{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:07:31Z","timestamp":1777482451758,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":3536,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1038\/sj.mt.6300016","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T16:02:57Z","timestamp":1169136177000},"page":"242-247","source":"Crossref","is-referenced-by-count":30,"title":["Adeno-associated Virus Type 5 Reduces Learning Deficits and Restores Glutamate Receptor Subunit Levels in MPS VII Mice CNS"],"prefix":"10.1016","volume":"15","author":[{"given":"Gumei","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A","family":"Heth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A","family":"Chiorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly L","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/sj.mt.6300016_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0022-3476(73)80162-3","article-title":"Beta glucuronidase deficiency: report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis","volume":"82","author":"Sly","year":"1973","journal-title":"J Pediatr"},{"key":"10.1038\/sj.mt.6300016_bib2","first-page":"2465","article-title":"The metabolic basis of inherited disease","author":"Neufeld","year":"1995"},{"key":"10.1038\/sj.mt.6300016_bib3","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1073\/pnas.90.14.6567","article-title":"A single-base-pair deletion in the \u03b2-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII","volume":"90","author":"Sands","year":"1995","journal-title":"PNAS"},{"key":"10.1038\/sj.mt.6300016_bib4","first-page":"207","article-title":"A murine model of mucopolysaccharidosis VII","volume":"136","author":"Vogler","year":"1990","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.mt.6300016_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s004010050562","article-title":"Neuropathology of murine mucopolysaccharidosis type VII","volume":"92","author":"Levy","year":"1996","journal-title":"Acta Neuropathol"},{"key":"10.1038\/sj.mt.6300016_bib6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/mthe.2001.0274","article-title":"Intracranial injection of recombinant adeno-associated virus improves cognitive function in a murine model of mucopolysaccharidosis type VII","volume":"3","author":"Frisella","year":"2001","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300016_bib7","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1172\/JCI1773","article-title":"Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function","volume":"101","author":"O'Connor","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.mt.6300016_bib8","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1172\/JCI117434","article-title":"Behavioral consequences of bone marrow transplantation in the treatment of murine mucopolysaccharidosis type VII","volume":"94","author":"Bastedo","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.mt.6300016_bib9","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.1073\/pnas.082011999","article-title":"Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors","volume":"99","author":"Brooks","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.mt.6300016_bib10","doi-asserted-by":"crossref","first-page":"9321","DOI":"10.1523\/JNEUROSCI.2936-05.2005","article-title":"Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors","volume":"25","author":"Liu","year":"2005","journal-title":"J Neurosci"},{"key":"10.1038\/sj.mt.6300016_bib11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00001756-199305000-00011","article-title":"Behavioural abnormalities in a murine model of a human lysosomal storage disease","volume":"4","author":"Chang","year":"1993","journal-title":"NeuroReport"},{"key":"10.1038\/sj.mt.6300016_bib12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/exnr.2000.7531","article-title":"Somatic gene therapy for a neurodegenerative disease using microencapsulated recombinant cells","volume":"166","author":"Ross","year":"2000","journal-title":"Exp Neurol"},{"key":"10.1038\/sj.mt.6300016_bib13","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1006\/mthe.2001.0325","article-title":"In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors","volume":"3","author":"Stein","year":"2001","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300016_bib14","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1128\/JVI.73.4.3424-3429.1999","article-title":"Systemic and central nervous system correction of lysosomal storage in mucopolysaccharidosis type VII mice","volume":"73","author":"Stein","year":"1999","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300016_bib15","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1089\/hum.1998.9.16-2331","article-title":"Extensive beta-glucuronidase activity in murine central nervous system after adenovirus-mediated gene transfer to brain","volume":"9","author":"Ghodsi","year":"1998","journal-title":"Hum Gene Ther"},{"key":"10.1038\/sj.mt.6300016_bib16","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1073\/pnas.94.4.1287","article-title":"Adenovirus-mediated gene transfer and expression of human beta-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice","volume":"94","author":"Ohashi","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.mt.6300016_bib17","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1089\/10430340050015194","article-title":"Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer","volume":"11","author":"Bosch","year":"2000","journal-title":"Hum Gene Ther"},{"key":"10.1038\/sj.mt.6300016_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ymthe.2004.03.018","article-title":"AAV-mediated intravitreal gene therapy reduces lysosomal storage in the retinal pigmented epithelium and improves retinal function in adult MPS VII mice","volume":"10","author":"Hennig","year":"2004","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300016_bib19","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1128\/JVI.77.12.7034-7040.2003","volume":"77","author":"Passini","year":"2003","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300016_bib20","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1089\/10430340050015707","article-title":"Recombinant adeno-associated virus-mediated correction of lysosomal storage within the central nervous system of the adult mucopolysaccharidosis type VII mouse","volume":"11","author":"Sferra","year":"2000","journal-title":"Hum Gene Ther"},{"key":"10.1038\/sj.mt.6300016_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/mthe.1999.0005","article-title":"Long-term and significant correction of brain lesions in adult mucopolysaccharidosis type VII mice