{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:55:52Z","timestamp":1788494152535,"version":"build-2803163510"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,9,3]],"date-time":"2003-09-03T00:00:00Z","timestamp":1062547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1038\/sj.npp.1300302","type":"journal-article","created":{"date-parts":[[2003,9,3]],"date-time":"2003-09-03T18:35:53Z","timestamp":1062614153000},"page":"108-116","source":"Crossref","is-referenced-by-count":135,"title":["Nicotinic Acetylcholine Receptor Distribution in Alzheimer's Disease, Dementia with Lewy Bodies, Parkinson's Disease, and Vascular Dementia: In Vitro Binding Study Using 5-[125I]-A-85380"],"prefix":"10.1038","volume":"29","author":[{"given":"S L","family":"Pimlott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Piggott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Greally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Court","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Jaros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R H","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E K","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wyper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,9,3]]},"reference":[{"key":"BF1300302_CR1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/j.1471-4159.1992.tb09752.x","volume":"58","author":"I Aubert","year":"1992","unstructured":"Aubert I, Araujo DM, Cecyre D, Robitaille Y, Gauthier S, Quirion R (1992a). Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases. J Neurochem 58: 529\u2013541.","journal-title":"J Neurochem"},{"key":"BF1300302_CR2","first-page":"363","volume-title":"Effects on Biological Systems II.","author":"I Aubert","year":"1992","unstructured":"Aubert I, Cecyre D, Gauthier S, Quirion R (1992b). Autoradiographic distribution of nicotinic receptor sites labeled with [3H]cytisine in the human brain. In: Clarke PBS, Quik M, Adlkofer F, Thurau K (eds). Effects on Biological Systems II.. Birkhauser Verlag: Basal. pp 363\u2013369."},{"key":"BF1300302_CR3","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S1053-8100(02)00013-2","volume":"11","author":"CG Ballard","year":"2002","unstructured":"Ballard CG, Court JA, Piggott M, Johnson M, O'Brien J, McKeith I et al (2002). Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex. Conscious Cogn 11: 461\u2013474.","journal-title":"Conscious Cogn"},{"key":"BF1300302_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","volume":"82","author":"H Braak","year":"1991","unstructured":"Braak H, Braak E (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82: 239\u2013259.","journal-title":"Acta Neuropathol (Berl)"},{"key":"BF1300302_CR5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0169-328X(00)00031-0","volume":"76","author":"L Burghaus","year":"2000","unstructured":"Burghaus L, Schutz U, Krempel U, de Vos RA, Jansen Steur EN, Wevers A et al (2000). Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients. Brain Res Mol Brain Res 76: 385\u2013388.","journal-title":"Brain Res Mol Brain Res"},{"key":"BF1300302_CR6","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1523\/JNEUROSCI.22-04-01208.2002","volume":"22","author":"N Champtiaux","year":"2002","unstructured":"Champtiaux N, Han ZY, Bessis A, Rossi FM, Zoli M, Marubio L et al (2002). Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci 22: 1208\u20131217.","journal-title":"J Neurosci"},{"key":"BF1300302_CR7","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0006-3223(00)01116-1","volume":"49","author":"J Court","year":"2001","unstructured":"Court J, Martin-Ruiz C, Piggott M, Spurden D, Griffiths M, Perry E (2001). Nicotinic receptor abnormalities in Alzheimer's disease. Biol Psychiatry 49: 175\u2013184.","journal-title":"Biol Psychiatry"},{"key":"BF1300302_CR8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0165-3806(97)00052-7","volume":"101","author":"JA Court","year":"1997","unstructured":"Court JA, Lloyd S, Johnson M, Griffiths M, Birdsall NJ, Piggott MA et al (1997). Nicotinic and muscarinic cholinergic receptor binding in the human hippocampal formation during development and aging. Brain Res Dev Brain Res 101: 93\u2013105.","journal-title":"Brain Res Dev Brain Res"},{"key":"BF1300302_CR9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0306-4522(98)00088-8","volume":"87","author":"JA Court","year":"1998","unstructured":"Court JA, Lloyd S, Thomas N, Piggott MA, Marshall EF, Morris CM et al (1998). Dopamine and nicotinic receptor binding and the levels of dopamine and homovanillic acid in human brain related to tobacco use. Neuroscience 87: 63\u201378.","journal-title":"Neuroscience"},{"key":"BF1300302_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0891-0618(00)00110-1","volume":"20","author":"JA Court","year":"2000","unstructured":"Court JA, Martin-Ruiz C, Graham A, Perry E (2000a). Nicotinic receptors in human brain: topography and pathology. J Chem Neuroanat 20: 281\u2013298.","journal-title":"J Chem Neuroanat"},{"key":"BF1300302_CR11","first-page":"85","volume-title":"CNS Neurotransmitters and Neuromodulators","author":"JA Court","year":"1995","unstructured":"Court JA, Perry EK (1995a). Distribution of nicotinic receptors in the CNS. In: Stone TW (ed). CNS Neurotransmitters and Neuromodulators. CRC Press: London. pp 85\u2013104."},{"key":"BF1300302_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0165-3806(96)83496-1","volume":"90","author":"JA Court","year":"1995","unstructured":"Court JA, Perry EK, Spurden D, Griffiths M, Kerwin JM, Morris CM et al (1995b). The role of the cholinergic system in the development of the human cerebellum. Brain Res Dev Brain Res 90: 159\u2013167.","journal-title":"Brain Res Dev Brain Res"},{"key":"BF1300302_CR13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0306-4522(00)00071-3","volume":"98","author":"JA Court","year":"2000","unstructured":"Court JA, Piggott MA, Lloyd S, Cookson N, Ballard CG, McKeith IG et al (2000b). Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication. Neuroscience 98: 79\u201387.","journal-title":"Neuroscience"},{"key":"BF1300302_CR14","first-page":"67","volume":"39","author":"RB Cross","year":"1982","unstructured":"Cross RB (1982). Demonstration of neurofibrillary tangles in paraffin sections: a quick and simple method using a modification of Palmgren's method. Med Lab Sci 39: 67\u201369.","journal-title":"Med Lab Sci"},{"key":"BF1300302_CR15","first-page":"31","volume":"41","author":"CM Flores","year":"1992","unstructured":"Flores CM, Rogers SW, Pabreza LA, Wolfe BB, Kellar KJ (1992). A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol 41: 31\u201337.","journal-title":"Mol Pharmacol"},{"key":"BF1300302_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/cercor\/6.2.165","volume":"6","author":"C Geula","year":"1996","unstructured":"Geula C, Mesulam MM (1996). Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease. Cereb Cortex 6: 165\u2013177.","journal-title":"Cereb Cortex"},{"key":"BF1300302_CR17","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1046\/j.1471-4159.2001.00019.x","volume":"76","author":"SR Grady","year":"2001","unstructured":"Grady SR, Meinerz NM, Cao J, Reynolds AM, Picciotto MR, Changeux JP et al (2001). Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. J Neurochem 76: 258\u2013268.","journal-title":"J Neurochem"},{"key":"BF1300302_CR18","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0306-4522(02)00223-3","volume":"113","author":"A Graham","year":"2002","unstructured":"Graham A, Court JA, Martin-Ruiz CM, Jaros E, Perry R, Volsen SG et al (2002). Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum. Neuroscience 113: 493\u2013507.","journal-title":"Neuroscience"},{"key":"BF1300302_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1046\/j.1471-4159.2000.0740237.x","volume":"74","author":"ZZ Guan","year":"2000","unstructured":"Guan ZZ, Zhang X, Ravid R, Nordberg A (2000). Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J Neurochem 74: 237\u2013243.","journal-title":"J Neurochem"},{"key":"BF1300302_CR20","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0361-9230(97)00449-8","volume":"46","author":"JM Henderson","year":"1998","unstructured":"Henderson JM, Dunnett SB (1998). Targeting the subthalamic nucleus in the treatment of Parkinson's disease. Brain Res Bull 46: 467\u2013474.","journal-title":"Brain Res Bull"},{"key":"BF1300302_CR21","doi-asserted-by":"publisher","first-page":"4169","DOI":"10.1021\/jm970377o","volume":"40","author":"MW Holladay","year":"1997","unstructured":"Holladay MW, Dart MJ, Lynch JK (1997). Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J Med Chem 40: 4169\u20134194.","journal-title":"J Med Chem"},{"key":"BF1300302_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0969-8051(98)00086-9","volume":"26","author":"AG Horti","year":"1999","unstructured":"Horti AG, Koren AO, Lee KS, Mukhin AG, Vaupel DB, Kimes AS et al (1999). Radiosynthesis and preliminary evaluation of 5-[I-123\/125]iodo3-(2(S)-azetidinylmethoxy)pyridine: a radioligand for nicotinic acetylcholine receptors. Nucl Med Biol 26: 175\u2013182.","journal-title":"Nucl Med Biol"},{"key":"BF1300302_CR23","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1046\/j.1471-4159.2002.00868.x","volume":"81","author":"JM Kulak","year":"2002","unstructured":"Kulak JM, Sum J, Musachio JL, McIntosh JM, Quik M (2002). 5-Iodo-A-85380 binds to alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors (nAChRs) as well as alpha 4 beta 2*subtypes. J Neurochem 81: 403\u2013406.","journal-title":"J Neurochem"},{"key":"BF1300302_CR24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1471-4159.1993.tb05838.x","volume":"60","author":"KW Lange","year":"1993","unstructured":"Lange KW, Wells FR, Jenner P, Marsden CD (1993). Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease. J Neurochem 60: 197\u2013203.","journal-title":"J Neurochem"},{"key":"BF1300302_CR25","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1093\/brain\/awf160","volume":"125","author":"M Lee","year":"2002","unstructured":"Lee M, Martin-Ruiz C, Graham A, Court J, Jaros E, Perry R et al (2002). Nicotinic receptor abnormalities in the cerebellar cortex in autism. Brain 125: 1483\u20131495.","journal-title":"Brain"},{"key":"BF1300302_CR26","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/j.1749-6632.1995.tb17467.x","volume":"757","author":"J Lindstrom","year":"1995","unstructured":"Lindstrom J, Anand R, Peng X, Gerzanich V, Wang F, Li Y (1995). Neuronal nicotinic receptor subtypes. Ann NY Acad Sci 757: 100\u2013116.","journal-title":"Ann NY Acad Sci"},{"key":"BF1300302_CR27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1034\/j.1600-0404.2000.00305.x","volume":"176","author":"C Martin-Ruiz","year":"2000","unstructured":"Martin-Ruiz C, Court J, Lee M, Piggott M, Johnson M, Ballard C et al (2000). Nicotinic receptors in dementia of Alzheimer, Lewy body and vascular types. Acta Neurol Scand Suppl 176: 34\u201341.","journal-title":"Acta Neurol Scand Suppl"},{"key":"BF1300302_CR28","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1046\/j.1471-4159.1999.0731635.x","volume":"73","author":"CM Martin-Ruiz","year":"1999","unstructured":"Martin-Ruiz CM, Court J, Molnar E, Lee M, Gotti C, Mamalaki A et al (1999). Alpha 4 but not alpha 3 and alpha 7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer' s disease. J Neurochem 73: 1635\u20131640.","journal-title":"J Neurochem"},{"key":"BF1300302_CR29","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/19756","volume":"398","author":"LM Marubio","year":"1999","unstructured":"Marubio LM, Mar Arroyo-Jimenez M, Cordero-Erausquin M, Lena C, Le Novere N, de Kerchove dA et al (1999). Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature 398: 805\u2013810.","journal-title":"Nature"},{"key":"BF1300302_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0006-8993(98)00558-7","volume":"801","author":"A Marutle","year":"1998","unstructured":"Marutle A, Warpman U, Bogdanovic N, Nordberg A (1998). Regional distribution of subtypes of nicotinic receptors in human brain and effect of aging studied by (+\/\u2212)-[H-3]epibatidine. Brain Res 801: 143\u2013149.","journal-title":"Brain Res"},{"key":"BF1300302_CR31","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","volume":"47","author":"IG McKeith","year":"1996","unstructured":"McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA et al (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47: 1113\u20131124.","journal-title":"Neurology"},{"key":"BF1300302_CR32","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1124\/mol.57.3.642","volume":"57","author":"AG Mukhin","year":"2000","unstructured":"Mukhin AG, Gundisch D, Horti AG, Koren AO, Tamagnan G, Kimes AS et al (2000). 5-Iodo-A-85380, an alpha 4 beta 2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57: 642\u2013649.","journal-title":"Mol Pharmacol"},{"key":"BF1300302_CR33","doi-asserted-by":"publisher","first-page":"L351","DOI":"10.1016\/S0024-3205(98)00180-5","volume":"62","author":"JL Musachio","year":"1998","unstructured":"Musachio JL, Scheffel U, Finley PA, Zhan YG, Mochizuki T, Wagner HN et al (1998). 5-[I-125\/123]iodo-3(2(S)-azetidinylmethoxy)pyridine, a radioiodinated analog of A-85380 for in vivo studies of central nicotinic acetylcholine receptors. Life Sci 62: L351\u2013L357.","journal-title":"Life Sci"},{"key":"BF1300302_CR34","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1016\/S0042-6989(97)00076-X","volume":"37","author":"L Nobili","year":"1997","unstructured":"Nobili L, Sannita WG (1997). Cholinergic modulation, visual function and Alzheimer's dementia. Vis Res 37: 3559\u20133571.","journal-title":"Vis Res"},{"key":"BF1300302_CR35","first-page":"9","volume":"39","author":"LA Pabreza","year":"1991","unstructured":"Pabreza LA, Dhawan S, Kellar KJ (1991). [3H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol 39: 9\u201312.","journal-title":"Mol Pharmacol"},{"key":"BF1300302_CR36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0301-0082(99)00045-3","volume":"61","author":"D Paterson","year":"2000","unstructured":"Paterson D, Nordberg A (2000). Neuronal nicotinic receptors in the human brain. Prog Neurobiol 61: 75\u2013111.","journal-title":"Prog Neurobiol"},{"key":"BF1300302_CR37","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/00002093-199307020-00002","volume":"7","author":"EK Perry","year":"1993","unstructured":"Perry EK, Irving D, Kerwin JM, McKeith IG, Thompson P, Collerton D et al (1993). Cholinergic transmitter and neurotrophic activities in Lewy body dementia: similarity to Parkinson's and distinction from Alzheimer disease. Alzheimer Dis Assoc Disord 7: 69\u201379.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"BF1300302_CR38","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/0306-4522(94)00410-7","volume":"64","author":"EK Perry","year":"1995","unstructured":"Perry EK, Morris CM, Court JA, Cheng A, Fairbairn AF, McKeith IG et al (1995). Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: possible index of early neuropathology. Neuroscience 64: 385\u2013395.","journal-title":"Neuroscience"},{"key":"BF1300302_CR39","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/BF02257646","volume":"2","author":"EK Perry","year":"1990","unstructured":"Perry EK, Smith CJ, Court JA, Perry RH (1990a). Cholinergic nicotinic and muscarinic receptors in dementia of Alzheimer, Parkinson and Lewy body types. J Neural Transm Park Dis Dement Sect 2: 149\u2013158.","journal-title":"J Neural Transm Park Dis Dement Sect"},{"key":"BF1300302_CR40","first-page":"117","volume":"5","author":"EK Perry","year":"1989","unstructured":"Perry EK, Smith CJ, Perry RH, Johnson M, Fairbairn AF (1989). Nicotine [3H]-nicotine receptor binding in human brain: characterization and involvement in cholinergic neuropathlogy. Neurosci Res Commun 5: 117\u2013124.","journal-title":"Neurosci Res Commun"},{"key":"BF1300302_CR41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0022-510X(90)90236-G","volume":"95","author":"RH Perry","year":"1990","unstructured":"Perry RH, Irving D, Blessed G, Fairbairn A, Perry EK (1990b). Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J Neurol Sci 95: 119\u2013139.","journal-title":"J Neurol Sci"},{"key":"BF1300302_CR42","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/374065a0","volume":"374","author":"MR Picciotto","year":"1995","unstructured":"Picciotto MR, Zoli M, Lena C, Bessis A, Lallemand Y, LeNovere N et al (1995). Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 374: 65\u201367.","journal-title":"Nature"},{"key":"BF1300302_CR43","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1093\/brain\/122.8.1449","volume":"122","author":"MA Piggott","year":"1999","unstructured":"Piggott MA, Marshall EF, Thomas N, Lloyd S, Court JA, Jaros E et al (1999). Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution. Brain 122(Part 8): 1449\u20131468.","journal-title":"Brain"},{"key":"BF1300302_CR44","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0891-0618(03)00002-4","volume":"25","author":"MA Piggott","year":"2003","unstructured":"Piggott MA, Owens J, O'Brien J, Colloby S, Fenwick J, Wyper D et al (2003). Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease. J Chem Neuroanat 25: 161\u2013173.","journal-title":"J Chem Neuroanat"},{"key":"BF1300302_CR45","volume-title":"2002 Abstract Viewer\/Itinerary Planner","author":"M Quik","year":"2002","unstructured":"Quik M, Okihara M, Forno L, Musachio JL (2002). The in vivo imaging ligand iodo-A-85380 and radiolabeled epibatidine bind to similar nicotinic receptor sites in human control and Parkinson disease brains in vitro, programme no. 887.12. 2002 Abstract Viewer\/Itinerary Planner. Society for Neuroscience: Washington, DC. Online."},{"key":"BF1300302_CR46","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0006-8993(91)90588-M","volume":"547","author":"JO Rinne","year":"1991","unstructured":"Rinne JO, Myllykyla T, Lonnberg P, Marjamaki P (1991). A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease. Brain Res 547: 167\u2013170.","journal-title":"Brain Res"},{"key":"BF1300302_CR47","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1093\/brain\/121.12.2249","volume":"121","author":"NR Selden","year":"1998","unstructured":"Selden NR, Gitelman DR, Salamon-Murayama N, Parrish TB, Mesulam MM (1998). Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain 121: 2249\u20132257.","journal-title":"Brain"},{"key":"BF1300302_CR48","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1471-4159.1986.tb12960.x","volume":"46","author":"S Shimohama","year":"1986","unstructured":"Shimohama S, Taniguchi T, Fujiwara M, Kameyama M (1986). Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia. J Neurochem 46: 288\u2013293.","journal-title":"J Neurochem"},{"key":"BF1300302_CR49","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/S0306-4522(97)00652-0","volume":"85","author":"W Sihver","year":"1998","unstructured":"Sihver W, Gillberg PG, Nordberg A (1998). Laminar distribution of nicotinic receptor subtypes in human cerebral cortex as determined by [H-3](\u2212)nicotine, [H-3]cytisine and [H-3]epibatidine in vitro autoradiography. Neuroscience 85: 