{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:14:10Z","timestamp":1770434050336,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":3324,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1038\/sj.mt.6300231","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T14:05:55Z","timestamp":1182261955000},"page":"1593-1599","source":"Crossref","is-referenced-by-count":48,"title":["DNAzyme-mediated Inhibition of Japanese Encephalitis Virus Replication in Mouse Brain"],"prefix":"10.1016","volume":"15","author":[{"given":"Mohan Babu","family":"Appaiahgari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhanshu","family":"Vrati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/sj.mt.6300231_bib1","first-page":"337","article-title":"Japanese encephalitis vaccines","volume":"73","author":"World Health Organization","year":"1998","journal-title":"Wkly Epidemiol Rec"},{"key":"10.1038\/sj.mt.6300231_bib2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4269\/ajtmh.1999.61.677","article-title":"Complete nucleotide sequence of an Indian strain of Japanese encephalitis virus: sequence comparison with other strains and phylogenetic analysis","volume":"61","author":"Vrati","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.1038\/sj.mt.6300231_bib3","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1128\/JVI.74.11.5108-5115.2000","article-title":"Mov34 protein from mouse brain interacts with the 3\u2032 noncoding region of Japanese encephalitis virus","volume":"74","author":"Ta","year":"2000","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300231_bib4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","article-title":"Flavivirus genome organization, expression, and replication","volume":"44","author":"Chambers","year":"1990","journal-title":"Annu Rev Microbiol"},{"key":"10.1038\/sj.mt.6300231_bib5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0042-6822(86)90012-7","article-title":"The 3\u2032-nucleotides of flavivirus genomic RNA form a conserved secondary structure","volume":"153","author":"Brinton","year":"1986","journal-title":"Virology"},{"key":"10.1038\/sj.mt.6300231_bib6","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/nar\/25.6.1194","article-title":"Secondary structure of the 3\u2032 untranslated region of flaviviruses: similarities and differences","volume":"25","author":"Proutski","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/sj.mt.6300231_bib7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0042-6822(86)90152-2","article-title":"Nucleotide sequence at the 3\u2032 end of Japanese encephalitis virus genomic RNA","volume":"152","author":"Takegami","year":"1986","journal-title":"Virology"},{"key":"10.1038\/sj.mt.6300231_bib8","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1021\/bi952398v","article-title":"Evidence for the existence of a pseudoknot structure at the 3\u2032 terminus of the flavivirus genomic RNA","volume":"35","author":"Shi","year":"1996","journal-title":"Biochemistry"},{"key":"10.1038\/sj.mt.6300231_bib9","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1099\/vir.0.82235-0","article-title":"Direct repeats in the 3\u2032 untranslated regions of mosquito-borne flaviviruses: possible implications for virus transmission","volume":"87","author":"Gritsun","year":"2006","journal-title":"J Gen Virol"},{"key":"10.1038\/sj.mt.6300231_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0022-2836(87)90455-4","article-title":"Conserved elements in the 3\u2032 untranslated region of flavivirus RNAs and potential cyclization sequences","volume":"198","author":"Hahn","year":"1987","journal-title":"J Mol Biol"},{"key":"10.1038\/sj.mt.6300231_bib11","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1128\/JVI.70.6.3930-3937.1996","article-title":"Dengue type 4 virus mutants containing deletions in the 3\u2032 noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys","volume":"70","author":"Men","year":"1996","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300231_bib12","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1128\/JVI.72.3.2132-2140.1998","article-title":"Spontaneous and engineered deletions in the 3\u2032 noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus","volume":"72","author":"Mandl","year":"1998","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300231_bib13","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1073\/pnas.94.9.4262","article-title":"A general purpose RNA-cleaving DNA enzyme","volume":"94","author":"Santoro","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.mt.6300231_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/1389201043376751","article-title":"DNAzymes: from creation in vitro to application in vivo","volume":"5","author":"Achenbach","year":"2004","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1038\/sj.mt.6300231_bib15","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/1541-7786.403.2.7","article-title":"Interleukin-10 induced activating transcription factor 3 transcriptional suppression of matrix metalloproteinase-2 gene expression in human prostate CPTX-1532 Cells","volume":"2","author":"Stearns","year":"2004","journal-title":"Mol Cancer Res"},{"key":"10.1038\/sj.mt.6300231_bib16","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1523-1755.2004.00777.x","article-title":"DNAzyme for TGF-beta suppressed extracellular matrix accumulation in experimental glomerulonephritis","volume":"66","author":"Isaka","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/sj.mt.6300231_bib17","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1093\/nar\/gkh626","article-title":"Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1","volume":"32","author":"Mitchell","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/sj.mt.6300231_bib18","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/15215","article-title":"New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury","volume":"5","author":"Santiago","year":"1999","journal-title":"Nat Med"},{"key":"10.1038\/sj.mt.6300231_bib19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0168-8278(99)80341-9","article-title":"Inhibition of hepatitis C virus-directed gene expression by a DNA ribonuclease","volume":"31","author":"Oketani","year":"1999","journal-title":"J Hepatol"},{"key":"10.1038\/sj.mt.6300231_bib20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/bj3530701","article-title":"Inhibition of hepatitis B virus X gene expression by novel DNA enzymes","volume":"353","author":"Goila","year":"2001","journal-title":"Biochem J"},{"key":"10.1038\/sj.mt.6300231_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-5793(00)01974-8","article-title":"Inhibition