{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:40:48Z","timestamp":1790707248039,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,6,14]],"date-time":"2002-06-14T00:00:00Z","timestamp":1024012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1038\/sj.npp.1300008","type":"journal-article","created":{"date-parts":[[2003,2,20]],"date-time":"2003-02-20T18:06:51Z","timestamp":1045764411000},"page":"86-99","source":"Crossref","is-referenced-by-count":47,"title":["Congenic D1A Dopamine Receptor Mutants: Ethologically Based Resolution of Behavioural Topography Indicates Genetic Background as a Determinant of Knockout Phenotype"],"prefix":"10.1038","volume":"28","author":[{"given":"Fergal N","family":"McNamara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah J","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orna","family":"Tighe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Kinsella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Drago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T","family":"Croke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L","family":"Waddington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,6,14]]},"reference":[{"key":"BF1300008_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0014-2999(98)00825-5","volume":"364","author":"G Andringa","year":"1999","unstructured":"Andringa G, Drukarch B, Leysen JE, Cools AR, Stoof JC (1999). The alleged dopamine D1 receptor agonist SKF 83959 is a dopamine D1 receptor antagonist in primate cells and interacts with other receptors. Eur J Pharmacol 364: 33\u201341.","journal-title":"Eur J Pharmacol"},{"key":"BF1300008_CR2","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/0014-2999(92)90690-6","volume":"213","author":"J Arnt","year":"1992","unstructured":"Arnt J, Hyttel J, Sanchez C (1992). Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro. Eur J Pharmacol 213: 259\u2013267.","journal-title":"Eur J Pharmacol"},{"key":"BF1300008_CR3","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0031-9384(01)00522-4","volume":"73","author":"TA Carter","year":"2001","unstructured":"Carter TA, Del Rio JA, Greenhall JA, Latronica ML, Lockhart DJ, Barlow C (2001). Chipping away at complex behavior: transcriptome\/phenotype correlations in the mouse brain. Physiol Behav 73: 849\u2013857.","journal-title":"Physiol Behav"},{"key":"BF1300008_CR4","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0893-133X(01)00246-9","volume":"25","author":"JJ Clifford","year":"2001","unstructured":"Clifford JJ, Kinsella A, Tighe O, Rubinstein M, Grandy DK, Low MJ et al (2001). Comparative, topographically based evaluation of behavioural phenotype and specification of D1-like:D2-like interactions in a line of incipient congenic mice with D2 dopamine receptor \u2018knockout\u2019. Neuropsychopharmacology 25: 527\u2013536.","journal-title":"Neuropsychopharmacology"},{"key":"BF1300008_CR5","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1016\/S0028-3908(98)00116-6","volume":"37","author":"JJ Clifford","year":"1998","unstructured":"Clifford JJ, Tighe O, Croke DT, Sibley DR, Drago J, Waddington JL (1998). Topographical evaluation of the phenotype of spontaneous behaviour in mice with targeted gene deletion of the D1A dopamine receptor: paradoxical elevation of grooming syntax. Neuropharmacology 37: 1595\u20131602.","journal-title":"Neuropharmacology"},{"key":"BF1300008_CR6","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/S0306-4522(99)00297-3","volume":"93","author":"JJ Clifford","year":"1999","unstructured":"Clifford JJ, Tighe O, Croke DT, Kinsella A, Sibley DR, Drago J et al (1999). Conservation of behavioural topography to dopamine D1-like receptor agonists in mutant mice lacking the D1A receptor implicates a D1-like receptor not coupled to adenylyl cyclase. Neuroscience 93: 1483\u20131489.","journal-title":"Neuroscience"},{"key":"BF1300008_CR7","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/S0028-3908(99)00150-1","volume":"39","author":"JJ Clifford","year":"2000","unstructured":"Clifford JJ, Usiello A, Vallone D, Kinsella A, Borrelli E, Waddington JL (2000). Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor. Neuropharmacology 39: 382\u2013390.","journal-title":"Neuropharmacology"},{"key":"BF1300008_CR8","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1126\/science.284.5420.1670","volume":"284","author":"JC Crabbe","year":"1999","unstructured":"Crabbe JC, Wahlsten D, Dudek BC (1999). Genetics of mouse behavior: interactions with laboratory environment. Science 284: 1670\u20131672.","journal-title":"Science"},{"key":"BF1300008_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s002130050327","volume":"132","author":"JN Crawley","year":"1997","unstructured":"Crawley JN, Belknap JK, Collins A, Crabbe JC, Frankel W, Henderson N et al (1997). Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 132: 107\u2013124.","journal-title":"Psychopharmacology"},{"key":"BF1300008_CR10","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1046\/j.1460-9568.1998.00250.x","volume":"10","author":"HC Cromwell","year":"1998","unstructured":"Cromwell HC, Berridge KC, Drago J, Levine MS (1998). Action sequencing is impaired in D1A-deficient mutant mice. Eur J Neurosci 10: 2426\u20132432.","journal-title":"Eur J Neurosci"},{"key":"BF1300008_CR11","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1111\/j.1476-5381.1995.tb16420.x","volume":"116","author":"AM Deveney","year":"1995","unstructured":"Deveney AM, Waddington JL (1995). Pharmacological characterization of behavioural responses to SK&F 83959 in relation to \u2018D1-like\u2019 dopamine receptors not linked to adenylyl cyclase. Br J Pharmacol 116: 2120\u20132126.","journal-title":"Br J Pharmacol"},{"key":"BF1300008_CR12","doi-asserted-by":"publisher","first-page":"12564","DOI":"10.1073\/pnas.91.26.12564","volume":"91","author":"J Drago","year":"1994","unstructured":"Drago J, Gerfen CR, Lachowicz JE, Steiner H, Hollon TR, Love PE et al (1994). Altered striatal function in a mutant mouse lacking D1A dopamine receptors. Proc Natl Acad Sci USA 91: 12564\u201312568.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1300008_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0166-2236(96)20020-7","volume":"19","author":"R Gerlai","year":"1996","unstructured":"Gerlai R (1996). Gene-targeting studies of mammalian behaviour: is it the mutation or the background genotype. Trends Neurosci 19: 177\u2013181.","journal-title":"Trends Neurosci"},{"key":"BF1300008_CR14","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/0006-2952(95)00035-X","volume":"49","author":"KK Gnanalingham","year":"1995","unstructured":"Gnanalingham KK, Hunter AJ, Jenner P, Marsden CD (1995). Stimulation of adenylate cyclase activity by benzazepine D-1 dopamine agonists with varying efficacies in the 6-hydroxydopamine lesioned rat\u2014relationship to circling behaviour. Biochem Pharmacol 49: 1185\u20131193.","journal-title":"Biochem Pharmacol"},{"key":"BF1300008_CR15","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1523\/JNEUROSCI.18-09-03470.1998","volume":"18","author":"MA Kelly","year":"1998","unstructured":"Kelly MA, Rubinstein M, Phillips TJ, Lessov CN, Burkhart-Kasch S, Zhang G et al (1998). Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J Neurosci 18: 3470\u20133479.","journal-title":"J Neurosci"},{"key":"BF1300008_CR16","doi-asserted-by":"publisher","first-page":"589","DOI":"10.2337\/diabetes.49.4.589","volume":"49","author":"Y Kido","year":"2000","unstructured":"Kido Y, Philippe N, Schaffer AA, Accilli D (2000). Genetic modifiers of the insulin resistance phenotype in mice. Diabetes 49: 589\u2013596.","journal-title":"Diabetes"},{"key":"BF1300008_CR17","first-page":"467","volume":"297","author":"WR Lariviere","year":"2001","unstructured":"Lariviere WR, Chesler EJ, Mogil JS (2001). Transgenic studies of pain and analgesia: mutation or background genotype? J Pharmacol Exp Ther 297: 467\u2013473.","journal-title":"J Pharmacol Exp Ther"},{"key":"BF1300008_CR18","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1073\/pnas.87.6.2196","volume":"87","author":"LC Mahan","year":"1990","unstructured":"Mahan LC, Burch RM, Monsma Jr FJ, Sibley DR (1990). Expression of striatal D1 dopamine receptors coupled to inositol phosphate production and Ca2+ mobilization in Xenopus oocytes. Proc Natl Acad Sci USA 87: 2196\u20132200.