using recombinant AAV vectors","volume":"1","author":"Bosch","year":"2000","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300016_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/exnr.1999.7176","article-title":"Sustained production of beta-glucuronidase from localized sites after AAV vector gene transfer results in widespread distribution of enzyme and reversal of lysosomal storage lesions in a large volume of brain in mucopolysaccharidosis VII mice","volume":"160","author":"Skorupa","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1038\/sj.mt.6300016_bib23","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/sj.gt.3300931","article-title":"Elimination of lysosomal storage in brains of MPS VII mice treated by intrathecal administration of an adeno-associated virus vector","volume":"6","author":"Elliger","year":"1999","journal-title":"Gene Ther"},{"key":"10.1038\/sj.mt.6300016_bib24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1128\/JVI.73.2.939-947.1999","article-title":"Human adeno-associated virus type 5 is only distantly related to other known primate helper-dependent parvoviruses","volume":"73","author":"Bantel-Schaal","year":"1999","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300016_bib25","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nm929","article-title":"Identification of PDGFR as a receptor for AAV-5 transduction","volume":"9","author":"Pasquale","year":"2003","journal-title":"Nat Med"},{"key":"10.1038\/sj.mt.6300016_bib26","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1128\/JVI.75.15.6884-6893.2001","article-title":"Adeno-associated virus serotype 4 (aav4) and aav5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity","volume":"75","author":"Kaludov","year":"2001","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300016_bib27","doi-asserted-by":"crossref","first-page":"20610","DOI":"10.1074\/jbc.M101559200","article-title":"Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer","volume":"276","author":"Walters","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/sj.mt.6300016_bib28","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1073\/pnas.97.7.3428","article-title":"Recombinant adeno-associated type 2, 4 and 5 vectors: transduction of variant cell types and regions in the mammalian CNS","volume":"97","author":"Davidson","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.mt.6300016_bib29","doi-asserted-by":"crossref","first-page":"10229","DOI":"10.1523\/JNEUROSCI.3558-04.2004","article-title":"Improved behavior and neuropathology in the mouse model of Sanfilippo type IIIB disease after adeno-associated virus-mediated gene transfer in the striatum","volume":"24","author":"Cressant","year":"2004","journal-title":"J Neurosci"},{"key":"10.1038\/sj.mt.6300016_bib30","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/ana.20870","article-title":"Gene therapy of the brain in the dog model of Hurler's syndrome","volume":"60","author":"Ciron","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1038\/sj.mt.6300016_bib31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ymthe.2005.04.019","article-title":"AAV2\/5 vector expressing galactocerebrosidase ameliorates CNS disease in the murine model of globoid-cell leukodystrophy more efficiently than AAV2","volume":"12","author":"Lin","year":"2005","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300016_bib32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrn1385","article-title":"NMDA receptors, place cells and hippocampal spatial memory","volume":"5","author":"Nakazawa","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1038\/sj.mt.6300016_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(02)00272-3","article-title":"Glutamate receptor function in learning and memory","volume":"140","author":"Riedel","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1038\/sj.mt.6300016_bib34","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nn910","article-title":"Spatial memory dissociations in mice lacking GluR1","volume":"5","author":"Reisel","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1038\/sj.mt.6300016_bib35","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0092-8674(00)81828-0","article-title":"Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice","volume":"87","author":"McHugh","year":"1996","journal-title":"Cell"},{"key":"10.1038\/sj.mt.6300016_bib36","first-page":"147","article-title":"[Mucopolysaccharidosis VII: familial study]","volume":"51","author":"Moreno","year":"1988","journal-title":"Arch Neurobiol (Madr)"},{"key":"10.1038\/sj.mt.6300016_bib37","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1097\/01.wnr.0000185015.44563.5d","article-title":"Reduction of NR1 and phosphorylated Ca2+\/calmodulin-dependent protein kinase II levels in Alzheimer's disease","volume":"16","author":"Amada","year":"2005","journal-title":"NeuroReport"},{"key":"10.1038\/sj.mt.6300016_bib38","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.284.5421.1811","article-title":"Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation","volume":"284","author":"Shi","year":"1999","journal-title":"Science"},{"key":"10.1038\/sj.mt.6300016_bib39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0896-6273(03)00640-8","article-title":"AMPA receptor trafficking at excitatory synapses","volume":"40","author":"Bredt","year":"2003","journal-title":"Neuron"},{"key":"10.1038\/sj.mt.6300016_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tins.2005.03.004","article-title":"Homeostatic plasticity and NMDA receptor trafficking","volume":"28","author":"Perez-Otano","year":"2005","journal-title":"Trends Neurosci"},{"key":"10.1038\/sj.mt.6300016_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1300.001","article-title":"Synaptic plasticity and AMPA receptor trafficking","volume":"1003","author":"Malenka","year":"2003","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/sj.mt.6300016_bib42","first-page":"668.7","article-title":"Correction of cellular pathology and behavioral deficits in adult \u03b2-glucuronidase-deficient mice after FIV vector-mediated gene transfer to murine brain","volume":"1","author":"Stein","year":"2000","journal-title":"Proc Soc Neurosci"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616312758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616312758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T20:13:12Z","timestamp":1587327192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616312758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1525001616312758"],"URL":"https:\/\/doi.org\/10.1038\/sj.mt.6300016","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}