{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:58:10Z","timestamp":1790377090089,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T00:00:00Z","timestamp":1191888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T00:00:00Z","timestamp":1191888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Psychiatry"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1038\/sj.mp.4002103","type":"journal-article","created":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T14:39:34Z","timestamp":1191940774000},"page":"1054-1059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["The effects of a neuregulin 1 variant on white matter density and integrity"],"prefix":"10.1038","volume":"13","author":[{"given":"A M","family":"McIntosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T W J","family":"Moorhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Job","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G K S","family":"Lymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mu\u00f1oz Maniega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"McKirdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E D","family":"Sussmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B J","family":"Baig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Bastin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Porteous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Johnstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Lawrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,10,9]]},"reference":[{"key":"BF4002103_CR1","volume-title":"The Role of Diagnosis in Psychiatry","author":"RE Kendell","year":"1975","unstructured":"Kendell RE . The Role of Diagnosis in Psychiatry. Blackwell: Edinburgh, 1975."},{"key":"BF4002103_CR2","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.biopsych.2005.03.044","volume":"58","author":"AM McIntosh","year":"2005","unstructured":"McIntosh AM, Job DE, Moorhead TW, Harrison LK, Lawrie SM, Johnstone EC . White matter density in patients with schizophrenia, bipolar disorder and their unaffected relatives. Biol Psychiatry 2005; 58: 254\u2013257.","journal-title":"Biol Psychiatry"},{"key":"BF4002103_CR3","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0006-3223(03)00007-6","volume":"54","author":"S Zhou","year":"2003","unstructured":"Zhou S, Suzuki M, Hagino H, Takahashi T, Kawasaki Y, Nohara S et al. Decreased volume and increased asymmetry of the anterior limb of the internal capsule in patients with schizophrenia. Biol Psychiatry 2003; 54: 427\u2013436.","journal-title":"Biol Psychiatry"},{"key":"BF4002103_CR4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/ajmg.b.30254","volume":"141B","author":"AM McIntosh","year":"2006","unstructured":"McIntosh AM, Job D, Moorhead TWJ, Harrison LK, Whalley HC, Johnstone EC et al. Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure. Am J Med Genet 2006; 141B: 76\u201383.","journal-title":"Am J Med Genet"},{"key":"BF4002103_CR5","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1148\/radiol.2223010311","volume":"222","author":"AC Guo","year":"2002","unstructured":"Guo AC, MacFall JR, Provenzale JM . Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter. Radiology 2002; 222: 729\u2013736.","journal-title":"Radiology"},{"key":"BF4002103_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0920-9964(01)00163-3","volume":"49","author":"ME Shenton","year":"2001","unstructured":"Shenton ME, Dickey CC, Frumin M, McCarley RW . A review of MRI findings in schizophrenia. Schizophr Res 2001; 49: 1\u201352.","journal-title":"Schizophr Res"},{"key":"BF4002103_CR7","doi-asserted-by":"crossref","unstructured":"Sussmann JE, Lymer GKS, McKirdy J, Moorhead TWJ, Maniega SM, Job D et al. White matter abnormalities in bipolar disorder detected using diffusion tensor magnetic resonance imaging. (in review) 2007.","DOI":"10.1016\/j.schres.2007.12.007"},{"key":"BF4002103_CR8","unstructured":"Maniega SM, Lymer GKS, Bastin ME, Marjoram D, Job DE, Moorhead TWJ et al. A DT-MRI study of subjects at high genetic risk of schizophrenia. In review 2007."