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1300008_CR19","doi-asserted-by":"publisher","first-page":"14928","DOI":"10.1073\/pnas.93.25.14928","volume":"93","author":"R Moratalla","year":"1996","unstructured":"Moratalla R, Xu M, Tonegawa S, Graybiel AM (1996). Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor. Proc Natl Acad Sci USA 93: 14928\u201314933.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1300008_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/35056009","volume":"2","author":"JH Nadeau","year":"2001","unstructured":"Nadeau JH (2001). Modifier genes in mice and humans. Nat Rev Genet 2: 165\u2013174.","journal-title":"Nat Rev Genet"},{"key":"BF1300008_CR21","first-page":"121","volume-title":"Handbook of Experimental Pharmacology: Dopamine in the CNS","author":"HB Niznik","year":"2002","unstructured":"Niznik HB, Sugamori KS, Clifford JJ, Waddington JL (2002). D1-like dopamine receptors: molecular biology and pharmacology. In: Di Chiara G (ed). Handbook of Experimental Pharmacology: Dopamine in the CNS. Springer: Heidelberg, 121\u2013158."},{"key":"BF1300008_CR22","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/S0028-3908(01)00011-9","volume":"40","author":"S Panchalingham","year":"2001","unstructured":"Panchalingham S, Undie AS (2001). SKF 83959 exhibits biochemical agonism by stimulating [35S]GTP\u03b3S binding and phos-phoinositide hydrolysis in rat and monkey brain. Neuropharmacology 40: 826\u2013837.","journal-title":"Neuropharmacology"},{"key":"BF1300008_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s002130051128","volume":"147","author":"TJ Phillips","year":"1999","unstructured":"Phillips TJ, Hen R, Crabbe JC (1999). Complications associated with genetic background effects in research using knockout mice. Psychopharmacology (Berl) 147: 5\u20137.","journal-title":"Psychopharmacology (Berl)"},{"key":"BF1300008_CR24","first-page":"148","volume":"298","author":"RJ Ralph","year":"2001","unstructured":"Ralph RJ, Paulus MP, Geyer MA (2001). Strain-specific effects of amphetamine on prepulse inhibition and patterns of locomotor behavior in mice. J Pharmacol Exp Ther 298: 148\u2013155.","journal-title":"J Pharmacol Exp Ther"},{"key":"BF1300008_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0166-4328(99)00072-8","volume":"105","author":"DC Rogers","year":"1999","unstructured":"Rogers DC, Jones DN, Nelson PR, Jones CM, Quilter CA, Robinson TL et al (1999). Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains. Behav Brain Res 105: 207\u2013217.","journal-title":"Behav Brain Res"},{"key":"BF1300008_CR26","doi-asserted-by":"publisher","first-page":"11038","DOI":"10.1073\/pnas.97.20.11038","volume":"97","author":"R Sandberg","year":"2000","unstructured":"Sandberg R, Yasuda R, Pankratz DG, Carter TA, Del Rio JA, Wodicka L et al (2000). Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci USA 97: 11038\u201311043.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1300008_CR27","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1385\/1-59259-220-1:217","volume-title":"Gene Knockout Protocols","author":"LP Sanford","year":"2001","unstructured":"Sanford LP, Kallapur S, Ormsby I, Doetschman T (2001). Influence of genetic background on knockout mouse phenotypes. In: Tymms MJ, Kola I (eds). Gene Knockout Protocols. Humana Press Inc: Totowa, NJ, 217\u2013226."