{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:27:01Z","timestamp":1791282421449,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2003,6,10]],"date-time":"2003-06-10T00:00:00Z","timestamp":1055203200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1038\/sj.npp.1300264","type":"journal-article","created":{"date-parts":[[2003,7,30]],"date-time":"2003-07-30T12:58:17Z","timestamp":1059569897000},"page":"1882-1888","source":"Crossref","is-referenced-by-count":90,"title":["Olanzapine Reduces Craving for Alcohol: A DRD4 VNTR Polymorphism by Pharmacotherapy Interaction"],"prefix":"10.1038","volume":"28","author":[{"given":"Kent E","family":"Hutchison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wooden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M","family":"Swift","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Smolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McGeary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndee","family":"Paris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,6,10]]},"reference":[{"key":"BF1300264_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0165-0173(98)00019-8","volume":"28","author":"KC Berridge","year":"1998","unstructured":"Berridge KC, Robinson TE (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28: 309\u2013369.","journal-title":"Brain Res Brain Res Rev"},{"key":"BF1300264_CR2","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/j.1530-0277.1995.tb01554.x","volume":"19","author":"MJ Bohn","year":"1995","unstructured":"Bohn MJ, Krahn DD, Staehler BA (1995). Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcohol Clin Exp Res 19: 600\u2013606.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF1300264_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1037\/1064-1297.4.1.5","volume":"4","author":"H de Wit","year":"1996","unstructured":"de Wit H (1996). Priming effects with drugs and other reinforcers. Exp Clin Psychopharmacol 4: 5\u201310.","journal-title":"Exp Clin Psychopharmacol"},{"key":"BF1300264_CR4","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1111\/j.1530-0277.1996.tb01142.x","volume":"20","author":"FK Del Boca","year":"1996","unstructured":"Del Boca FK, Kranzler HR, Brown J, Korner PF (1996). Assessment of medication compliance in alcoholics through UV light detection of a riboflavin tracer. Alcohol Clin Exp Res 20: 1412\u20131417.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF1300264_CR5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1073\/pnas.012464099","volume":"99","author":"Y-C Ding","year":"2002","unstructured":"Ding Y-C, Chi H-C, Grady DL, Morishima A, Kidd JR, Kidd KK et al (2002). Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci 99: 309\u2013314.","journal-title":"Proc Natl Acad Sci"},{"key":"BF1300264_CR6","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/oxfordjournals.schbul.a033464","volume":"26","author":"RE Drake","year":"2000","unstructured":"Drake RE, Xie H, McHugo GJ, Green AI (2000). The effects of clozapine on alcohol and drug use disorders among patients with schizophrenia. Schizophr Bull 26: 441\u2013449.","journal-title":"Schizophr Bull"},{"key":"BF1300264_CR7","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1037\/1064-1297.8.3.264","volume":"8","author":"E Gordis","year":"2000","unstructured":"Gordis E (2000). Contributions of behavioral science to alcohol research: understanding who is at risk and why [In Process Citation]. Exp Clin Psychopharmacol 8: 264\u2013270.","journal-title":"Exp Clin Psychopharmacol"},{"key":"BF1300264_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3109\/10673229909017206","volume":"6","author":"AI Green","year":"1999","unstructured":"Green AI, Zimmet SV, Strous RD, Schildkraut JJ (1999). Clozapine for comorbid substance use disorder and schizophrenia: do patients with schizophrenia have a reward-deficiency syndrome that can be ameliorated by clozapine? Harvard Rev Psychiatry 6: 287\u2013296.","journal-title":"Harvard Rev Psychiatry"},{"key":"BF1300264_CR9","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1037\/0021-843X.111.1.134","volume":"111","author":"KE Hutchison","year":"2002","unstructured":"Hutchison KE, LaChance H, Niaura R, Bryan AD, Smolen A (2002a). The DRD4 VNTR poylmorphism influences reactivity to smoking cues. J Abnorm Psychol 111: 134\u2013143.","journal-title":"J Abnorm Psychol"},{"key":"BF1300264_CR10","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1037\/0278-6133.21.2.139","volume":"21","author":"KE Hutchison","year":"2002","unstructured":"Hutchison KE, McGeary J, Smolen A, Bryan AD, Swift RM (2002b). The DRD4 VNTR polymorphism moderates craving after alcohol consumption. Health Psychol 21: 139\u2013146.","journal-title":"Health Psychol"},{"key":"BF1300264_CR11","first-page":"66a","volume":"25","author":"KE Hutchison","year":"2001","unstructured":"Hutchison KE, McGeary J, Smolen A, Wooden A (2001). Craving after alcohol consumption: olanzapine and the DRD4 VNTR polymorphism. Alcoholism: Clin Exp Res 25: 66a.","journal-title":"Alcoholism: Clin Exp Res"},{"key":"BF1300264_CR12","doi-asserted-by":"crossref","unstructured":"Hutchison KE, Stallings M, McGeary J, Bryan A . Population stratification in the candidate gene study: fatal threat or red herring? Psychol Bull (in press).","DOI":"10.1037\/0033-2909.130.1.66"},{"key":"BF1300264_CR13","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1007\/s00213-002-1002-9","volume":"160","author":"BA Johnson","year":"2002","unstructured":"Johnson BA, Roache JD, Ait-Daoud N, Zanca NA, Velazquez M (2002). Ondansetron reduces the craving of biologically predisposed alcoholics. Psychopharmacology (Berl) 160: 408\u2013413.","journal-title":"Psychopharmacology (Berl)"},{"key":"BF1300264_CR14","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1176\/ajp.154.11.1525","volume":"154","author":"S Kapur","year":"1997","unstructured":"Kapur S, Zipursky RB, Jones C, Wilson AA, DaSilva JD, Houle S (1997). Cyproheptadine: a potent in vivo serotonin antagonist [letter]. Am J Psychiatry 154: 884.","journal-title":"Am J Psychiatry"},{"key":"BF1300264_CR15","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/S0140-6736(88)92178-2","volume":"1","author":"N Lench","year":"1988","unstructured":"Lench N, Stanier P, Williamson R (1988). Simple non-invasive method to obtain DNA for gene analysis. Lancet 1: 1356\u20131358.","journal-title":"Lancet"},{"key":"BF1300264_CR16","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/hmg\/2.6.767","volume":"2","author":"JB Lichter","year":"1993","unstructured":"Lichter JB, Barr CL, Kennedy JL, Van Tol HH, Kidd KK, Livak KJ (1993). A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 2: 767\u2013773.","journal-title":"Hum Mol Genet"},{"key":"BF1300264_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1530-0277.1993.tb00739.x","volume":"17","author":"CS Martin","year":"1993","unstructured":"Martin CS, Earleywine M, Musty RE, Perrine MW, Clinic PU, Swift RM (1993). Development and validation of the Biphasic Alcohol Effects Scale. Alcoholism: Clin Exp Res 17: 140\u2013146.","journal-title":"Alcoholism: Clin Exp Res"},{"key":"BF1300264_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1176\/jnp.7.1.15","volume":"7","author":"JG Modell","year":"1995","unstructured":"Modell JG, Mountz JM (1995). Focal cerebral blood flow change during craving for alcohol measured by SPECT. J Neuropsychiatry Clin Neurosci 7: 15\u201322.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"BF1300264_CR19","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1530-0277.1993.tb00755.x","volume":"17","author":"JG Modell","year":"1993","unstructured":"Modell JG, Mountz JM, Glaser FB, Lee JY (1993). Effect of haloperidol on measures of craving and impaired control in alcoholic subjects. Alcohol Clin Exp Res 17: 234\u2013240.","journal-title":"Alcohol Clin Exp Res"},{"key":"BF1300264_CR20","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","volume":"18","author":"TE Robinson","year":"1993","unstructured":"Robinson TE, Berridge KC (1993). The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18: 247\u2013291.","journal-title":"Brain Res Brain Res Rev"},{"key":"BF1300264_CR21","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/(SICI)1096-8628(19970919)74:5<483::AID-AJMG5>3.0.CO;2-P","volume":"74","author":"T Sander","year":"1997","unstructured":"Sander T, Harms H, Dufeu P, Kuhn S, Rommelspacher H, Schmidt LG (1997). Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics. Am J Med Genet 74: 483\u2013487.","journal-title":"Am J Med Genet"},{"key":"BF1300264_CR22","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1037\/0021-843X.91.3.199","volume":"91","author":"HA Skinner","year":"1982","unstructured":"Skinner HA, Allen BA (1982). Alcohol dependence syndrome: measurement and validation. J Abnorm Psychol 91: 199\u2013209.","journal-title":"J Abnorm Psychol"},{"key":"BF1300264_CR23","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/B978-0-08-022997-3.50015-6","volume-title":"Evaluating Alcohol and Drug Abuse Treatment Effectiveness: Recent Advances","author":"LC Sobell","year":"1980","unstructured":"Sobell LC, Sobell MB (1980). Convergent validity: an approach to increasing confidence in treatment outcome conclusions with alcohol and drug abusers. In: Sobell LC, Sobell MB, Ward E (eds) Evaluating Alcohol and Drug Abuse Treatment Effectiveness: Recent Advances pp 177\u2013183, Pergamon Press: New York."},{"key":"BF1300264_CR24","first-page":"207","volume":"23","author":"RM Swift","year":"1999","unstructured":"Swift RM (1999). Medications and alcohol craving. Alcohol Res Health 23: 207\u2013213.","journal-title":"Alcohol Res Health"},{"key":"BF1300264_CR25","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1176\/ajp.151.10.1463","volume":"151","author":"RM Swift","year":"1994","unstructured":"Swift RM, Whelihan W, Kuznetsov O, Buongiorno G, Hsuing H (1994). Naltrexone-induced alterations in human ethanol intoxication. Am J Psychiatry 151: 1463\u20131467.","journal-title":"Am J Psychiatry"},{"key":"BF1300264_CR26","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/jnci\/92.14.1151","volume":"92","author":"S Wacholder","year":"2000","unstructured":"Wacholder S, Rothman N, Caporaso N (2000). Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst 92: 1151\u20131158.","journal-title":"J Natl Cancer Inst"},{"key":"BF1300264_CR27","first-page":"41","volume-title":"Human Metabolism of Alcohol","author":"PE Watson","year":"1989","unstructured":"Watson PE (1989). Total body water and blood alcohol levels: updating the fundamentals. In: Crow KE, Batt RD (ed) Human Metabolism of Alcohol pp 41\u201356, CRC Press: Boca Raton, FL."},{"key":"BF1300264_CR28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1037\/0021-843X.97.2.118","volume":"97","author":"RA Wise","year":"1988","unstructured":"Wise RA (1988). The neurobiology of craving: implications for the understanding and treatment of addiction. J Abnorm Psychol 97: 118\u2013132.","journal-title":"J Abnorm Psychol"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/1300264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300264","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T06:44:44Z","timestamp":1684219484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1300264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["BF1300264"],"URL":"https:\/\/doi.org\/10.1038\/sj.npp.1300264","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,10]]}}}