1121\u20131133.","journal-title":"Neuroscience"},{"key":"BF1300302_CR50","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0891-0618(97)00038-0","volume":"13","author":"DP Spurden","year":"1997","unstructured":"Spurden DP, Court JA, Lloyd S, Oakley A, Perry R, Pearson C et al (1997). Nicotinic receptor distribution in the human thalamus: autoradiographical localization of [3H]nicotine and [125I] alpha-bungarotoxin binding. J Chem Neuroanat 13: 105\u2013113.","journal-title":"J Chem Neuroanat"},{"key":"BF1300302_CR51","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1097\/00001756-199511270-00033","volume":"6","author":"U Warpman","year":"1995","unstructured":"Warpman U, Nordberg A (1995). Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains. Neuroreport 6: 2419\u20132423.","journal-title":"Neuroreport"},{"key":"BF1300302_CR52","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1046\/j.1460-9568.1999.00676.x","volume":"11","author":"A Wevers","year":"1999","unstructured":"Wevers A, Monteggia L, Nowacki S, Bloch W, Schutz U, Lindstrom J et al (1999). Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein. Eur J Neurosci 11: 2551\u20132565.","journal-title":"Eur J Neurosci"},{"key":"BF1300302_CR53","first-page":"913","volume":"57","author":"P Whiteaker","year":"2000","unstructured":"Whiteaker P, McIntosh JM, Luo S, Collins AC, Marks MJ (2000). 125I-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain. Mol Pharmacol 57: 913\u2013925.","journal-title":"Mol Pharmacol"},{"key":"BF1300302_CR54","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1212\/WNL.38.5.720","volume":"38","author":"PJ Whitehouse","year":"1988","unstructured":"Whitehouse PJ, Martino AM, Wagster MV, Price DL, Mayeux R, Atack JR et al (1988). Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study. Neurology 38: 720\u2013723.","journal-title":"Neurology"},{"key":"BF1300302_CR55","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0166-2236(96)10073-4","volume":"20","author":"S Wonnacott","year":"1997","unstructured":"Wonnacott S (1997). Presynaptic nicotinic ACh receptors. Trends Neurosci 20: 92\u201398.","journal-title":"Trends Neurosci"},{"key":"BF1300302_CR56","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0022-510X(90)90155-G","volume":"99","author":"JH Xuereb","year":"1990","unstructured":"Xuereb JH, Perry EK, Candy JM, Bonham JR, Perry RH, Marshall E (1990). Parameters of cholinergic neurotransmission in the thalamus in Parkinson's disease and Alzheimer's disease. J Neurol Sci 99: 185\u2013197.","journal-title":"J Neurol Sci"},{"key":"BF1300302_CR57","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0969-8051(00)00188-8","volume":"28","author":"SS Zoghbi","year":"2001","unstructured":"Zoghbi SS, Tamagnan G, Baldwin MF, Al Tikriti MS, Amici L, Seibyl JP et al (2001). Measurement of plasma metabolites of (S)-5-[123I]iodo-3-(2azetidinylmethoxy)pyridine (5-IA-85380), a nicotinic acetylcholine receptor imaging agent, in nonhuman primates. Nucl Med Biol 28: 91\u201396.","journal-title":"Nucl Med Biol"},{"key":"BF1300302_CR58","doi-asserted-by":"publisher","first-page":"4461","DOI":"10.1523\/JNEUROSCI.18-12-04461.1998","volume":"18","author":"M Zoli","year":"1998","unstructured":"Zoli M, Lena C, Picciotto MR, Changeux JP (1998). Identification of four classes of brain nicotinic receptors using beta2 mutant mice. J Neurosci 18: 4461\u20134472.","journal-title":"J Neurosci"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/1300302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300302","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T06:45:01Z","timestamp":1684219501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1300302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,3]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["BF1300302"],"URL":"https:\/\/doi.org\/10.1038\/sj.npp.1300302","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,3]]}}}