},{"key":"BF1300008_CR28","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1146\/annurev.pharmtox.39.1.313","volume":"39","author":"DR Sibley","year":"1999","unstructured":"Sibley DR (1999). New insights into dopaminergic receptor function using antisense and genetically altered animals. Annu Rev Pharmacol Toxicol 39: 313\u2013341.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"BF1300008_CR29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0306-4522(97)00608-8","volume":"86","author":"DR Smith","year":"1998","unstructured":"Smith DR, Striplin CD, Geller AM, Mailman RB, Drago J, Lawler CP et al (1998). Behavioural assessment of mice lacking D1A dopamine receptors. Neuroscience 86: 135\u2013146.","journal-title":"Neuroscience"},{"key":"BF1300008_CR30","first-page":"987","volume":"253","author":"AS Undie","year":"1990","unstructured":"Undie AS, Friedman E (1990). Stimulation of a dopamine D1 receptor enhances inositol phosphates formation in rat brain. J Pharmacol Exp Ther 253: 987\u2013992.","journal-title":"J Pharmacol Exp Ther"},{"key":"BF1300008_CR31","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1046\/j.1471-4159.1994.62052045.x","volume":"62","author":"AS Undie","year":"1994","unstructured":"Undie AS, Weinstock J, Sarau HM, Friedman E (1994). Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J Neurochem 62: 2045\u20132048.","journal-title":"J Neurochem"},{"key":"BF1300008_CR32","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/S0278-5846(01)00152-X","volume":"25","author":"JL Waddington","year":"2001","unstructured":"Waddington JL, Clifford JJ, McNamara FN, Tomiyama K, Koshikawa N, Croke DT (2001). The psychopharmacology-molecular biology interface: exploring the behavioural roles of dopamine receptor subtypes using targeted gene deletion (\u2018knockout\u2019). Prog Neuropsychopharmacol Biol Psychiatry 25: 925\u2013964.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BF1300008_CR33","first-page":"511","volume-title":"Dopamine Receptors and Transporters","author":"JL Waddington","year":"1994","unstructured":"Waddington JL, Daly SA, McCauley PG, O'Boyle KM (1994). Levels of functional interaction between D1-like and D2-like dopamine receptor systems. In: Niznik HB (ed). Dopamine Receptors and Transporters. Marcel Dekker: New York, 511\u2013537."},{"key":"BF1300008_CR34","first-page":"45","volume-title":"Dopamine Receptor Subtypes","author":"JL Waddington","year":"1998","unstructured":"Waddington JL, Deveney AM, Clifford J, Tighe O, Croke DT, Sibley DR et al (1998). D1-like dopamine receptors: regulation of psychomotor behaviour, D1-like:D2-like interactions and effects of D1A targeted gene deletion. In: Jenner P, Demirdamar R (eds). Dopamine Receptor Subtypes. IOS Press: Amsterdam, 45\u201353."},{"key":"BF1300008_CR35","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/0092-8674(94)90026-4","volume":"79","author":"M Xu","year":"1994","unstructured":"Xu M, Hu XT, Cooper DC, Moratalla R, Graybiel AM, White FJ et al (1994a). Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell 79: 945\u2013955.","journal-title":"Cell"},{"key":"BF1300008_CR36","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0092-8674(94)90557-6","volume":"79","author":"M Xu","year":"1994","unstructured":"Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM et al (1994b). Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79: 729\u2013742.","journal-title":"Cell"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/1300008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300008","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T07:43:50Z","timestamp":1684223030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1300008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,14]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["BF1300008"],"URL":"https:\/\/doi.org\/10.1038\/sj.npp.1300008","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,14]]}}}