{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:58:37Z","timestamp":1790809117889,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":4872,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/100001260","name":"National Organization for Rare Disorders","doi-asserted-by":"publisher","award":["5K08CA74431-02"],"award-info":[{"award-number":["5K08CA74431-02"]}],"id":[{"id":"10.13039\/100001260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neoplasia"],"published-print":{"date-parts":[[2001]]},"DOI":"10.1038\/sj.neo.7900158","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T17:27:08Z","timestamp":1032456428000},"page":"173-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Novel DNA Copy Number Losses in Chromosome 12g12-q13 in Adenoid Cystic Carcinoma"],"prefix":"10.1016","volume":"3","author":[{"given":"Wa'el","family":"El-Rifai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Rutherford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakari","family":"Knuutila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"jr.","given":"Henry F.","family":"Frierson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Moskaluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/sj.neo.7900158_bib1","series-title":"Tumors of the Salivary Glands (3rd ed)","author":"Ellis","year":"1996"},{"key":"10.1038\/sj.neo.7900158_bib2","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2255::AID-CNCR22>3.0.CO;2-D","article-title":"Prognostic factors for long-term results of the treatment of patients with malignant submandibular gland tumors","volume":"85","author":"Vander Poorten","year":"1999","journal-title":"Cancer"},{"key":"10.1038\/sj.neo.7900158_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1079-2104(96)80223-X","article-title":"Cytogenetic analysis of salivary gland type tumors","volume":"82","author":"Mark","year":"1996","journal-title":"Oral Surg, Oral Med, Oral Pathol, Oral Radiol Endod"},{"key":"10.1038\/sj.neo.7900158_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0964-1955(95)00078-X","article-title":"Malignant salivary gland neoplasms: a cytogenetic study of 19 cases","volume":"32B","author":"Martins","year":"1996","journal-title":"Eur J Cancer, Part B. Oral Oncol"},{"key":"10.1038\/sj.neo.7900158_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/gcc.2870100206","article-title":"Nonrandom chromosome rearrangements in adenoid cystic carcinoma of the salivary glands","volume":"10","author":"Nordkvist","year":"1994","journal-title":"Genes, Chromosomes Cancer"},{"key":"10.1038\/sj.neo.7900158_bib6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/(SICI)1098-2264(199611)17:3<166::AID-GCC4>3.0.CO;2-2","article-title":"Identification of a yeast artificial chromosome spanning the 8g12 translocation breakpoint in pleomorphic adenomas with t(3;8)(p21;gl2)","volume":"17","author":"Roijer","year":"1996","journal-title":"Genes, Chromosomes Cancer"},{"key":"10.1038\/sj.neo.7900158_bib7","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0046-8177(96)90316-0","article-title":"Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands","volume":"27","author":"Yamamoto","year":"1996","journal-title":"Hum Pathol"},{"key":"10.1038\/sj.neo.7900158_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1440-1827.1998.tb03905.x","article-title":"DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining","volume":"48","author":"Yamamoto","year":"1998","journal-title":"Pathol Int"},{"key":"10.1038\/sj.neo.7900158_bib9","first-page":"1151","article-title":"Allelotype of salivary gland tumors","volume":"56","author":"Johns","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/sj.onc.1201480","article-title":"A refined localization of two deleted regions in chromosome 6q associated with salivary gland carcinomas","volume":"16","author":"Queimado","year":"1998","journal-title":"Oncogene"},{"key":"10.1038\/sj.neo.7900158_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ng0197-87","article-title":"Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis","volume":"15","author":"Hemminki","year":"1997","journal-title":"Nat Genet"},{"key":"10.1038\/sj.neo.7900158_bib12","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/1097-0142(19840915)54:6<1062::AID-CNCR2820540622>3.0.CO;2-E","article-title":"Histologic grading of adenoid cystic carcinoma of the salivary glands","volume":"54","author":"Szanto","year":"1984","journal-title":"Cancer"},{"key":"10.1038\/sj.neo.7900158_bib13","series-title":"AJCC Cancer Staging Manual (5th ed)","author":"Fleming","year":"1997"},{"key":"10.1038\/sj.neo.7900158_bib14","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1038\/sj.neo.7900158_bib15","first-page":"699","article-title":"Optimization of comparative genomic hybridization using fluorochrome conjugated to dCTP and dUTP nucleotides","volume":"77","author":"El- Rifai","year":"1997","journal-title":"Lab Invest"},{"key":"10.1038\/sj.neo.7900158_bib16","first-page":"3230","article-title":"DNA copy number losses in chromosome 14: an early change in gastrointestinal stromal tumors","volume":"56","author":"El-Rifai","year":"1996","journal-title":"CancerRes"},{"key":"10.1038\/sj.neo.7900158_bib17","first-page":"3899","article-title":"DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance","volume":"60","author":"El-Rifai","year":"2000","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib18","first-page":"1547","article-title":"Microdissection and PCR amplification of genomic DNA from histologic tissue sections","volume":"150","author":"Moskaluk","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.neo.7900158_bib19","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0002-9440(10)65386-2","article-title":"Mapping of genetic deletions on the long arm of chromosome 4 in human esophageal adenocarcinomas","volume":"154","author":"Rumpel","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.neo.7900158_bib20","first-page":"1855","article-title":"Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis","volume":"57","author":"Emmert-Buck","year":"1997","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0002-9440(10)64579-8","article-title":"On-line access to CGH data of DNA sequence copy number changes","volume":"157","author":"Knuutila","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.neo.7900158_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/(SICI)1098-2264(200002)27:2<162::AID-GCC7>3.0.CO;2-9","article-title":"Molecular genetic alterations in carcinoma expleomorphic adenoma: a putative progression model?","volume":"27","author":"El-Naggar","year":"2000","journal-title":"Genes, Chromosomes