{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:56:59Z","timestamp":1790416619826,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":3171,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1038\/sj.mt.6300367","type":"journal-article","created":{"date-parts":[[2008,1,25]],"date-time":"2008-01-25T15:03:10Z","timestamp":1201273390000},"page":"296-301","source":"Crossref","is-referenced-by-count":123,"title":["Efficient Retrograde Neuronal Transduction Utilizing Self-complementary AAV1"],"prefix":"10.1016","volume":"16","author":[{"given":"Edmund R","family":"Hollis II","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kadoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Samulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H","family":"Tuszynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.mt.6300367_bib1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2174\/1566523054064968","article-title":"AAV hybrid serotypes: improved vectors for gene delivery","volume":"5","author":"Choi","year":"2005","journal-title":"Curr Gene Ther"},{"key":"10.1038\/sj.mt.6300367_bib2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/sj.gt.3301514","article-title":"Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis","volume":"8","author":"McCarty","year":"2001","journal-title":"Gene Ther"},{"key":"10.1038\/sj.mt.6300367_bib3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.ymthe.2003.08.021","article-title":"Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain","volume":"8","author":"Fu","year":"2003","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300367_bib4","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/sj.gt.3302134","article-title":"Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo","volume":"10","author":"McCarty","year":"2003","journal-title":"Gene Ther"},{"key":"10.1038\/sj.mt.6300367_bib5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jgm.885","article-title":"Immune responses to AAV in a phase I study for Canavan disease","volume":"8","author":"McPhee","year":"2006","journal-title":"J Gene Med"},{"key":"10.1038\/sj.mt.6300367_bib6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00439-006-0165-6","article-title":"Treatment of human disease by adeno-associated viral gene transfer","volume":"119","author":"Warrington","year":"2006","journal-title":"Hum Genet"},{"key":"10.1038\/sj.mt.6300367_bib7","first-page":"482","article-title":"Clinical trials in neurological disorders using AAV vectors: promises and challenges","volume":"6","author":"Mandel","year":"2004","journal-title":"Curr Opin Mol Ther"},{"key":"10.1038\/sj.mt.6300367_bib8","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1086137","article-title":"Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model","volume":"301","author":"Kaspar","year":"2003","journal-title":"Science"},{"key":"10.1038\/sj.mt.6300367_bib9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1172\/JCI26210","article-title":"Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia","volume":"116","author":"Pirozzi","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.mt.6300367_bib10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1227\/01.NEU.0000044459.24519.3E","article-title":"Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery","volume":"52","author":"Boulis","year":"2003","journal-title":"Neurosurgery"},{"key":"10.1038\/sj.mt.6300367_bib11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ymthe.2004.05.024","article-title":"Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2,and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system","volume":"10","author":"Burger","year":"2004","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300367_bib12","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1128\/JVI.75.14.6615-6624.2001","article-title":"Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors","volume":"75","author":"Halbert","year":"2001","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300367_bib13","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1128\/JVI.74.8.3852-3858.2000","article-title":"Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer","volume":"74","author":"Zabner","year":"2000","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300367_bib14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1172\/JCI0215780","article-title":"Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins","volume":"110","author":"Auricchio","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1038\/sj.mt.6300367_bib15","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/jgm.759","article-title":"Enhancing rAAV vector expression in the lung","volume":"7","author":"Virella-Lowell","year":"2005","journal-title":"J Gene Med"},{"key":"10.1038\/sj.mt.6300367_bib16","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/sj.gt.3302011","article-title":"Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain","volume":"10","author":"Wang","year":"2003","journal-title":"Gene Ther"},{"key":"10.1038\/sj.mt.6300367_bib17","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1006\/mthe.2000.0219","article-title":"Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors","volume":"2","author":"Chao","year":"2000","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300367_bib18","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1128\/JVI.77.4.2768-2774.2003","article-title":"Characterization of tissue tropism determinants of adeno-associated virus type 1","volume":"77","author":"Hauck","year":"2003","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300367_bib19","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/sj.gt.3302895","article-title":"Efficiency of eight different AAV serotypes in transducing rat myocardiumin vivo","volume":"14","author":"Palomeque","year":"2007","journal-title":"Gene Ther"},{"key":"10.1038\/sj.mt.6300367_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/hum.2006.178","article-title":"Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7 and 8 in mouse brain","volume":"18","author":"Taymans","year":"2007","journal-title":"Hum Gene Ther"},{"key":"10.1038\/sj.mt.6300367_bib21","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/jgm.782","article-title":"Adeno-associated virus serotypes 1 to 5 mediated tumor cell directed gene transfer and improvement of transduction efficiency","volume":"7","author":"Hacker","year":"2005","journal-title":"J Gene Med"},{"key":"10.1038\/sj.mt.6300367_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1113\/expphysiol.2004.028159","article-title":"Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system, in vitro and in vivo","volume":"90","author":"Shevtsova","year":"2005","journal-title":"Exp Physiol"},{"key":"10.1038\/sj.mt.6300367_bib23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/mthe.2001.0520","article-title":"Targeted retrograde gene delivery for neuronal protection","volume":"5","author":"Kaspar","year":"2002","journal-title":"Mol Ther"},{"key":"10.1038\/sj.mt.6300367_bib24","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1128\/JVI.72.3.2224-2232.1998","article-title":"Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus","volume":"72","author":"Xiao","year":"1998","journal-title":"J Virol"},{"key":"10.1038\/sj.mt.6300367_bib25","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1128\/JVI.71.7.5236-5243.1997","article-title":"Role for highly regulated rep gene expression in adeno-associated virus vector production","volume":"71","author":"Li","year":"1997","journal-title":"J Virol"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616313958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001616313958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T06:09:07Z","timestamp":1588313347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001616313958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S1525001616313958"],"URL":"https:\/\/doi.org\/10.1038\/sj.mt.6300367","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}