 2003; 278: 20812\u201320820.","journal-title":"J Biol Chem"},{"key":"BF4002001_CR10","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/sj.mp.4001662","volume":"10","author":"T Kato","year":"2005","unstructured":"Kato T, Iwamoto K, Kakiuchi C, Kuratomi G, Okazaki Y . Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders. Mol Psychiatry 2005; 10: 622\u2013630.","journal-title":"Mol Psychiatry"},{"key":"BF4002001_CR11","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/0006-3223(94)00364-9","volume":"37","author":"I Kusumi","year":"1995","unstructured":"Kusumi I, Ohmori T, Kohsaka M, Ito M, Honma H, Koyama T . Chronobiological approach for treatment-resistant rapid cycling affective disorders. Biol Psychiatry 1995; 37: 553\u2013559.","journal-title":"Biol Psychiatry"},{"key":"BF4002001_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/ng1235","volume":"35","author":"C Kakiuchi","year":"2003","unstructured":"Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I et al. Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nat Genet 2003; 35: 171\u2013175.","journal-title":"Nat Genet"},{"key":"BF4002001_CR13","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1073\/pnas.94.6.2284","volume":"94","author":"T Ushijima","year":"1997","unstructured":"Ushijima T, Morimura K, Hosoya Y, Okonogi H, Tatematsu M, Sugimura T et al. Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors. Proc Natl Acad Sci USA 1997; 94: 2284\u20132289.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4002001_CR14","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10038-004-0136-5","volume":"49","author":"K Iwamoto","year":"2004","unstructured":"Iwamoto K, Bundo M, Washizuka S, Kakiuchi C, Kato T . Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. J Hum Genet 2004; 49: 227\u2013231.","journal-title":"J Hum Genet"},{"key":"BF4002001_CR15","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0024-3205(02)01725-3","volume":"71","author":"T Kato","year":"2002","unstructured":"Kato T, Ishiwata M, Nagai T . Mitochondrial calcium response in human transformed lymphoblastoid cells. Life Sci 2002; 71: 581\u2013590.","journal-title":"Life Sci"},{"key":"BF4002001_CR16","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1126\/science.8438152","volume":"259","author":"N Lisitsyn","year":"1993","unstructured":"Lisitsyn N, Wigler M . Cloning the differences between two complex genomes. Science 1993; 259: 946\u2013951.","journal-title":"Science"},{"key":"BF4002001_CR17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0022-2836(87)90689-9","volume":"196","author":"M Gardiner-Garden","year":"1987","unstructured":"Gardiner-Garden M, Frommer M . CpG islands in vertebrate genomes. J Mol Biol 1987; 196: 261\u2013282.","journal-title":"J Mol Biol"},{"key":"BF4002001_CR18","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","volume":"18","author":"LC Li","year":"2002","unstructured":"Li LC, Dahiya R . MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002; 18: 1427\u20131431.","journal-title":"Bioinformatics"},{"key":"BF4002001_CR19","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/sj.mp.4001437","volume":"9","author":"K Iwamoto","year":"2004","unstructured":"Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T . Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol Psychiatry 2004; 9: 406\u2013416.","journal-title":"Mol Psychiatry"},{"key":"BF4002001_CR20","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2144\/03351md01","volume":"35","author":"S Colella","year":"2003","unstructured":"Colella S, Shen L, Baggerly KA, Issa JP, Krahe R . Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites. Biotechniques 2003; 35: 146\u2013150.","journal-title":"Biotechniques"},{"key":"BF4002001_CR21","doi-asserted-by":"publisher","first-page":"10604","DOI":"10.1073\/pnas.0500398102","volume":"102","author":"MF Fraga","year":"2005","unstructured":"Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005; 102: 10604\u201310609.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4002001_CR22","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.ygeno.2003.09.018","volume":"83","author":"M Onishi","year":"2004","unstructured":"Onishi M, Yasunaga T, Tanaka H, Nishimune Y, Nozaki M . Structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b. Genomics 2004; 83: 647\u2013657.","journal-title":"Genomics"},{"key":"BF4002001_CR23","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s000180050299","volume":"55","author":"SF Gothel","year":"1999","unstructured":"Gothel SF, Marahiel MA . Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell Mol Life Sci 1999; 55: 423\u2013436.","journal-title":"Cell Mol Life Sci"},{"key":"BF4002001_CR24","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/ajmg.b.30140","volume":"134","author":"HM Abdolmaleky","year":"2005","unstructured":"Abdolmaleky HM, Cheng KH, Russo A, Smith CL, Faraone SV, Wilcox M et al. Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet 2005; 134: 60\u201366.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BF4002001_CR25","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1093\/nar\/gkf401","volume":"30","author":"Y Chen","year":"2002","unstructured":"Chen Y, Sharma RP, Costa RH, Costa E, Grayson DR . On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res 2002; 30: 2930\u20132939.","journal-title":"Nucleic Acids Res"},{"key":"BF4002001_CR26","doi-asserted-by":"publisher","first-page":"5376","DOI":"10.1523\/JNEUROSCI.0766-05.2005","volume":"25","author":"K Iwamoto","year":"2005","unstructured":"Iwamoto K, Bundo M, Yamada K, Takao H, Iwayama-Shigeno Y, Yoshikawa T et al. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J Neurosci 2005; 25: 5376\u20135381.","journal-title":"J Neurosci"},{"key":"BF4002001_CR27","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1176\/ajp.154.7.976","volume":"154","author":"M Emamghoreishi","year":"1997","unstructured":"Emamghoreishi M, Schlichter L, Li PP, Parikh S, Sen J, Kamble A et al. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder. Am J Psychiatry 1997; 154: 976\u2013982.","journal-title":"Am J Psychiatry"},{"key":"BF4002001_CR28","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1017\/S1461145703003717","volume":"6","author":"T Kato","year":"2003","unstructured":"Kato T, Ishiwata M, Mori K, Washizuka S, Tajima O, Akiyama T et al. Mechanisms of altered Ca2+ signaling in transformed lymphoblastoid cells from patients with bipolar disorder. Int J Neuropsychopharmacol 2003; 6: 379\u2013389.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BF4002001_CR29","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1034\/j.1399-5618.2002.00108.x","volume":"4","author":"RH Belmaker","year":"2002","unstructured":"Belmaker RH, Shapiro J, Vainer E, Nemanov L, Ebstein RP, Agam G . Reduced inositol content in lymphocyte-derived cell lines from bipolar patients. Bipolar Disord 2002; 4: 67\u201369.","journal-title":"Bipolar Disord"},{"key":"BF4002001_CR30","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1176\/ajp.155.3.422","volume":"155","author":"T Tsujita","year":"1998","unstructured":"Tsujita T, Niikawa N, Yamashita H, Imamura A, Hamada A, Nakane Y et al. Genomic discordance between monozygotic twins discordant for schizophrenia. Am J Psychiatry 1998; 155: 422\u2013424.","journal-title":"Am J Psychiatry"},{"key":"BF4002001_CR31","doi-asserted-by":"publisher","first-page":"E16","DOI":"10.1136\/jmg.40.2.e16","volume":"40","author":"P McDonald","year":"2003","unstructured":"McDonald P, Lewis M, Murphy B, O\u2019Reilly R, Singh SM . Appraisal of genetic and epigenetic congruity of a monozygotic twin pair discordant for schizophrenia. J Med Genet 2003; 40: E16.","journal-title":"J Med Genet"},{"key":"BF4002001_CR32","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/oxfordjournals.schbul.a006988","volume":"29","author":"A Petronis","year":"2003","unstructured":"Petronis A, Gottesman II, Kan P, Kennedy JL, Basile VS, Paterson AD et al. Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? Schizophr Bull 2003; 29: 169\u2013178.","journal-title":"Schizophr Bull"},{"key":"BF4002001_CR33","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1093\/hmg\/11.11.1317","volume":"11","author":"R Weksberg","year":"2002","unstructured":"Weksberg R, Shuman C, Caluseriu O, Smith AC, Fei YL, Nishikawa J et al. Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome. Hum Mol Genet 2002; 11: 1317\u20131325.","journal-title":"Hum Mol Genet"},{"key":"BF4002001_CR34","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000015641","volume":"90","author":"A Vilain","year":"2000","unstructured":"Vilain A, Bernardino J, Gerbault-Seureau M, Vogt N, Niveleau A, Lefrancois D et al. DNA methylation and chromosome instability in lymphoblastoid cell lines. Cytogenet Cell Genet 2000; 90: 93\u2013101.","journal-title":"Cytogenet Cell Genet"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4002001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4002001","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4002001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T12:12:41Z","timestamp":1648815161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4002001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,1]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["BF4002001"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4002001","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,1]]},"assertion":[{"value":"11 September 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}