Cancer"},{"key":"10.1038\/sj.neo.7900158_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-4608(98)00280-5","article-title":"Cytogenetic analysis of a primary salivary gland myoepithelioma","volume":"113","author":"El-Naggar","year":"1999","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1038\/sj.neo.7900158_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1098-2264(199901)24:1<94::AID-GCC14>3.0.CO;2-2","article-title":"Involvement of 12812-13 is a nonrandom chromosome change in renal oncocytoma","volume":"24","author":"Dal Cin","year":"1999","journal-title":"Genes, Chromosomes Cancer"},{"key":"10.1038\/sj.neo.7900158_bib25","first-page":"2029","article-title":"Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells","volume":"57","author":"Abdollahi","year":"1997","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib26","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1038\/sj.onc.1201034","article-title":"Identification of a zinc-finger gene at 6825: a chromosomal region implicated in development of many solid tumors","volume":"14","author":"Abdollahi","year":"1997","journal-title":"Oncogene"},{"key":"10.1038\/sj.neo.7900158_bib27","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1038\/sj.onc.1202933","article-title":"Loss of expression of the candidate tumor- suppressor gene ZAC in breast cancer cell lines and primary tumors","volume":"18","author":"Bilanges","year":"1999","journal-title":"Oncogene"},{"key":"10.1038\/sj.neo.7900158_bib28","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/emboj\/16.10.2814","article-title":"Regulation of apoptosis and cell cycle arrest by Zaci, a novel zinc-finger protein expressed in the pituitary gland and the brain","volume":"16","author":"Spengler","year":"1997","journal-title":"EMBO J"},{"key":"10.1038\/sj.neo.7900158_bib29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0002-9440(10)65166-8","article-title":"DNA copy number losses in human neoplasms","volume":"155","author":"Knuutila","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1038\/sj.neo.7900158_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/geno.1998.5405","article-title":"Amplification of DNA sequences from chromosome 19813.1 in human pancreatic cell lines","volume":"53","author":"Curtis","year":"1998","journal-title":"Genomics"},{"key":"10.1038\/sj.neo.7900158_bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/(SICI)1098-2264(199801)21:1<8::AID-GCC3>3.0.CO;2-5","article-title":"Cytogenetic and fluorescence in situ hybridization analyses of chromosome 19 aberrations in pancreatic carcinomas: frequent loss of 19p13.3 and gain of 19813.1-13.2","volume":"21","author":"Hoglund","year":"1998","journal-title":"Genes, Chromosomes Cancer"},{"key":"10.1038\/sj.neo.7900158_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/(SICI)1098-2264(199605)16:1<46::AID-GCC7>3.0.CO;2-3","article-title":"Overrepresentation of 3q and 8q material and loss of 18q material are recurrent findings in advanced human ovarian cancer","volume":"16","author":"Arnold","year":"1996","journal-title":"Genes, Chromosomes Cancer"},{"key":"10.1038\/sj.neo.7900158_bib33","first-page":"1877","article-title":"Mapping of novel regions of DNA gain and loss by comparative genomic hybridization in esophageal carcinoma in the Black and colored populations of South Africa","volume":"59","author":"Du Plessis","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib34","series-title":"The Genetic Basis of Human Cancer","year":"1998"},{"key":"10.1038\/sj.neo.7900158_bib35","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/(SICI)1097-0215(19990812)82:4<498::AID-IJC5>3.0.CO;2-S","article-title":"Detection of recurrent chromosomal gains and losses in primary nasopharyngeal carcinoma by comparative genomic hybridisation","volume":"82","author":"Hui","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1038\/sj.neo.7900158_bib36","first-page":"5325","article-title":"Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas","volume":"56","author":"Bockmuhl","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib37","first-page":"1010","article-title":"Comparative genomic hybridization detects novel deletions and amplifications in head and neck squamous cell carcinomas","volume":"55","author":"Speicher","year":"1995","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib38","first-page":"2116","article-title":"Comparative genomic hybridization analysis detects frequent, often high-level, overrepresentation of DNA sequences at 3q, 5p, 7p, and 8q in human non-small cell lung carcinomas","volume":"57","author":"Balsara","year":"1997","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib39","first-page":"2331","article-title":"Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung","volume":"57","author":"Petersen","year":"1997","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/bjc.1997.13","article-title":"Small cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p","volume":"75","author":"Petersen","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1038\/sj.neo.7900158_bib41","first-page":"1801","article-title":"Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization","volume":"54","author":"Ried","year":"1994","journal-title":"Cancer Res"},{"key":"10.1038\/sj.neo.7900158_bib42","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/386623a0","article-title":"Genetic instability in colorectal cancers","volume":"386","author":"Lengauer","year":"1997","journal-title":"Nature"},{"key":"10.1038\/sj.neo.7900158_bib43","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/S0046-8177(99)90044-8","article-title":"Analysis of chromosome 9p21 deletion and p16 gene mutation in salivary gland carcinomas","volume":"30","author":"Cerilli","year":"1999","journal-title":"Hum Pathol"}],"container-title":["Neoplasia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558601800403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476558601800403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:02:17Z","timestamp":1761483737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476558601800403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001]]}},"alternative-id":["S1476558601800403"],"URL":"https:\/\/doi.org\/10.1038\/sj.neo.7900158","relation":{},"ISSN":["1476-5586"],"issn-type":[{"value":"1476-5586","type":"print"}],"subject":[],"published":{"date-parts":[[2001]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel DNA Copy Number Losses in Chromosome 12g12-q13 in Adenoid Cystic Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Neoplasia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/sj.neo.7900158","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Neoplasia Press, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}