of influenza virus replication in cultured cells by RNA-cleaving DNA enzyme","volume":"481","author":"Toyoda","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1038\/sj.mt.6300231_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0014-5793(04)00073-0","article-title":"A new modified DNA enzyme that targets influenza virus A mRNA inhibits viral infection in cultured cells","volume":"560","author":"Takahashi","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1038\/sj.mt.6300231_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0042-6822(87)90144-9","article-title":"Complete nucleotide sequence of the Japanese encephalitis virus genome RNA","volume":"161","author":"Sumiyoshi","year":"1987","journal-title":"Virology"},{"key":"10.1038\/sj.mt.6300231_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1042\/bj3570147","article-title":"Inhibition of HIV-1 gene expression by novel macrophage-tropic DNA enzymes targeted to cleave HIV-1 TAT\/Rev RNA","volume":"357","author":"Unwalla","year":"2001","journal-title":"Biochem J"},{"key":"10.1038\/sj.mt.6300231_bib25","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1006\/jmbi.2000.3491","article-title":"Design of nuclease resistant protein kinase calpha DNA enzymes with potential therapeutic application","volume":"296","author":"Sioud","year":"2000","journal-title":"J Mol Biol"},{"key":"10.1038\/sj.mt.6300231_bib26","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1097\/00001756-200006260-00025","article-title":"Astrocytic alteration induced by Japanese encephalitis virus infection","volume":"11","author":"Chen","year":"2000","journal-title":"Neuroreport"},{"key":"10.1038\/sj.mt.6300231_bib27","first-page":"143","article-title":"Growth and cytopathic effect of Japanese encephalitis virus in astrocyte-enriched cell cultures from neonatal mouse brains","volume":"39","author":"Suri","year":"1995","journal-title":"Acta Virol"},{"key":"10.1038\/sj.mt.6300231_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00689518","article-title":"Immunohistochemical demonstration of viral antigens in Japanese encephalitis","volume":"70","author":"Iwasaki","year":"1986","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1038\/sj.mt.6300231_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/viro.1997.8791","article-title":"Ultrastructure and localization of E proteins in cultured neuron cells infected with Japanese encephalitis virus","volume":"238","author":"Wang","year":"1997","journal-title":"Virology"},{"key":"10.1038\/sj.mt.6300231_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/glia.10148","article-title":"Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system","volume":"40","author":"Husemann","year":"2002","journal-title":"Glia"},{"key":"10.1038\/sj.mt.6300231_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2003.10.043","article-title":"Microglial activation by uptake of fDNA via a scavenger receptor","volume":"147","author":"Li","year":"2004","journal-title":"J Neuroimmunol"},{"key":"10.1038\/sj.mt.6300231_bib32","first-page":"399","article-title":"Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease","volume":"148","author":"Christie","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.mt.6300231_bib33","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF01191555","article-title":"Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS","volume":"23","author":"Bell","year":"1994","journal-title":"J Neurocytol"},{"key":"10.1038\/sj.mt.6300231_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/oli.1.1998.8.75","article-title":"The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain","volume":"8","author":"Sommer","year":"1998","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"10.1038\/sj.mt.6300231_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0167-0115(95)00096-T","article-title":"Cellular uptake of intracerebrally administered oligodeoxynucleotides in mouse brain","volume":"59","author":"Ogawa","year":"1995","journal-title":"Regul Pept"},{"key":"10.1038\/sj.mt.6300231_bib36","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/AAC.43.11.2689","article-title":"Oligonucleotides tethered to a short polyguanylic acid stretch are targeted to macrophages: enhanced antiviral activity of a vesicular stomatitis virus-specific antisense oligonucleotide","volume":"43","author":"Prasad","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1038\/sj.mt.6300231_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0168-0102(02)00014-7","article-title":"Delivery of antisense oligonucleotides to PC12 cells","volume":"43","author":"Acosta","year":"2002","journal-title":"Neurosci Res"},{"key":"10.1038\/sj.mt.6300231_bib38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/oli.1.1998.8.67","article-title":"Cellular uptake properties of oligonucleotides in LLC-PK1 renal epithelial cells","volume":"8","author":"Takakura","year":"1998","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"10.1038\/sj.mt.6300231_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/ard.1993.3.53","article-title":"Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides","volume":"3","author":"Zhao","year":"1993","journal-title":"Antisense Res Dev"},{"key":"10.1038\/sj.mt.6300231_bib40","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1023\/A:1016002606705","article-title":"Interactions of phosphodiester and phosphorothioate oligonucleotides with intestinal epithelial Caco-2 cells","volume":"13","author":"Beck","year":"1996","journal-title":"Pharm Res"},{"key":"10.1038\/sj.mt.6300231_bib41","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/glia.20474","article-title":"Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis","volume":"55","author":"Ghoshal","year":"2007","journal-title":"Glia"},{"key":"10.1038\/sj.mt.6300231_bib42","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1099\/0022-1317-80-7-1665","article-title":"Molecular characterization of an Indian isolate of Japanese encephalitis virus that shows an extended lag phase during growth","volume":"80","author":"Vrati","year":"1999","journal-title":"J Gen Virol"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616320226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616320226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T04:11:11Z","timestamp":1707970271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616320226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S1525001616320226"],"URL":"https:\/\/doi.org\/10.1038\/sj.mt.6300231","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}