},{"key":"BF4002103_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/schbul\/sbj033","volume":"32","author":"N Craddock","year":"2006","unstructured":"Craddock N, O'Donovan MC, Owen MJ . Genes for schizophrenia and bipolar disorder? Implications for psychiatric Nosology. Schizophr Bull 2006; 32: 9\u201316.","journal-title":"Schizophr Bull"},{"key":"BF4002103_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1086\/342734","volume":"71","author":"H Stefansson","year":"2002","unstructured":"Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Brynjolfsson J et al. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002; 71: 185.","journal-title":"Am J Hum Genet"},{"key":"BF4002103_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1086\/345442","volume":"72","author":"H Stefansson","year":"2003","unstructured":"Stefansson H, Sarginson J, Kong A, Yates P, Steinthorsdottir V, Gudfinnsson E et al. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet 2003; 72: 83\u201387.","journal-title":"Am J Hum Genet"},{"key":"BF4002103_CR12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/sj.mp.4001889","volume":"12","author":"PA Thomson","year":"2007","unstructured":"Thomson PA, Christoforou A, Morris SW, Adie E, Pickard BS, Porteous DJ et al. Association of neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population. Mol Psychiatry 2007; 12: 94\u2013104.","journal-title":"Mol Psychiatry"},{"key":"BF4002103_CR13","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1001\/archpsyc.62.6.642","volume":"62","author":"EK Green","year":"2005","unstructured":"Green EK, Raybould R, MacGregor S, Gordon-Smith K, Heron J, Hyde S et al. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Arch Gen Psychiatry 2005; 62: 642\u2013648.","journal-title":"Arch Gen Psychiatry"},{"key":"BF4002103_CR14","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1093\/hmg\/ddl122","volume":"15","author":"D Li","year":"2006","unstructured":"Li D, Collier DA, He L . Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet 2006; 15: 1995\u20132002.","journal-title":"Hum Mol Genet"},{"key":"BF4002103_CR15","doi-asserted-by":"publisher","first-page":"6747","DOI":"10.1073\/pnas.0602002103","volume":"103","author":"AJ Law","year":"2006","unstructured":"Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R et al. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5\u2032 SNPs associated with the disease. Proc Natl Acad Sci USA 2006; 103: 6747\u20136752.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF4002103_CR16","doi-asserted-by":"publisher","first-page":"24343","DOI":"10.1074\/jbc.M702953200","volume":"282","author":"W Tan","year":"2007","unstructured":"Tan W, Wang Y, Gold B, Chen J, Dean M, Harrison PJ et al. Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem 2007; 282: 24343\u201324351.","journal-title":"J Biol Chem"},{"key":"BF4002103_CR17","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1038\/nn1795","volume":"9","author":"J Hall","year":"2006","unstructured":"Hall J, Whalley HC, Job DE, Baig BJ, McIntosh AM, Evans KL et al. A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms. Nat Neurosci 2006; 9: 1477\u20131478.","journal-title":"Nat Neurosci"},{"key":"BF4002103_CR18","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.biopsych.2006.11.015","volume":"62","author":"NC Stefanis","year":"2007","unstructured":"Stefanis NC, Trikalinos TA, Avramopoulos D, Smyrnis N, Evdokimidis I, Ntzani EE et al. Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biol Psychiatry 2007; 62: 784\u2013792.","journal-title":"Biol Psychiatry"},{"key":"BF4002103_CR19","first-page":"89","volume":"3","author":"KJ Friston","year":"1995","unstructured":"Friston KJ, Frith CD . Schizophrenia: a disconnection syndrome? Clin Neurosci 1995; 3: 89\u201397.","journal-title":"Clin Neurosci"},{"key":"BF4002103_CR20","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/sj.mp.4001906","volume":"12","author":"AM Addington","year":"2007","unstructured":"Addington AM, Gornick MC, Shaw P, Seal J, Gogtay N, Greenstein D et al. Neuregulin 1 (8p12) and childhood-onset schizophrenia: susceptibility haplotypes for diagnosis and brain developmental trajectories. Mol Psychiatry 2007; 12: 195\u2013205.","journal-title":"Mol Psychiatry"},{"key":"BF4002103_CR21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cell.2006.01.042","volume":"125","author":"G Lopez-Bendito","year":"2006","unstructured":"Lopez-Bendito G, Cautinat A, Sanchez JA, Bielle F, Flames N, Garratt AN et al. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell 2006; 125: 127\u2013142.","journal-title":"Cell"},{"key":"BF4002103_CR22","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nn1258","volume":"7","author":"G Corfas","year":"2004","unstructured":"Corfas G, Roy K, Buxbaum J . Neuregulin 1-erbB signaling and the molecular\/cellular basis of schizophrenia. Nat Neurosci 2004; 7: 575\u2013580.","journal-title":"Nat Neurosci"},{"issue":"Part 1","key":"BF4002103_CR23","first-page":"t-36","volume":"14","author":"CD Good","year":"2001","unstructured":"Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS . A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14 (Part 1): t-36.","journal-title":"Neuroimage"},{"key":"BF4002103_CR24","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.neuroimage.2007.01.008","volume":"35","author":"MD Spencer","year":"2007","unstructured":"Spencer MD, Moorhead TW, McIntosh AM, Stanfield AC, Muir WJ, Hoare P et al. Grey matter correlates of early psychotic symptoms in adolescents at enhanced risk of psychosis: a voxel-based study. Neuroimage 2007; 35: 1181\u20131191.","journal-title":"Neuroimage"},{"key":"BF4002103_CR25","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.neuroimage.2003.12.012","volume":"22","author":"TWJ Moorhead","year":"2004","unstructured":"Moorhead TWJ, Job DE, Whalley HC, Sanderson TL, Johnstone EC, Lawrie SM . Voxel-based morphometry of comorbid schizophrenia and learning disability: analyses in normalized and native spaces using parametric and nonparametric statistical methods. Neuroimage 2004; 22: 188\u2013202.","journal-title":"Neuroimage"},{"key":"BF4002103_CR26","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/ajmg.b.30254","volume":"141","author":"AM McIntosh","year":"2006","unstructured":"McIntosh AM, Job DE, Moorhead WJ, Harrison LK, Whalley HC, Johnstone EC et al. Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure. Am J Med Genet B Neuropsychiatr Genet 2006; 141: 76\u201383.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BF4002103_CR27","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1006\/nimg.1998.0411","volume":"9","author":"P Fletcher","year":"1999","unstructured":"Fletcher P, McKenna PJ, Friston KJ, Frith CD, Dolan RJ . Abnormal cingulate modulation of fronto-temporal connectivity in schizophrenia. Neuroimage 1999; 9: 337\u2013342.","journal-title":"Neuroimage"},{"key":"BF4002103_CR28","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/S0006-3223(02)01316-1","volume":"51","author":"SM Lawrie","year":"2002","unstructured":"Lawrie SM, Buechel C, Whalley HC, Frith CD, Friston KJ, Johnstone EC . Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry 2002; 51: 1008\u20131011.","journal-title":"Biol Psychiatry"},{"issue":"Part 9","key":"BF4002103_CR29","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1093\/brain\/awh556","volume":"128","author":"HC Whalley","year":"2005","unstructured":"Whalley HC, Simonotto E, Marshall I, Owens DG, Goddard NH, Johnstone EC et al. Functional disconnectivity in subjects at high genetic risk of schizophrenia. Brain 2005; 128 (Part 9): 2097\u20132108.","journal-title":"Brain"},{"key":"BF4002103_CR30","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.biopsych.2005.11.002","volume":"60","author":"PJ Harrison","year":"2006","unstructured":"Harrison PJ, Law AJ . Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 2006; 60: 132\u2013140.","journal-title":"Biol Psychiatry"}],"container-title":["Molecular Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/4002103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4002103","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/4002103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T12:33:26Z","timestamp":1648816406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/4002103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,9]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["BF4002103"],"URL":"https:\/\/doi.org\/10.1038\/sj.mp.4002103","relation":{},"ISSN":["1359-4184","1476-5578"],"issn-type":[{"value":"1359-4184","type":"print"},{"value":"1476-5578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,9]]},"assertion":[{"value":"26 June 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}