{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:44:52Z","timestamp":1778622292945,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":3202,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA100830"],"award-info":[{"award-number":["CA100830"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GU0505"],"award-info":[{"award-number":["01GU0505"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1038\/sj.mt.6300343","type":"journal-article","created":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T10:43:59Z","timestamp":1197369839000},"page":"146-153","source":"Crossref","is-referenced-by-count":67,"title":["Exponential Enhancement of Oncolytic Vesicular Stomatitis Virus Potency by Vector-mediated Suppression of Inflammatory Responses In Vivo"],"prefix":"10.1016","volume":"16","author":[{"given":"Jennifer","family":"Altomonte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia","family":"Meseck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Garc\u00eda-Sastre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savio LC","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/sj.mt.6300343_bib1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/89901","article-title":"Replication-selective virotherapy for cancer: biological principles, risk management, and future directions","volume":"7","author":"Kirn","year":"2001","journal-title":"Nat Med"},{"key":"10.1038\/sj.mt.6300343_bib2","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1126\/science.282.5392.1332","article-title":"Reovirus therapy of tumors with activated Ras pathway","volume":"282","author":"Coffey","year":"1998","journal-title":"Science"},{"key":"10.1038\/sj.mt.6300343_bib3","first-page":"6017","article-title":"Complete regression of human fibrosarcoma xenografts after local Newcastle disease virus therapy","volume":"54","author":"Lorence","year":"1994","journal-title":"Cancer Res"},{"key":"10.1038\/sj.mt.6300343_bib4","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1182\/blood.V98.7.2002","article-title":"Systemic therapy of myeloma xenografts by an attenuated measles virus","volume":"98","author":"Peng","year":"2001","journal-title":"Blood"},{"key":"10.1038\/sj.mt.6300343_bib5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/77558","article-title":"Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus","volume":"6","author":"Stojdl","year":"2000","journal-title":"Nat Med"},{"key":"10.1038\/sj.mt.6300343_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/tvjl.1998.0303","article-title":"Vesicular stomatitis","volume":"157","author":"Letchworth","year":"1999","journal-title":"Vet J"},{"key":"10.1038\/sj.mt.6300343_bib7","series-title":"Fields Virology","first-page":"1221","article-title":"Rhabdoviridae: the viruses and their replication","author":"Rose","year":"2001"},{"key":"10.1038\/sj.mt.6300343_bib8","first-page":"163","article-title":"Estimates of the worldwide frequency of twelve major cancers","volume":"62","author":"Parkin","year":"1984","journal-title":"Bull World Health Organ"},{"key":"10.1038\/sj.mt.6300343_bib9","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.274.5288.740","article-title":"Evidence-based health policy\u2014lessons from the Global Burden of Disease Study","volume":"274","author":"Murray","year":"1996","journal-title":"Science"},{"key":"10.1038\/sj.mt.6300343_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ijc.1440","article-title":"Estimating the world cancer burden: Globocan 2000","volume":"94","author":"Parkin","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1038\/sj.mt.6300343_bib11","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJM199903113401001","article-title":"Rising incidence of hepatocellular carcinoma in the United States","volume":"340","author":"El-Serag","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1038\/sj.mt.6300343_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2036.2005.02504.x","article-title":"Review article: the changing epidemiology of hepatocellular carcinoma in Canada","volume":"22","author":"Dyer","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1038\/sj.mt.6300343_bib13","first-page":"3605","article-title":"Oncolytic vesicular stomatitis virus for treatment of orthotopic hepatocellular carcinoma in immune-competent rats","volume":"63","author":"Ebert","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/sj.mt.6300343_bib14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ymthe.2003.12.004","article-title":"Oncolysis of multifocal hepatocellular carcinoma in the rat liver by hepatic artery infusion of vesicular stomatitis virus","volume":"9","author":"Shinozaki","year":"2004","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300343_bib15","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1158\/0008-5472.CAN-03-3753","article-title":"Syncytia induction enhances the oncolytic potential of vesicular stomatitis virus in virotherapy for cancer","volume":"64","author":"Ebert","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/sj.mt.6300343_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.immunol.19.1.65","article-title":"Noncytolytic control of viral infections by the innate and adaptive immune response","volume":"19","author":"Guidotti","year":"2001","journal-title":"Ann Rev Immunol"},{"key":"10.1038\/sj.mt.6300343_bib17","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0952-7915(94)90006-X","article-title":"Chemokines, leukocyte trafficking, and inflammation","volume":"6","author":"Schall","year":"1994","journal-title":"Curr Opin Immunol"},{"key":"10.1038\/sj.mt.6300343_bib18","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1182\/blood.V90.3.909","article-title":"Chemokines","volume":"90","author":"Rollins","year":"1997","journal-title":"Blood"},{"key":"10.1038\/sj.mt.6300343_bib19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic","volume":"392","author":"Baggiolini","year":"1998","journal-title":"Nature"},{"key":"10.1038\/sj.mt.6300343_bib20","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri980","article-title":"Viral mimicry of cytokines, chemokines and their receptors","volume":"3","author":"Alcami","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/sj.mt.6300343_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1189\/jlb.72.1.24","article-title":"Viral chemokine-binding proteins","volume":"72","author":"Seet","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1038\/sj.mt.6300343_bib22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/emboj\/cdg092","article-title":"Glycoprotein G isoforms from some alphaherpesviruses function as broad-spectrum chemokine binding proteins","volume":"22","author":"Bryant","year":"2003","journal-title":"EMBO J"},{"key":"10.1038\/sj.mt.6300343_bib23","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1073\/pnas.92.10.4477","article-title":"Recombinant vesicular stomatitis viruses from DNA","volume":"92","author":"Lawson","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.mt.6300343_bib24","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1073\/pnas.92.18.8388","article-title":"Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones","volume":"92","author":"Whelan","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.mt.6300343_bib25","doi-asserted-by":"crossref","first-page":"13705","DOI":"10.1128\/JVI.79.21.13705-13713.2005","article-title":"Prophylactic alpha interferon treatment increases the therapeutic index of oncolytic vesicular stomatitis virus virotherapy for advanced hepatocellular carcinoma in immune-competent rats","volume":"79","author":"Shinozaki","year":"2005","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300343_bib26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/hep.20536","article-title":"Eradication of advanced hepatocellular carcinoma in rats via repeated hepatic arterial infusions of recombinant VSV","volume":"41","author":"Shinozaki","year":"2005","journal-title":"Hepatology"},{"key":"10.1038\/sj.mt.6300343_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0065-2776(08)60664-1","article-title":"Biology of natural killer cells","volume":"47","author":"Trinchieri","year":"1989","journal-title":"Adv Immunol"},{"key":"10.1038\/sj.mt.6300343_bib28","first-page":"169","article-title":"Regulation of virus infections by natural killer cells","volume":"5","author":"Welsh","year":"1986","journal-title":"Nat Immun Cell Growth Regul"},{"key":"10.1038\/sj.mt.6300343_bib29","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1128\/jvi.69.7.3967-3971.1995","article-title":"Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells","volume":"69","author":"Brutkiewicz","year":"1995","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300343_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.bmt.1701825","article-title":"Natural killer (NK) cells prevent virus production in cell culture","volume":"24","author":"Baraz","year":"1999","journal-title":"Bone Marrow Transplant"},{"key":"10.1038\/sj.mt.6300343_bib31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.immunol.17.1.189","article-title":"Natural killer cells in antiviral defense: function and regulation by innate cytokines","volume":"17","author":"Biron","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/sj.mt.6300343_bib32","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/ni1102-1006","article-title":"Viral evasion of natural killer cells","volume":"3","author":"Orange","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1038\/sj.mt.6300343_bib33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0952-7915(00)00241-7","article-title":"NK cells and NKT cells in innate defense against viral infections","volume":"13","author":"Biron","year":"2001","journal-title":"Curr Opin Immunol"},{"key":"10.1038\/sj.mt.6300343_bib34","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.4049\/jimmunol.162.11.6410","article-title":"Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells","volume":"162","author":"Eberl","year":"1999","journal-title":"J Immunol"},{"key":"10.1038\/sj.mt.6300343_bib35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2567.2007.02652.x","article-title":"Regulation of ligands for the activating receptor NKG2D","volume":"121","author":"Mistry","year":"2007","journal-title":"Immunology"},{"key":"10.1038\/sj.mt.6300343_bib36","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4049\/jimmunol.170.3.1362","article-title":"Mimicry of native peptide antigens by the corresponding retro-inverso analogs is dependent on their intrinsic structure and interaction propensities","volume":"170","author":"Nair","year":"2003","journal-title":"J Immunol"},{"key":"10.1038\/sj.mt.6300343_bib37","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1073\/pnas.0400937101","article-title":"Recognition of single-stranded RNA viruses by Toll-like receptor 7","volume":"101","author":"Lund","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.mt.6300343_bib38","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1073\/pnas.101136398","article-title":"Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing","volume":"98","author":"Todo","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/sj.mt.6300343_bib39","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1525-0016(03)00236-3","article-title":"HSV-1 therapy of primary tumors reduces the number of metastases in an immune-competent model of metastatic breast cancer","volume":"8","author":"Thomas","year":"2003","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300343_bib40","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1089\/hum.2005.16.765","article-title":"Oncolytic HSV exerts direct antiangiogenic activity in ovarian carcinoma","volume":"16","author":"Benencia","year":"2005","journal-title":"Hum Gene Ther"},{"key":"10.1038\/sj.mt.6300343_bib41","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1111\/j.1572-0241.2005.00229.x","article-title":"Natural history of untreated nonsurgical hepatocellular carcinoma","volume":"100","author":"Yeung","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1038\/sj.mt.6300343_bib42","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/sj.gt.3302038","article-title":"Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells","volume":"10","author":"Wakimoto","year":"2003","journal-title":"Gene Ther"},{"key":"10.1038\/sj.mt.6300343_bib43","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/sj.gt.3302143","article-title":"Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis","volume":"11","author":"Wakimoto","year":"2004","journal-title":"Gene Ther"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616313740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616313740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T07:10:03Z","timestamp":1684134603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616313740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S1525001616313740"],"URL":"https:\/\/doi.org\/10.1038\/sj.mt.6300343","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}